Biotin and derivatives
Medchemexpress LLC DBCO-NHS ester 2 250mg | 1384870-47-6 | 250 MG
DBCO-NHS ester 2 is a dibenzocyclooctyne-derived N-hydroxysuccinimide (NHS) ester used as an amine-reactive linker for copper-free click chemistry and antibody-drug conjugate synthesis. The activated NHS ester enables rapid conjugation to primary amines, while the DBCO moiety enables strain-promoted azide-alkyne cycloaddition (SPAAC) without copper catalysts.
- Amine-reactive NHS ester for efficient amide bond formation
- Enables strain-promoted azide-alkyne cycloaddition (SPAAC) for copper-free click chemistry
- High purity (99.69%) suitable for bioconjugation applications
- Molecular weight 430.45 Da; formula C25H22N2O5
- Powder form; store at -20°C for long-term stability
- Packaged as a 250 mg solid for laboratory use
Medchemexpress LLC Biotin-C5-azide | 1260586-88-6 | 98.9% | 255.34 g/mol | C10H17N5OS | 10 MG
Biotin-C5-Azide is a biotinylation reagent containing a terminal azide group for click chemistry. It is intended for research use to prepare biotinylated conjugates via copper-catalyzed or strain-promoted azide-alkyne cycloaddition.
Medchemexpress LLC DBCO-NHS ester | 1353016-71-3 | 99.1% | 402.40 g·mol⁻1 | C23H18N2O5 | 5 MG
DBCO-NHS ester is a dibenzocyclooctyne-derived N-hydroxysuccinimide (NHS) ester for copper-free click bioconjugation via strain-promoted alkyne-azide cycloaddition (SPAAC). It is used to install linkers and conjugate azide-bearing molecules in chemical biology and antibody-drug conjugate (ADC) workflows.
- Enables copper-free SPAAC with azide-containing molecules.
- Suitable for linker installation and bioconjugation in ADC and biomolecule conjugation workflows.
- Reported high purity for analytical and preparative use.
- Available in small research quantities, including 5 MG format.
Medchemexpress LLC DBCO-biotin | 1418217-95-4 | MFCD22380751 | 98.5% | 502.63 g·mol⁻¹ | C28H30N4O3S | 5MG
DBCO-biotin is a dibenzocyclooctyne (DBCO)-linked biotin reagent designed for copper-free, bioorthogonal click chemistry. It enables rapid biotinylation of azide-functionalized molecules for affinity capture, labeling, and conjugation workflows, and is suitable as a linker component in PROTAC and bioconjugation applications.
- Enables copper-free click conjugation to azide-containing molecules.
- Provides a biotin tag for affinity capture and detection.
- High reported purity for consistent experimental performance.
- Available in small research quantities for method development.
- Solid, easy-to-handle form with standard storage recommendations.
Medchemexpress LLC 3aS 4S 6aR -Biotin- 100mg
(3aS 4S 6aR)-Biotin-PEG4-Alkyne is an alkyne-activated biotinylation reagent (3aS 4S 6aR)-Biotin-PEG4-Alkyne can be reacted with azides via a copper-catalyzed click reaction Biotin-labeled biomolecules can be bound to avidin or streptavidin for further purification and detection[1]
Medchemexpress LLC 3aS 4S 6aR -Biotin- 50mg
(3aS 4S 6aR)-Biotin-PEG4-Alkyne is an alkyne-activated biotinylation reagent (3aS 4S 6aR)-Biotin-PEG4-Alkyne can be reacted with azides via a copper-catalyzed click reaction Biotin-labeled biomolecules can be bound to avidin or streptavidin for further purification and detection[1]
Medchemexpress LLC Endo-BCN-NHS carbonate | 1426827-79-3 | MFCD19705416 | ≥97.0% | 291.30 g·mol⁻1 | C15H17NO5 | 500 MG
endo-BCN-NHS carbonate is an NHS-activated bicyclo[6.1.0]non-4-yne (BCN) carbonate reagent for bioconjugation. It couples to primary amines to install a strained cyclooctyne handle for strain-promoted azide-alkyne cycloaddition (SPAAC), enabling copper-free bioorthogonal labeling of proteins, peptides, and polymers.
- NHS-activated carbonate enables efficient coupling to primary amines.
- Introduces a strained BCN handle for copper-free SPAAC reactions.
- High purity suitable for analytical and preparative bioconjugation.
- Solid form with recommended storage at -20°C for prolonged stability.
- Compatible with proteins, peptides, and polymer modification workflows.
Medchemexpress LLC Bcn-ss-nhs | 95.0% | 454.56 g/mol | C20H26N2O6S2 | 25 MG
BCN-SS-NHS is a cleavable antibody-drug conjugate (ADC) linker and click-chemistry reagent containing a bicyclo[6.1.0]nonyne (BCN) group and an N-hydroxysuccinimide (NHS) ester for conjugation. It is used for bioconjugation and ADC synthesis, enabling copper-free strain-promoted alkyne-azide cycloaddition (SPAAC) and disulfide-based release in reducing environments.
- Cleavable disulfide linker for intracellular release
- N-hydroxysuccinimide ester for efficient amine coupling
- BCN moiety enables copper-free click chemistry (SPAAC)
- High purity suitable for conjugation (95.0% by NMR)
- Molecular weight 454.56 g/mol; formula C20H26N2O6S2
Medchemexpress LLC DBCO-NHS ester 2 1g | 1384870-47-6 | 1 G
DBCO-NHS ester 2 is a dibenzoazacyclooctyne (DBCO)-containing N-hydroxysuccinimide (NHS) ester reagent for strain-promoted alkyne-azide cycloaddition (SPAAC). It is used to install a DBCO handle on amine-containing molecules for copper-free click conjugation to azide-functionalized partners and as a cleavable linker in bioconjugation workflows.
