Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Larllt tfa | 99.9% | 799.88 | 25 MG
LARLLT TFA is an EGFR-binding peptide with potential for research into EGFR overexpressing cancers. This peptide is suitable for studies involving lung, ovarian, and colorectal cancer.
- EGFR-binding peptide
- Potential for research into EGFR overexpressing cancers
- Suitable for lung, ovarian, and colorectal cancer studies
Medchemexpress LLC NN1177 (TFA) | 98.7% | 4570.07 (free base) | 25 MG
NN1177 TFA is a long-acting GLP-1/glucagon receptor co-agonist. It induces dose-dependent body weight loss in diet-induced obese mice. This product is for research use only.
- Long-acting GLP-1/glucagon receptor co-agonist
- Induces dose-dependent body weight loss in diet-induced obese mice
- Reduces CYP3A4 mRNA expression and activity in human hepatocytes
- Improves glucose tolerance in diet-induced obese mice
- Reduces liver fat and inflammatory biomarkers in NASH model mice
Medchemexpress LLC Mambalgin 1 TFA | 95.72% | 6554.54 (free acid) | 500 UG
Mambalgin 1 TFA is a potent and selective inhibitor of ASIC1a. It exhibits IC50 values of 192 nM for human ASIC1a and 72 nM for ASIC1a/1b dimer, binding to closed/inactive channels. This compound demonstrates high selectivity for ASIC1a over a range of other channels including ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2, and Kv1.2. Research indicates its ability to increase the latency of withdrawal response in mouse tail-flick and paw-flick tests.
- Selective ASIC1a inhibitor
- Binds to closed/inactive channels
- Increases latency of withdrawal response in mouse tail-flick and paw-flick tests
Medchemexpress LLC Z-VRPR-FMK TFA | 1926163-57-6 | MFCD18782585 | 95.9% | 790.81 | 100 UG
Z-VRPR-FMK (TFA) (VRPR), a tetrapeptide, is a selective and irreversible MALT1 (Mucosa-associated lymphoid tissue lymphoma translocation protein 1) inhibitor. It can protect against influenza A virus (IAV) infection.
- Selective and irreversible MALT1 inhibitor
- Tetrapeptide
- Protects against influenza A virus (IAV) infection
Medchemexpress LLC CGGRGD TFA | 98.7% | 677.61 | 5 MG
CGGRGD TFA is a derivative of RGD (Arginine-Glycine-Aspartic acid) that includes cysteine at its N-terminal. This product is intended for research applications only and not for human use. It is referenced in publications regarding the functionalization of PCL fibrous membranes with RGD peptide.
- Biological activity: a derivative of RGD with cysteine at its N-terminal
- Purity: 98.66%
- Molecular weight: 677.61
- Formula: C21H34F3N9O11S
- Appearance: solid
- Color: white to off-white
- Sequence: Cys-Gly-Gly-Arg-Gly-Asp
- Sequence shortening: CGGRGD
- Solubility in vitro: soluble in DMSO at 100 mg/mL (147.58 mM); ultrasonic assistance may be needed, and newly opened DMSO is recommended due to hygroscopic impact on solubility
Medchemexpress LLC CCZ01048 TFA | 98.5% | 1622.75 | 1 MG
CCZ01048 TFA is an α-MSH analogue that demonstrates high binding affinity to melanocortin 1 receptor (MC1R) with a Ki of 0.31 nM. It rapidly internalizes into B16F10 melanoma cells and exhibits high in vivo stability, making it a promising candidate for PET imaging of malignant melanoma. The cationic Pip linker used in CCZ01048 improves tumor uptake and generates high tumor-to-normal tissue contrast in PET imaging within a preclinical melanoma model.
- Exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a Ki of 0.31 nM
- Rapid internalization into B16F10 melanoma cells
- Shows high in vivo stability
- Promising candidate for PET imaging of malignant melanoma
- Cationic Pip linker improves tumor uptake
- Generates high tumor-to-normal tissue contrast with PET imaging in a preclinical melanoma model
Medchemexpress LLC G7-18NATE TFA | 98.1% | 1417.50 | 1 MG
G7-18NATE TFA is a peptide inhibitor of Grb7. It binds to the Grb7-SH2 domain with micromolar affinity (Kd = 18.1 μM). G7-18NATE TFA inhibits cell proliferation, motility, cell invasion, and 3D culture formation in several cancer cell lines.
