Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC UNC8732 TFA | 2929304-06-1 | 99.07% | 723.74 | 1 MG
UNC8732 (TFA) is a NSD2 inhibitor and degrader.
- NSD2 inhibitor and degrader.
- For research use only.
Medchemexpress LLC LY117018 TFA 5mg | 2390041-98-0 | 573.58 | C29H26F3NO6S | 5 MG
LY117018 TFA is the trifluoroacetic acid salt of LY117018, a raloxifene analog and selective estrogen receptor modulator reported to exert antiproliferative effects on breast cancer cell lines. It is provided as a research reagent for in vitro and in vivo studies of estrogen receptor signaling and related pathways.
- Selective estrogen receptor modulator with reported antiproliferative activity.
- Soluble in DMSO up to 100 mg/mL; sonication may be required.
- In vivo formulations reported with solubility ≈5 mg/mL using common co-solvent systems.
- Recommended storage: solid sealed and kept away from moisture; in solution store at -80°C (up to 6 months) or -20°C (up to 1 month).
- Molecular formula C29H26F3NO6S; molecular weight 573.58.
Medchemexpress LLC Galantide TFA | 98.1% | 2313.55 | 5 MG
Galantide TFA from MedChemExpress is a synthetic peptide, identified by its chemical structure L-Methioninamide, glycyl-L-tryptophyl-L-threonyl-L-leucyl-L-asparaginyl-L-seryl-L-alanylglycyl-L-tyrosyl-L-leucyl-L-leucylglycyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanyl-glycyl-L-leucyl- (TFA). This compound, with a molecular weight of 2313.55, is provided as a white to off-white solid with a purity of 98.09% as determined by LCMS.
- High purity of 98.09%
- White to off-white solid appearance
- Recommended storage at -80°C for up to 2 years in powder form
Medchemexpress LLC Bio-AMS TFA | 00-00-0 | 98.0% | 685.65 g/mol | C22H30F3N9O9S2 | 5 MG
Bio-AMS TFA is a bacterial biotin protein ligase inhibitor supplied as the trifluoroacetate (TFA) salt for research use. It shows selective activity against Mycobacterium tuberculosis and disrupts fatty acid and lipid biosynthesis.
- Potent biotin protein ligase inhibition.
- Selective activity against Mycobacterium tuberculosis.
- Provided as the TFA salt to aid handling and solubility.
- High purity: 98.0%.
- Molecular weight 685.65 g/mol; formula C22H30F3N9O9S2.
- Available in small research pack sizes, including 5 mg.
- Suitable for biochemical and microbiology research applications.
Medchemexpress LLC MPSD control peptide (TFA) | 99.8% | 3080.76 (free base) | 1 MG
MPSD TFA (MARCKS-ED TFA) is the TFA salt form of MPSD, a 25-amino acid peptide derived from the myristoylated alanine-rich C-kinase substrate (MARCKS). It functions as a biological probe capable of sensing membrane curvature and recognizing phosphatidylserine, making it useful for studying membrane shape and lipid composition.
- Derived from MARCKS effector domain sequence
- Senses membrane curvature
- Recognizes phosphatidylserine
- Useful for studying membrane shape and lipid composition
- Appears as a white to off-white solid
- High purity (99.8%)
- Molecular weight: 3080.76 (free base)
Medchemexpress LLC Dendrotoxin-I TFA | 99.9% | 7149.24 | 1 MG
Dendrotoxin-I TFA (DTX-I TFA) is a potent K+ channel blocker with IC50s of 0.13-50 nM for voltage-gated potassium channel subunits Kv1.1, Kv1.2, and Kv1.6. This neurotoxin shows potential for cancer research.
- Potent K+ channel blocker
- Targets voltage-gated potassium channel subunits Kv1.1, Kv1.2, and Kv1.6
- Displays tumor growth inhibition effect with hyperthermia in vivo studies
- White to off-white solid appearance
![Medchemexpress LLC L-Prolinamide, N,N-bis(phenylmethyl)glycyl]-4-[4-[[4-[[(phenylmethyl)amino]phosphonomethyl] | 99.87% | 1323.35 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000384391-logo.png-250.jpg){kind=logo}
Medchemexpress LLC L-Prolinamide, N,N-bis(phenylmethyl)glycyl]-4-[4-[[4-[[(phenylmethyl)amino]phosphonomethyl] | 99.87% | 1323.35 | 25 MG
L-Prolinamide, N,N-bis(phenylmethyl)glycyl]-4-[4-[[4-[[(phenylmethyl)amino]phosphonomethyl] | 99.87% | 1323.35 | 25 MG
Medchemexpress LLC LP17 TFA (LQVTDSGLYRCVIYHPP TFA) | 99.2% | 1961.24 | 5 MG
LP17 (LQVTDSGLYRCVIYHPP) TFA is a BBB-penetrable triggering receptor expressed on myeloid cells (TREM-1) inhibitory peptide. It substantially alleviates ischemia-induced infarction and neuronal injury by accessing the brain and blocking TREM-1. For research use only.
