Lactams
Medchemexpress LLC Thalidomide-O-PEG4-azide | 2380318-57-8 | 98.0% | C23H29N5O9 | 100 MG
Thalidomide-O-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the thalidomide based cereblon ligand and a linker used in PROTAC technology. It is a click chemistry reagent, containing an azide group that can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups, and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide based cereblon ligand
- Used in PROTAC technology
- Click chemistry reagent containing an azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc)
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC)
- Molecular weight of 519.50
- Appears as a colorless to light yellow oil
Medchemexpress LLC Thalidomide-O-PEG4-amine hydrochloride | 2820929-03-9 | C23H32ClN3O9 | 250MG
Thalidomide-O-PEG4-amine hydrochloride is a synthesized E3 ligase ligand-linker conjugate. It incorporates a Thalidomide-based cereblon ligand and a linker used in PROTAC technology. This compound is designed to exploit the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based cereblon ligand
- Used in PROTAC technology
- Designed for selective degradation of target proteins
Medchemexpress LLC Thalidomide-5-o-c9-nh2 hydrochloride | 99.6% | 451.94 g·mol⁻1 | C22H30ClN3O5 | 10 MG
Thalidomide-5-O-C9-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand intended for chemical biology research. Supplied as the hydrochloride salt, it is used as an E3 ligase recruiting moiety in PROTACs and related conjugates. The product is reported with molecular formula C22H30ClN3O5 and molecular weight 451.94 g·mol⁻1.
- High purity: 99.6%.
- Hydrochloride salt form for improved handling and solubility.
- Designed for recruitment of cereblon (CRBN) in PROTAC construction.
- Suitable for synthesis, assay development, and linker conjugation.
- Available in small research pack sizes for laboratory use.
![eMolecules Broadpharm / D-acid-PEG4-Thalidomide-5-(PEG4-acid) / 100mg / 779524498 / BP-29724 / 98.000 / / [null] / 770.782 / C35H50N2O17](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502473531.JPG-250.jpg)
eMolecules Broadpharm / D-acid-PEG4-Thalidomide-5-(PEG4-acid) / 100mg / 779524498 / BP-29724 / 98.000 / / [null] / 770.782 / C35H50N2O17
Broadpharm / D-acid-PEG4-Thalidomide-5-(PEG4-acid) / 100mg / 779524498 / BP-29724 / 98.000 / / [null] / 770.782 / C35H50N2O17
![Medchemexpress LLC Butanoic acid, 4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl | 2308035-51-8 | 98.4% | 417.37 g/mol | C19H19N3O8 | 1 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000244795.png-250.jpg)
Medchemexpress LLC Butanoic acid, 4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl | 2308035-51-8 | 98.4% | 417.37 g/mol | C19H19N3O8 | 1 G
Thalidomide-O-amido-C3-COOH is an E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon ligand with a short carboxylic-acid linker for use in PROTAC design, synthesis, and degradation studies.
- Used as a cereblon E3 ligase ligand in PROTAC design and synthesis.
- High purity (98.4%) suitable for research applications.
- White to off-white solid with molecular weight 417.37 g/mol.
- Contains a carboxylic acid functional handle for conjugation chemistry.
- Available in small lab-scale quantities and supplied with a certificate of analysis.
Medchemexpress LLC Thalidomide-O-COOH | 1061605-21-7 | MFCD31560477 | 99.9% | 332.27 g·mol⁻¹ | C15H12N2O7 | 10 MG
Thalidomide-O-COOH is a carboxylic acid-functionalized thalidomide derivative that serves as a cereblon (CRBN) ligand for targeted protein recruitment. It is used as an E3 ligase recruiter in PROTAC design and related chemical biology research.
- Carboxylic acid-functionalized thalidomide cereblon ligand.
- Used as an E3 ligase recruiter in PROTAC design and degrader development.
- Molecular formula C15H12N2O7, molecular weight 332.27 g·mol⁻¹.
- CAS number 1061605-21-7.
- For research use only; not for human or diagnostic applications.
Sigma Aldrich Fine Chemicals Biosciences Pomalidomide >=98% (HPLC) | 19171-19-8 | MFCD12756407 | 25MG
Pomalidomide >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 273.24 | 19171-19-8 | MFCD12756407 | 25MG
Medchemexpress LLC Thalidomide-5-O-C8-NH2 hydrochloride | ≥98% | 437.92 | 5 MG
Thalidomide-5-O-C8-NH2 hydrochloride is a cereblon ligand derived from Thalidomide. It is utilized to recruit CRBN protein and can be linked to a target protein ligand via a linker to form PROTACs.
