Oxazinanes
Medchemexpress LLC Inolitazone dihydrochloride | 223132-38-5 | 98.5% | 575.51 | 100 MG
Inolitazone dihydrochloride is a novel high-affinity PPARγ agonist, demonstrating potent anti-proliferative activities both in vitro and in vivo, with an IC50 of 0.8 nM for growth inhibition. Its biological activity is dependent on PPARγ.
- Upregulates the cell cycle kinase inhibitor p21WAF1/CIP1
- Activates PPARγ:RXRα-dependent transcription at 10 nM
- Specifically activates PPARγ, unlike PPARα or PPARδ
- Exhibits a low EC50 of 1 nM for activating PPARγ in DRO cells
- Potently inhibits growth with an IC50 of 0.8 nM
- Shows additive antiproliferative activity when combined with paclitaxel
- Inhibits tumor growth in a dose-responsive manner in vivo, including established DRO and ARO tumors
Medchemexpress LLC Pyridine, 2-methyl-3-[(2S)-2-pyrrolidinylmethoxy]-, hydrochloride (1:2). | 161416-61-1 | 99.1% | 265.18 | 50 MG
Pozanicline dihydrochloride is an orally bioavailable nicotinic acetylcholine receptor (nAChR) agonist, highly selective for α4β2- and α6β2-nAChR subtypes. It has been shown to reverse nicotine withdrawal-induced deficits in contextual fear conditioning in mice.
- Orally bioavailable nicotinic acetylcholine receptor (nAChR) agonist.
- Highly selective for α4β2- and α6β2-nAChR subtypes.
- Involved in Phase 2 clinical trials for Attention Deficit Hyperactivity Disorder, Alzheimer's Disease, and Nicotine Addiction.
- Reverses nicotine withdrawal-induced deficits in contextual fear conditioning in mice.
Medchemexpress LLC Mirodenafil dihydrochloride | 862189-96-6 | MFCD28139019 | 99.9% | 604.59 g/mol | C26H39Cl2N5O5S | 10 MG
Mirodenafil dihydrochloride is an orally active, potent, reversible, and selective phosphodiesterase 5 (PDE5) inhibitor with reported glucocorticoid receptor modulatory activity. It has been used in preclinical research to modulate Wnt/β-catenin signaling and is studied for erectile dysfunction, Alzheimer's disease, and systemic sclerosis research applications.
- Potent and selective PDE5 inhibition for target-specific studies.
- Reversible inhibitor enabling transient modulation in assays.
- Modulates glucocorticoid receptor activity relevant to receptor signaling studies.
- Activates Wnt/β-catenin signaling via Dkk1 downregulation.
- High purity suitable for biochemical and cellular assays.
- Available in solid form and as DMSO solution for flexible dosing.
Medchemexpress LLC Landiolol hydrochloride | 144481-98-1 | MFCD01937430 | >98.0% | 546.05 | C25H40ClN3O8 | 50 MG
Landiolol hydrochloride is an analytical standard of an ultra-short-acting, highly β1-selective beta-adrenergic receptor antagonist supplied for research and analytical use, suitable for quantification, calibration, and method development in biochemical and pharmacological studies.
- Analytical standard grade for research and method development.
- High purity, >98% (HPLC) as reported by suppliers.
- Molecular formula C25H40ClN3O8 and molecular weight 546.05 Da.
- CAS number 144481-98-1 for unambiguous identification.
- Supplied in small quantities suitable for analytical use, e.g. 50 MG.
- Intended for calibration, quantification, and analytical characterization in biological and formulation samples.
- Store under conditions specified in the certificate of analysis.
Medchemexpress LLC Landiolol hydrochloride | 144481-98-1 | MFCD01937430 | 99.8% | 546.05 g·mol⁻¹ | C25H40ClN3O8 | 25 MG
Landiolol hydrochloride is the hydrochloride salt of landiolol, an ultra-short-acting, highly selective β1-adrenergic receptor antagonist used in research to reduce heart rate and investigate cardioprotective and sepsis-related effects. Supplied as a high-purity solid analytical standard, it is intended for in vitro and preclinical studies where transient β1 blockade is required.
- Highly selective β1-adrenergic receptor antagonist.
- Ultra-short acting profile for transient β1 blockade.
- High purity suitable for analytical and preclinical use.
- Supplied as a solid powder for easy weighing and formulation.
- Defined storage recommendations to maintain stability.
Medchemexpress LLC Pyrithioxin dihydrochloride | 10049-83-9 | 98.0% | 500 MG
Pyrithioxin (Pyritinol) dihydrochloride is the dihydrochloride salt of Pyrithioxin. Pyrithioxin (Pyritinol) is an orally active neurodynamic compound. Pyrithioxin can promote the metabolism of glucose and amino acids, increase carotid blood flow and improve cerebral blood flow. Pyrithioxin exhibits anti-inflammation, anti-tumor and neuroprotective effect. Pyrithioxin can be used for the researches of cancer, inflammation, immunology, metabolic and neurological disease such as cerebral infarct, epilepsy, fibrosarcomas and rheumatoid polyarthritis.