- Decreases mRNA levels of pro-inflammatory cytokines and chemokines.
- Attenuates extracellular protein levels of IL-1β and IL-18 in a microglia oxygen-glucose deprivation (OGD) model.
- Interacts with microglial SYK.
- Alleviates ischemia-induced infarction and neuronal injury in mice.
- Reduces infarct volume by 27.3%.
- Reduces TUNEL positive cells and FJC positive neurons.
- Rescues neurological deficits and cognitive dysfunction.
- Inhibits microglial M1 polarization and neutrophil infiltration.
Medchemexpress LLC Vm24-toxin (Vaejovis mexicanus peptide 24) | 1373890-79-9 | 3863.59 | 1 MG
Vm24-toxin (Vaejovis mexicanus peptide 24) is a 36-residue peptide that acts as a potent and selective Kv1.3 blocker with a Kd of approximately 3 pM in lymphocytes. It exhibits over 1500-fold higher affinity for Kv1.3 compared to other assayed potassium channels. Vm24-toxin possesses a distorted cystine-stabilized α/β motif, comprising a single-turn α-helix and a three-stranded antiparallel β-sheet, stabilized by four disulfide bridges. This peptide can attenuate the CD4+ effector memory T cell response to T cell receptor (TCR) stimulation.
- Potent and selective Kv1.3 blocker
- High affinity for Kv1.3 over other potassium channels (>1500-fold)
- Attenuates CD4+ effector memory T cell response to T cell receptor (TCR) stimulation
Medchemexpress LLC QL47B TFA | 96.0% | 992.07 | 5 MG
QL47B TFA is a biotinylated analogue of QL47 (HY-80003), functioning as a potent inhibitor of BTK with an IC50 value of 1.3 μM. It also exhibits anti-tumor activity.
- Potent inhibitor of BTK (IC50 value of 1.3 μM).
- Exhibits anti-tumor activity.
Medchemexpress LLC Mtvkpabc-p5 TFA | 98.8% | 1190.22 | C54H74F3N11O16 | 25 MG
MTvkPABC-P5 TFA is the trifluoroacetic acid (TFA) salt of a synthetic Toll-like receptor 7 (TLR7) agonist. It functions as an immune stimulant used in research applications, including the synthesis of immune-stimulating antibody conjugates (ISACs).
- Acts as a TLR7 agonist and immune stimulant.
- Suitable for synthesis of immune-stimulating antibody conjugates (ISACs).
- Provided as a solid TFA salt.
- High purity, 98.8%.
- Molecular weight 1190.22, formula C54H74F3N11O16.
- Available as 25 MG quantity.
Medchemexpress LLC PSMA I&S TFA | 98.15% | 1413.43 | 5 MG
PSMA I&S (TFA) is a precursor of the 99mTc-labeled PSMA-targeting ligand, intended for research use only.
- Precursor of 99mTc-labeled PSMA-targeting ligand
- For research use only
Medchemexpress LLC Cilengitide TFA | 199807-35-7 | 99.9% | 702.68 | 25 MG
Cilengitide is a potent and selective integrin inhibitor for αvβ3 and αvβ5 receptor, with IC50 values of 4 nM and 79 nM, respectively. It inhibits integrin-mediated binding to vitronectin.
- Potent and selective integrin inhibitor
- Targets αvβ3 receptor with IC50 of 4 nM
- Targets αvβ5 receptor with IC50 of 79 nM
Medchemexpress LLC Thanatin TFA | 99.7% | 2433.92 (free base) | 5 MG
Thanatin TFA is an inducible cationic antimicrobial peptide (AMP) with a single-disulfide-bond-containing β-hairpin structure. It exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria, as well as various fungal species. This peptide functions by competitively replacing divalent cations from the bacterial outer membrane, leading to its disruption.
- Exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria.
- Effective against various species of fungi.
- Disrupts bacterial outer membrane.
- Potent inhibitory effect on NDM-1-producing E. coli and K. pneumoniae strains.
- Increases survival rates and decreases bacterial titers in infected mice.
- Rescues pathological damages in a dose-dependent manner in vivo.
Medchemexpress LLC Vh4127 TFA | 1034.35 (free base) | 5 MG
VH4127 TFA is a cyclic peptide that targets the low-density lipoprotein receptor (LDLR) with a KD of 18 nM for human LDLR. It specifically binds to the rodent and human epidermal growth factor (EGF) homology domain of LDLR. It is intended for research use only.
- Targets the low density lipoprotein receptor (LDLR)
- High affinity with a KD of 18 nM for human LDLR
- Specifically binds to rodent and human epidermal growth factor (EGF) homology domain of LDLR
- Documentation: data sheet and handling instructions are available
- Formulation: supplied as a solid
- For research use only