Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Vu0364572 TFA | 1240514-89-9 | MFCD31618417 | 99.3% | 487.51 g/mol | C23H32F3N3O5 | 5 MG
VU0364572 TFA is the trifluoroacetate salt of a selective M1 muscarinic receptor agonist intended for use in in vitro and in vivo pharmacology research. It is supplied as a high-purity solid powder for laboratory research applications.
- High purity (99.3%) suitable for research use.
- Trifluoroacetate salt form to aid solubility and handling.
- Solid powder form for convenient weighing and formulation.
- Available in small pack sizes appropriate for discovery and preclinical studies.
- Recommended sealed storage away from moisture and light; follow solvent storage guidelines for long-term stability.
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid ReagentPlus(R), 99% | 76-05-1 | MFCD00004169 | 2L
Trifluoroacetic acid ReagentPlus(R), 99% | Purity: 99% | Mol Wt: 114.02 | 76-05-1 | MFCD00004169 | 2L
Supply Solutions Trifluoroacetic acid | 76-05-1 | 114.02 g/mol | 10x1ml
Trifluoroacetic acid | 76-05-1 | 114.02 g/mol | 10x1ml
Medchemexpress LLC Qtx125 tfa | 2989537-78-0 | 99.9% | 25 MG
QTX125 TFA is the trifluoroacetate salt of QTX125, a potent and highly selective HDAC6 inhibitor with reported antitumor activity. It is supplied as a high-purity off-white to gray solid for biochemical and cell-based research.
- Potent, selective inhibition of HDAC6.
- High purity (99.9%) suitable for research applications.
- Available in 25 MG solid packs for laboratory use.
- Stable when stored sealed away from moisture; recommended storage at 4°C, with longer-term solvent storage at -80°C.
- Applicable to biochemical assays and cell-based antitumor studies.
Medchemexpress LLC Lys-bradykinin trifluoroacetate | 99.9% | 1188.4 g/mol | C56H85N17O12 · x C2HF3O2 | 5 MG
Lys-bradykinin trifluoroacetate is the trifluoroacetic acid (TFA) salt form of the peptide Lys-Bradykinin (kallidin 380-389). It is supplied as a purified powder for research applications where it serves as a ligand for kallidin and bradykinin receptors. Reported purity is 99.85% and the free-base molecular weight is 1188.38 g/mol.
- TFA salt of Lys-Bradykinin peptide.
- High purity (99.85%).
- Provided as a solid powder suitable for dissolution in common solvents.
- Recommended storage: sealed, protected from moisture and light; powder stable at -80°C for up to 2 years.
- Intended for research use as a ligand in receptor binding or signaling studies.