Lactams
![Medchemexpress LLC Glycine, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]- | 2412056-27-8 | 95.0% | C15H13N3O6 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
Medchemexpress LLC Glycine, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]- | 2412056-27-8 | 95.0% | C15H13N3O6 | 25 MG
Thalidomide-5-NH2-CH2-COOH (compound 114) is a potent and selective inhibitor of tropomyosin receptor kinase (trk) and functions as a ligand of E3 ligase. This PROTAC leverages the intracellular ubiquitin-proteasome system to selectively degrade target proteins, holding potential for researching various diseases, as extracted from patent WO2021170109A1. This product is for research use only.
- Potent and selective inhibitor of tropomyosin receptor kinase (trk)
- Functions as a ligand for E3 ligase
- PROTAC (proteolysis-targeting chimera) technology
- Utilizes the ubiquitin-proteasome system to degrade target proteins
- Potential for researching various diseases
Medchemexpress LLC Thalidomide-propargyl | 2098487-39-7 | 99.97% | 312.28 | 100MG
Thalidomide-propargyl is a Thalidomide-based Cereblon ligand used to recruit the CRBN protein. It can be linked to a target protein ligand via a linker to form IMiD-containing PROTACs. It is also a click chemistry reagent containing an Alkyne group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules.
- Used to recruit the Cereblon protein
- Can be linked to a target protein ligand to form IMiD-containing PROTACs
- Click chemistry reagent containing an alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition with azide-containing molecules
Medchemexpress LLC Thalidomide-1-Me-5-NH2 | 1468761-60-5 | >98.0% | 287.27 g/mol | C14H13N3O4 | 25 MG
Thalidomide-1-Me-5-NH2 is an aminated analogue of thalidomide supplied as a research reagent. It acts as an E3 ligase ligand building block and can be derivatized at its amine for use in PROTAC design; it is not for medical, clinical diagnostic, or food use.
- Aminated thalidomide analogue suitable as an E3 ligase ligand.
- Can be derivatized at the amine for PROTAC and degrader design.
- High purity (>98.0%) appropriate for chemical biology research.
- Molecular formula C14H13N3O4, molecular weight 287.27 g/mol.
- Available in small quantities suitable for synthesis, for example 25 MG sizes.
- Supplied for research use only; not for medical or diagnostic use.
Medchemexpress LLC Thalidomide-propargyl | 2098487-39-7 | 99.97% | 312.28 | 25 MG
Thalidomide-propargyl is a Thalidomide-based Cereblon ligand used for the recruitment of CRBN protein. It can be linked to a protein ligand via a linker to form IMiD-containing PROTACs. This compound is also a click chemistry reagent, featuring an Alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Cereblon ligand
- Recruits CRBN protein
- Forms IMiD-containing PROTACs
- Click chemistry reagent
- Features an Alkyne group
- Participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc)
Medchemexpress LLC Thalidomide-O-COOH | 1061605-21-7 | MFCD31560477 | >98.0% | 332.27 | C15H12N2O7 | 10 G
Thalidomide-O-COOH is a thalidomide-derived cereblon (CRBN) ligand used as an E3 ligase recruiting moiety in PROTAC and targeted protein degradation design. The compound is supplied as a solid with molecular formula C15H12N2O7 and molecular weight 332.27 g/mol (CAS 1061605-21-7).
- Serves as a cereblon (CRBN) binding ligand for PROTAC construction.
- Suitable for medicinal chemistry and chemical biology research.
- Provided in multiple laboratory-scale pack sizes for synthesis and screening.
- Characterized by manufacturer datasheet and SDS for handling and storage guidance.
Medchemexpress LLC Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride | 2341841-02-7 | MFCD32705133 | 99.3% | 410.81 | 50 MG
Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride is a chemical compound designed for the development of PROTACs (Proteolysis Targeting Chimeras). It functions by incorporating a cereblon (CRBN) ligand, which is essential for E3 ubiquitin ligase binding, alongside a linker. This product is strictly for research purposes and is not intended for patient use or clinical applications.
- Incorporates a cereblon (CRBN) ligand for E3 ubiquitin ligase binding
- Features a versatile linker for PROTAC design
- A key component for PROTAC research and development
- Facilitates targeted protein degradation studies
- Suitable for chemical biology and drug discovery research
eMolecules 2341840-99-9 | Medchem Express | Thalidomide-4-O-C2-NH2 (hydrochloride) | 10mg | 761506298 | HY-136162 | 353.76 | C15H16ClN3O5
ChemScene | 5-Methoxyquinolin-6-amine | 100mg | 687357489 | CS-0197274 | 54620-48-3 | MFCD18971257 | 174.203 | C10H10N2O
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Medchemexpress LLC Thalidomide-O-C8-Boc | 2225148-52-5 | MFCD32701934 | 95.1% | C26H34N2O7 | 10MG
Thalidomide-O-C8-Boc is a thalidomide-derived Cereblon (CRBN) ligand intended for use as the E3 ligase-recruiting moiety in PROTAC design. It features an O-linked eight-carbon spacer with a Boc-protected terminus to enable linker attachment. Manufacturer data report molecular formula C26H34N2O7, molecular weight 486.56, and typical purity ~95%.
