Lactams
Medchemexpress LLC Thalidomide-o-amido-PEG4-azide | 2411681-89-3 | 99.2% | C25H32N6O10 | 25 MG
Thalidomide-O-amido-PEG4-azide is a PEG-based PROTAC linker primarily used in the synthesis of PROTACs. This compound also functions as a versatile click chemistry reagent due to its azide group, enabling both copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with appropriate alkyne-containing molecules. PROTACs, which utilize this linker, are designed to leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- PEG-based PROTAC linker
- Used for synthesizing PROTACs
- Functions as a click chemistry reagent
- Facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- Exploits the ubiquitin-proteasome system
- Supports selective degradation of target proteins
Medchemexpress LLC 5-bromo-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione | 2740657-28-5 | MFCD34180776 | >98.0% | 355.12 g/mol | C13H8BrFN2O4 | 100 MG
Thalidomide-4-F,5-Br is a thalidomide analogue used as a cereblon ligand in chemical biology and targeted protein degradation research. The compound is supplied as a solid research reagent (CAS 2740657-28-5) with a reported formula of C13H8BrFN2O4 and reported purity >98% in supplier documentation. Typical applications include PROTAC development, biochemical assays, and studies of E3 ligase-mediated ubiquitination.
- Acts as a cereblon ligand for recruiting E3 ubiquitin ligase.
- Useful in PROTAC design and targeted protein degradation studies.
- High reported purity suitable for research applications.
- Solid form stable for standard laboratory storage conditions.
- CAS-registered for unambiguous chemical identification.
Medchemexpress LLC Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride | 2983037-00-7 | 98.01% | 586.03 | 50 MG
Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand. It is used in PROTAC technology, which exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Incorporates Thalidomide based cereblon ligand
- Used in PROTAC technology
- Targets E3 ubiquitin ligase
- Facilitates selective degradation of target proteins
Apexbio Technology LLC Thalidomide-O-amido-C4-NH2 TFA 1799711-25-3 10mg
Thalidomide-O-amido-C4-NH2 TFA (CAS 1799711-25-3) is a synthetic small molecule composed of a thalidomide-derived cereblon ligand conjugated to a chemical linker This compound selectively binds to cereblon (CRBN) a substrate receptor of the CRL4CRBN E3 ubiquitin ligase complex By facilitating the recruitment of target proteins to the CRBN complex it enables their ubiquitination and subsequent proteasomal degradation Thalidomide-O-amido-C4-NH2 TFA serves as a molecular tool in the development of proteolysis targeting chimeras (PROTACs) and other targeted protein degradation strategies in biomedical research
Medchemexpress LLC Thalidomide-4-O-C10-NH2 hydrochloride | 00-00-0 | 95.6% | C23H32ClN3O5 | 10MG
Thalidomide-4-O-C10-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand formulated as a hydrochloride salt for use in PROTAC design and related biochemical research. Supplied as a solid with reported high purity, it is intended for small-scale laboratory studies and compound linking applications.
- Hydrochloride salt form for improved stability
- High purity suitable for research applications
- Molecular formula C23H32ClN3O5 and molecular weight 465.97
- Available in small packaging sizes for synthesis and screening
- Solid form for convenient handling and storage
Medchemexpress LLC Thalidomide-NH-PEG2-COOH | 2412056-45-0 | MFCD34368531 | ≥95.0% | 433.41 g/mol | C20H23N3O8 | 5 MG
Thalidomide-NH-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon (CRBN) ligand with a short PEG2 carboxylic acid linker. It is designed as a building block for PROTAC (proteolysis targeting chimera) synthesis and related chemical biology research. For research use only.
- Provides CRBN engagement via a thalidomide-derived ligand.
- Contains a PEG2 spacer terminating in a carboxylic acid for linker conjugation.
- Suitable as a building block for PROTAC synthesis and E3 ligase recruitment studies.
- Characterized by analytical data, including HPLC, LC-MS, and NMR files.
- Available in small research-scale quantities for medicinal chemistry applications.
Medchemexpress LLC Thalidomide-Piperazine-PEG2-NH2 (diTFA) | 99.7% | 701.57 | 25 MG
Thalidomide-Piperazine-PEG2-NH2 diTFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide-based cereblon ligand and a linker used in PROTAC technology. It is for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based cereblon ligand
- Includes a linker used in PROTAC technology
- Targets Cereblon
- Utilizes the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Thalidomide-5-OH | 64567-60-8 | 98.2% | 274.23 | 25 G
Thalidomide-5-OH is a thalidomide-based cereblon ligand. It is used in the recruitment of CRBN protein and can be connected to a target protein ligand via a linker to form PROTACs.
