Lactams
Medchemexpress LLC Thalidomide-NH-C6-NH2 TFA | 2093386-51-5 | 99.8% | 500 MG
Thalidomide-NH-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate. It incorporates a Thalidomide-based cereblon ligand and a linker used in PROTAC technology. This product is for research use only and not sold to patients.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates a Thalidomide-based cereblon ligand
- Used in PROTAC technology
- For research use only
- Related to autophagy and apoptosis
Medchemexpress LLC Thalidomide-4,5-F | 2222115-19-5 | 98.0% | 294.21 g/mol | C13H8F2N2O4 | 250 MG
Thalidomide-4,5-F is a fluorinated thalidomide analogue used as a cereblon (CRBN) ligand and E3 ligase recruiter for chemical biology and PROTAC research. It promotes ubiquitinylation of target proteins and can be derivatized at fluorine positions. Supplied as a solid powder with high purity and recommended cold storage conditions.
- Fluorinated analogue designed for cereblon engagement.
- High purity suitable for research applications.
- Available in multiple milligram-scale pack sizes.
- Stable solid form with defined cold storage conditions.
- Modifiable at fluorine positions for derivatization.
Medchemexpress LLC Thalidomide-5-methyl | 40313-92-6 | 99.9% | 272.26 | 50 MG
Thalidomide-5-methyl is a cereblon (CRBN) ligand, based on Thalidomide, used in the recruitment of CRBN protein. It can be utilized for the synthesis of PROTACs and is intended for research use only.
- Cereblon (CRBN) ligand
- Recruits CRBN protein
- Utilized for PROTAC synthesis
- Molecular weight: 272.26
- Solid appearance, gray to gray purple color
- Soluble in DMSO (50 mg/mL with warming)
- Recommended storage at 4°C, sealed, away from moisture
- In solvent, store at -80°C for 6 months or -20°C for 1 month
Medchemexpress LLC Thalidomide-5-O-C8-NH2 hydrochloride | 2636798-38-2 | >95.0% | 437.92 g/mol | C21H28ClN3O5 | 10 MG
Thalidomide-5-O-C8-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as the hydrochloride salt for research applications. It is used as a recruiting moiety in PROTACs and other E3 ligase-targeting conjugates to facilitate targeted protein degradation and chemical biology studies. Supplied as a white to off-white solid in small laboratory pack sizes, it supports synthetic conjugation through an alkyl linker.
- Serves as a cereblon-recruiting ligand for targeted protein degradation
- Supplied as a hydrochloride salt for improved stability and handling
- Solid form suitable for storage and synthetic manipulation
- Provides an alkyl linker attachment point for PROTAC assembly
- Compatible with standard organic synthesis and conjugation workflows
- Intended for research use in chemical biology and drug discovery
Medchemexpress LLC Thalidomide-NH-C4-NH-Boc | 2093388-52-2 | 99.6% | 25 MG
Thalidomide-NH-C4-NH-Boc (compound 15) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide-based cereblon ligand and a linker used in PROTAC technology. This product is for research use only.
- Targets cereblon
- Molecular weight: 444.48
- Chemical formula: C22H28N4O6
- Appearance: Solid
- Color: Yellow to green
- Solubility in DMSO: 100 mg/mL (224.98 mM)
- Shipping at room temperature in continental US
- Storage at 4°C, protected from light
- Storage in solvent: -80°C for 6 months; -20°C for 1 month (protected from light)
Medchemexpress LLC Thalidomide-piperazine-PEG2-COOH | 2797430-20-5 | 99.8% | C24H30N4O8 | 10MG
Thalidomide-Piperazine-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate that pairs a thalidomide-derived cereblon ligand with a PEG2-containing piperazine linker. It is intended for use in proteolysis-targeting chimera (PROTAC) research and supports conjugation via a terminal carboxylic acid for downstream coupling.
- High purity suitable for research applications.
- Contains a carboxylic acid functional group for facile coupling.
- Designed to recruit the cereblon E3 ligase in degrader constructs.
- PEG2 linker provides short, flexible spacer for conjugation.
- Characterized by molecular formula C24H30N4O8 and molecular weight 502.52 g·mol⁻¹.
Medchemexpress LLC Thalidomide-O-C8-Boc | 2225148-52-5 | MFCD32701934 | 95.1% | C26H34N2O7 | 10MG
Thalidomide-O-C8-Boc is a thalidomide-derived Cereblon (CRBN) ligand intended for use as the E3 ligase-recruiting moiety in PROTAC design. It features an O-linked eight-carbon spacer with a Boc-protected terminus to enable linker attachment. Manufacturer data report molecular formula C26H34N2O7, molecular weight 486.56, and typical purity ~95%.
