Lactams
Medchemexpress LLC Biotin-thalidomide | 2230857-87-9 | MFCD32851674 | 99.7% | C44H64N8O13S | 10MG
Biotin-thalidomide is a biotin-conjugated thalidomide derivative that binds the cereblon (CRBN) E3 ligase and is supplied as a high-purity reagent for use in PROTAC synthesis and biochemical assays.
- Binds cereblon (CRBN) E3 ligase
- Suitable for PROTAC synthesis and biochemical binding studies
- Facilitates affinity capture and pull-down assays via biotin tag
- Provided as a high-purity reagent for research use
- Characterized by molecular formula and SMILES for cheminformatics
Medchemexpress LLC Thalidomide-5-PEG7-NH2 hydrochloride | 618.07 g/mol | C27H40ClN3O11 | 10 MG
Thalidomide-5-PEG7-NH2 hydrochloride is a thalidomide-derived cereblon ligand with a PEG7 spacer provided as the hydrochloride salt. It is designed for use as an E3 ligase ligand in PROTAC and ligand-linker conjugate synthesis and is supplied as a solid for research applications.
- Thalidomide-derived cereblon ligand for recruitment of CRBN.
- PEG7 spacer offers a flexible linker for conjugation to target ligands.
- Provided as the hydrochloride salt to aid handling and solubility.
- White to off-white solid physical form.
- Molecular formula C27H40ClN3O11 and molecular weight 618.07 g/mol.
- Store sealed at -20°C; in solution store at -80°C for up to 6 months or at -20°C for up to 1 month.
- Available in small mg quantities for laboratory research use.
Medchemexpress LLC Tz-thalidomide (tetrazine tagged thalidomide) | 2087490-42-2 | 98.6% | 571.58 g/mol | C29H29N7O6 | 50 MG
Tz-thalidomide is a tetrazine-tagged derivative of thalidomide designed for research applications in click chemistry and targeted protein degradation. It is supplied as a pink to red solid with high purity and is formulated for solubility in DMSO for in vitro use.
- Tetrazine-functionalized thalidomide scaffold for iEDDA click reactions.
- High purity (98.6%) suitable for biochemical assays.
- Solid, pink to red form that is stable under recommended storage conditions.
- Good solubility in DMSO (50 mg/mL) for stock preparation.
- Available in small research quantities compatible with probe synthesis.
- Applicable as an E3 ligase ligand for PROTAC and molecular-glue studies.
Medchemexpress LLC Thalidomide 5-fluoride | 835616-61-0 | 276.22 g/mol | C13H9FN2O4 | 5 G
Thalidomide 5-fluoride is a 5-fluoro derivative of thalidomide that functions as a cereblon (CRBN) ligand for use in the design and synthesis of PROTACs and other E3 ligase-recruiting molecules.
- Used as a cereblon ligand in PROTAC and degrader synthesis.
- CAS number 835616-61-0.
- Molecular formula C13H9FN2O4.
- Molecular weight 276.22 g/mol.
- Packaged as a 5 g quantity.
Medchemexpress LLC Thalidomide-O-C8-Boc | 2225148-52-5 | 95.1% | 100 MG
Thalidomide-O-C8-Boc is a Thalidomide-based Cereblon ligand designed for recruiting CRBN protein. It can be linked to a target protein ligand via a linker to form PROTACs, making it suitable for research use in laboratory chemical manufacturing. This substance is stable under recommended storage conditions and is not classified as a hazardous substance or mixture.
