Lactams
Medchemexpress LLC Thalidomide-4-O-C2-NH2 hydrochloride | 2341840-99-9 | 99.4% | 353.76 | 25 MG
Thalidomide-4-O-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate. It incorporates a Thalidomide based cereblon ligand and a linker used in PROTAC technology, which exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- E3 ligase ligand-linker conjugate
- Incorporates cereblon ligand
- Utilizes PROTAC technology
- Exploits ubiquitin-proteasome system
- Selectively degrades target proteins
- Targets Cereblon
- Involved in Apoptosis and Autophagy pathways
Medchemexpress LLC Thalidomide-PEG5-COOH | 2688100-28-7 | 95.9% | 522.50 | 25 MG
Thalidomide-PEG5-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates a thalidomide-based cereblon ligand and a linker utilized in PROTAC technology. This product is intended for research purposes only and not for medical, clinical diagnostic, or food use in humans or animals.
- Purity: 95.90%
- Appearance: Oil
- Color: Light yellow to brown
- Solubility: Soluble in DMSO at 50 mg/mL (95.69 mM)
Medchemexpress LLC Thalidomide 4-fluoride | 835616-60-9 | 99.8% | 276.22 | 10 G
Thalidomide 4-fluoride (Cereblon ligand 4) is a Cereblon-based ligand derived from Thalidomide. It functions by recruiting the CRBN protein. This compound can be linked to an IRAK4 protein ligand using a linker to create PROTAC IRAK4 degrader-1 (HY-129966).
- Thalidomide-based Cereblon ligand
- Used in the recruitment of CRBN protein
- Can be connected to other ligands via a linker to form PROTACs
Medchemexpress LLC Thalidomide-4-O-C9-NH2 hydrochloride | >98.0% | 451.94 g/mol | C22H30ClN3O5 | 10 MG
Thalidomide-4-O-C9-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand intended for use in targeted protein degradation and PROTAC development. Supplied as the hydrochloride salt for conjugation chemistry, the compound is offered for research use and is commonly provided in small milligram quantities for medicinal chemistry and chemical biology applications.
- Acts as a cereblon (CRBN) ligand for E3 ligase recruitment.
- Designed for use in PROTAC and targeted protein degradation research.
- Provided as a hydrochloride salt suitable for conjugation chemistry.
- Reported purity ≥98% according to vendor listings.
- Molecular weight ~451.94 g/mol; formula C22H30ClN3O5.
- Store sealed at -20°C to maintain stability.
Medchemexpress LLC Vh 101 phenol-alkylC6-amine dihydrochloride | 2564467-16-7 | ≥95% | 704.72 | 250 MG
VH 101 phenol-alkylC6-amine dihydrochloride is a functionalized von-Hippel-Lindau (VHL) protein-ligand designed for optimal PROTAC (Proteolysis Targeting Chimeras) functionality. It binds the VHL protein, enabling ubiquitination of target proteins, and the terminal amine on its C6 linker allows conjugation to target ligands for PROTAC synthesis.
- Functionalized VHL protein-ligand.
- Designed for optimal PROTAC functionality.
- Binds VHL protein to recruit E3 ligase.
- Enables ubiquitination of target proteins.
- Terminal amine on C6 linker allows conjugation to target ligands.
- Used in PROTAC synthesis against various targets.
Medchemexpress LLC Thalidomide-O-COOH | 1061605-21-7 | MFCD31560477 | 99.9% | 332.26 g/mol | C15H12N2O7 | 5 G
Thalidomide-O-COOH is a thalidomide-derived carboxylic acid used as a cereblon (CRBN) ligand building block in PROTAC design and E3 ligase recruitment studies. It is supplied as a high-purity research chemical in small laboratory pack sizes for medicinal chemistry and chemical biology applications.
- Thalidomide-derived cereblon ligand for PROTAC design.
- Carboxylic acid functionality enables linker attachment and derivatization.
- Supplied as a solid suitable for standard laboratory storage.
- Provided in small research pack sizes for synthesis and assay development.
- High reported purity supports use in chemical biology experiments.
Medchemexpress LLC Thalidomide 5-fluoride | 835616-61-0 | MFCD30188075 | 100.0% | 276.22 g/mol | C13H9FN2O4 | 10 G
Thalidomide 5-fluoride is a thalidomide-derived cereblon ligand used as a building block in PROTAC degraders and other bifunctional molecules. It is supplied as a high-purity solid reagent intended for research and chemical biology applications.
- High purity solid (99.96%).
- Molecular weight 276.22 g/mol.
- Molecular formula C13H9FN2O4.
- Available in laboratory pack sizes, including 10 G.
- Storage: powder at -20°C for long-term, 4°C for shorter term; in solvent store at -80°C.
Apexbio Technology LLC Brucine 20mg
N1490 is a small-molecule inhibitor designed for biomedical research It exerts its effects by selectively targeting and modulating specific intracellular signaling pathways implicated in disease progression N1490 has been explored in cellular assays for its ability to interfere with relevant molecular interactions resulting in altered downstream signaling events This compound serves as a valuable tool for investigating cellular mechanisms regulated by these pathways and may facilitate the discovery of novel therapeutic strategies in areas such as oncology immunology or metabolic research
Medchemexpress LLC Thalidomide-propargyne-PEG2-COOH | 2797619-65-7 | 98.7% | 428.39 g/mol | C21H20N2O8 | 5 MG
Thalidomide-Propargyne-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate combining a thalidomide-derived cereblon ligand with a PEG2 linker terminating in a propargyl carboxylic acid. It is intended for PROTAC construction and click-chemistry applications, providing an alkyne handle for downstream conjugation.
- Contains terminal propargyl (alkyne) group for copper-catalyzed azide-alkyne cycloaddition.
- Incorporates a PEG2 linker to improve solubility and provide appropriate spacer length.
- Acts as a cereblon ligand to recruit CRBN for targeted protein degradation strategies.
- High purity suitable for research and synthetic applications.
- Available in small pack sizes for efficient use in medicinal chemistry workflows.
Medchemexpress LLC N-me-thalidomide 4-fluoride | 2244520-92-9 | MFCD34563580 | 99.4% | 290.25 | C14H11FN2O4 | 250 MG
N-Me-Thalidomide 4-fluoride is a thalidomide-based cereblon (E3 ligase) ligand used in PROTAC design and in the synthesis of related research compounds. Supplied as a characterized solid for research use, the compound is accompanied by analytical data and safety documentation to support laboratory workflows.
- High purity (99.4%) suitable for research applications.
- Molecular formula C14H11FN2O4 and molecular weight 290.25 Da.
- Available in multiple pack sizes from 250 mg to 10 g.
- Analytical documentation: COA, HNMR, and RP-HPLC provided.
- Safety documentation: SDS and handling instructions available.
- Designed for use as a cereblon ligand in PROTAC conjugation chemistry.
Medchemexpress LLC Thalidomide-NH-C6-NH2 hydrochloride | 2375194-37-7 | 99.6% | 100 MG
Thalidomide-NH-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates a Thalidomide-based cereblon ligand and a linker commonly used in PROTAC technology. PROTACs are designed to exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This product is intended for research use only and is not sold to patients.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates a thalidomide-based cereblon ligand
- Features a linker used in PROTAC technology
- Designed to exploit the ubiquitin-proteasome system
- Selectively degrades target proteins
- Molecular weight: 408.88
- Chemical formula: C19H25ClN4O4
- Appearance: Light yellow to yellow solid
- Recommended storage: -20°C in sealed container, away from moisture and light
- Long-term solvent storage: 6 months at -80°C or 1 month at -20°C