- Provides an O-linked C8 spacer with a Boc-protected terminus for linker attachment.
- Suitable for recruiting Cereblon (CRBN) as the E3 ligase in degrader strategies.
- Reported purity approximately 95.1%.
- High solubility in DMSO (100 mg/mL); manufacturer lists example in vivo formulations.
- Recommended storage: solid at -20°C under nitrogen; in solution -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Thalidomide-pinacolborane | 2229725-98-6 | 97.0% | 384.19 | C19H21BN2O6 | 100 MG
Thalidomide-pinacolborane is a thalidomide analogue that incorporates a boronic pinacol ester (Bpin). It is used as an E3 ligase ligand in PROTAC research and as a boronate building block for cross-coupling chemistry. Intended for research use only.
- Contains a boronic pinacol ester (Bpin) suitable for Suzuki cross-coupling.
- Acts as a ligand for E3 ligase in PROTAC applications.
- Characterized identity with CAS 2229725-98-6 and molecular weight 384.19.
- Purity typically reported as 97.0% by supplier.
- Recommended storage under nitrogen at -20°C; in solvent, store at -80°C for up to 6 months.
Medchemexpress LLC Thalidomide-C2-amido-C2-COOH | 2353496-84-9 | 98.5% | 416.38 g/mol | C19H20N4O7 | 5 MG
Thalidomide-C2-amido-C2-COOH is an E3 ligase ligand-linker conjugate that incorporates a cereblon-binding thalidomide-derived moiety and a carboxylic acid linker. It is intended for use as a research reagent in PROTAC design and related chemical biology studies; not for human or clinical use.
- CAS number: 2353496-84-9.
- Molecular formula: C19H20N4O7.
- Molecular weight: 416.38 g/mol.
- Purity: 98.45% (typical by supplier).
- Solubility: DMSO up to 100 mg/mL (may require sonication).
- Storage: powder at -20°C; stock solutions at -80°C for long term.
- Intended use: CRBN ligand for PROTAC design and E3 ligase studies.
- Available in small mg quantities for research use.
Selleck Chemical LLC Tazobactam Sodium-E0167-25MG
Tazobactam (Tazobactam acid Tazobactamum) Sodium is a beta-lactamase inhibitor that prevents the breakdown of other antibiotics by beta-lactamase enzyme producing organisms
Medchemexpress LLC Thalidomide-o-amido-peg3-c2-nh2 (TFA) | 1957236-21-3 | MFCD31656717 | 99.6% | 620.53 g/mol | C25H31F3N4O11 | 50 MG
Thalidomide-O-amido-PEG3-C2-NH2 TFA is a Thalidomide-based cereblon E3 ligase ligand-linker conjugate provided as the trifluoroacetate salt. It contains a three-unit polyethylene glycol (PEG3) linker and a terminal C2 primary amine for conjugation, and is intended as a building block for PROTAC synthesis and cereblon recruitment studies.
- Cereblon-binding thalidomide ligand with a three-unit PEG linker.
- Terminal primary amine (C2) for facile conjugation to targeting ligands.
- Provided as a trifluoroacetate (TFA) salt for handling stability.
- High purity confirmed by LCMS (~99.6%).
- Molecular weight 620.53 g/mol and CAS 1957236-21-3 for unambiguous identification.
Medchemexpress LLC Thalidomide-O-COOH | 1061605-21-7 | MFCD31560477 | 99.9% | 332.27 g·mol⁻¹ | C15H12N2O7 | 10 MG
Thalidomide-O-COOH is a carboxylic acid-functionalized thalidomide derivative that serves as a cereblon (CRBN) ligand for targeted protein recruitment. It is used as an E3 ligase recruiter in PROTAC design and related chemical biology research.
- Carboxylic acid-functionalized thalidomide cereblon ligand.
- Used as an E3 ligase recruiter in PROTAC design and degrader development.
- Molecular formula C15H12N2O7, molecular weight 332.27 g·mol⁻¹.
- CAS number 1061605-21-7.
- For research use only; not for human or diagnostic applications.
eMolecules Broadpharm / Thalidomide-5-(PEG4-amine) / 100mg / 713699642 / BP-28032 / / / [null] / 520.539 / C24H32N4O9
Broadpharm / Thalidomide-5-(PEG4-amine) / 100mg / 713699642 / BP-28032 / / / [null] / 520.539 / C24H32N4O9