Lactams
Medchemexpress LLC N-(4-aminobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide TFA salt | 1799711-25-3 | MFCD31560484 | 99.9% | 516.42 g·mol⁻¹ | C21H23F3N4O8 | 2 G
Thalidomide-O-amido-C4-NH2 TFA is a thalidomide-derived cereblon ligand-linker conjugate provided as the trifluoroacetate (TFA) salt for use in PROTAC design and other chemical biology applications. It is supplied as a white to off-white solid with high analytical purity and a molecular weight of 516.42 g·mol⁻¹.
- Thalidomide-derived cereblon ligand-linker conjugate.
- Provided as the trifluoroacetate (TFA) salt.
- High purity by LCMS (reported 99.92%).
- White to off-white solid appearance.
- Molecular formula C21H23F3N4O8; molecular weight 516.42 g·mol⁻¹.
- Intended for research use only; not for human or diagnostic use.
Medchemexpress LLC Thalidomide-O-amido-PEG2-C2-NH2 (TFA) | 1957235-75-4 | 576.48 | 500 MG
Thalidomide-O-amido-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate. It incorporates the Thalidomide based cereblon ligand and a 2-unit PEG linker used in PROTAC technology. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide based cereblon ligand
- Uses a 2-unit PEG linker
- Utilized in PROTAC technology
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Thalidomide-5-nh2-c8-nh2 tfa | 2097509-49-2 | 98.3% | 514.49 | 100 MG
Thalidomide-5-NH2-C8-NH2 TFA is a chemical compound that can be used for compound synthesis. It is for research purposes only and not for sale to patients.
- Appearance: Solid
- Color: Light yellow to green yellow
- Molecular Formula: C23H29F3N4O6
![Medchemexpress LLC 6H-Thieno[3,2-f]triazolo[4,3-a]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, cyclopropyl ester, (6S)- | 3077900-08-1 | 98.31% | 440.95 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000386961-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 6H-Thieno[3,2-f]triazolo[4,3-a]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, cyclopropyl ester, (6S)- | 3077900-08-1 | 98.31% | 440.95 | 50 MG
DDL-357 is a potent secreted clusterin enhancer. It reduces phospho-tau in the brain and improves memory in the murine 3xTg-AD model.
- Reduces phospho-tau in brain.
- Improves memory in the murine 3xTg-AD model.
Medchemexpress LLC 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-methyl- | 40313-92-6 | 99.9% | 272.26 | 25 MG
Thalidomide-5-methyl is a cereblon (CRBN) ligand derived from Thalidomide, used for recruiting CRBN protein. It can be utilized in the synthesis of PROTACs.
- Thalidomide-based cereblon (CRBN) ligand.
- Used in the recruitment of CRBN protein.
- Can be used to synthesize PROTACs.
Medchemexpress LLC Thalidomide-O-PEG4-amine hydrochloride | 2820929-03-9 | C23H32ClN3O9 | 250MG
Thalidomide-O-PEG4-amine hydrochloride is a synthesized E3 ligase ligand-linker conjugate. It incorporates a Thalidomide-based cereblon ligand and a linker used in PROTAC technology. This compound is designed to exploit the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based cereblon ligand
- Used in PROTAC technology
- Designed for selective degradation of target proteins
Medchemexpress LLC Thalidomide-O-COOH | 1061605-21-7 | MFCD31560477 | 99.9% | 332.27 g·mol⁻¹ | C15H12N2O7 | 10 MG
Thalidomide-O-COOH is a carboxylic acid-functionalized thalidomide derivative that serves as a cereblon (CRBN) ligand for targeted protein recruitment. It is used as an E3 ligase recruiter in PROTAC design and related chemical biology research.
- Carboxylic acid-functionalized thalidomide cereblon ligand.
- Used as an E3 ligase recruiter in PROTAC design and degrader development.
- Molecular formula C15H12N2O7, molecular weight 332.27 g·mol⁻¹.
- CAS number 1061605-21-7.
- For research use only; not for human or diagnostic applications.
