Lactams
![eMolecules Broadpharm / Thalidomide-5-(PEG4-acid) / 100mg / 713699648 / BP-28034 / 98.000 / / [null] / 549.533 / C25H31N3O11](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502475017.JPG-250.jpg)
eMolecules Broadpharm / Thalidomide-5-(PEG4-acid) / 100mg / 713699648 / BP-28034 / 98.000 / / [null] / 549.533 / C25H31N3O11
Broadpharm / Thalidomide-5-(PEG4-acid) / 100mg / 713699648 / BP-28034 / 98.000 / / [null] / 549.533 / C25H31N3O11
Medchemexpress LLC Thalidomide-O-amido-C3-PEG3-C1-NH2 | 1799711-29-7 | 99.1% | 648.58 g/mol | C27H35F3N4O11 | 5 MG
Thalidomide-O-amido-C3-PEG3-C1-NH2 is a thalidomide-derived cereblon E3 ligase ligand conjugated to a three-unit PEG linker and a short C3 spacer terminating in an amine. Supplied for research use, it is intended as a linker-ligand building block for PROTAC design and related chemical biology applications.
- Thalidomide-based cereblon ligand for E3 ligase recruitment.
- Three-unit PEG linker and C3 spacer terminating in an amine for conjugation.
- High purity suitable for research applications (~99.1%).
- Available in small pack sizes for discovery work (mg scale).
- Store sealed at 4°C; in solution store at -80°C (6 months) or -20°C (1 month).
- For research use only, not for human use.
Medchemexpress LLC 5-fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione | 2230957-36-3 | 97.0% | 290.25 g/mol | C14H11FN2O4 | 5 G
A fluorinated thalidomide analogue that functions as an E3 ligase (Cereblon) activator and a synthetic building block for targeted protein degradation research. Suitable for recruiting CRBN in PROTAC design and for further chemical derivatization via nucleophilic aromatic substitution (SNAr).
- Fluorinated thalidomide analogue
- Acts as an E3 ligase (Cereblon) activator
- Useful as a PROTAC ligand building block
- Compatible with SNAr derivatization
- Typical purity approximately 97.0%
- Molecular formula C14H11FN2O4; molecular weight 290.25 g/mol
Medchemexpress LLC Thalidomide-4-O-C6-NH2 hydrochloride | 2245697-88-3 | 98.5% | 409.86 | C19H24ClN3O5 | 5 MG
Thalidomide-4-O-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate supplied as the hydrochloride salt for research use. It is used as a building block in PROTAC dTAG-13, a degrader of FKBP12F36V and BET proteins, and is provided with supporting analytical data and handling documentation.
- Provided as the hydrochloride salt suitable for synthetic applications.
- High purity (98.5% by HPLC) with supporting analytical data.
- Analytical files include data sheet, COA, H NMR, and LCMS.
- Available in multiple pack sizes from milligrams to grams.
- Intended for research use only; not for human or therapeutic use.
Medchemexpress LLC Thalidomide-CH2NH2 hydrochloride | 444287-40-5 | MFCD32183715 | 98.0% | 323.73 g/mol | C14H14ClN3O4 | 10 MG
Thalidomide-CH2NH2 hydrochloride is a thalidomide analogue supplied as the hydrochloride salt for research use. It features a primary aminomethyl substituent that enables further functionalization and utility as a ligand-like scaffold in biochemical studies. The compound is provided as a high-purity solid suitable for synthetic chemistry and assay development.
- Contains a primary aminomethyl group for synthetic functionalization.
- Supplied as the hydrochloride salt for improved stability and handling.
- High purity suitable for research and assay development.
- Serves as a ligand scaffold for E3 ligase-related studies.
- Available in small-scale quantities for discovery workflows.
Medchemexpress LLC Thalidomide-5-CH2-NH2 hydrochloride | 1010100-22-7 | MFCD32666042 | 98.6% | 323.73 | C14H14ClN3O4 | 50 MG
Thalidomide-5-CH2-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand used as an E3 ligase recruiting moiety in PROTAC design and targeted protein degradation research. Supplied as a solid with high purity, it serves as a linker-compatible building block for medicinal chemistry and chemical biology applications.
- High purity suitable for research.
- Solid form, easy to handle and store.
- Compatible with linker conjugation for PROTAC synthesis.
- Facilitates CRBN-mediated target recruitment.
- Available in multiple small pack sizes for synthesis workflows.
Medchemexpress LLC Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride | 2245697-84-9 | MFCD31656717 | 98.3% | 542.97 | C23H31ClN4O9 | 50 MG
Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) E3 ligase ligand provided as a hydrochloride salt for research use in PROTAC design and chemical biology. Supplied as a solid with defined molecular properties and high reported purity, it serves as a linker/ligand building block for medicinal chemistry and degradation probe synthesis.
- High purity (>98%).
- Solid, off-white to yellow appearance.
- Molecular formula C23H31ClN4O9; molecular weight 542.97.
- Suitable as a CRBN E3 ligase ligand in PROTAC and protein degradation studies.
- Available in milligram-scale quantities for laboratory research.
