Lactams
![Medchemexpress LLC N-[2-amino-5-(2-thienyl)phenyl]-2-(1-piperazinyl)-6-quinolinecarboxamide | 1609389-52-7 | 99.6% | 429.54 g/mol | C24H23N5OS | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000243882.png-250.jpg)
Medchemexpress LLC N-[2-amino-5-(2-thienyl)phenyl]-2-(1-piperazinyl)-6-quinolinecarboxamide | 1609389-52-7 | 99.6% | 429.54 g/mol | C24H23N5OS | 100 MG
ACY-957 is a small-molecule, orally active inhibitor selective for histone deacetylases HDAC1 and HDAC2, used in preclinical research to modulate epigenetic regulation and induce γ-globin expression. CAS 1609389-52-7; formula C24H23N5OS; molecular weight 429.54 g/mol.
- Selective inhibition of HDAC1 and HDAC2 (IC50 7 nM and 18 nM)
- Markedly reduced activity against HDAC3 (IC50 ≈ 1,300 nM), supporting class I selectivity
- Orally active in preclinical models, suitable for in vivo dosing studies
- High reported purity for research-grade material (~99.6%)
- Solid, light yellow to yellow form; stable when stored at -20 °C
- Used to study epigenetic regulation and hemoglobin induction in preclinical research
eMolecules AstaTech / (S)-3-((TERT-BUTYLDIMETHYLSILYL)OXY)PYRROLIDIN-2-ONE / 0.25g / 296387864 / W11603 / 95.000 / 130403-91-7 / MFCD26394938 / 215.368 / C10H21NO2Si
AstaTech / (S)-3-((TERT-BUTYLDIMETHYLSILYL)OXY)PYRROLIDIN-2-ONE / 0.25g / 296387864 / W11603 / 95.000 / 130403-91-7 / MFCD26394938 / 215.368 / C10H21NO2Si
Medchemexpress LLC Thalidomide-pinacolborane | 2229725-98-6 | 97.0% | 384.19 g/mol | C19H21BN2O6 | 250 MG
Thalidomide-pinacolborane is a thalidomide analogue that incorporates a boronic pinacol ester (Bpin). It is used as a synthetic intermediate for cross-coupling chemistry and as an E3 ligase (cereblon) ligand in chemical biology and targeted protein degradation research.
- Contains a boronic pinacol ester suitable for Suzuki-Miyaura cross-coupling.
- Functions as an E3 ligase (cereblon) ligand for PROTAC and degradation studies.
- High purity appropriate for research applications.
- Available in research-scale quantities for assay development.
- Molecular formula C19H21BN2O6; molecular weight 384.19 g/mol.
Medchemexpress LLC Tetrazine-tagged thalidomide | 2087490-42-2 | MFCD34706062 | 98.6% | 571.58 g/mol | C29H29N7O6 | 5 MG
Tz-Thalidomide is a tetrazine-tagged derivative of thalidomide developed as an E3 ligase ligand and click-chemistry reagent. It is designed to undergo inverse electron-demand Diels-Alder (iEDDA) reactions with strained alkenes and has demonstrated binding activity to BRD4 in biochemical assays.
- Tetrazine functional group for rapid iEDDA click reactions with TCO-modified partners.
- Reported BRD4 binding (IC50: 46.25 μM for BRD4-1; 62.55 μM for BRD4-2).
- High purity suitable for research applications (98.6%).
- Solid, pink to red appearance for easy handling.
- Soluble in DMSO (~50 mg/mL), facilitating stock solution preparation.
- Storage conditions provided to support stability in powder and solution.
![eMolecules Broadpharm / Thalidomide-O-acetamido-C4-amine HCl salt / 100mg / 686681011 / BP-27849 / 98.000 / 1799711-24-2 / [null] / 402.407 / C19H22N4O6](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502475321.JPG-250.jpg)
eMolecules Broadpharm / Thalidomide-O-acetamido-C4-amine HCl salt / 100mg / 686681011 / BP-27849 / 98.000 / 1799711-24-2 / [null] / 402.407 / C19H22N4O6
Broadpharm / Thalidomide-O-acetamido-C4-amine HCl salt / 100mg / 686681011 / BP-27849 / 98.000 / 1799711-24-2 / [null] / 402.407 / C19H22N4O6