Medchemexpress LLC Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride | 2245697-84-9 | MFCD31656717 | 98.3% | 542.97 | C23H31ClN4O9 | 250 MG
Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride is a thalidomide-derived cereblon ligand-linker conjugate used as an intermediate in the design and synthesis of PROTACs and targeted protein degraders. Supplied as the hydrochloride salt, it is provided as an off-white to yellow solid with high reported purity for research applications.
- High purity suitable for research and synthetic use.
- Hydrochloride salt form for improved handling and stability.
- Good solubility in DMSO and water; may require ultrasonic aid.
- Available in multiple package sizes, including 250 mg.
- Recommended storage at -20°C sealed, away from moisture.
Medchemexpress LLC 1H-Isoindole-1,3(2H)-dione, 5-[2-(2-chloroethoxy)ethoxy]-2-(2,6-dioxo-3-piperidinyl)- | 2230956-57-5 | 96.6% | 380.78 | 25 MG
Thalidomide-5-PEG2-Cl is a thalidomide-based cereblon ligand that facilitates the recruitment of CRBN protein. It can be linked to a target protein ligand to create PROTACs, which are designed to harness the intracellular ubiquitin-proteasome system for selective protein degradation.
- Functions as a thalidomide-based cereblon ligand
- Used in the recruitment of CRBN protein
- Can be connected to a protein ligand via a linker to form PROTACs
- PROTACs utilize the ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Thalidomide-O-PEG4-azide | 2380318-57-8 | 98.0% | C23H29N5O9 | 50 MG
Thalidomide-O-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that integrates a Thalidomide-based cereblon ligand with a linker used in PROTAC technology. This compound is intended for research use only.
- Acts as a click chemistry reagent due to its Azide group
- Participates in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing Alkyne groups
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups
Medchemexpress LLC Thalidomide-NH-PEG2-COOH | 2412056-45-0 | 99.0% | 433.41 | 100 MG
Thalidomide-NH-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate designed for PROTAC technology. It incorporates a Thalidomide-based cereblon ligand and is intended for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based cereblon ligand
- Utilized in PROTAC technology
- High purity: 99.0%
- Molecular weight: 433.41
- Molecular formula: C20H23N3O8
- Appearance: Light green to green solid
- Recommended storage: -20°C, sealed, away from moisture and light
- For research use only
Medchemexpress LLC Thalidomide-piperazine-PEG1-NH2 (diTFA) | 2984178-51-8 | 99.4% | 657.52 | 25 MG
Thalidomide-Piperazine-PEG1-NH2 (diTFA) is a chemical compound suitable for laboratory research. It is stable under recommended storage conditions and is not classified as a hazardous substance.
- Molecular formula: C25H29F6N5O9
- Molecular weight: 657.52
- Purity: 99.4%
- Appearance: White to yellow solid
- Storage conditions: 4°C sealed, away from moisture; in solvent: -80°C for 6 months, -20°C for 1 month
- For research use only
Medchemexpress LLC Thalidomide-PEG5-NH2 hydrochloride | 2703775-06-6 | C23H31N3O9 | 10MG
Thalidomide-PEG5-NH2 hydrochloride is a thalidomide-derived cereblon ligand-linker conjugate intended for PROTAC development and related chemical biology applications. It links a thalidomide-based CRBN-binding moiety to a PEG5 primary amine, enabling coupling to target-binding warheads while providing documentation for synthetic and screening use.
- Thalidomide-based cereblon ligand for CRBN recruitment.
- PEG5 amine linker enabling facile conjugation to warheads.
- Provided as a hydrochloride salt for the amine functionality.
- Available in small milligram quantities suitable for medicinal chemistry.
- Supplied with purity documentation and safety data sheet.
Medchemexpress LLC 5-fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione | 2230957-36-3 | >98.0% | 290.25 | C14H11FN2O4 | 500 MG
5-Fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione is a fluorinated thalidomide analogue described as an E3 ligase activator for research use. Supplied as a powder, it can serve as a synthetic building block for further derivatization, particularly by nucleophilic aromatic substitution (SNAr).
- Fluorinated thalidomide analogue useful for E3 ligase activation studies.
- Suitable as a synthetic building block for derivatization via SNAr.
- Supplied as a powder suitable for laboratory handling and storage.
- High purity; commonly listed as >98.0%.
- Typical pack sizes: 100 mg-1 g.