Lactams
Medchemexpress LLC Thalidomide-O-C8-Boc | 2225148-52-5 | 95.1% | 1 ML
Thalidomide-O-C8-Boc is a Thalidomide-based Cereblon ligand utilized for the recruitment of CRBN protein. It can be linked to a target protein ligand via a linker to create PROTACs.
- Cereblon ligand
- Used for recruitment of CRBN protein
- Can be linked to a target protein ligand via a linker to create PROTACs
- For research use only
Medchemexpress LLC Thalidomide-1-me-5-nh2 | 1468761-60-5 | >98.0% | 287.27 g·mol-1 | C14H13N3O4 | 50 MG
Thalidomide-1-Me-5-NH2 is an aminated thalidomide analogue used as a cereblon E3 ligase ligand and building block for PROTAC design and related chemical biology research. It is intended for derivatization at the amine for linker attachment and is supplied as a high-purity research reagent suitable for synthetic applications.
- Aminated thalidomide analogue enabling linker derivatization
- Serves as a cereblon E3 ligase ligand for PROTAC design
- High purity for research applications (>98.0%)
- Supplied in small milligram-scale quantities suitable for synthesis (50 mg)
- Molecular formula C14H13N3O4, molecular weight 287.27 g·mol-1
- CAS number 1468761-60-5 for unambiguous identification
eMolecules 2245697-88-3 | Medchem Express | Thalidomide-4-O-C6-NH2 (hydrochloride) | 5mg | 599150703 | HY-135250B | 409.87 | C19H24ClN3O5
Medchem Express | Canthaxanthin | 5mg | 446274074 | HY-B1960 | 514-78-3 | MFCD00016364 | 564.854 | C40H52O2
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Medchemexpress LLC Thalidomide-5-COOH | 1216805-11-6 | 99.9% | 302.24 | 100 MG
Thalidomide-5-COOH is a Thalidomide-based cereblon ligand that recruits the CRBN protein. It can be linked to a target protein ligand via a linker to form PROTACs. PROTACs utilize the intracellular ubiquitin-proteasome system to specifically degrade target proteins. It is for research use only.
- Thalidomide-based cereblon ligand
- Recruits CRBN protein
- Can be linked via a linker to form PROTACs
- Utilizes the intracellular ubiquitin-proteasome system
- Specifically degrades target proteins
- For research use only
Medchemexpress LLC Thalidomide-O-amido-C6-NH2 TFA | 1950635-14-9 | 99.8% | 544.48 | 1 G
Thalidomide-O-amido-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, and can be used in the synthesis of PROTACs.
- Can be used in the synthesis of PROTACs.
- PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Incorporates the Thalidomide based cereblon ligand.
![Medchemexpress LLC Propanoic acid, 3-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl] oxy] | 2682112-08-7 | MFCD00869897 | 97.0% | C20H22N2O9 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000262032.png-250.jpg)
Medchemexpress LLC Propanoic acid, 3-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl] oxy] | 2682112-08-7 | MFCD00869897 | 97.0% | C20H22N2O9 | 10MG
Thalidomide-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon ligand with a PEG3 spacer terminating in a carboxylic acid. It is designed as a building block for PROTAC and targeted protein degradation research, supplied as a solid with high reported purity and DMSO solubility.
- Incorporates cereblon-binding thalidomide scaffold for E3 recruitment.
- PEG3 linker provides a flexible spacer for target engagement.
- Terminal carboxylic acid enables amide coupling and conjugation chemistry.
- High reported purity (96.95%) suitable for synthesis and analytical work.
- Soluble in DMSO for straightforward stock solution preparation.
- Available in small laboratory pack sizes for research use.
Medchemexpress LLC Thalidomide-5-O-C7-NH2 hydrochloride | 98.13% | 423.89 | 5 MG
Thalidomide-5-O-C7-NH2 hydrochloride is a Thalidomide (HY-10984)-based cereblon ligand that is used for recruiting CRBN protein. It can be connected to a ligand for protein by a linker to form PROTACs.
- Used in the recruitment of CRBN protein
- Can be connected to a ligand for protein by a linker
- Forms PROTACs
- For research use only
Medchemexpress LLC Thalidomide-5-peg2-cl | 2230956-57-5 | 96.6% | 380.78 g/mol | C17H17ClN2O6 | 5 MG
Thalidomide-5-PEG2-Cl is a thalidomide-derived cereblon ligand intended for use as the E3 ligase-recruiting component in proteolysis-targeting chimera (PROTAC) synthesis. It contains a two-unit polyethylene glycol linker and a terminal chloro functional group to facilitate conjugation to target ligands. Intended for research use only.
- Enables cereblon recruitment in PROTAC constructs.
- Contains a PEG2 linker for flexible conjugation.
- Terminal chloro group for facile chemical coupling.
- High purity suitable for research applications.
- Available in small milligram quantities for screening and synthesis.
