Piperazines
Apexbio Technology LLC Dexrazoxane HCl (ICRF-187, ADR-529) 149003-01-0 100mg
Dexrazoxane HCl (ICRF-187 ADR-529) is a small-molecule inhibitor targeting topoisomerase II It is designed to inhibit topoisomerase II activity and sequester intracellular iron thereby reducing DNA strand cleavage and mitigating iron-dependent oxidative stress Dexrazoxane HCl exerts its biological activity primarily through intracellular iron chelation and inhibition of topoisomerase II which attenuates reactive oxygen species formation and stabilizes DNA structure Based on these pharmacological properties Dexrazoxane HCl holds research potential in investigating cardioprotective strategies particularly against anthracycline-induced cardiotoxicity
Apexbio Technology LLC Dexrazoxane HCl (ICRF-187, ADR-529) 149003-01-0 10mM (in 1mL DMSO)
Dexrazoxane HCl (ICRF-187 ADR-529) is a small-molecule inhibitor targeting topoisomerase II It is designed to inhibit topoisomerase II activity and sequester intracellular iron thereby reducing DNA strand cleavage and mitigating iron-dependent oxidative stress Dexrazoxane HCl exerts its biological activity primarily through intracellular iron chelation and inhibition of topoisomerase II which attenuates reactive oxygen species formation and stabilizes DNA structure Based on these pharmacological properties Dexrazoxane HCl holds research potential in investigating cardioprotective strategies particularly against anthracycline-induced cardiotoxicity
Apexbio Technology LLC Dexrazoxane HCl (ICRF-187, ADR-529) 149003-01-0 50mg
Dexrazoxane HCl (ICRF-187 ADR-529) is a small-molecule inhibitor targeting topoisomerase II It is designed to inhibit topoisomerase II activity and sequester intracellular iron thereby reducing DNA strand cleavage and mitigating iron-dependent oxidative stress Dexrazoxane HCl exerts its biological activity primarily through intracellular iron chelation and inhibition of topoisomerase II which attenuates reactive oxygen species formation and stabilizes DNA structure Based on these pharmacological properties Dexrazoxane HCl holds research potential in investigating cardioprotective strategies particularly against anthracycline-induced cardiotoxicity
Selleck Chemical LLC Piperazine Erastin-E1063-25MG
Piperazine Erastin is an analog of Erastin which can induces ferroptosis in cancer cells an iron-dependent form of nonapoptotic cell death
Selleck Chemical LLC Dexrazoxane
Dexrazoxane (ICRF-187) is an anticancer drug able to block mitosis and to arrest dividing cells It is an iron chelator and provides cardioprotection against anthracycline toxicity
Apexbio Technology LLC Dexrazoxane 24584-09-6 100mg
Dexrazoxane is a cell-permeable iron chelator that suppresses intracellular superoxide radical generation via iron sequestration thereby exhibiting antioxidant activity Dexrazoxane exerts its biological effects primarily by modulating oxidative stress and ferroptosis pathways In cell-based studies including myocardial H9c2 cell models dexrazoxane inhibits ferroptosis by suppressing the HMGB1 pathway and induces DNA damage and apoptosis in various tumor cell lines Based on these pharmacological properties dexrazoxane holds research potential in the study of cardioprotective mechanisms tumor-related DNA damage responses ferroptosis and oxidative stress processes
Apexbio Technology LLC Dexrazoxane 24584-09-6 25mg
Dexrazoxane is a cell-permeable iron chelator that suppresses intracellular superoxide radical generation via iron sequestration thereby exhibiting antioxidant activity Dexrazoxane exerts its biological effects primarily by modulating oxidative stress and ferroptosis pathways In cell-based studies including myocardial H9c2 cell models dexrazoxane inhibits ferroptosis by suppressing the HMGB1 pathway and induces DNA damage and apoptosis in various tumor cell lines Based on these pharmacological properties dexrazoxane holds research potential in the study of cardioprotective mechanisms tumor-related DNA damage responses ferroptosis and oxidative stress processes
Medchemexpress LLC Piperazine erastin | 1538593-71-3 | 99.1% | 645.19 g·mol⁻¹ | C35H41ClN6O4 | 1 MG
Piperazine erastin is a small-molecule analog of erastin that triggers an iron-dependent form of non-apoptotic cell death known as ferroptosis. It is provided as a research reagent for cellular and biochemical studies investigating ferroptosis mechanisms and cancer biology.
