Biotin and derivatives
Medchemexpress LLC Biotin-TEG-ATFBA | 1264662-85-2 | C27H37F4N7O6S | 25 MG
Biotin-TEG-ATFBA is a click chemistry reagent that incorporates a perfluorophenylazide group. This reagent forms a highly stable azene intermediate which undergoes insertion and addition reactions (non-intermolecular rearrangement) in moderate to good yields after photolysis. It also has an azide group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. Additionally, it can undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups. It is intended for research use only.
- Contains a perfluorophenylazide group
- Forms a highly stable azene intermediate upon photolysis
- Undergoes insertion and addition reactions
- Features an azide group for CuAAc with alkyne-containing molecules
- Can undergo SPAAC with DBCO or BCN groups
Medchemexpress LLC Biotin-PEG8-amine | 2183447-27-8 | 99.8% | C28H54N4O10S | 250 MG
Biotin-PEG8-amine is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Biotin-labeled, PEG-based PROTAC linker.
- Used in the synthesis of PROTACs.
- For research use only.
- Appearance: solid, white to off-white.
Medchemexpress LLC M-PEG14-NHS ester | 773.86 | 50 MG
m-PEG14-NHS ester is a chemical compound commonly used in laboratory research and the manufacture of various substances. This product is supplied as a solid and exhibits chemical stability when stored under recommended conditions.
- Used in laboratory research
- Suitable for the manufacture of substances
- Supplied as a solid
- Chemically stable under recommended storage conditions
Medchemexpress LLC Biotin-PEG6-Thalidomide | 2144775-48-2 | 98.3% | C37H53N5O12S | 25 MG
Biotin-PEG6-Thalidomide is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. These PROTACs contain two distinct ligands connected by a linker: one targets an E3 ubiquitin ligase, and the other targets a specific protein. They leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This product is for research use only.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Targets E3 ligase ligand-linker conjugates
- Targets Cereblon
- For research use only
Medchemexpress LLC Biotin-LC-LC-NHS | 89889-52-1 | 98.0% | 567.7 g/mol | C26H41N5O7S | 50 MG
Biotin-LC-LC-NHS is a long-chain N-hydroxysuccinimide (NHS) activated biotinylation reagent used to label proteins, antibodies, and small molecules. The LC-LC spacer reduces steric hindrance during conjugation, and the NHS ester reacts with primary amines to form stable amide bonds.
- Provides long-chain spacer (LC-LC) to reduce steric hindrance.
- Reactive NHS ester for amine-selective conjugation.
- Suitable for labeling antibodies and small molecules.
- Solid, white to light yellow appearance; store under inert gas and protect from light.
- Soluble in DMSO; follow recommended solvent and storage guidance.
Medchemexpress LLC Biotin-PEG10-NHS ester | 98.0% | C37H64N4O16S | 25 MG
This PEG-based linker is utilized in the synthesis of degraders, specifically within the PROTAC (Proteolysis Targeting Chimeras) modality. PROTACs are designed to leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins. They function by connecting a ligand for an E3 ubiquitin ligase with a ligand for the target protein.
- Intended for research use only
Medchemexpress LLC Bis-PEG9-NHS ester 500mg | 1008402-79-6 | 708.71 | C30H48N2O17 | 500 MG
Bis-PEG9-NHS ester is a PEG9-based bifunctional linker bearing two N-hydroxysuccinimide (NHS) ester groups, designed for amine-targeted bioconjugation and linker applications such as PROTAC and ADC synthesis. It provides a hydrophilic spacer to improve solubility and reduce aggregation during conjugation.
- Bifunctional amine-reactive crosslinker with two NHS ester groups.
- PEG9 spacer increases hydrophilicity and solubility in aqueous media.
- Suitable for PROTAC, ADC, and general bioconjugation to primary amines.
- High chemical purity (≥98%) for reliable conjugation performance.
- Viscous, colorless to light yellow material; moisture sensitive - store sealed and protected from moisture.
- Molecular weight ≈ 708.71 g/mol; molecular formula C30H48N2O17.
eMolecules Mal-PEG11-alcohol | Broadpharm |581.656 | C26H47NO13 | 98.000 | OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN1C(=O)C=CC1=O | 1g | 599128887
Mal-PEG11-alcohol | Broadpharm |581.656 | C26H47NO13 | 98.000 | OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN1C(=O)C=CC1=O | 1g | 599128887
Medchemexpress LLC Nsp-dmae-nhs | 194357-64-7 | 99.5% | 1 MG
NSP-DMAE-NHS is an acridinium ester chemiluminescence reagent containing an N-sulfopropyl group. It is useful in the clinical diagnostics industry, especially in automated immunochemistry analyzers. The product is for research use only and not sold to patients.
