Lactams
Medchemexpress LLC Thalidomide-propargyne-PEG2-COOH | 2797619-65-7 | 98.7% | 428.39 g/mol | C21H20N2O8 | 5 MG
Thalidomide-Propargyne-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate combining a thalidomide-derived cereblon ligand with a PEG2 linker terminating in a propargyl carboxylic acid. It is intended for PROTAC construction and click-chemistry applications, providing an alkyne handle for downstream conjugation.
- Contains terminal propargyl (alkyne) group for copper-catalyzed azide-alkyne cycloaddition.
- Incorporates a PEG2 linker to improve solubility and provide appropriate spacer length.
- Acts as a cereblon ligand to recruit CRBN for targeted protein degradation strategies.
- High purity suitable for research and synthetic applications.
- Available in small pack sizes for efficient use in medicinal chemistry workflows.
Medchemexpress LLC N-me-thalidomide 4-fluoride | 2244520-92-9 | MFCD34563580 | 99.4% | 290.25 | C14H11FN2O4 | 250 MG
N-Me-Thalidomide 4-fluoride is a thalidomide-based cereblon (E3 ligase) ligand used in PROTAC design and in the synthesis of related research compounds. Supplied as a characterized solid for research use, the compound is accompanied by analytical data and safety documentation to support laboratory workflows.
- High purity (99.4%) suitable for research applications.
- Molecular formula C14H11FN2O4 and molecular weight 290.25 Da.
- Available in multiple pack sizes from 250 mg to 10 g.
- Analytical documentation: COA, HNMR, and RP-HPLC provided.
- Safety documentation: SDS and handling instructions available.
- Designed for use as a cereblon ligand in PROTAC conjugation chemistry.
Medchemexpress LLC Thalidomide-O-C4-COOH | 2169266-67-3 | 97.0% | 100 MG
Thalidomide-O-C4-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. It is for research use only and not sold to patients.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide based cereblon ligand
- Used in PROTAC technology
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
- For research use only
Medchemexpress LLC Thalidomide-1-Me,4-OH | 2244568-06-5 | ≥98.0% | 288.26 | C14H12N2O5 | 50 MG
Thalidomide-1-Me,4-OH is a thalidomide analogue bearing a 4-hydroxy substituent and a 1-methyl modification. It serves as a cereblon/E3 ligase ligand and is used as a recruiter in PROTAC and targeted protein degradation research. Supplied as a research-grade chemical for biochemical and cellular studies.
- Ligand for E3 ligase (cereblon) used in PROTAC applications.
- Thalidomide derivative with 4-hydroxy and 1-methyl modifications.
- Molecular formula C14H12N2O5; molecular weight 288.26.
- Purity ≥98.0% suitable for research use.
- Storage guidance: powder -20°C (3 years), 4°C (2 years).
Medchemexpress LLC Thalidomide-o-amido-PEG4-azide | 2411681-89-3 | 99.2% | C25H32N6O10 | 25 MG
Thalidomide-O-amido-PEG4-azide is a PEG-based PROTAC linker primarily used in the synthesis of PROTACs. This compound also functions as a versatile click chemistry reagent due to its azide group, enabling both copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with appropriate alkyne-containing molecules. PROTACs, which utilize this linker, are designed to leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- PEG-based PROTAC linker
- Used for synthesizing PROTACs
- Functions as a click chemistry reagent
- Facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- Exploits the ubiquitin-proteasome system
- Supports selective degradation of target proteins
Medchemexpress LLC 5-bromo-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione | 2740657-28-5 | MFCD34180776 | >98.0% | 355.12 g/mol | C13H8BrFN2O4 | 100 MG
Thalidomide-4-F,5-Br is a thalidomide analogue used as a cereblon ligand in chemical biology and targeted protein degradation research. The compound is supplied as a solid research reagent (CAS 2740657-28-5) with a reported formula of C13H8BrFN2O4 and reported purity >98% in supplier documentation. Typical applications include PROTAC development, biochemical assays, and studies of E3 ligase-mediated ubiquitination.
- Acts as a cereblon ligand for recruiting E3 ubiquitin ligase.
- Useful in PROTAC design and targeted protein degradation studies.
- High reported purity suitable for research applications.
- Solid form stable for standard laboratory storage conditions.
- CAS-registered for unambiguous chemical identification.
