Cycloheptathiophenes
Apexbio Technology LLC Fesoterodine Fumarate 286930-03-8 10mg
Fesoterodine Fumarate (CAS 286930-03-8) is a synthetic antimuscarinic agent that acts as a competitive antagonist at muscarinic acetylcholine receptors particularly the M3 subtype in the bladder detrusor muscle By inhibiting these receptors the compound modulates involuntary bladder contractions reducing symptoms associated with overactive bladder syndrome such as urgency and frequency Fesoterodine Fumarate is utilized in biomedical research to study cholinergic signaling mechanisms involved in urinary function and to explore pharmacological interventions targeting muscarinic pathways in urological disorders
Selleck Chemical LLC Clemastine fumarate S1847-10mM/1mL
Clemastine fumarate is a selective histamine H1 receptor antagonist with IC50 of 3 nM Clemastine stimulates autophagy via mTOR pathway
Medchemexpress LLC Diethyl fumarate | 623-91-6 | 98.97% | 172.18 | 100 G
Diethyl fumarate is a decomposition product of Malathion 9 (a pesticide) and a reactant in the Diels-Alder reaction. It is a reputed skin irritant and can cause non-immunologic contact urticaria on the skin. When hybridized with Curcumin, Diethyl fumarate can exert neuroprotective effects.
- Reactant in the Diels-Alder reaction.
- Exerts neuroprotective effects in combination with curcumin.
- Available in various quantities (mg, g) and solutions.
- High purity (98.97%).
Medchemexpress LLC 2-butenedioic-2,3-d2 acid, 1-methyl ester, (2E)- | 253122-44-0 | 98.2% | 132.11 | C5H4D2O4 | 5 MG
Monomethyl fumarate-d2 is the deuterium-labeled analogue of monomethyl fumarate, supplied as a solid research reagent for use in analytical, pharmacological, and metabolic studies. It serves as an internal standard and tracer in mass spectrometry and mechanistic experiments, and represents the active metabolite of dimethyl fumarate (DMF).
- Deuterium labeled for isotope-tracing and mass spectrometry applications.
- High purity suitable for analytical reference and research use.
- Solid form for stable storage and handling.
- Useful as a tracer in metabolic and pharmacokinetic studies.
- CAS 253122-44-0 corresponds to the d2 isotopologue.
Medchemexpress LLC Ro 48-8071 Fumarate | 189197-69-1 | 99.13% | 564.44 | 5 MG
Ro 48-8071 is an inhibitor of oxidosqualene cyclase (OSC) with an IC50 of approximately 6.5 nM. It has demonstrated the ability to reduce cholesterol synthesis in HepG2 cells with an IC50 value of approximately 1.5 nM. In various cancer cell lines, Ro 48-8071 has shown cytotoxicity and can induce apoptosis. It has also been observed to lower LDL-C in hamsters and significantly reduce in vivo tumor growth in mice without causing weight loss.
- Inhibits oxidosqualene cyclase.
- Reduces cholesterol synthesis.
- Exhibits cytotoxicity against certain cancer cells.
- Induces apoptosis in specific cancer cell lines.
- Lowers ldl-c in animal models.
- Reduces in vivo tumor growth.
Medchemexpress LLC NS3861 fumarate | 216853-59-7 | 99.8% | 284.22 | 1 ML
NS3861 is an agonist of nicotinic acetylcholine receptors (nAChRs) that binds with high affinity to the heteromeric α3β4 nAChR. It is intended for research use only.
- Selectively activates α3-containing nAChRs.
- Displays higher efficacy at the α3β2 receptor compared to the α3β4 receptor.
- Exhibits high affinity and partial agonist properties in α3β4-expressed nAChRs.
- Appears as an off-white to light yellow solid.
- Soluble in DMSO at 50 mg/mL.
Medchemexpress LLC Bedaquiline fumarate | 845533-86-0 | MFCD28167761 | 100.0% | 671.58 g/mol | C36H35BrN2O6 | 10 MG
Bedaquiline fumarate is an analytical reference standard of the diarylquinoline antibiotic bedaquiline in its fumarate salt form, supplied as a white to off-white solid for research and analytical applications. It is intended for method development, validation, and quantitative or qualitative assays in chromatography and mass spectrometry, and is provided with supporting documentation for safe handling and traceability.
- Analytical standard for HPLC, GC, and MS method development.
- High purity suitable for quantitative and qualitative assays.
- White to off-white solid form for ease of use and handling.
- Available in small reference sizes appropriate for analytical workflows.
- Supplied with SDS and certificate of analysis for traceability.
Selleck Chemical LLC Ensitrelvir fumarate-10MM/1ML
S-217622 (Ensitrelvir fumarate) is the first orally active non-covalent non-peptidic SARS-CoV-2 3CL protease inhibitor with IC50 of 13 nM
Medchemexpress LLC Ibutilide (fumarate) | 122647-32-9 | 99.7% | 50 MG
Ibutilide fumarate is an action potential-prolonging antiarrhythmic agent and a potent blocker of the rapidly activating delayed rectifier K+ current (IKr) in AT-1 cells. It is for research use only.
- Potent IKr blocker with an EC50 value of 20 nM at +20 mV in atrial tumor myocytes (AT-1) cells.
- Blocks IKr in cells expressing HERG+MDR1*1 to the same extent as cells expressing HERG alone (IC50: 22.5 nM vs 27.4 nM).
- Cells expressing MDR1*7 show resistance (IC50: 105.3 nM vs 27.4 nM).
- Prolongs cardiac repolarization in vitro and in vivo.
- Cumulative doses (0.01, 0.02, and 0.05 mg/kg i.v., 10-min infusion) resulted in polymorphic and monomorphic non-sustained ventricular tachycardia in animal models.
- Increased action potential duration at 90% (APD90) prolongation in congestive heart failure (CHF) dogs compared to controls at 0.01 mg/kg.
Medchemexpress LLC Ibutilide (fumarate) | 122647-32-9 | 99.7% | 100 MG
Ibutilide fumarate is an action potential-prolonging antiarrhythmic agent. It is a potent blocker of the rapidly activating delayed rectifier K+ current (IKr) in AT-1 cells, playing a role in cardiac repolarization. This product is suitable for research applications in cardiac physiology and pharmacology.
- Potent IKr blocker
- Prolongs cardiac repolarization
- Relevant for studies on atrial tumor myocytes
- Useful in research related to congestive heart failure models
Medchemexpress LLC Clemastine fumarate | 14976-57-9 | 100.0% | 200 MG
Clemastine fumarate | 14976-57-9 | 100.0% | 200 MG
Cayman Chemical DImethyl fumarate 25g
A lipophilic electrophile that has profound effects on oxidative and immunological pathways; activates the transcription factor Nrf2, resulting in heme oxygenase-1 expression and increased glutathione levels; suppresses the expression of pro-inflammatory cytokines and inhibits angiogenesis