Phenylpropanoids and polyketides
Medchemexpress LLC Naringenin chalcone | 73692-50-9 | MFCD00016762 | 100 MG
Naringenin chalcone is an orally active intermediate in flavonol biosynthesis. It induces apoptosis and inhibits the production of MCP-1 and NO. This compound exhibits anticancer activity against glioblastoma and possesses anti-inflammatory and anti-allergic properties. Intended for research use only.
- Induces apoptosis in glioblastoma cells.
- Inhibits production of MCP-1, TNF-α, and NO in macrophages.
- Increases adiponectin mRNA levels and protein secretion in adipocytes.
- Reduces eosinophilic airway inflammation and airway hyperresponsiveness.
- Suppresses Th2 cytokine production and reduces mucus overproduction.
- Reduces tumor volume and weight in glioblastoma xenograft models.
- Increases plasma adiponectin levels in diabetic mice.
- Inhibits anaphylactic response to IgE-mediated passive cutaneous anaphylaxis.
eMolecules 492-14-8 | Medchem Express | (-)-Butin | 1mg | 705861649 | HY-N6020 | MFCD21606964 | 272.256 | C15H12O5
Medchem Express | Maxacalcitol-d6 | 1mg | 446265465 | HY-15329 | | MFCD22417101 | 424.655 | C26H42O4
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eMolecules 36651-81-7 | 5-Methyl-8-hydroxycoumarin | Synthonix - Stock | MFCD18450566 | 176.171 | C10H8O3 | 95.000 | Cc1ccc(O)c2oc(=O)ccc12 | 1g | 495880208
5-Methyl-8-hydroxycoumarin | Synthonix - Stock | 36651-81-7 | MFCD18450566 | 176.171 | C10H8O3 | 95.000 | Cc1ccc(O)c2oc(=O)ccc12 | 1g | 495880208
Medchemexpress LLC (E)-Naringenin chalcone | 25515-46-2 | 5 MG
(E)-Naringenin chalcone is an orally active anti-allergic agent. It also possesses antioxidant and anti-inflammatory activities, and can improve adipocyte functions. It inhibits histamine release from rat peritoneal mast cells.
- Anti-allergic agent: Inhibits histamine release from mast cells and reduces ear-swelling in allergic mice.
- Antioxidant activity: Demonstrated antioxidant properties.
- Anti-inflammatory activity: Inhibits production of TNF-alpha, MCP-1, and nitric oxide by LPS-stimulated macrophages.
- Adipocyte function improvement: Enhances adiponectin production and stimulates PPARγ activity.
- High purity: 98.87%.
- Appearance: Solid, light yellow to yellow.
- Molecular weight: 272.26.
- Chemical formula: C15H12O5.
- Initial source: Plants (Solanaceae, *Solanum lycopersicum L.*).
Medchemexpress LLC Myricetin-3-O-rutinoside | 41093-68-9 | 25 MG
Myricetin-3-O-rutinoside is a natural product isolated from Picea abies. It has demonstrated antineuroinflammatory activity in human BV2 cells by inhibiting LPS-induced NO production after 24 hours, with an IC50 of 74.74 μM.
- Natural product
- Isolated from Picea abies
- Light yellow to yellow solid appearance
- Molecular weight: 626.52
- Formula: C27H30O17
- Purity: 96.98%
- Soluble in ethanol (25 mg/mL)
- For research use only
- Exhibits antineuroinflammatory activity
Medchemexpress LLC 3,6-Dihydroxyflavone | 108238-41-1 | 25 MG
3,6-Dihydroxyflavone is an anti-cancer agent that decreases cell viability and induces apoptosis. It works by activating the caspase cascade and cleaving poly (ADP-ribose) polymerase (PARP). Additionally, it increases intracellular oxidative stress and lipid peroxidation.
- Decreases cell viability and induces apoptosis
- Activates caspase cascade
- Cleaves poly (ADP-ribose) polymerase (PARP)
- Increases intracellular oxidative stress
- Increases lipid peroxidation
- Appears as a light yellow to light brown solid
- Has a molecular weight of 254.24
- Chemical formula is C15H10O4
- Purity is 98.06%
- Soluble in DMSO at 66.67 mg/mL
Apexbio Technology LLC Sodium ferulic 24276-84-4 500mg
Sodium ferulic (CAS 24276-84-4) is a small molecule inhibitor targeting fibroblast growth factor receptors specifically FGFR1 and FGFR2 It demonstrates inhibitory activity with IC50 values of 3 78 M for FGFR1 and 12 5 M for FGFR2 At the cellular level sodium ferulic suppresses intracellular signaling pathways involved in cell proliferation This compound is utilized in biomedical research to investigate signaling mechanisms and to assess therapeutic potential in disease models such as cancer
Medchemexpress LLC Chrysin-7-O-glucuronide | 35775-49-6 | 1 ML
Chrysin-7-O-glucuronide is a flavonoid extracted from *Scutellaria baicalensis*, possessing antioxidant activity. It inhibits α-glucosidase and α-amylase, suppresses NF-κB signaling activity, scavenges free radicals, acts as a tight junction protector, and mitigates intestinal mucosal barrier injury. This compound is suitable for research related to type 2 diabetes and severe acute pancreatitis-induced intestinal barrier injury.
- Inhibits alpha-glucosidase and alpha-amylase
- Suppresses NF-κB signaling activity
- Scavenges free radicals
- Acts as a tight junction protector
- Mitigates intestinal mucosal barrier injury
- Restores ZO-1 expression and tight junction structure
- Ameliorates SAP-induced intestinal mucosal barrier injury in rats
Medchemexpress LLC 4-Hydroxycoumarin | 1076-38-6 | MFCD00006856 | 500 G
4-Hydroxycoumarin is an orally active coumarin derivative and a versatile heterocyclic scaffold, utilized in the synthesis of various organic compounds. It possesses both electrophilic and nucleophilic properties.
- Orally active coumarin derivative
- Versatile heterocyclic scaffold for organic synthesis
- Possesses both electrophilic and nucleophilic properties
- Functions as an HIV protease inhibitor
- Acts as a tyrosine kinase inhibitor
- Exhibits anti-inflammatory effects
- Exhibits antibacterial effects
- Exhibits anti-tumor effects
TARGETMOL CHEMICALS INC Catechin Hydrate 1G
Also available in 1 mL, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. (+)-Catechin Hydrate is an antioxidant flavonoid of plant origin; a free radical scavenger, preventing free radical-mediated damage in a variety of biological systems. Purity 99.03%
Apexbio Technology LLC 7,3＇,4＇-Trihydroxyflavone 2150-11-0 5mg
73p4p-Trihydroxyflavone is a small-molecule inhibitor targeting cyclooxygenase-1 (COX-1) and pathways involved in osteoclastogenesis It is designed to inhibit oxidative radical formation and osteoclast differentiation thereby regulating inflammatory and bone resorption pathways 73p4p-Trihydroxyflavone exerts its biological activity primarily through free radical scavenging and downregulation of osteoclast marker genes In in vitro studies 73p4p-Trihydroxyflavone demonstrates inhibition of reactive oxygen species in rat kidney tissue homogenates and suppresses RANKL-induced osteoclastogenesis in mouse bone marrow-derived macrophages Based on these pharmacological properties 73p4p-Trihydroxyflavone holds research potential in biochemical pharmacological antimicrobial and bone metabolism studies
Medchemexpress LLC Naringenin chalcone | 73692-50-9 | 1 MG
Naringenin chalcone is an orally active intermediate in flavonol biosynthesis.