- Acridinium ester chemiluminescence reagent
- Contains n-sulfopropyl group
- Useful in the clinical diagnostics industry
- Applicable in automated immunochemistry analyzers
Medchemexpress LLC Azido-PEG3-NHS ester | 1092654-47-1 | ≥98.0% | C12H18N4O7 | 250 MG
Azido-PEG3-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, capable of participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules, and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. This compound is integral in the development of PROTACs, which harness the ubiquitin-proteasome system to selectively degrade target proteins.
- Peg-based protac linker
- Used in the synthesis of protacs
- Click chemistry reagent
- Contains an azide group
- Participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Engages in strain-promoted alkyne-azide cycloaddition (SPAAC)
- Enables selective degradation of target proteins
Medchemexpress LLC MeCY5-NHS ester triethylamine | 00-00-0 | 96.2% | 777.94 g/mol | C36H40N3KO10S2 | 5 MG
MeCY5-NHS ester (potassium) is an amine-reactive Cy5-family fluorescent dye supplied as the NHS-ester potassium salt for labeling proteins, peptides, and nucleic acids in fluorescence assays and imaging.
- Reactive N-hydroxysuccinimide (NHS) ester for covalent labeling of primary amines.
- Cy5-family near-infrared fluorescence, approx. 649/670 nm excitation/emission.
- Potassium salt form with improved water solubility for aqueous labeling.
- Supplied with analytical documentation, including SDS, COA, 1H NMR, and LC-MS.
- Available in lab-scale quantities suitable for conjugation experiments.
![Medchemexpress LLC 2,5-pyrrolidinedione, 1,1'-[oxybis[(1-oxo-3,1-propanediyl)oxy]]bis- (9CI) | 65869-64-9 | MFCD20226397 | 97.0% | 356.28 | C14H16N2O9 | 500 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000203008.png-250.jpg)
Medchemexpress LLC 2,5-pyrrolidinedione, 1,1'-[oxybis[(1-oxo-3,1-propanediyl)oxy]]bis- (9CI) | 65869-64-9 | MFCD20226397 | 97.0% | 356.28 | C14H16N2O9 | 500 MG
Bis-PEG1-NHS ester is a non-cleavable 1-unit polyethylene glycol (PEG) linker designed for antibody-agent conjugation (ADC) research applications. It contains two N-hydroxysuccinimide (NHS) ester reactive groups that enable conjugation to primary amines on proteins or payload molecules, and is supplied with high purity for analytical and synthetic workflows.
- Non-cleavable 1-unit PEG linker for antibody-agent conjugation.
- Contains two NHS ester reactive groups for conjugation to primary amines.
- Intended for research use in ADC linker synthesis and bioconjugation workflows.
- Purity 97.0% by HPLC.
- Available in a 500 MG pack size suitable for preparative work.
Apexbio Technology LLC Cy3 Bis NHS ester 25mg
Cy3 Bis NHS ester is a water-soluble fluorescent labeling reagent containing two amine-reactive NHS ester groups on a single dye molecule This compound specifically reacts with primary amines such as lysine residues on proteins or amine-modified nucleic acids enabling covalent fluorescent conjugation Upon formation of stable amide bonds with target molecules Cy3 fluorescence can be detected with standard fluorescence instruments exhibiting excitation at approximately 550 nm and emission near 570 nm Typical applications encompass labeling proteins peptides antibodies nucleic acids and other amine-containing biomolecules for fluorescence microscopy flow cytometry and biochemical assays as well as single-molecule fluorescence resonance energy transfer (FRET) studies
Medchemexpress LLC Biotinamidocaproyl hydrazide | 109276-34-8 | MFCD00077659 | 99.8% | 371.50 g/mol | C16H29N5O3S | 10 MG
Biotin LC hydrazide is a long-chain biotinylation reagent used to derivatize periodate-oxidized carbohydrates on glycoproteins and other biomolecules. The hydrazide moiety reacts with aldehydes generated by mild oxidation to form stable hydrazone linkages, while the long-chain spacer arm improves accessibility for detection and affinity capture. Intended for research use only.
- Reacts with periodate-oxidized carbohydrates and glycoproteins.
- Introduces a biotin tag via hydrazide chemistry for avidin/streptavidin detection.
- Long-chain spacer reduces steric hindrance and improves binding accessibility.
- Suitable for labeling, detection, and affinity purification workflows.
- Provided as a stable white solid for easy handling and storage.
Medchemexpress LLC NHS-modified monomethyl auristatin F (TFA salt) | 1404073-10-4 | 96.0% | 1051.32 g/mol | C55H86N8O12 | 10 MG
NHS-Modified MMAF TFA is an NHS-activated derivative of monomethyl auristatin F provided as the trifluoroacetic acid (TFA) salt and used as a drug-linker intermediate for preparing antibody-drug conjugates (ADCs).
- NHS-activated ester for efficient conjugation to primary amines
- Provided as the TFA salt for isolation and handling
- Intended as a drug-linker intermediate for ADC synthesis
- Molecular formula C55H86N8O12; molecular weight 1051.32 g/mol
- Commonly supplied in a 10 mg pack size