Medchemexpress LLC Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride | 2983037-00-7 | 98.01% | 586.03 | 50 MG
Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand. It is used in PROTAC technology, which exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Incorporates Thalidomide based cereblon ligand
- Used in PROTAC technology
- Targets E3 ubiquitin ligase
- Facilitates selective degradation of target proteins
Medchemexpress LLC Thalidomide-4-O-C5-NH2 hydrochloride | 2419145-66-5 | 96.9% | 395.84 | 50 MG
Thalidomide-4-O-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate, incorporating a Thalidomide-based cereblon ligand and a linker used in PROTAC technology. This compound exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- E3 ligase ligand-linker conjugate
- Incorporates thalidomide-based cereblon ligand
- Used in PROTAC technology
- Targets E3 ligase ligand-linker conjugates
- Targets apoptosis and autophagy pathways
- Targets cereblon
Medchemexpress LLC N-Me-thalidomide 4-fluoride | 2244520-92-9 | MFCD34563580 | 99.4% | 290.25 g/mol | C14H11FN2O4 | 1 G
N-Me-Thalidomide 4-fluoride is a research-grade small molecule ligand for E3 ligase used in chemical biology and PROTAC development. It functions as a building block in the synthesis of targeted degraders and related small-molecule tools. Supplied for laboratory research use only.
- Ligand for E3 ligase.
- Useful building block for synthesis of targeted degraders and anti-inflammatory agents.
- High reported purity (99.41%).
- Molecular formula C14H11FN2O4; molecular weight 290.25 g/mol.
- Available in research pack sizes suitable for small-scale synthesis.
Medchemexpress LLC Thalidomide 4-fluoride | 835616-60-9 | 99.9% | 276.22 | 5 G
Thalidomide 4-fluoride is a Thalidomide-based Cereblon ligand that recruits CRBN protein and can be linked to the ligand for IRAK4 protein to create PROTAC IRAK4 degrader-1. This compound targets cereblon (CRBN), a ubiquitous protein involved in the cullin-4 E3 ubiquitin ligase complex CRL4, facilitating the ubiquitination and subsequent proteasomal degradation of target proteins.
- Recruits CRBN protein.
- Can be linked to IRAK4 protein ligand.
- Targets cereblon (CRBN).
- Facilitates ubiquitination and proteasomal degradation of target proteins.
- Molecular weight: 276.22.
- Physical state: solid.
- Color: off-white to gray.
- Soluble in DMSO.
- Store powder at -20°C for 3 years or 4°C for 2 years.
- Store in solvent at -80°C for 2 years or -20°C for 1 year.
- Avoid repeated freeze-thaw cycles after preparation into solution.
Medchemexpress LLC Thalidomide-4-O-C10-NH2 hydrochloride | 00-00-0 | 95.6% | C23H32ClN3O5 | 10MG
Thalidomide-4-O-C10-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand formulated as a hydrochloride salt for use in PROTAC design and related biochemical research. Supplied as a solid with reported high purity, it is intended for small-scale laboratory studies and compound linking applications.
- Hydrochloride salt form for improved stability
- High purity suitable for research applications
- Molecular formula C23H32ClN3O5 and molecular weight 465.97
- Available in small packaging sizes for synthesis and screening
- Solid form for convenient handling and storage
eMolecules 28562-53-0 | 4-Acetoxy-2-azetidinone | Ambeed | MFCD00010593 | 129.115 | C5H7NO3 | 97.000 | CC(=O)OC1CC(=O)N1 | 250mg | 552638482
4-Acetoxy-2-azetidinone | Ambeed | 28562-53-0 | MFCD00010593 | 129.115 | C5H7NO3 | 97.000 | CC(=O)OC1CC(=O)N1 | 250mg | 552638482
eMolecules 17557-84-5 | 3-Azetidinone hydrochloride | Synthonix - Stock | MFCD01861742 | 107.540 | C3H6ClNO | 97.000 | Cl.O=C1CNC1 | 1g | 525905203
3-Azetidinone hydrochloride | Synthonix - Stock | 17557-84-5 | MFCD01861742 | 107.540 | C3H6ClNO | 97.000 | Cl.O=C1CNC1 | 1g | 525905203
eMolecules 17557-84-5 | Azetidin-3-one hydrochloride | AA Blocks LLC | MFCD01861742 | 107.540 | C3H6ClNO | 0.000 | Cl.O=C1CNC1 | 250mg | 779494524
Azetidin-3-one hydrochloride | AA Blocks LLC | 17557-84-5 | MFCD01861742 | 107.540 | C3H6ClNO | 0.000 | Cl.O=C1CNC1 | 250mg | 779494524