Lactams
![eMolecules 73804-69-0 | rel-(1S,2S,5R)-3-azabicyclo[3.1.0]hexane-2-carboxylic acid;hydrochloride | MFCD08457561 | 1g](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502136107.JPG-250.jpg)
eMolecules 73804-69-0 | rel-(1S,2S,5R)-3-azabicyclo[3.1.0]hexane-2-carboxylic acid;hydrochloride | MFCD08457561 | 1g
Pharmablock | rel-(1S,2S,5R)-3-azabicyclo[3.1.0]hexane-2-carboxylic acid;hydrochloride | 1g | 551143363 | PBN20122091-1 | 73804-69-0 | MFCD08457561 | 163.600 | C6H10ClNO2
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eMolecules Building Block Tool<|a>
Medchemexpress LLC Thalidomide-NH-PEG3-propionic acid | 2138440-82-9 | 99.72% | 477.46 | 25 MG
Thalidomide-NH-PEG3-propionic acid is a synthesized E3 ligase ligand-linker conjugate used in PROTAC technology. It incorporates a thalidomide-based cereblon ligand and a 3-unit PEG linker.
- PROTACs contain two different ligands connected by a linker.
- One ligand is for an E3 ubiquitin ligase and the other is for the target protein.
- PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Stable under recommended storage conditions.
- Recommended storage temperature: 4°C, protect from light.
Medchemexpress LLC Thalidomide-PEG4-COOH | 2828438-28-2 | 95.4% | 478.45 | 25 MG
Thalidomide-PEG4-COOH is a synthesized E3 ligase ligand-linker conjugate, incorporating a Thalidomide-based cereblon ligand and a linker utilized in PROTAC technology. This product is intended for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates a Thalidomide-based cereblon ligand
- Utilized in PROTAC technology
- Targets cereblon
- Associated with cancer, cancer targeted therapy, cancer metabolism, and metastasis research
- Relevant to autophagy and apoptosis studies
- Functions as an inhibitor
Medchemexpress LLC Thalidomide-NH-CBP/p300 ligand 2 (P-007) | 2484739-21-9 | 98.6% | 922.03 | 100 MG
Thalidomide-NH-CBP/p300 ligand 2 (P-007) is a PROTAC-based CBP and p300 degrader, extracted from patent WO2020173440. This product is for research use only.
- PROTAC-based CBP and p300 degrader
- Extracted from patent WO2020173440
- For research use only
- Targets cereblon
Medchemexpress LLC Thalidomide-piperazine-peg1-cooh | 2731007-11-5 | 99.2% | 458.46 | 50 MG
Thalidomide-Piperazine-PEG1-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide-based cereblon ligand
- Used in PROTAC technology
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Thalidomide 4-fluoride | 835616-60-9 | 99.8% | 276.22 | 100 G
Thalidomide 4-fluoride, also known as Cereblon ligand 4, is a Thalidomide-based Cereblon ligand. It is utilized in the recruitment of CRBN protein, a component of the cullin-4 E3 ubiquitin ligase complex. This compound mediates the ubiquitination and subsequent proteasomal degradation of target proteins, and can be connected to other ligands to form PROTAC degraders.
- Thalidomide-based cereblon ligand.
- Used in the recruitment of CRBN protein.
- Targets cereblon (CRBN), a part of the E3 ubiquitin ligase complex.
- Mediates ubiquitination and proteasomal degradation of target proteins.
- Can be used to form PROTAC degraders.
Medchemexpress LLC Thalidomide-PEG2-C2-NH2 (hydrochloride) | 2245697-87-2 | >99.9% | 100 MG
Thalidomide-PEG2-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a 2-unit PEG linker used in PROTAC technology. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Used in PROTAC technology.
- Exploits the intracellular ubiquitin-proteasome system.
- Selectively degrades target proteins.
- Incorporates thalidomide based cereblon ligand.
- Features a 2-unit PEG linker.
- For research use only.
Medchemexpress LLC Thalidomide-pyrrolidine hydrochloride | 2616553-35-4 | 98.0% | 335.74 g·mol⁻¹ | C15H14ClN3O4 | 100 MG
Thalidomide-pyrrolidine hydrochloride is an E3 ligase ligand (compound 18) used as a building block in the synthesis of PROTACs. Provided as the hydrochloride salt at research-grade purity, it is supplied in milligram-scale packages and includes storage recommendations for long-term stability.
- E3 ligase ligand suitable for PROTAC assembly.
- Hydrochloride salt form for improved handling.
- High purity: 98.0%.
- Molecular weight: 335.74 g·mol⁻¹.
- CAS number: 2616553-35-4.
- Available in multiple package sizes including 100 mg.
- Storage recommendations: in solvent -80°C for 2 years, -20°C for 1 year.
Medchemexpress LLC Thalidomide-NH-C6-NH2 TFA | 2093386-51-5 | 99.8% | 1 G
Thalidomide-NH-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate, incorporating a Thalidomide-based cereblon ligand and a linker used in PROTAC technology. This compound is characterized by its high purity of 99.8%.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based cereblon ligand
- Features a linker used in PROTAC technology
- Designed for use in PROTACs that exploit the intracellular ubiquitin-proteasome system
Medchemexpress LLC Thalidomide-4-O-CH2-COO(t-Bu) | 1950635-36-5 | 99.26% | 388.37 | 100 MG
Thalidomide-4-O-CH2-COO(t-Bu) is a t-Bu modified Thalidomide, which is the final step intermediate in the synthesis of Thalidomide-4-OH. It acts as a Cereblon ligand to recruit CRBN proteins. The t-Bu protecting group can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. It is a key intermediate in the synthesis of CRBN-based designed PROTAC molecules.
- Acts as a Cereblon ligand to recruit CRBN proteins.
- The t-Bu protecting group can be removed under acidic conditions to participate in the synthesis of PROTAC molecules.
- Key intermediate in the synthesis of CRBN-based designed PROTAC molecules.
Medchemexpress LLC Thalidomide-pinacolborane | 2229725-98-6 | 95.0% | 384.19 g·mol⁻¹ | C19H21BN2O6 | 10 MG
Thalidomide-pinacolborane is a thalidomide-derived small molecule bearing a pinacol boronic ester (Bpin). It serves as an E3 ligase (cereblon) ligand useful in targeted protein degradation (PROTAC) research and as a synthetic intermediate for cross-coupling chemistries.
Medchemexpress LLC Sulbactam sodium | 69388-84-7 | 99.4% | 50 MG
Sulbactam sodium (Standard) is an analytical standard intended for research and analytical applications. It functions as a competitive, irreversible beta-lactamase inhibitor, demonstrating antimicrobial activity against multidrug-resistant (MDR) acinetobacter calcoaceticus--Acinetobacter baumannii (Acb) complex.
- Used as a reference standard for assays
- Competitive, irreversible beta-lactamase inhibitor
- Shows antimicrobial activity against multidrug-resistant acinetobacter calcoaceticus--Acinetobacter baumannii (Acb) complex
- Utilized in qualitative, quantitative, and methodological research experiments such as HPLC, GC, and MS
Medchemexpress LLC Thalidomide-O-C8-Boc | 2225148-52-5 | 95.1% | 50 MG
Thalidomide-O-C8-Boc is a thalidomide-based cereblon ligand that is used to recruit the CRBN protein. It can be linked to a protein ligand by a linker to create PROTACs. This product is intended for research use only.
- Functions as a thalidomide-based cereblon ligand
- Utilized for recruitment of CRBN protein
- Connects to protein ligands via a linker to form PROTACs
- Targets cereblon