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Organic bicyclic compounds that consist of a seven-membered ring fused with a thiophene ring; thiophenes are a five-membered ring with four carbon atoms and one sulfur atom.
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Fumarate hydratase-IN-1 (compound 2) is a cell-permeable fumarate hydratase inhibitor Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC50 of 2 2 M1]
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Zilurgisertib fumarate(INCB-000928 fumarate NBU-928 fumarate) is a selective ALK 2 inhibitor It is under development for the treatment of heterotopic ossification and fibrodysplasia ossificans progressiva
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Zamifenacin fumarate is a gut-selective muscarinic M3 receptor antagonist provided for research use. It reduces colonic motility and is commonly used in pharmacology studies of muscarinic receptor function. The compound is available as a solid or as pre-made DMSO solution (typical 10 mM, 1 mL), with reported purity around 99.0% and molecular weight 531.60 g/mol.
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Also available in 10 mg 25 mg 50 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Tenofovir Disoproxil Fumarate (GS-1278 Disoproxil Fumarate) is a pro-drug fumaric acid salt form of tenofovir a nucleoside reverse transcriptase inhibitor analog of adenosine. Tenofovir disoproxil fumarate is prescribed to treat HIV and chronic hepatitis B virus (HBV) in adults. purity: 99%
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Clemastine Fumarate (CAS 14976-57-9) is a small molecule that functions as a selective antagonist of the histamine H1 receptor It demonstrates high affinity for the receptor with an inhibitory concentration (IC50) of 3 nM By blocking histamine H1 receptor-mediated signaling clemastine fumarate is utilized in research to study histaminergic pathways and allergic responses It is also employed to investigate the pharmacological modulation of H1 receptor activity in various cellular and in vivo models
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Zilurgisertib fumarate(INCB-000928 fumarate NBU-928 fumarate) is a selective ALK 2 inhibitor It is under development for the treatment of heterotopic ossification and fibrodysplasia ossificans progressiva
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Ro 60-0175 fumarate (CAS 169675-09-6) is a selective agonist of the 5-HT2C serotonin receptor known to specifically activate serotonergic signaling pathways By targeting 5-HT2C receptors it modulates neurotransmitter release and neuronal circuitry influencing processes such as appetite regulation mood stabilization and cognitive function Ro 60-0175 fumarate is widely utilized in neuropharmacological research to investigate central nervous system mechanisms and to assess the pharmacological properties and therapeutic potential of 5-HT2C receptor agonists in models of depression anxiety obesity and related neuropsychiatric conditions
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Also available in 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Rupatadine Fumarate (Rinialer) (UR-12592 Fumarate) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM. purity: 99%
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( )-Anatoxin A fumarate (CAS 1219922-30-1) is a naturally occurring alkaloid isolated from freshwater cyanobacteria It functions as an agonist at nicotinic acetylcholine receptors exhibiting high binding affinity for rat brain 4 2 (K i 1 25 nM) and lower affinity for 7 (K i 1 84 M) subtypes In functional assays ( )-Anatoxin A fumarate induces dopamine release in rat striatal synaptosomes with an EC 50 of 134 nM This compound is utilized in neuroscience research to investigate cholinergic signaling and dopaminergic mechanisms in the central nervous system
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Fumarate hydratase-IN-1 is a small molecule cell-permeable inhibitor of fumarate hydratase It induce alteration of TCA cycle metabolites modulation of cytosolic processes and substantial redox stress responses
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