Lactams
Cayman Chemical AzIdo-ThalIdomIde 10mg
A PROTAC building block; contains thalidomide, which is a ligand for the E3 ubiquitin ligase cereblon, and can be conjugated to alkynylated ligands for target proteins via click chemistry; has been used in the synthesis of a SirReal-based PROTAC for the degradation of Sirt2 in cells
Medchemexpress LLC 5-fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione | 2230957-36-3 | MFCD30188075 | 99.9% | 276.22 g/mol | C13H9FN2O4 | 100 MG
5-Fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione is a fluorinated thalidomide derivative that functions as an E3 ligase (cereblon) ligand. It is provided as a high-purity solid and is intended for use as a chemical building block in targeted protein degradation research and for further derivatization via nucleophilic aromatic substitution (SNAr).
- Functions as an E3 ligase (cereblon) ligand.
- Useful as a building block for PROTAC and targeted protein degradation design.
- Fluorinated position enables SNAr-based further derivatization.
- Supplied as a high-purity small-molecule solid suitable for synthetic chemistry.
- Molecular formula C13H9FN2O4; molecular weight 276.22 g/mol.
eMolecules Ethyl 4-((tert-butyldimethylsilyl)oxy)cyclohexanecarboxylate | 676560-15-9 | MFCD24038913 | 1g
Ambeed | Ethyl 4-((tert-butyldimethylsilyl)oxy)cyclohexanecarboxylate | 1g | 490561494 | A433149 | | 676560-15-9 | MFCD24038913 | 286.487 | C15H30O3Si
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