Lactams
Medchemexpress LLC Thalidomide-5-O-CH2-COOH | 2467425-53-0 | 95.0% | 332.26 g/mol | C15H12N2O7 | 25 MG
Thalidomide-5-O-CH2-COOH is a thalidomide-derived E3 ligase ligand-linker conjugate used as a cereblon ligand in chemical biology and targeted protein degradation research. It is supplied as a solid reagent intended for in vitro studies and synthetic applications.
- Acts as a cereblon (CRBN) ligand for targeted protein degradation studies.
- Designed as a ligand-linker conjugate to enable attachment to target-binding warheads.
- High solubility in DMSO (125 mg/mL) facilitates preparation of concentrated stocks.
- Supplied with typical purity of 95.0% suitable for research use.
- Molecular weight 332.26 g/mol and formula C15H12N2O7 for accurate dosing.
- Stable as a powder when stored frozen for long-term retention.
- Accompanied by datasheet, certificate of analysis, and safety data for handling guidance.
Medchemexpress LLC Thalidomide-pinacolborane | 2229725-98-6 | 95.0% | 384.19 g·mol⁻¹ | C19H21BN2O6 | 10 MG
Thalidomide-pinacolborane is a thalidomide-derived small molecule bearing a pinacol boronic ester (Bpin). It serves as an E3 ligase (cereblon) ligand useful in targeted protein degradation (PROTAC) research and as a synthetic intermediate for cross-coupling chemistries.
![Medchemexpress LLC N-[2-amino-5-(2-thienyl)phenyl]-2-(1-piperazinyl)-6-quinolinecarboxamide | 1609389-52-7 | 99.6% | 429.54 g/mol | C24H23N5OS | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000244271.png-250.jpg)
Medchemexpress LLC N-[2-amino-5-(2-thienyl)phenyl]-2-(1-piperazinyl)-6-quinolinecarboxamide | 1609389-52-7 | 99.6% | 429.54 g/mol | C24H23N5OS | 1 ML
ACY-957 is an orally active, selective small-molecule inhibitor of histone deacetylases HDAC1 and HDAC2 used in preclinical research to modulate epigenetic regulation and induce fetal hemoglobin expression. Reported IC50 values are 7 nM (HDAC1), 18 nM (HDAC2), and 1,300 nM (HDAC3). Supplied for in vitro and in vivo studies.
- Selective inhibition of HDAC1 and HDAC2 with low-nanomolar potency.
- Demonstrated activity in cellular models of globin gene induction.
- Orally active in preclinical pharmacology studies.
- Suitable for both in vitro and in vivo research applications.
- Characterized with vendor-provided purity and analytical data.
Medchemexpress LLC Biotin-thalidomide | 2230857-87-9 | MFCD32851674 | 99.7% | 945.09 g/mol | C44H64N8O13S | 5 MG
Biotin-Thalidomide is a biotin-conjugated thalidomide derivative that binds the cereblon (CRBN) E3 ligase and is supplied for research use in target engagement studies and PROTAC synthesis. It is provided as a high-purity chemical probe for biochemical assays, affinity capture, and conjugation workflows; not for human therapeutic use.
- High purity (≈99.7%) suitable for research applications
- Cereblon-binding probe useful for PROTAC development
- Biotin tag enables affinity capture and pull-down assays
- Compatible with conjugation and synthetic workflows
- Intended for research use only
Medchemexpress LLC Tetrazine tagged thalidomide | 2087490-42-2 | 98.6% | 571.58 g/mol | C29H29N7O6 | 1 ML
Tz-Thalidomide is a tetrazine-tagged thalidomide derivative supplied for research use as an E3 ligase ligand and chemical biology probe. It is offered as a ready-to-use 10 mM solution in DMSO (1 mL) and in solid quantities for synthesis and assay use, and is intended for applications in targeted protein degradation and PROTAC development.
- Tetrazine functional group enables rapid inverse electron demand Diels-Alder (iEDDA) click reactions.
- Supplied as a 10 mM solution in DMSO for immediate experimental use.
- High purity (98.6%) appropriate for biological testing and chemical biology workflows.
- Molecular weight 571.58 and formula C29H29N7O6 for accurate dosing and formulation.
- Available in solid amounts for synthetic chemistry and scale-up experiments.
Medchemexpress LLC Deoxy-thalidomide-5-iodine | 2291364-01-5 | MFCD32853043 | 98.0% | 370.14 g/mol | C13H11IN2O3 | 250 MG
Deoxy-thalidomide-5-iodine is a thalidomide analog used as a cereblon-binding ligand in targeted protein degradation and PROTAC research. It is provided as a characterized small-molecule building block suitable for conjugation in bifunctional degrader synthesis and related chemical biology applications.
- Used as cereblon-binding ligand for PROTAC development.
- High reported purity: 98.0% (NMR).
- Molecular weight 370.14 g/mol and formula C13H11IN2O3.
- Solid; store at 4°C and protect from light.
- Available in multiple package sizes, including 250 mg.