- Provides an O-linked C8 spacer with a Boc-protected terminus for linker attachment.
- Suitable for recruiting Cereblon (CRBN) as the E3 ligase in degrader strategies.
- Reported purity approximately 95.1%.
- High solubility in DMSO (100 mg/mL); manufacturer lists example in vivo formulations.
- Recommended storage: solid at -20°C under nitrogen; in solution -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Thalidomide-O-COOH | 1061605-21-7 | MFCD31560477 | 99.9% | 332.27 g·mol⁻¹ | C15H12N2O7 | 1 G
Thalidomide-O-COOH is a thalidomide-derived small-molecule ligand that recruits the CRBN E3 ubiquitin ligase and is commonly used as the E3 ligase component in PROTAC design and other chemical biology applications.
- Used as a cereblon (CRBN) E3 ligase ligand for PROTAC construction.
- CAS number 1061605-21-7; molecular formula C15H12N2O7; molecular weight 332.27 g·mol⁻¹.
- Reported high purity suitable for research and synthesis workflows.
- Functional handle (carboxylic acid) enables conjugation to linkers and building blocks.
- Supplied as a solid for storage and handling in synthetic and analytical protocols.
Medchemexpress LLC Thalidomide-5-OH | 64567-60-8 | 98.2% | 274.23 | 1 ML
Thalidomide-5-OH is a Thalidomide-based cereblon ligand that recruits the CRBN protein. It can be linked to a ligand for protein to form PROTACs. It is intended for research use only.
- Thalidomide-based cereblon ligand.
- Recruits CRBN protein.
- Can be connected to a ligand for protein by a linker to form PROTACs.
Medchemexpress LLC Thalidomide-PEG2-C2-NH2 hydrochloride | 2245697-87-2 | 99.9% | 25 MG
Thalidomide-PEG2-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate. It incorporates a Thalidomide-based cereblon ligand and a 2-unit PEG linker, making it suitable for use in PROTAC technology.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates a cereblon ligand
- Features a 2-unit PEG linker
- Utilized in PROTAC technology
- For research use only
Medchemexpress LLC Thalidomide-PEG2-C2-NH2 hydrochloride | 2245697-87-2 | 99.9% | 10 MG
Thalidomide-PEG2-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate. It incorporates a thalidomide based cereblon ligand and a 2-unit PEG linker, making it suitable for PROTAC technology applications. This product is for research use only.
- Used in PROTAC technology
- Suitable for autophagy research
- Applicable for apoptosis studies
- E3 ligase ligand-linker conjugate
- Targets cereblon
- Relevant for cancer targeted therapy research
- Used in cancer metabolism and metastasis studies
- Acts as an inhibitor
Medchemexpress LLC Thalidomide-O-C8-COOH | 2225148-51-4 | 97.4% | 430.45 g/mol | C22H26N2O7 | 5 MG
Thalidomide-O-C8-COOH is a thalidomide-derived cereblon ligand with a carboxy-terminated eight-carbon linker, developed for use as an E3 ligase recruiter in targeted protein degradation. It is provided as a high-purity solid optimized for conjugation into PROTACs and other bifunctional degraders, with documented solubility and storage recommendations for research workflows.
- High purity (97.4%) suitable for research applications.
- Carboxy-terminated C8 linker for convenient coupling chemistry.
- Molecular weight 430.45 g/mol; formula C22H26N2O7.
- High solubility in DMSO for preparation of concentrated stock solutions.
- Storage and solvent stability data provided for reliable handling.
Medchemexpress LLC 5-fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione | 2230957-36-3 | 290.25 | C14H11FN2O4 | 250 MG
Thalidomide-1-Me,5-F is a fluorinated thalidomide derivative used as an E3 ubiquitin ligase activator in research. Supplied as a solid for laboratory use, it functions as a synthetic building block for further derivatization and for studies that probe E3 ligase-mediated pathways. Consult the product datasheet for lot-specific purity and analytical data.
- Fluorinated E3 ligase activator suitable for biochemical assays
- Reactive position enables SNAr derivatization for synthesis
- Supplied as a solid in multiple laboratory scales
- Molecular formula C14H11FN2O4; molecular weight 290.25
- Powder storage: -20°C (long term) or 4°C (short term)
- Data sheet and certificate of analysis available for purity and handling
Medchemexpress LLC Thalidomide-4,5-F | 2222115-19-5 | 98.0% | 294.21 g/mol | C13H8F2N2O4 | 250 MG
Thalidomide-4,5-F is a fluorinated thalidomide analogue used as a cereblon (CRBN) ligand and E3 ligase recruiter for chemical biology and PROTAC research. It promotes ubiquitinylation of target proteins and can be derivatized at fluorine positions. Supplied as a solid powder with high purity and recommended cold storage conditions.
- Fluorinated analogue designed for cereblon engagement.
- High purity suitable for research applications.
- Available in multiple milligram-scale pack sizes.
- Stable solid form with defined cold storage conditions.
- Modifiable at fluorine positions for derivatization.