Lactams
Medchemexpress LLC Thalidomide-Propargyne-PEG2-COOH | 2797619-65-7 | 98.7% | 428.39 | 25 MG
Thalidomide-Propargyne-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the thalidomide based cereblon ligand and a linker used in PROTAC technology. It is a click chemistry reagent, containing an alkyne group, and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups.
- Synthesized E3 ligase ligand-linker conjugate.
- Incorporates thalidomide based cereblon ligand.
- Uses a linker in PROTAC technology.
- Click chemistry reagent.
- Contains an alkyne group.
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc).
Medchemexpress LLC Thalidomide-4-o-c10-nh2 hydrochloride | 2460022-53-9 | 50 MG
Thalidomide-4-O-C10-NH2 hydrochloride is a thalidomide-based cereblon ligand used in the recruitment of CRBN protein. It is intended for use as a laboratory chemical and for the manufacture of substances, strictly for research purposes. This product has not been fully validated for medical applications.
- Thalidomide-based cereblon ligand
- Used in the recruitment of CRBN protein
- For research use only
- Intended for use as laboratory chemicals
- Intended for the manufacture of substances
- Recommended storage temperature: -20°C (solid)
- For solutions, store at -80°C for 6 months or -20°C for 1 month
- Shipped at room temperature if transit is less than 2 weeks
- Store away from moisture and light
Medchemexpress LLC Thalidomide-O-C6-azide | 2411389-65-4 | 99.1% | 399.40 g·mol⁻¹ | C19H21N5O5 | 10 MG
Thalidomide-O-C6-azide is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon ligand with a six-carbon azide-containing linker. It is intended as a building block for PROTAC design and related targeted protein degradation research, providing a clickable azide handle for conjugation or labeling in chemical biology applications.
- High purity suitable for research applications (≈99.1%).
- Azide functional group enables copper-free and copper-catalyzed click chemistry.
- Six-carbon linker provides flexible spacing for bifunctional molecule design.
- Storage-stable when sealed at low temperature, with extended stability in solvent at -80°C.
- Available in multiple small-scale quantities for synthesis and assay development.
Medchemexpress LLC Thalidomide-4-O-C11-NH2 hydrochloride | 99.9% | 480.00 g·mol⁻¹ | C24H34ClN3O5 | 10 MG
Thalidomide-4-O-C11-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as the hydrochloride salt for research use in targeted protein degradation and PROTAC development. It is intended as an E3 ligase ligand-linker conjugate for synthesis and biochemical studies involving CRBN recruitment.
- High purity (99.94%) suitable for synthetic applications.
- Hydrochloride salt form for improved handling and solubility.
- Molecular formula C24H34ClN3O5; molecular weight 480.00 g·mol⁻¹.
- Available in small mg-scale pack sizes for research workflows.
- Designed for use as a cereblon ligand in PROTAC design and E3 ligase recruitment studies.
Medchemexpress LLC Thalidomide-NH-C6-NH-Boc | 2093536-13-9 | 96.1% | 250 MG
Thalidomide-NH-C6-NH-Boc is a synthesized E3 ligase ligand-linker conjugate. It incorporates a Thalidomide-based cereblon ligand and a linker that was utilized in the synthesis of MI-389 (compound 22). MI-389 is recognized as a potent phthalimide PROTAC degrader, derived from the multi-targeted receptor tyrosine kinase inhibitor sunitinib (HY-10255A). This product is intended for research use only and is not sold to patients.
- E3 ligase ligand-linker conjugate: contains a Thalidomide-based cereblon ligand.
- PROTAC component: the linker is used in the synthesis of MI-389, a potent phthalimide PROTAC degrader.
- Research use only: exclusively for research purposes.
Medchemexpress LLC Thalidomide-NH-C5-NH2 hydrochloride | 2375194-03-7 | 99.9% | 394.85 | 250 MG
Thalidomide-NH-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. It is for research use only and not sold to patients.
- Targets cereblon.
- Utilizes PROTAC technology for selective degradation of target proteins.
- Soluble in DMSO at 250 mg/mL (633.15 mM) with ultrasonication.
- In vivo dissolution protocols available for clear solutions.
- Ships at room temperature in continental US.
- Solid storage at -20°C, sealed, away from moisture and light.
- Storage in solvent at -80°C for 6 months or -20°C for 1 month.
Medchemexpress LLC Thalidomide-NH-C10-COOH | 2428400-33-1 | 97.5% | 100 MG
Thalidomide-NH-C10-COOH (compound 6b) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based CRBN ligand and a linker used in PROTAC technology. It has a molecular weight of 457.52 and the formula C24H31N3O6. It appears as a light yellow to yellow solid. It is for research use only and not sold to patients.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based CRBN ligand
- Used in PROTAC technology
- Molecular weight: 457.52
- Formula: C24H31N3O6
- Appearance: Light yellow to yellow solid
- Purity: 97.5%
- Target: Cereblon
- Solubility in DMSO: 50 mg/mL (109.28 mM)
Medchemexpress LLC Thalidomide-NH-CBP/p300 ligand 2 | 2484739-21-9 | 98.6% | 922.03 | 25 MG
Thalidomide-NH-CBP/p300 ligand 2 (P-007) is a PROTAC-based CBP and p300 degrader, as extracted from patent WO2020173440. This compound is intended for research use only.