- Promotes metabolism of glucose and amino acids
- Increases carotid blood flow and improves cerebral blood flow
- Exhibits anti-inflammation effects
- Exhibits anti-tumor effects
- Provides neuroprotective effects
Medchemexpress LLC 3-Amino-2-oxazolidinone | 80-65-9 | 98.0% | 102.09 | 10 MG
3-Amino-2-oxazolidinone (AOZ) is a metabolite of Furazolidone used as an indicator for furazolidone residues in vivo. It is orally active and inhibits monoamine oxidase (MAO), increasing monoamine neurotransmitter levels in the brain and lowering blood pressure.
- Used as an indicator for furazolidone residues
- Orally active
- Inhibits monoamine oxidase (MAO)
- Increases levels of monoamine neurotransmitters
- Lowers blood pressure in renal hypertensive rats
Medchemexpress LLC THAM hydrochloride (Tris HCl) | 1185-53-1 | 98.0% | 500 G
THAM hydrochloride (Tris HCl) is a biologically inert amino alcohol of low toxicity, which buffers carbon dioxide and acids in vitro and in vivo. It is an effective amine compound for pH control in the physiological range.
- Biologically inert amino alcohol of low toxicity
- Buffers carbon dioxide and acids in vitro and in vivo
- Effective amine compound for pH control in the physiological range
eMolecules 163105-90-6 | 2-Methoxypyridine-3-boronic acid | Combi-Blocks | MFCD03411572 | 152.940 | C6H8BNO3 | 97.000 | COc1ncccc1B(O)O | 25g | 117520972
2-Methoxypyridine-3-boronic acid | Combi-Blocks | 163105-90-6 | MFCD03411572 | 152.940 | C6H8BNO3 | 97.000 | COc1ncccc1B(O)O | 25g | 117520972
eMolecules 163105-89-3 | 6-Methoxy-pyridine-3-boronic acid | J & W PharmLab, LLC | MFCD02093044 | 152.940 | C6H8BNO3 | 96.000 | COc1ccc(cn1)B(O)O | 5g | 249978088
6-Methoxy-pyridine-3-boronic acid | J & W PharmLab, LLC | 163105-89-3 | MFCD02093044 | 152.940 | C6H8BNO3 | 96.000 | COc1ccc(cn1)B(O)O | 5g | 249978088
Medchemexpress LLC Tebanicline dihydrochloride | 209326-19-2 | 99.5% | C9H13Cl3N2O | 1 ML
Tebanicline dihydrochloride is a potent, orally effective analgesic that modulates neuronal nicotinic acetylcholine receptors (nAChRs). It exhibits high selectivity for neuronal nAChRs, acting as an agonist, and effectively inhibits cytisine binding to α4β2 neuronal nAChRs. This product is investigated for its potential in treating various types of pain and for its anxiolytic-like properties.
- Potent and orally effective analgesic.
- Highly selective for neuronal nAChRs.
- Shows efficacy in models of acute, persistent, chemical, and neuropathic pain.
- Investigated for anxiolytic-like activity.
Medchemexpress LLC 5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid | 956317-36-5 | 100.0% | C10H9N3O2 | 25 G
5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid is a chemical compound supplied as a white to off-white solid with a purity of 99.99%. It is stable under recommended storage conditions and is intended for use as a laboratory chemical and in the manufacture of substances.
- High purity
- White to off-white solid form
- Melting point between 175.4-175.8°C
- Boiling point of 413°C at 760 mmHg
- Flash point of 204°C
- Chemically stable under recommended storage conditions
- Identified for laboratory chemical use
- Identified for the manufacture of substances
Medchemexpress LLC Tebanicline dihydrochloride | 209326-19-2 | 99.5% | C9H13Cl3N2O | 50 MG
Tebanicline dihydrochloride is a nAChR modulator with potent, orally effective analgesic activity. It inhibits the binding of cytisine to α4β2 neuronal nAChRs with a Ki of 37 pM.
- nAChR modulator
- Potent and orally effective analgesic activity
- Inhibits binding of cytisine to α4β2 neuronal nAChRs with a Ki of 37 pM
- Potent antinociceptive agent with full efficacy in models of acute and persistent pain
- Produces significant antinociceptive effects in mice against acute noxious thermal stimulation
- Orally active
- Has antinociceptive effects in rat models of acute thermal, persistent chemical, and neuropathic pain
Medchemexpress LLC (2-Phenylquinolin-7-yl)methanol | 361457-37-6 | C16H13NO | 250 MG
(2-Phenylquinolin-7-yl)methanol is a drug intermediate used for the synthesis of various active compounds.
- Drug intermediate for synthesis
- Suitable for various active compounds