- It is a cereblon ligand.
- It is used in the recruitment of CRBN protein.
- It can be connected to a ligand for protein by a linker to form PROTACs.
- It is intended for research purposes only and not for sale to patients.
Medchemexpress LLC Thalidomide 5-fluoride | 835616-61-0 | MFCD30188075 | 100.0% | 276.22 g/mol | C13H9FN2O4 | 1 G
Thalidomide 5-fluoride is a thalidomide-derived cereblon ligand used as an E3 ligase recruiting moiety in chemical biology and PROTAC research. It is supplied as a powder and as a 10 mM DMSO solution for laboratory use.
- High purity: 99.96%
- Molecular weight: 276.22 g/mol
- Chemical formula: C13H9FN2O4
- Available sizes: 1 mL (10 mM in DMSO), 1 G, 5 G, 10 G, 25 G, 50 G
- Recommended storage: powder -20°C (up to 3 years) or 4°C (up to 2 years); in solvent -80°C (up to 6 months) or -20°C (up to 1 month)
- Safety and quality documents: SDS and COA provided by manufacturer
Medchemexpress LLC Thalidomide-5-O-C14-NH2 hydrochloride | 97.7% | 522.08 g/mol | C27H40ClN3O5 | 10 MG
Thalidomide-5-O-C14-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied for research use in targeted protein degradation and PROTAC development. It is provided as a small-quantity, high-purity solid suitable for conjugation through linkers to build bifunctional degraders and other CRBN-recruiting constructs.
- High purity of 97.7%.
- Molecular weight 522.08 g/mol and chemical formula C27H40ClN3O5.
- White to off-white solid appearance.
- Storage recommendations: -20 °C; in solvent: -80 °C (6 months) or -20 °C (1 month), protect from light, store under nitrogen.
- Suitable for use as a CRBN-recruiting ligand in PROTAC synthesis.
![eMolecules Medchem Express / Thalidomide-4-O-C2-NH2 (hydrochloride) / 10mg / 761506298 / HY-136162 / / 2341840-99-9 / [null] / 353.760 / C15H16ClN3O5](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502457212.PNG-250.jpg)
eMolecules Medchem Express / Thalidomide-4-O-C2-NH2 (hydrochloride) / 10mg / 761506298 / HY-136162 / / 2341840-99-9 / [null] / 353.760 / C15H16ClN3O5
Medchem Express / Thalidomide-4-O-C2-NH2 (hydrochloride) / 10mg / 761506298 / HY-136162 / / 2341840-99-9 / [null] / 353.760 / C15H16ClN3O5
Medchemexpress LLC Thalidomide-NH-C5-NH2 hydrochloride | 2375194-03-7 | 99.9% | 394.85 | 250 MG
Thalidomide-NH-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. It is for research use only and not sold to patients.
- Targets cereblon.
- Utilizes PROTAC technology for selective degradation of target proteins.
- Soluble in DMSO at 250 mg/mL (633.15 mM) with ultrasonication.
- In vivo dissolution protocols available for clear solutions.
- Ships at room temperature in continental US.
- Solid storage at -20°C, sealed, away from moisture and light.
- Storage in solvent at -80°C for 6 months or -20°C for 1 month.
Medchemexpress LLC Thalidomide-4,5-F | 2222115-19-5 | 98.0% | 294.21 g/mol | C13H8F2N2O4 | 250 MG
Thalidomide-4,5-F is a fluorinated thalidomide analogue used as a cereblon (CRBN) ligand and E3 ligase recruiter for chemical biology and PROTAC research. It promotes ubiquitinylation of target proteins and can be derivatized at fluorine positions. Supplied as a solid powder with high purity and recommended cold storage conditions.
- Fluorinated analogue designed for cereblon engagement.
- High purity suitable for research applications.
- Available in multiple milligram-scale pack sizes.
- Stable solid form with defined cold storage conditions.
- Modifiable at fluorine positions for derivatization.
Medchemexpress LLC Thalidomide-5-PEG2-Cl | 2230956-57-5 | 96.57% | 380.78 | 100 MG
Thalidomide-5-PEG2-Cl is a Thalidomide-based cereblon ligand involved in the recruitment of CRBN protein. It can be connected to a protein's ligand via a linker to form PROTACs. PROTACs utilize two different ligands connected by a linker: one binds to an E3 ubiquitin ligase, and the other targets the desired protein, leveraging the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- Utilized in the recruitment of CRBN protein
- Can be linked to a protein's ligand to form PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Enables selective degradation of target proteins
- Functions as an E3 ligase ligand-linker conjugate