Cycloheptathiophenes
Cayman Chemical Monmethyl fumarate 250g
An active metabolite of dimethyl fumarate; an agonist of HCA2/GPR109A (EC50 = 9.4 µM); reduces neutrophil adhesion to endothelial cells stimulated with TNF, decreases CXCL2-directed neutrophil migration, and increases the expression of the Nrf2 target gene NQO1 in wild-type but not HCA2-/- macrophages; inhibits proliferation and induces differentiation in keratinocytes, as well as decreases TPA-induced levels of TNF-α in keratinocytes at 1 mM; reduces symptoms of EAE in mice at 1 mg/day
Medchemexpress LLC Tesmilifene fumarate | 1185241-83-1 | MFCD09878272 | 99.9% | 399.48 g·mol⁻¹ | C23H29NO5 | 1 ML
Tesmilifene fumarate is the fumarate salt of tesmilifene, an H1C receptor antagonist and chemical sensitizer used in oncology research. Supplied as a 10 mM stock solution in DMSO (1 mL), it is intended for in vitro research applications including chemosensitization and cytotoxicity studies.
- Ready-to-use 10 mM stock solution in DMSO
- Concentrated 1 mL volume suitable for multiple assays
- High purity (99.9%) for research use
- Applicable to chemosensitization and cytotoxicity assays
- Provided with molecular weight and CAS identifiers for reporting
Apexbio Technology LLC Ketotifen Fumarate 34580-14-8 1g
Ketotifen fumarate is a noncompetitive antagonist of histamine H1 receptors and functions additionally as a mast cell stabilizer It inhibits histamine-mediated allergic responses through preventing histamine receptor activation and limiting mast cell degranulation Its pharmacological activity involves suppression of calcium influx into mast cells thus inhibiting histamine release Ketotifen fumarate is extensively utilized in biomedical research focusing on allergy and asthma pathophysiology to assess mast-cell-mediated mechanisms and histamine signaling pathways In vitro studies report its IC50 values ranging approximately from 0 8 to 2 5 M depending on assay parameters and cell types This compound commonly serves as a pharmacological tool when investigating allergic inflammation asthma and histamine-dependent cellular events
Apexbio Technology LLC Bedaquiline fumarate 845533-86-0 5mg
Bedaquiline fumarate (CAS 845533-86-0) is a small-molecule inhibitor targeting ATP synthase of Mycobacterium tuberculosis It is designed to inhibit mycobacterial ATP synthase thereby disrupting ATP biosynthesis and bacterial energy metabolism Bedaquiline fumarate exerts its biological activity primarily through selective inhibition of ATP synthase In biochemical assays bedaquiline fumarate demonstrates potent inhibitory activity with an IC50 value of approximately 30 nM against M tuberculosis ATP synthase Based on these pharmacological properties bedaquiline fumarate holds research potential in studying tuberculosis pathogenesis mechanisms of antibiotic resistance and evaluating therapeutic strategies for mycobacterial infections
Medchemexpress LLC 2-Butenedioic acid (2E)-, 1-ethyl ester | 2459-05-4 | MFCD00002699 | 99.6% | 144.13 g·mol-1 | C6H8O4 | 10 G
Monoethyl fumarate is the monoethyl ester of fumaric acid supplied for research use. It functions as an activator of the Nrf2 pathway and is used in biochemical research, and as a preservative and polymerization agent for macromolecular materials. The compound is a white to off-white solid with reported high purity and a molecular weight of 144.13 g·mol-1.
- Activates the Nrf2 pathway in biochemical assays.
- Useful as a preservative and polymerization agent for macromolecular materials.
- Supplied as a solid suitable for formulation or dissolution in common solvents.
- High reported purity supports reproducible experimental results.
- Available in multiple package sizes for experimental flexibility.
- Simple molecular structure amenable to analytical characterization.
TARGETMOL CHEMICALS INC VUF11207 fumarate 10MG
Also available in 1 mL, 1 mg, 2 mg, 5 mg, 25 mg, 50 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes. VUF11207 fumarate is an agonist of CXCR7 and a high-potency ligand of CXCR7 (pKi 8.1). Purity 99.5%
TARGETMOL CHEMICALS INC Bedaquiline fumarate 25MG
Also available in 1 mL, 5 mg, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg and bulk. Please contact Fisher for quotes. Bedaquiline fumarate (TMC207), a diarylquinoline antibiotic that targets ATP synthase, is effective for the treatment of Mycobacterium tuberculosis infections. It blocks the proton pump for ATP synthase of mycobacteria. It is the first member of a new class of drugs called diarylquinolines. Purity 99.77%