Biotin and derivatives
Medchemexpress LLC B7-H4 Human Biotin 50ug | 50ug
The B7-H4 protein acts as a negative regulator inhibiting T cell-mediated immune responses including activation proliferation cytokine production and cytotoxicity When expressed on tumor macrophages it cooperates with regulatory T cells to suppress tumor-associated antigen-specific T cell immunity B7-H4 Protein Human (Biotinylated HEK293 His-Avi) is the recombinant human-derived B7-H4 protein expressed by HEK293 with C-Avi C-His labeled tag
Medchemexpress LLC Endo-BCN-NHS carbonate | 1426827-79-3 | MFCD19705416 | 99.5% | 291.30 g/mol | C15H17NO5 | 1 G
endo-BCN-NHS carbonate is an NHS carbonate reagent that installs a bicyclo[6.1.0]non-4-ynyl (BCN) strained alkyne onto primary amines, forming carbamate linkages. The BCN handle enables copper-free strain-promoted azide-alkyne cycloaddition (SPAAC) for efficient bioconjugation of proteins, peptides, and polymers, and is commonly used to functionalize biomolecules for hydrogel cross-linking and cell-encapsulation studies.
- Reacts with primary amines to form stable carbamate linkages.
- Provides a strained alkyne handle for copper-free SPAAC bioconjugation.
- Enables efficient functionalization of proteins, peptides, and polymers.
- Facilitates hydrogel cross-linking and cell encapsulation applications.
- Supplied as a high-purity solid suitable for research use.
Medchemexpress LLC Biotin-PEG3-acid 1g | 252881-76-8 | 447.55 | C19H33N3O7S | 1 G
Biotin-PEG3-acid is a biotin-labeled, PEG-based PROTAC linker used to introduce a biotin tag with a short PEG3 spacer in PROTAC synthesis and bioconjugation workflows. The material is supplied as a 1 g purified solid (typical purity 98.0%) with molecular weight 447.55 g/mol and chemical formula C19H33N3O7S, and is accompanied by a batch-specific certificate of analysis.
- Provides a biotin handle separated by a PEG3 spacer to reduce steric hindrance
- Designed for incorporation into PROTACs and other bioconjugates
- Improves aqueous solubility compared with direct biotinylation
- Typically supplied with batch certificate showing ~98.0% purity
- Solid form with known molecular weight and formula for formulation planning
Medchemexpress LLC Biotin-PEG5-NHS ester | 98.0% | 632.72 | 25 MG
Biotin-PEG5-NHS ester | 98.0% | 632.72 | 25 MG
![Medchemexpress LLC M-PEG-NHS ester | 92451-01-9 | 98.0% | Poly(oxy-1,2-ethanediyl), α-[2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-2-oxoethyl]-ω-methoxy- | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
Medchemexpress LLC M-PEG-NHS ester | 92451-01-9 | 98.0% | Poly(oxy-1,2-ethanediyl), α-[2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-2-oxoethyl]-ω-methoxy- | 100 MG
M-PEG-NHS ester (MW 10000) is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs are designed to selectively degrade target proteins by exploiting the intracellular ubiquitin-proteasome system.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system
- Selectively degrades target proteins
Apexbio Technology LLC 5-Carboxyfluorescein diacetate N-succinimidyl ester 150206-05-6 10mg
5-Carboxyfluorescein diacetate N-succinimidyl ester (CAS 150206-05-6) is a fluorescent cell-permeable dye It is designed to enable stable cell labeling by facilitating intracellular conversion and covalent attachment to cellular amines 5-Carboxyfluorescein diacetate N-succinimidyl ester exerts its activity through membrane permeation intracellular esterase-mediated cleavage of acetate groups and subsequent covalent coupling to intracellular targets resulting in persistent fluorescence through cell division Based on these properties 5-Carboxyfluorescein diacetate N-succinimidyl ester holds research potential in tracking lymphocyte migration analyzing cell proliferation and investigating cell dynamics and interactions in various in vitro and in vivo experimental models
Medchemexpress LLC Mal-PEG1-NHS ester | 1807518-72-4 | MFCD26127783 | 99.6% | 310.26 g/mol | C13H14N2O7 | 5 G
Mal-PEG1-NHS ester is a PEG-based, heterobifunctional linker supplied for research use that functions as a non-cleavable ADC linker and as a PEG-based PROTAC linker in small-molecule and bioconjugation synthesis.