- Induces iron-dependent ferroptosis in cell-based assays
- Suitable for studies of ferroptosis pathways and cancer research
- High purity appropriate for in vitro experiments
- Offered in small solid and solution quantities for laboratory use
- Stable when stored according to recommended temperature conditions
Apexbio Technology LLC Dexrazoxane 24584-09-6 10mg
Dexrazoxane is a cell-permeable iron chelator that suppresses intracellular superoxide radical generation via iron sequestration thereby exhibiting antioxidant activity Dexrazoxane exerts its biological effects primarily by modulating oxidative stress and ferroptosis pathways In cell-based studies including myocardial H9c2 cell models dexrazoxane inhibits ferroptosis by suppressing the HMGB1 pathway and induces DNA damage and apoptosis in various tumor cell lines Based on these pharmacological properties dexrazoxane holds research potential in the study of cardioprotective mechanisms tumor-related DNA damage responses ferroptosis and oxidative stress processes
Medchemexpress LLC Piperazine erastin | 1538593-71-3 | 99.1% | 645.19 | C35H41ClN6O4 | 25 MG
Piperazine erastin is a small-molecule ferroptosis inducer and an analog of erastin. It promotes iron-dependent, non-apoptotic cell death in cellular models and is used in mechanistic and cancer research. The compound is supplied as a high-purity solid or as a DMSO solution and is provided with standard quality and safety documentation for laboratory use.
- Induces iron-dependent ferroptosis in cell models.
- High purity suitable for research applications.
- Available as solid and as a solution in DMSO.
- Stable under recommended low-temperature storage to preserve activity.
- Provided with COA and SDS for quality and safety information.
Medchemexpress LLC Piperazine erastin | 1538593-71-3 | 99.1% | 645.19 g/mol | C35H41ClN6O4 | 1 ML
Piperazine erastin is a research reagent that induces ferroptosis, an iron-dependent form of non-apoptotic cell death. It is used in cellular and cancer research to investigate ferroptotic mechanisms; the piperazine substitution improves water solubility and metabolic stability relative to erastin.
- Induces ferroptosis in cell models.
- Improved water solubility and metabolic stability compared with erastin.
- Available as a ready-to-use 10 mM solution in DMSO (1 mL).
- Also available as a solid in multiple milligram quantities for flexibility.
- High purity, typically 99.12% as reported by the manufacturer.
- Useful for cancer research and studies of iron-dependent cell death pathways.
Cayman Chemical Dexrazoxane 25mg
An intracellular iron chelator and an inhibitor of topoisomerase IIα that is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury; scavenges hydroxyl (IC50 = 2.1 mM), superoxide (IC50 = 0.4 mM), lipid (IC50 = 4.4 mM), DPPH (IC50 = 3.5 μM), and ABTS+ (IC50 = 3.8 mM) free radicals
Cayman Chemical Dexrazoxane 50mg
An intracellular iron chelator and an inhibitor of topoisomerase IIα that is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury; scavenges hydroxyl (IC50 = 2.1 mM), superoxide (IC50 = 0.4 mM), lipid (IC50 = 4.4 mM), DPPH (IC50 = 3.5 μM), and ABTS+ (IC50 = 3.8 mM) free radicals
TARGETMOL CHEMICALS INC DEXRAZOXANE 500MG
Also available in 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Dexrazoxane (ICRF-187) is an anticancer drug used to block mitosis and arrest dividing cells. It is an iron chelator and provides cardioprotection against anthracycline toxicity. purity: 99%
TARGETMOL CHEMICALS INC PIPERAZINE ERASTIN 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Piperazine erastin is an analog of erastin. It causes an iron-dependent form of non-apoptotic cell death termed ferroptosis. purity: 97%
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