Cycloheptathiophenes
Medchemexpress LLC Fumarate hydratase-I 10mM 1mL
Fumarate hydratase-IN-1 (compound 2) is a cell-permeable fumarate hydratase inhibitor Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC50 of 2 2 M1]
Selleck Chemical LLC Clemastine fumarate S1847-1g
Clemastine fumarate is a selective histamine H1 receptor antagonist with IC50 of 3 nM Clemastine stimulates autophagy via mTOR pathway
Medchemexpress LLC 2-butenedioic acid (2E)-, 1-ethyl ester | 2459-05-4 | MFCD00002699 | 99.6% | 144.13 g/mol | C6H8O4 | 50 G
Monoethyl fumarate is the monoethyl ester of fumaric acid supplied as a research reagent and reported Nrf2 activator. It is used in biochemical research and as a preservative and polymerization agent for macromolecular materials. The compound is available as a solid and as a 10 mM solution in DMSO for experimental convenience.
- Activates Nrf2 signaling in research assays.
- High reported purity (99.62%).
- Molecular weight 144.13 g/mol and chemical formula C6H8O4.
- Available in multiple pack sizes and solution form.
- Useful as a preservative and polymerization agent for macromolecular materials.
- For research use only; not for clinical use.
Medchemexpress LLC Bedaquiline fumarate | 845533-86-0 | 99.99% | 671.58 | 5 MG
Bedaquiline fumarate is a diarylquinoline antibiotic that targets ATP synthase and is effective for the treatment of Mycobacterium tuberculosis infections.
- Inhibits the growth of TDR Mycobacterium tuberculosis strains.
- Highest activity against Mycobacterium avium among slowly growing mycobacteria.
- Shows moderate in vitro activity against NTM species.
- Excellent in vitro activity against multidrug-resistant Mycobacterium tuberculosis.
Sigma Aldrich Fine Chemicals Biosciences Ketotifen fumarate salt1G
Ketotifen fumarate salt is an antihistamine drug.
Medchemexpress LLC Diroximel fumarate | 1577222-14-0 | MFCD10057039 | >98.0% | 255.22 | C11H13NO6 | 25 MG
Diroximel fumarate is an orally active prodrug of monomethyl fumarate used in research to investigate Nrf2 pathway activation and multiple sclerosis-related pharmacology. The compound is provided with analytical data for identification and formulation of stock solutions.
- Orally active prodrug of monomethyl fumarate.
- Useful for in vitro and in vivo studies of Nrf2-mediated pathways.
- Provided with analytical specifications including CAS, formula, and molecular weight for traceability.
- Available in mg-scale quantities suitable for preclinical research.
Medchemexpress LLC Formoterol fumarate | 43229-80-7 | >99.9% | C19H24N2O4 . 1/2C4H4O4 | 1 ML
Formoterol fumarate is a selective β2-adrenoceptor agonist, demonstrating similar β2-adrenoceptor selectivity to Salbutamol and Terbutaline. This compound is known for its ability to abolish the contraction induced by Acetylcholine in bronchioles. It is commonly utilized in research applications for conditions such as chronic obstructive pulmonary disease and bronchial asthma.
- Selective β2-adrenoceptor agonist
- Abolishes acetylcholine-induced contraction in bronchioles
- Used in research for chronic obstructive pulmonary disease
- Utilized in research for bronchial asthma
Medchemexpress LLC Cevipabulin fumarate (TTI-237 fumarate) | 849550-67-0 | 99.9% | 580.89 | 1 ML
Cevipabulin fumarate (TTI-237 fumarate) is an oral, microtubule-active, antitumor compound. It inhibits the binding of [3H]NSC 49842 to tubulin, with an IC50 of 18-40 nM for cytotoxicity in human tumor cell lines. It is for research use only.
- Inhibits tubulin binding with IC50 values of 18-40 nM in human tumor cells.
- Active against ovarian, breast, prostate, and cervical tumor cell lines.
- Induces sub-G1 nuclei at 20-40 nM and G2-M block above 50 nM.
- Demonstrates in vitro cytotoxicity (IC50 18-40 nM) in human cancer cell lines.
- Active in vivo via i.v. and p.o. administration against human tumor xenografts.
- Shows dose-dependent antitumor activity in mouse xenograft models.
Medchemexpress LLC Ocifisertib (fumarate) | 1616420-30-4 | 99.3% | 650.72 g/mol | C37H38N4O7 | 100MG
Ocifisertib (fumarate) is the fumarate salt form of a potent and selective ATP-competitive inhibitor of polo-like kinase 4 (PLK4) supplied for laboratory research. It is provided as a solid research reagent with molecular formula C37H38N4O7 and molecular weight 650.72 g/mol.
Apexbio Technology LLC Ro 60-0175 fumarate 169675-09-6 50mg
Ro 60-0175 fumarate (CAS 169675-09-6) is a selective agonist of the 5-HT2C serotonin receptor known to specifically activate serotonergic signaling pathways By targeting 5-HT2C receptors it modulates neurotransmitter release and neuronal circuitry influencing processes such as appetite regulation mood stabilization and cognitive function Ro 60-0175 fumarate is widely utilized in neuropharmacological research to investigate central nervous system mechanisms and to assess the pharmacological properties and therapeutic potential of 5-HT2C receptor agonists in models of depression anxiety obesity and related neuropsychiatric conditions
Medchemexpress LLC VTP50469 fumarate | 2169919-29-1 | 99.8% | 804.93 | 1 ML
VTP50469 fumarate is a highly selective and orally active Menin-MLL interaction inhibitor. It demonstrates potent anti-leukemia activity by targeting MLL-rearranged and NPM1-mutant leukemia. This compound is intended for research use only.
- Potently inhibits Menin-MLL interaction with a Ki of 104 pM.
- Inhibits cell proliferation in MLL-rearranged and ALL cell lines.
- Induces apoptosis in MLL-r B cell ALL cell lines.
- Promotes differentiation in MLL-r AML cell lines.
- Displaces Menin from protein complexes.
- Effective in in vivo models of leukemia, improving survival.