- used for antibody-drug conjugate and PROTAC synthesis
- high purity suitable for research applications
- white to off-white solid appearance
- molecular weight 310.26 g/mol and formula C13H14N2O7
- storage: powder at -20 °C (stable for 3 years)
- storage in solvent: -80 °C (6 months) or -20 °C (1 month)
- packaging sizes include 100 mg, 250 mg, 1 g, 5 g, 10 g, 50 g
Medchemexpress LLC Digoxigenin NHS ester | 129273-26-3 | MFCD02093394 | 99.0% | 658.78 g/mol | C35H50N2O10 | 10 MG
Digoxigenin NHS ester is an activated N-hydroxysuccinimide (NHS) ester that conjugates the digoxigenin hapten to primary amines on proteins, peptides, or oligonucleotides under mild conditions. Supplied as a purified powder for biomolecule labeling and detection workflows, it is commonly used to prepare non-radioactive probes for in situ hybridization and immunodetection.
- High purity, typically 99.0%.
- Reacts with primary amines under mild conditions.
- Suitable for labeling proteins and oligonucleotides.
- Supplied as a stable powder with defined storage recommendations.
- Enables non-radioactive detection in molecular assays.
Medchemexpress LLC DBCO-Biotin | 1418217-95-4 | MFCD22380751 | 98.5% | 502.63 g/mol | C28H30N4O3S | 100MG
DBCO-Biotin is a dibenzocyclooctyne-linked biotin reagent designed for copper-free click chemistry and efficient biotinylation of azide-functionalized molecules. It is used for catalyst-free conjugation in labeling, enrichment, and linker assembly workflows, including PROTAC synthesis. The reagent is DMSO-soluble and supplied with recommended storage conditions to preserve stability.
Medchemexpress LLC Bis-PEG21-NHS ester | 2221948-98-5 | 99.9% | 500 MG
Bis-PEG21-NHS ester is a PEG/Alkyl/ether-based PROTAC linker primarily used in the synthesis of PROTACs. It also serves as a cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs).
- PEG/Alkyl/ether-based linker
- PROTAC linker for targeted protein degradation
- Cleavable ADC linker
- Utilizes the ubiquitin-proteasome system
- Suitable for PROTACs synthesis
- Suitable for ADC synthesis
Medchemexpress LLC (+)-Biotin-SLC | 1864003-57-5 | ≥97.0% | 500 MG
(+)-Biotin-SLC is an alkyl chain-based PROTAC linker. It can be used in the synthesis of PROTACs, which are designed to exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This product is for research use only.
- Alkyl chain-based PROTAC linker
- Used in the synthesis of PROTACs
- PROTACs exploit the intracellular ubiquitin-proteasome system
- PROTACs selectively degrade target proteins
- For research use only
Medchemexpress LLC Biotin-azide | 908007-17-0 | 99.84% | 500 MG
Biotin-azide is a form of biotin with a terminal azide group, designed for Click Chemistry applications. It enables the preparation of various biotinylated conjugates through copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules, and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. This reagent has been used in vitro for post-crosslinking chemical functionalization to isolate transcriptional protein complexes from yeast cells.
- Used in Click Chemistry to prepare biotinylated conjugates.
- Facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions.
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions.
- Applied in post-crosslinking chemical functionalization to isolate transcriptional protein complexes.
Medchemexpress LLC Biotin-PEG7-amine | 1334172-76-7 | MFCD21363308 | 98.0% | C26H50N4O9S | 10MG
Biotin-PEG7-amine is a PEG-based biotinylation reagent containing a seven-unit polyethylene glycol spacer terminating in a primary amine. It is used as a linker in PROTAC synthesis and for bioconjugation to introduce a biotin tag for affinity capture and detection.
- PEG7 spacer improves solubility and reduces steric hindrance.
- Terminal primary amine enables coupling to activated carboxyl groups or NHS esters.
- Biotin tag allows efficient affinity capture using streptavidin or avidin systems.
- Compatible with standard peptide- and small-molecule coupling chemistries.
- High purity supports synthetic and analytical applications.
Medchemexpress LLC Bis-PEG21-NHS ester | 2221948-98-5 | 98.0% | 1 G
Bis-PEG21-NHS ester is a versatile PEG/Alkyl/ether-based linker. It serves as a PROTAC linker for the synthesis of PROTACs, which are compounds designed to recruit target proteins to E3 ubiquitin ligases for degradation. Additionally, this molecule functions as a cleavable ADC linker, essential for the construction of antibody-drug conjugates (ADCs).
- PEG/Alkyl/ether-based linker structure
- Enables synthesis of PROTACs
- Functions as a cleavable ADC linker
- For research use only
Medchemexpress LLC 3aS 4S 6aR -Biotin- 50mg
(3aS 4S 6aR)-Biotin-PEG4-Alkyne is an alkyne-activated biotinylation reagent (3aS 4S 6aR)-Biotin-PEG4-Alkyne can be reacted with azides via a copper-catalyzed click reaction Biotin-labeled biomolecules can be bound to avidin or streptavidin for further purification and detection[1]