- Thalidomide-based cereblon ligand
- Recruits CRBN protein
- Connects to protein ligands via a linker to form PROTACs
- Targets cereblon
Medchemexpress LLC Thalidomide-PEG2-C2-NH2 (hydrochloride) | 2245697-87-2 | >99.9% | 100 MG
Thalidomide-PEG2-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a 2-unit PEG linker used in PROTAC technology. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Used in PROTAC technology.
- Exploits the intracellular ubiquitin-proteasome system.
- Selectively degrades target proteins.
- Incorporates thalidomide based cereblon ligand.
- Features a 2-unit PEG linker.
- For research use only.
Medchemexpress LLC Thalidomide-iodo | 2509137-01-1 | MFCD31735039 | 98.0% | 384.13 | C13H9IN2O4 | 100 MG
Thalidomide-iodo is an iodinated derivative of thalidomide supplied as a research reagent. It acts as an E3 ligase activator and is suitable as a synthetic building block for further derivatization via substitution of the iodine. Typical specifications include CAS 2509137-01-1, molecular formula C13H9IN2O4, molecular weight 384.13, and reported purity of 98.0%.
- Iodinated E3 ligase activator for probe and degrader research.
- Synthetic building block amenable to substitution of iodine.
- High purity suitable for analytical and synthetic workflows.
- Available in multiple pack sizes for small-scale research.
- Intended for laboratory research use only.
Medchemexpress LLC Thalidomide-pinacolborane | 2229725-98-6 | 97.0% | 384.19 g/mol | C19H21BN2O6 | 50 MG
Thalidomide-pinacolborane is a thalidomide analogue containing a pinacol boronate (Bpin) group, supplied as a research reagent for use in synthetic chemistry and chemical biology. It is suitable as a building block for cross-coupling reactions and as a probe to investigate E3 ligase-mediated ubiquitination in degradation studies.
- Contains a pinacol boronate functional group for cross-coupling chemistry.
- Useful as a synthetic intermediate in Suzuki-Miyaura reactions.
- Acts as a thalidomide analogue for studying E3 ligase activity.
- Supplied as a high-purity research chemical suitable for analytical and preparative use.
- Provided in small-quantity packaging for laboratory experiments.
Sigma Aldrich Fine Chemicals Biosciences Pomalidomide | 19171-19-8 | MFCD12756407 | 5mg
Pomalidomide | 98% (HPLC) | 273.24 | 19171-19-8 | MFCD12756407 | 5mg
Apexbio Technology LLC Thalidomide-O-amido-C4-NH2 TFA 1799711-25-3 50mg
Thalidomide-O-amido-C4-NH2 TFA (CAS 1799711-25-3) is a synthetic small molecule composed of a thalidomide-derived cereblon ligand conjugated to a chemical linker This compound selectively binds to cereblon (CRBN) a substrate receptor of the CRL4CRBN E3 ubiquitin ligase complex By facilitating the recruitment of target proteins to the CRBN complex it enables their ubiquitination and subsequent proteasomal degradation Thalidomide-O-amido-C4-NH2 TFA serves as a molecular tool in the development of proteolysis targeting chimeras (PROTACs) and other targeted protein degradation strategies in biomedical research
Medchemexpress LLC Thalidomide-4-O-C7-NH2 hydrochloride | 00-00-0 | 99.8% | C20H26ClN3O5 | 10MG
Thalidomide-4-O-C7-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand-linker conjugate provided as the hydrochloride salt for research use in PROTAC development and E3 ligase recruitment studies. It is supplied as a high-purity, well-characterized reagent suitable for biochemical assays, linker conjugation, and medicinal chemistry workflows.
- High purity (99.8%) suitable for research applications.
- Hydrochloride salt form for consistent handling and storage.
- Characterized molecular formula C20H26ClN3O5 and molecular weight 387.43 g/mol.
- Functions as a cereblon (CRBN) E3 ligase ligand for PROTAC design.
- Available in small, lab-scale quantities for screening and synthesis.
- Datasheet and certificate of analysis available from the supplier.