Cayman Chemical AzIdo-ThalIdomIde 50mg
A PROTAC building block; contains thalidomide, which is a ligand for the E3 ubiquitin ligase cereblon, and can be conjugated to alkynylated ligands for target proteins via click chemistry; has been used in the synthesis of a SirReal-based PROTAC for the degradation of Sirt2 in cells
Medchemexpress LLC Thalidomide-O-amido-PEG3-C2-NH2 TFA | 1957236-21-3 | MFCD31560482 | 99.6% | 660.67 g/mol | C23H30F3N5O9 | 25 MG
Thalidomide-O-amido-PEG3-C2-NH2 TFA is a trifluoroacetate salt E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon ligand with a three-unit polyethylene glycol (PEG3) linker for use in PROTAC synthesis and related chemical biology research. It is supplied as a high-purity solid and is intended for research use only.
- Contains a thalidomide-based cereblon ligand for cereblon-mediated degradation studies.
- PEG3 linker provides flexibility and solubility for linker optimization in PROTAC design.
- Offered as a solid TFA salt for convenient handling and storage.
- High purity suitable for synthetic chemistry and biological probe development.
- Recommended storage: powder at -20°C; in solution, store at -80°C for long-term preservation.
Medchemexpress LLC Thalidomide-O-amido-PEG3-C2-NH2 TFA | 1957236-21-3 | MFCD31560482 | >98.0% | 572.5 g/mol | C24H27F3N4O9 | 5 MG
Thalidomide-O-amido-PEG3-C2-NH2 TFA is a thalidomide-based cereblon E3 ligase ligand-linker conjugate provided as the trifluoroacetic acid (TFA) salt. It is intended as a building block for PROTAC synthesis, combining a thalidomide-derived CRBN-binding moiety with a three-unit polyethylene glycol (PEG3) spacer and a short C2 amine handle for conjugation.
- Provides a cereblon-binding thalidomide ligand for PROTAC design.
- Includes a PEG3 linker to improve solubility and flexibility.
- Features a C2 amine handle for facile coupling to warheads.
- Offered as the TFA salt to aid handling and stability.
- Supplied at high purity (>98%) suitable for synthetic use.
- Available in small research-scale quantities for method development.
Medchemexpress LLC (S)-Thalidomide | 841-67-8 | MFCD00210219 | 99.52% | 258.23 | 50 MG
(S)-Thalidomide is the S-enantiomer of Thalidomide. It exhibits immunomodulatory, anti-inflammatory, antiangiogenic, and pro-apoptotic effects. (S)-Thalidomide induces teratogenic effects by binding to cereblon (CRBN).
- It is the S-enantiomer of thalidomide.
- It exhibits immunomodulatory effects.
- It has anti-inflammatory properties.
- It shows antiangiogenic effects.
- It possesses pro-apoptotic effects.
- It binds to cereblon (CRBN).
Medchemexpress LLC Thalidomide-4-OH | 5054-59-1 | MFCD03699892 | 99.9% | 274.23 g·mol⁻¹ | C13H10N2O5 | 10 G
Thalidomide-4-OH is a 4-hydroxylated metabolite of thalidomide used as a Cereblon (CRBN) ligand in chemical biology and PROTAC research. It is supplied as a high-purity solid for synthetic and biochemical applications, with recommended storage under inert atmosphere.
- High purity suitable for synthesis and assays.
- Molecular formula C13H10N2O5; molecular weight 274.23 g·mol⁻¹.
- Used as a CRBN ligand for recruitment of cereblon in PROTACs.
- Available in gram-scale quantities for research workflows.
- Solid with melting point 273-275 °C.
- Recommended storage: 4 °C under nitrogen; in solvent: -80 °C (6 months) or -20 °C (1 month).
Medchemexpress LLC Thalidomide-O-amido-PEG3-C2-NH2 TFA | 1957236-21-3 | 99.6% | 620.53 g/mol | C25H31F3N4O11 | 10 MG
Thalidomide-O-amido-PEG3-C2-NH2 TFA is a thalidomide-based cereblon ligand-linker conjugate (trifluoroacetic acid salt) designed as a building block for PROTAC synthesis. It links a thalidomide-derived E3 ligase ligand to a three-unit PEG spacer terminating in a C2 amino handle, enabling attachment to targeting ligands and facilitating cereblon-mediated target degradation.
- Thalidomide-based cereblon ligand for E3 ligase recruitment.
- Three-unit PEG linker providing flexible spacing and solubility.
- C2 amino terminal suitable for amide or urea coupling.
- Trifluoroacetic acid salt form for improved handling and stability.
- Molecular formula C25H31F3N4O11; molecular weight 620.53 g/mol.
- Soluble in DMSO at 50 mg/mL; ultrasonic may be required.
- Recommended storage: 4°C sealed; in solvent store at -80°C (6 months) or -20°C (1 month).
- Available in small research quantities suitable for synthesis, e.g., 10 mg.