Medchemexpress LLC Thalidomide-propargyne-PEG3-COOH | 2797649-54-6 | MFCD34473293 | 98.0% | 472.45 g/mol | C23H24N2O9 | 5 MG
Thalidomide-propargyne-PEG3-COOH is a thalidomide-based E3 ligase ligand-linker conjugate with a propargyl (alkynyl) handle and a PEG3 linker terminating in a carboxylic acid. Designed as a building block for PROTAC assembly and related chemical biology work, it is compatible with click chemistry and standard amide-coupling reactions. CAS 2797649-54-6; formula C23H24N2O9; MW 472.45; typical purity ~98%.
- Contains a propargyl (alkynyl) handle for CuAAC click chemistry.
- Includes a PEG3 linker terminating in a carboxylic acid for conjugation.
- Acts as a cereblon (CRBN) E3 ligase ligand for PROTAC design.
- Suitable for amide coupling and linker attachment.
- Supplied as a solid with high purity for research use.
Medchemexpress LLC Thalidomide-O-COOH | 1061605-21-7 | MFCD31560477 | 99.9% | 332.27 | C15H12N2O7 | 25 G
Thalidomide-O-COOH is a thalidomide-derived cereblon (CRBN) ligand used as an E3 ligase recruiter in PROTAC and chemical biology research. It is supplied as a solid research reagent with high purity and characterized molecular properties for use in biochemical and cellular assays.
- High purity: 99.85%.
- Molecular formula: C15H12N2O7.
- Molecular weight: 332.27 g/mol.
- Appearance: solid, white to off-white.
- Available package sizes include 25 G for bulk research use.
- Intended use: cereblon recruitment and PROTAC design in research applications.
Medchemexpress LLC Thalidomide-4,5-F | 2222115-19-5 | 98.0% | 294.21 g·mol⁻¹ | C13H8F2N2O4 | 100 MG
Thalidomide-4,5-F is a fluorinated analogue of thalidomide supplied for laboratory research. It promotes protein ubiquitinylation and serves as a cereblon-binding ligand; the fluorine substitutions allow further chemical derivatization. Intended for scientific research use only.
- Fluorinated thalidomide analogue enabling further derivatization.
- Promotes ubiquitinylation and binds cereblon for E3 ligase recruitment.
- High purity (98.0%) suitable for research applications.
- Available in multiple package sizes from 25 mg to 10 g.
- White to off-white solid, suitable for storage and handling.
- Recommended storage: powder at -20°C (up to 3 years) or 4°C (up to 2 years).
![eMolecules Pharmablock / tert-butyl N-(2-azabicyclo[2.2.1]heptan-6-yl)carbamate / 25mg / 588505928 / PBLJ18135 / 0.000 / 2227205-60-7 / [null] / 212.293 / C11H20N2O2](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502458980.PNG-250.jpg)
eMolecules Pharmablock / tert-butyl N-(2-azabicyclo[2.2.1]heptan-6-yl)carbamate / 25mg / 588505928 / PBLJ18135 / 0.000 / 2227205-60-7 / [null] / 212.293 / C11H20N2O2
Pharmablock / tert-butyl N-(2-azabicyclo[2.2.1]heptan-6-yl)carbamate / 25mg / 588505928 / PBLJ18135 / 0.000 / 2227205-60-7 / [null] / 212.293 / C11H20N2O2
Apexbio Technology LLC Brucine 10mM (in 1mL DMSO)
N1490 is a small-molecule inhibitor designed for biomedical research It exerts its effects by selectively targeting and modulating specific intracellular signaling pathways implicated in disease progression N1490 has been explored in cellular assays for its ability to interfere with relevant molecular interactions resulting in altered downstream signaling events This compound serves as a valuable tool for investigating cellular mechanisms regulated by these pathways and may facilitate the discovery of novel therapeutic strategies in areas such as oncology immunology or metabolic research
Medchemexpress LLC Thalidomide-NH-PEG3-COOH | 2375283-62-6 | 98.9% | C22H27N3O9 | 10MG
Thalidomide-NH-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate that links a thalidomide-derived cereblon (CRBN) ligand to a three-unit polyethylene glycol (PEG3) spacer terminated with a carboxylic acid. It is designed as a building block for PROTAC synthesis to recruit the CRBN E3 ligase and enable conjugation to target-binding ligands.
- High reported purity (98.9%).
- Includes a thalidomide-derived cereblon ligand for CRBN recruitment.
- PEG3 spacer provides flexible, hydrophilic linkage.
- Terminal carboxylic acid enables standard coupling chemistries.
- Soluble in DMSO for common assay and synthesis workflows.
- Supplied as a solid suitable for storage and handling in research labs.
Medchemexpress LLC 14-3-3 epsilon Antibody (YA2629) | 100 UL
The 14-3-3 epsilon antibody (YA2629) is a rabbit-derived, non-conjugated IgG monoclonal antibody designed to target the 14-3-3 epsilon protein. This protein acts as an adapter involved in the regulation of diverse cellular signaling pathways by binding to phosphoserine or phosphothreonine motifs, thereby modulating the activity of binding partners. The antibody shows reactivity with human, mouse, and rat samples and is supplied as a liquid formulation.
- Reactivity with human, mouse, and rat samples
- Suitable for WB, IHC-P, ICC/IF, and FC applications
- Formulated in 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide, and 0.05% BSA
- Store at -20°C for 1 year
- Avoid repeated freeze/thaw cycles
- Shipping with blue ice