- Protac-based CBP and p300 degrader
- Extracted from patent WO2020173440
- For research use only
Sigma Aldrich Fine Chemicals Biosciences Pomalidomide >=98% (HPLC) | 19171-19-8 | MFCD12756407 | 25MG
Pomalidomide >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 273.24 | 19171-19-8 | MFCD12756407 | 25MG
Medchemexpress LLC Thalidomide-O-C6-NHBoc | 2509093-23-4 | 95.99% | C24H31N3O7 | 50 MG
Thalidomide-O-C6-NHBoc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. It is for research use only and not sold to patients. The product appears as an off-white to light yellow solid with a molecular weight of 473.52.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide based cereblon ligand
- Linker used in PROTAC technology
- For research use only
- Appears as an off-white to light yellow solid
- Molecular weight of 473.52
Medchemexpress LLC Thalidomide-5-PEG6-NH2 hydrochloride | 574.02 g/mol | C25H36ClN3O10 | 10 MG
Thalidomide-5-PEG6-NH2 hydrochloride is a thalidomide-derived cereblon ligand designed as a synthetic building block for targeted protein degradation research. The molecule includes a PEG6 linker terminating in a primary amine (hydrochloride salt) that enables conjugation to linkers or target ligands for PROTAC construction. Storage and handling conditions are provided to maintain stability.
Medchemexpress LLC Thalidomide-NH-PEG2-COOH | 2412056-45-0 | MFCD34368531 | 99.0% | C20H23N3O8 | 10MG
Thalidomide-NH-PEG2-COOH is a thalidomide-derived cereblon (CRBN) ligand-linker conjugate designed as a building block for PROTAC and targeted protein degradation research. It couples a CRBN-recruiting thalidomide moiety to a short PEG2 spacer terminated with a carboxylic acid, facilitating conjugation to warheads or scaffolds for degrader design.
- Thalidomide-based cereblon ligand for CRBN recruitment.
- PEG2 linker terminated with carboxylic acid for conjugation.
- Suitable as a building block for PROTAC synthesis and linker optimization.
- High purity (99.0%) supporting reproducible conjugation chemistry.
- Molecular formula C20H23N3O8; molecular weight 433.41 g/mol.
- Supplied in small milligram pack sizes for research use.
![Medchemexpress LLC Tert-butyl 4-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]piperazine-1-carboxylate | 2222114-64-7 | MFCD32705088 | 98.8% | C22H26N4O6 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000259258.png-250.jpg)
Medchemexpress LLC Tert-butyl 4-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]piperazine-1-carboxylate | 2222114-64-7 | MFCD32705088 | 98.8% | C22H26N4O6 | 10MG
Thalidomide-piperazine-Boc is a Boc-protected piperazine derivative of thalidomide used as a synthetic intermediate for assembling E3 ligase ligand-linker conjugates such as PROTACs. It is supplied as a high-purity research reagent with defined solubility and storage recommendations.
- High purity (98.8%).
- Boc-protected piperazine for linker attachment.
- Soluble in DMSO (~41.7 mg/mL) with ultrasonic assistance.
- Powder stable at -20°C for long-term storage; solvent storage recommendations apply.
- Intended for research use only.
Medchemexpress LLC Thalidomide-4-O-CH2-COO(t-Bu) | 1950635-36-5 | MFCD32643096 | 99.3% | 388.37 | C19H20N2O7 | 10 MG
Thalidomide-4-O-CH2-COO(t-Bu) is a tert-butyl protected thalidomide derivative used as a cereblon (CRBN) binding ligand and as a synthetic intermediate in the preparation of PROTAC molecules. It is supplied for research use only and is not intended for human use.
- Tert-butyl protected thalidomide derivative suitable for deprotection under acidic conditions.
- Functions as a cereblon (CRBN) binding ligand for use in PROTAC design.
- High reported purity (~99.3%) for reliable research applications.
- Available in small research pack sizes (mg scale) for synthetic workflows.
- Stable at room temperature for extended storage; follow solvent storage recommendations for longer-term stability.
Medchemexpress LLC Thalidomide-NH-PEG2-COOH | 2412056-45-0 | 99.0% | 433.41 | 25 MG
Thalidomide-NH-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate. It incorporates the Thalidomide based cereblon ligand and a linker that is utilized in PROTAC technology. This product is intended for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Utilizes PROTAC technology
- Incorporates Thalidomide based cereblon ligand
- Intended for research use only