Lactams
Medchemexpress LLC Recombinant human 14-3-3 epsilon protein, GST-tagged | >95.0% | 100 UG
Recombinant human 14-3-3 epsilon protein with an N-terminal GST tag supplied as a lyophilized powder. The product contains full-length human YWHAE sequence (M1-Q255) expressed in E. coli, intended for research use. It is provided with low endotoxin and high purity for biochemical and cell-based assays and should be stored frozen and reconstituted per the supplier recommendations.
Medchemexpress LLC Thalidomide 10 mM * 1 mL in DMSO Solution
Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ∼250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties. Thalidomide can work as molecular glue to potentiate substrate.
Medchemexpress LLC Thalidomide-NH-C6-NH2 (hydrochloride) | 2375194-37-7 | 99.6% | 250 MG
Thalidomide-NH-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This product is for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide based cereblon ligand
- Used in PROTAC technology
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
Medchemexpress LLC Thalidomide-NH-PEG3-NH-Boc | 2204246-03-5 | 97.2% | 548.59 | 100 MG
Thalidomide-NH-PEG3-NH-Boc is a chemical compound with a molecular weight of 548.59. It appears as a light yellow to yellow oil and its structure is consistent with LCMS analysis. This product has been tested and complies with the given specifications.
- Molecular formula: C26H36N4O9
- Storage in pure form: -20°C for 3 years; 4°C for 2 years
- Storage in solvent: -80°C for 6 months; -20°C for 1 month
- Purity: 97.20%
- Appearance: Light yellow to yellow (oil)
Medchemexpress LLC Thalidomide-4-O-C9-NH2 hydrochloride | >98.0% | 451.94 g/mol | C22H30ClN3O5 | 10 MG
Thalidomide-4-O-C9-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand intended for use in targeted protein degradation and PROTAC development. Supplied as the hydrochloride salt for conjugation chemistry, the compound is offered for research use and is commonly provided in small milligram quantities for medicinal chemistry and chemical biology applications.
- Acts as a cereblon (CRBN) ligand for E3 ligase recruitment.
- Designed for use in PROTAC and targeted protein degradation research.
- Provided as a hydrochloride salt suitable for conjugation chemistry.
- Reported purity ≥98% according to vendor listings.
- Molecular weight ~451.94 g/mol; formula C22H30ClN3O5.
- Store sealed at -20°C to maintain stability.
Medchemexpress LLC VH 101 phenol-alkylC4-amine dihydrochloride | 2564467-03-2 | 676.67 | 25 MG
VH 101 phenol-alkylC4-amine dihydrochloride is a von-Hippel-Lindau protein ligand (VHL). It incorporates an E3 ligase ligand and an alkylC4 linker.
- Von-Hippel-Lindau protein ligand (VHL)
- Incorporates an E3 ligase ligand
- Incorporates an alkylC4 linker
- Can be used for PROTAC research (extracted from patent WO2022051326A1)
Medchemexpress LLC 2,6-piperidinedione, 3-(1,3-dihydro-5-iodo-1-oxo-2H-isoindol-2-yl) | 2291364-01-5 | MFCD32853043 | 98.0% | 370.14 | C13H11IN2O3 | 50 MG
Deoxy-thalidomide-5-iodine is an iodinated thalidomide analog intended for chemical biology and PROTAC applications; it functions as a cereblon-binding ligand for E3 ligase recruitment and is supplied with analytical data confirming identity and high purity.
- Iodinated thalidomide analog useful for PROTAC research.
- Binds cereblon to enable E3 ligase recruitment.
- High purity: 98.0% by NMR.
- Molecular weight 370.14; formula C13H11IN2O3.
- Appearance: blue to blue-green solid.
- Store protected from light at 4°C; in solvent keep at -80°C (6 months) or -20°C (1 month).
- Supplied in small research quantities (50 mg).
Medchemexpress LLC Thalidomide-5-O-C11-NH2 hydrochloride | >98.0% | 480.00 | C24H34ClN3O5 | 10 MG
Thalidomide-5-O-C11-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand used to recruit the CRBN E3 ligase in targeted protein degradation constructs. Supplied as a white to off-white solid, it is intended for research use in PROTAC synthesis and ligand-linker conjugation. Handle under light protection and low-temperature storage to maintain stability.
- Thalidomide-derived cereblon ligand for E3 ligase recruitment.
- High purity (>98.0% HPLC) suitable for synthetic applications.
- White to off-white solid, convenient for handling and weighing.
- Stable under low-temperature, light-protected storage when handled under nitrogen.
- Available in small research quantities for conjugation and PROTAC development.
![Medchemexpress LLC Cyclopropyl (S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f]triazolo[4,3-a]diazepin-6-yl) | 3077900-08-1 | 98.3% | 440.95 | C22H21ClN4O2S | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000294895.png-250.jpg)
Medchemexpress LLC Cyclopropyl (S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f]triazolo[4,3-a]diazepin-6-yl) | 3077900-08-1 | 98.3% | 440.95 | C22H21ClN4O2S | 10 MG
DDL-357 is a small-molecule secreted clusterin (sCLU) enhancer used as a research probe to increase sCLU levels in brain, reduce pathological phospho-tau, and improve memory in Alzheimer's disease mouse models. It is supplied as a 10 mg research sample intended for preclinical and in vitro studies.
- Potent secreted clusterin enhancer that increases sCLU in brain.
- Reduces phospho-tau and improves cognitive performance in murine 3xTg-AD models.
- Suitable for preclinical in vivo and in vitro research applications.
- Provided as a 10 mg research sample with 98.3% purity.
- Molecular weight 440.95; molecular formula C22H21ClN4O2S; CAS 3077900-08-1.
eMolecules 4-Benzoyloxy-2-azetidinone | 28562-58-5 | 5G | Purity: 95%
Combi-Blocks | 4-Benzoyloxy-2-azetidinone | 5G | 28562-58-5 | MFCD00012317
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Research Products International Corp Aztreonam, 100 MG
Aztreonam is a synthetic monocyclic beta-lactam antibiotic, with the nucleus based on a simpler monobactam isolated from Chromobacterium violaceum.
Medchemexpress LLC 5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione | 26166-92-7 | MFCD30188073 | 97.0% | 337.13 | C13H9BrN2O4 | 25 MG
Thalidomide-5-Br (5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione) is a brominated thalidomide derivative supplied as a research reagent and used in studies of inflammation, tumor biology, and neurology.
- contains a brominated thalidomide core
- used in inflammation research
- applicable to tumor biology studies
- suitable for neurology research
- available in small research quantities