- Peptide inhibitor of Grb7
- Binds to the Grb7-SH2 domain with micromolar affinity (Kd = 18.1 μM)
- Inhibits cell proliferation, motility, cell invasion, and 3D culture formation in several cancer cell lines
Medchemexpress LLC Ribupatide (TFA) | 2940971-65-1 | >91.6% | 4907.523 | 25 MG
Ribupatide (TFA) is a dual gastric inhibitory polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) receptor agonist, suitable for various laboratory research applications. This synthetic peptide is often studied in antidiabetic research and related metabolic disease areas.
- Dual GIP/GLP-1 receptor agonist
- Ideal for antidiabetic research
- High purity for reliable results
- Synthetic peptide for consistent quality
- Suitable for various laboratory applications
Medchemexpress LLC MIP-1095 (TFA) | 99.8% | 678.35 | 25 MG
MIP-1095 TFA (RPS-001 TFA) is a potent inhibitor of PSMA, demonstrating good biodistribution and efficient targeting of tumor lesions. It is utilized as an imaging probe to identify and monitor tumor progression, particularly when isotopically labeled with 131I. This labeling results in 131I-MIP-1095 showing higher renal uptake in mice.
- Potent inhibitor of PSMA
- Good biodistribution
- Efficient targeting of tumor lesions
- Can be isotopically labeled as an imaging probe
- Higher renal uptake in mice when labeled with 131I
- Used as an imaging probe to indicate tumor progression
Medchemexpress LLC LAGIPRA peptide (TFA) | 98.2% | 5756.50 (free base) | 5 MG
LAGIPRA peptide TFA is a long-acting GIP1R agonist that enhances insulin sensitivity by augmenting glucose disposal. It also reduces branched-chain amino acids (BCAAs) and ketoacids, making it a potential subject for research into type 2 diabetes.
- Long-acting GIP1R agonist
- Enhances insulin sensitivity by augmenting glucose disposal
- Reduces branched-chain amino acids (BCAAs) and ketoacids
- Potential for research into type 2 diabetes
Medchemexpress LLC DV1 TFA | 98.53% | 2424.85 | 25 MG
DV1 TFA is a selective antagonist for CXC chemokine receptor 4 (CXCR4). It exhibits antiviral activity by blocking HIV-1 entry through the CXCR4 co-receptor, making it suitable for research applications.
- Selective antagonist for CXC chemokine receptor 4 (CXCR4)
- Exhibits antiviral activity
- Blocks HIV-1 entry
Medchemexpress LLC Cys-TAT(47-57) TFA | 98.1% | 1661.99 | 10 MG
Cys-TAT(47-57) (Cys-[HIV-Tat (47-57)]) is an arginine rich cell penetrating peptide derived from the HIV-1 transactivating protein. This product is intended for research use only and is not sold to patients.
- Purity: 98.1%
- Molecular weight: 1661.99 (free base)
- Appearance: Solid
- Color: White to off-white
- Solubility in H2O: 100 mg/mL (ultrasonic needed)
- Solubility in DMSO: ≥ 100 mg/mL
Medchemexpress LLC SsK36 TFA | 99.3% | 1771.04 (free base) | 5 MG
ssK36 TFA is a supersubstrate peptide of the histone methyltransferase (SET) domain protein 2 (SETD2). It is designed for the SETD2 protein, a specific PKMT, responsible in human cells for adding methyl groups to the 36th lysine residue of histone H3 (H3K36) to form H3K36me3. This peptide can be methylated by SETD2 at a rate more than 100 times faster than the natural substrate H3K36 and can be used to study the catalytic mechanism of PKMTs, especially substrate specificity and catalytic efficiency.
- Purity of 99.34%
- Molecular weight of 1771.04 (free base)
- Formula: C79H127N29O18.xC2HF3O2
- Appearance: Solid
- Color: White to off-white
- Sequence: Ala-Pro-Arg-Phe-Gly-Gly-Val-Lys-Arg-Pro-Asn-Arg-Tyr-Arg-Pro
- Sequence shortening: APRFGGVKRPNRYRP
- Solubility (in vitro): 1 mg/mL in H2O (requires ultrasonic)
Medchemexpress LLC SAR441255 (TFA) | 99.9% | 4866.56 | 25 MG
SAR441255 TFA is a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. It displays high potency with balanced activation of all three target receptors and shows positive acute glucoregulatory effects in diabetic obese monkeys.
- Potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist.
- Displays high potency with balanced activation of all three target receptors.
- Shows positive acute glucoregulatory effects in diabetic obese monkeys.
Medchemexpress LLC Pediocin PA 1 TFA | 95.24% | 4624.12 | 1 MG
Pediocin PA 1 TFA | 95.24% | 4624.12 | 1 MG