Diterpenoids
Medchemexpress LLC Topoisomerase IIα-in-8 | 1251578-67-2 | 314.32 | C15H15FN6O | 1 MG
Topoisomerase IIα-IN-8 is a research-grade small-molecule inhibitor of human DNA topoisomerase IIα reported as a weak inhibitor (IC50 = 462 ± 38.0 μM). It is supplied as a powder for laboratory use, has molecular formula C15H15FN6O and molecular weight 314.32 g·mol-1, and is provided with downloadable product and safety documentation. For research use only.
- Weak inhibitor of human DNA topoisomerase IIα (IC50 = 462 ± 38.0 μM).
- Shows limited antiproliferative activity (GI50 > 100 μM in HEK293 and HT-29 cells).
- Supplied as a powder with specified storage recommendations for powder and solutions.
- Molecular formula C15H15FN6O; molecular weight 314.32 g·mol-1.
- Datasheet and safety data sheet available for handling and purity details.
Medchemexpress LLC Paclitaxel-2′-succinate NHS ester | 245110-80-9 | 98.8% | 1051.05 | 1 MG
Paclitaxel-2′-succinate NHS ester is a derivative of paclitaxel that features a succinic acid linker, with the carboxyl group activated by an NHS ester. The NHS ester group demonstrates high reactivity with amino or hydroxyl groups.
- Suitable for conjugation with various molecules, including peptides, proteins, antibodies, enzymes, or polymers.
- Intended for use in the development of nanomedicines.
- Used in cancer therapy research.
eMolecules 54706-99-9 | Medchem Express | 20-Deoxyingenol | 5mg | 446275477 | HY-N0866 | MFCD30207875 | 332.44 | C20H28O4
Medchem Express | 20-Deoxyingenol | 5mg | 446275477 | HY-N0866 | 54706-99-9 | MFCD30207875 | 332.440 | C20H28O4
Medchemexpress LLC HY-N0134 5mg Medchemexpress, Tanshinone I CAS:568-73-0 Purity:>98%
Medchemexpress, HY-N0134 5mg Tanshinone I CAS:568-73-0 Tanshinone I is an inhibitor of type IIA human recombinant sPLA 2 ( IC 50 =11 μM) and rabbit recombinant cPLA 2 ( IC 50 =82 μM). Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
AdipoGen (+)-Aphidicolin,Chemical. CAS: 38966-21-1
(+)-Aphidicolin, AdipoGen Life Sciences. Chemical. CAS: 38966-21-1. Formula: C20H34O4. MW: 338.5. Isolated from Phoma sp. BS 7210. Phytotoxin. Antibiotic. Antiviral and antineoplastic agent. Antileishmanial agent. Reversible inhibitor of eukaryotic nuclear DNA replication. Useful for cell synchronization. Blocks the cell cycle at G1/S phase. Prolongs the half life of DNA methyltransferase. DNA methylation/demethylation modulator. Specific DNA polymerase alpha and delta inhibitor in eukaryotic cells and in some viruses of animal origin. Acts synergistically with vincristine and doxorubicin. Apoptosis inhibitor/inducer.
Cayman Chemical 10-acetyl Docetaxel 50mg
A derivative of paclitaxel and an inhibitor of microtubule depolymerization; inhibits calcium-induced depolymerization of calf brain MTP in a cell-free assay at 20 µM; cytotoxic to J774.2 cells (EC50 = 0.05 µM)
Selleck Chemical LLC 10-deacetyl-paclitaxel S3933-5mg
10-deacetyl-paclitaxel (10-DAT Deacetyl Paclitaxel) is a semi-synthetic precursor of Paclitaxel
TARGETMOL CHEMICALS INC Docetaxel 500MG
Also available in 1 g, 1 mL, 25 mg, 50 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes. Docetaxel (RP-56976), a semi-synthetic analog of paclitaxel, is a microtubule depolymerization inhibitor (IC50=0.2 uM) that attenuates the effects of bcl-2 and bcl-xL gene expression and exhibits apoptosis-inducing, anti-tumor activity. Purity 99.1%
Medchemexpress LLC Docetaxel | 114977-28-5 | 99.9% | C43H53NO14 | 1 ML
Docetaxel is a microtubule depolymerization inhibitor with an IC50 of 0.2 μM. It attenuates the effects of bcl-2 and bcl-xL gene expression, leading to cell cycle arrest at G2/M and subsequent apoptosis. This compound demonstrates anti-cancer activity.
- Microtubule depolymerization inhibitor
- Attenuates effects of bcl-2 and bcl-xL gene expression
- Arrests cell cycle at G2/M
- Leads to cell apoptosis
- Demonstrates anti-cancer activity
Medchemexpress LLC Docetaxel (standard) | 114977-28-5 | 99.9% | C43H53NO14 | 100 MG
Docetaxel (standard) is an analytical standard of Docetaxel, developed for research and analytical applications. It functions as a microtubule depolymerization inhibitor and attenuates the effects of bcl-2 and bcl-xL gene expression. This compound arrests the cell cycle at G2/M and induces cell apoptosis, demonstrating anti-cancer activity.
- Acts as a microtubule depolymerization inhibitor
- Attenuates bcl-2 and bcl-xL gene expression
- Arrests cell cycle at G2/M
- Induces cell apoptosis
- Utilized in qualitative, quantitative, and methodological research experiments (e.g., HPLC, GC, MS)
- Appears as a white to off-white solid
Cayman Chemical -AphIdIcolIn 25mg
A natural tetracyclic diterpene with antiviral activity against herpes simplex; a cell-permeable, reversible inhibitor of DNA replication in eukaryotic cells, specifically blocking the activity of DNA polymerases α, δ, and ε when used at low micromolar levels.
Selleck Chemical LLC Docetaxel S1148-1g
Docetaxel an analog of paclitaxel is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules
eMolecules 568-73-0 | Tanshinone i | MFCD00210563 | 1g
Combi-Blocks, Inc. | Tanshinone i | 1g | 603145422 | QC-9410 | 95.000 | 568-73-0 | MFCD00210563 | 276.291 | C18H12O3
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool<|a>