- Used to recruit CRBN protein
- Can be linked to a target protein ligand via a linker to form PROTACs
- Suitable for laboratory chemical manufacturing
- Stable under recommended storage conditions
- Not classified as a hazardous substance or mixture
- Recommended storage temperature: -20°C, stored under nitrogen
- Molecular formula: C26H34N2O7
- Molecular weight: 486.56
- Appearance: Solid, white to off-white
TARGETMOL CHEMICALS INC Thalidomide-O-amido-C4-N3 10MG
Also available in 1 mL, 2 mg, 5 mg, 25 mg, 50 mg and bulk. Please contact Fisher for quotes.Thalidomide-O-amido-C4-N3 (Cereblon Ligand-Linker Conjugates 4) is an E3 ligase ligand-linker conjugate incorporating the Thalidomide-based cereblon ligand and a linker. Purity 97.01%
Medchemexpress LLC Thalidomide-O-amido-C6-NH2 (hydrochloride) | 2376990-31-5 | 99.3% | 466.92 | 25 MG
Thalidomide-O-amido-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that integrates the Thalidomide-based cereblon ligand with a linker, making it suitable for synthesizing PROTACs. PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins by connecting an E3 ubiquitin ligase ligand with a ligand for the target protein via a linker.
- Synthesized E3 ligase ligand-linker conjugate.
- Incorporates Thalidomide based cereblon ligand and a linker.
- Can be used in the synthesis of PROTACs.
- PROTACs exploit the ubiquitin-proteasome system for selective protein degradation.
- For research use only.
Medchemexpress LLC Thalidomide-5-O-C10-NH2 hydrochloride | 99.4% | 465.97 | 25 MG
Thalidomide-5-O-C10-NH2 hydrochloride is a Thalidomide-based cereblon ligand. It is used to recruit CRBN protein and can be linked to a protein ligand via a linker to form PROTACs. This product is for research use in laboratory settings and for the manufacture of substances.
- Cereblon ligand
- Recruits CRBN protein
- Forms PROTACs with protein ligands
- For research use only
- Appearance: Solid
- Color: White to off-white
Medchemexpress LLC 5-((14-Aminotetradecyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride | 97.7% | 522.08 | 5 MG
Thalidomide-5-O-C14-NH2 hydrochloride is a Thalidomide (HY-10984)-based cereblon ligand. It is utilized in the recruitment of CRBN protein and can be connected to a ligand for protein by a linker to form PROTACs. This compound is for research use only.
- Utilized in the recruitment of CRBN protein
- Can be connected to a ligand for protein by a linker
- Forms PROTACs
Medchemexpress LLC Thalidomide-5-O-C9-NH2 hydrochloride | 99.6% | 451.94 | 25 MG
Thalidomide-5-O-C9-NH2 hydrochloride is a thalidomide-based cereblon ligand used in the recruitment of CRBN protein. It can be connected to a ligand for protein by a linker to form PROTACs.
- Cereblon ligand
- Forms PROTACs
- Recruits CRBN protein
- Target: Cereblon
- Molecular formula: C22H30ClN3O5
- Appearance: Solid
- Color: White to off-white
Medchemexpress LLC Thalidomide-5-NH-C-alkyne | 2357110-24-6 | MFCD34563706 | 98.0% | 311.29 g/mol | C16H13N3O4 | 25 MG
Thalidomide-5-NH-C-alkyne is a thalidomide-derived E3 ligase ligand-linker conjugate bearing a terminal alkyne for click chemistry. It is supplied as a high-purity synthetic building block intended for conjugation in PROTAC synthesis and targeted protein degradation research.
- Contains an E3 ligase ligand with a terminal alkyne for click chemistry.
- Ready for conjugation to target molecules in PROTAC synthesis.
- High purity: 98.0%.
- Provided as 25 MG powder for small-scale research use.
- Molecular weight 311.29 g/mol; formula C16H13N3O4.
- Suitable for medicinal chemistry and chemical biology applications.
Medchemexpress LLC Thalidomide-pyrrolidine hydrochloride | 2616553-35-4 | 98.0% | 335.74 | C15H14ClN3O4 | 5 MG
Thalidomide-pyrrolidine hydrochloride is a cereblon-binding E3 ligase ligand supplied as the hydrochloride salt for use as a building block in PROTAC synthesis and targeted protein degradation research. It is intended for research use and is accompanied by quality documentation.
- Cereblon-binding E3 ligase ligand for PROTAC synthesis.
- Hydrochloride salt form for handling and stability.
- High purity: 98.0%.
- Documented quality: data sheet, certificate of analysis, and safety data sheet available.
- Storage recommendations: store dry at room temperature; in solvent, -80°C (2 years) or -20°C (1 year).