Lactams
Medchemexpress LLC Thalidomide-NH-C9-NH2 hydrochloride | 2305936-77-8 | 99.9% | 450.96 g/mol | C22H31ClN4O4 | 10 MG
Thalidomide-NH-C9-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as a hydrochloride salt for use in proteolysis-targeting chimera (PROTAC) construction and related chemical biology research. Provided as a light yellow solid with high purity and defined storage stability, it is intended for laboratory research use only.
- High purity (99.85%) suitable for research applications.
- Hydrochloride salt form to aid handling and solubility considerations.
- Available in small research pack sizes, including 10 mg, for synthesis workflows.
- Designed to act as a CRBN-binding E3 ligase ligand in PROTAC constructs.
- Recommended storage: -20°C sealed; in solvent: -80°C up to 6 months or -20°C up to 1 month.
Medchemexpress LLC Thalidomide-4-O-C6-NH2 hydrochloride | 2245697-88-3 | 98.5% | 409.86 | C19H24ClN3O5 | 5 MG
Thalidomide-4-O-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate supplied as the hydrochloride salt for research use. It is used as a building block in PROTAC dTAG-13, a degrader of FKBP12F36V and BET proteins, and is provided with supporting analytical data and handling documentation.
- Provided as the hydrochloride salt suitable for synthetic applications.
- High purity (98.5% by HPLC) with supporting analytical data.
- Analytical files include data sheet, COA, H NMR, and LCMS.
- Available in multiple pack sizes from milligrams to grams.
- Intended for research use only; not for human or therapeutic use.
Apexbio Technology LLC Brucine 10mM (in 1mL DMSO)
N1490 is a small-molecule inhibitor designed for biomedical research It exerts its effects by selectively targeting and modulating specific intracellular signaling pathways implicated in disease progression N1490 has been explored in cellular assays for its ability to interfere with relevant molecular interactions resulting in altered downstream signaling events This compound serves as a valuable tool for investigating cellular mechanisms regulated by these pathways and may facilitate the discovery of novel therapeutic strategies in areas such as oncology immunology or metabolic research
Medchemexpress LLC Thalidomide 5-fluoride | 835616-61-0 | 100.0% | 276.22 g/mol | C13H9FN2O4 | 25 G
Thalidomide 5-fluoride is a thalidomide-derived cereblon ligand used in targeted protein degradation research and PROTAC synthesis. It is supplied as a high-purity solid and as a DMSO solution, with analytical data and safety documentation available.
- Thalidomide-based cereblon ligand for PROTAC development and E3 ligase recruitment studies.
- Molecular formula C13H9FN2O4; molecular weight 276.22 g/mol.
- High purity (99.96%).
- Available as solid in 1 g, 5 g, 10 g, 25 g quantities.
- Solution option available as 10 mM in DMSO.
- Supplied with supporting documentation including COA, SDS, HNMR, RP-HPLC, and MS.
Medchemexpress LLC Fc epsilon RIA/FCER1 50ug
Recombinant human Fc epsilon RI alpha (extracellular domain) supplied as 50 μg lyophilized material with an N-terminal His-SUMO tag, intended for binding and functional studies involving human IgE.
- Prepared as lyophilized powder for long-term storage and transport.
- Includes N-terminal His-SUMO tag to facilitate affinity purification.
- Expression system: E. coli for efficient production.
- High purity (>95%) as determined by reducing SDS-PAGE.
- Approximate molecular weight ~37 kDa for molecular characterization.
- Demonstrated IgE binding in ELISA with reported ED50 of 5.864 μg/mL.
Medchemexpress LLC 14-3-3 epsilon Antibody (YA2629) | 100 UL
The 14-3-3 epsilon antibody (YA2629) is a rabbit-derived, non-conjugated IgG monoclonal antibody designed to target the 14-3-3 epsilon protein. This protein acts as an adapter involved in the regulation of diverse cellular signaling pathways by binding to phosphoserine or phosphothreonine motifs, thereby modulating the activity of binding partners. The antibody shows reactivity with human, mouse, and rat samples and is supplied as a liquid formulation.
- Reactivity with human, mouse, and rat samples
- Suitable for WB, IHC-P, ICC/IF, and FC applications
- Formulated in 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide, and 0.05% BSA
- Store at -20°C for 1 year
- Avoid repeated freeze/thaw cycles
- Shipping with blue ice
Medchemexpress LLC CD23/Fc epsilon RII 5ug
CD23/Fc epsilon RII Protein a low-affinity receptor for IgE and CR2/CD21 regulates IgE production and B cell differentiation On B cells it initiates IgE-dependent antigen uptake and presentation to T cells On macrophages IgE binding induces intracellular killing of parasites through the L-Arginine-nitric oxide pathway CD23/Fc epsilon RII homotrimer interacts with IGHE to regulate IgE homeostasis and with CR2/CD21 for binding CD23/Fc epsilon RII Protein Mouse (HEK293 His) is the recombinant mouse-derived CD23/Fc epsilon RII protein expressed by HEK293 with N-His labeled tag