- Amine-reactive NHS ester for efficient coupling to primary amines.
- DBCO group enables strain-promoted copper-free click chemistry with azides.
- Suitable for bioconjugation and linker formation in antibody-drug conjugates.
- High reported purity for reproducible conjugation performance.
- Supplied as a 1 g quantity for small-scale synthesis and labeling.
Medchemexpress LLC DBCO-Biotin | 1418217-95-4 | MFCD22380751 | 98.5% | 502.63 g/mol | C28H30N4O3S | 100MG
DBCO-Biotin is a dibenzocyclooctyne-linked biotin reagent designed for copper-free click chemistry and efficient biotinylation of azide-functionalized molecules. It is used for catalyst-free conjugation in labeling, enrichment, and linker assembly workflows, including PROTAC synthesis. The reagent is DMSO-soluble and supplied with recommended storage conditions to preserve stability.
Medchemexpress LLC Endo-BCN-NHS carbonate | 1426827-79-3 | MFCD19705416 | 99.5% | 291.30 g·mol⁻¹ | C15H17NO5 | 50 MG
endo-BCN-NHS carbonate is an NHS-activated bicyclononyne carbonate reagent used for bioconjugation. It functionalizes primary amines to introduce BCN handles that enable strain-promoted azide-alkyne cycloaddition (SPAAC) for copper-free click chemistry, commonly applied to modify elastin-like proteins and to form cross-linked hydrogels for cell encapsulation studies.
- Reacts with primary amines to install BCN functional groups.
- Enables copper-free strain-promoted azide-alkyne cycloaddition (SPAAC).
- Facilitates hydrogel formation and protein cross-linking for cell encapsulation.
- High purity supports reproducible conjugation chemistry.
- Powder stable at -20°C for long-term storage; solvent stability varies.
Medchemexpress LLC Dbco-biotin | 1418217-95-4 | MFCD22380751 | 98.5% | 502.63 g/mol | C28H30N4O3S | 25MG
DBCO-Biotin is a copper-free click chemistry reagent that installs a biotin tag on azide-functionalized biomolecules via strain-promoted alkyne-azide cycloaddition (SPAAC). Supplied as a white powder, it is used for bioconjugation, affinity purification and detection, and as a linker component in targeted degrader synthesis. Store at -20 °C, protect from light, and maintain under inert atmosphere when possible.
- Enables copper-free SPAAC bioconjugation to azide-labeled targets.
- Introduces a biotin affinity handle for pull-down and detection assays.
- High purity suitable for analytical and preparative applications.
- Stable solid form when stored at -20 °C and protected from light.
- Compatible with proteins, peptides, and other biomolecules.
Medchemexpress LLC Cyclooctyne-O-NHS ester | 1425803-45-7 | MFCD28898688 | 95.0% | 279.29 g/mol | C14H17NO5 | 1 G
Cyclooctyne-O-NHS ester is an activated N-hydroxysuccinimide ester of a cyclooctyne derivative that installs a strained alkyne handle onto primary amines for bioconjugation. It is used in laboratory research to enable copper-catalyzed or strain-promoted azide-alkyne cycloaddition for attaching payloads, labels, or linkers.
- Reacts with primary amines to form amide bonds.
- Installs a strained cyclooctyne handle for copper-catalyzed or strain-promoted azide-alkyne cycloaddition.
- Useful for antibody-drug conjugate linker installation and general bioconjugation workflows.
- Commonly supplied in milligram to gram quantities and listed at approximately 95.0% purity.
- Molecular weight 279.29 g/mol; intended for research use only.
Medchemexpress LLC DBCO-NHS ester 2 100mg | 1384870-47-6 | 100 MG
DBCO-C6-NHS ester is a DBCO-derived N-hydroxysuccinimide (NHS) ester used to introduce a DBCO handle onto amine-containing molecules for copper-free, strain-promoted alkyne-azide cycloaddition (SPAAC) bioconjugation and antibody-drug conjugate (ADC) linker synthesis.
- Amine-reactive NHS ester for covalent coupling to primary and secondary amines.
- Facilitates copper-free SPAAC click chemistry with azide-functionalized partners.
- Suitable for bioconjugation, ADC synthesis, and labeling of proteins or small molecules.
- Available in multiple sizes; typical laboratory scale is 100 mg.
- Soluble in DMSO (~14.29 mg/mL); store powder at -20°C for long-term stability.
Medchemexpress LLC Endo-BCN-NHS carbonate | 1426827-79-3 | MFCD19705416 | 99.5% | 291.30 g/mol | C15H17NO5 | 1 G
endo-BCN-NHS carbonate is an NHS carbonate reagent that installs a bicyclo[6.1.0]non-4-ynyl (BCN) strained alkyne onto primary amines, forming carbamate linkages. The BCN handle enables copper-free strain-promoted azide-alkyne cycloaddition (SPAAC) for efficient bioconjugation of proteins, peptides, and polymers, and is commonly used to functionalize biomolecules for hydrogel cross-linking and cell-encapsulation studies.
- Reacts with primary amines to form stable carbamate linkages.
- Provides a strained alkyne handle for copper-free SPAAC bioconjugation.
- Enables efficient functionalization of proteins, peptides, and polymers.
- Facilitates hydrogel cross-linking and cell encapsulation applications.
- Supplied as a high-purity solid suitable for research use.