Piperidines
Medchemexpress LLC Avibactam sodium hydrate | 2938989-90-1 | 99.6% | 305.24 g/mol | C7H12N3NaO7S | 10 MG
Avibactam sodium hydrate is a covalent, reversible, non-β-lactam β-lactamase inhibitor provided for research and analytical applications. It is used in enzyme inhibition assays and antibiotic resistance studies to characterize inhibition of class A and related β-lactamases.
- Covalent and reversible non-β-lactam β-lactamase inhibitor.
- Inhibits TEM-1 (IC50 = 8 nM) and CTX-M-15 (IC50 = 5 nM).
- CAS number 2938989-90-1.
- Chemical formula C7H12N3NaO7S; molecular weight 305.24 g/mol.
- Purity 99.6%.
- Available as solids (5 mg-1 g) and prepared solution (10 mM x 1 mL).
- Supplied with supporting documents: data sheet, COA, SDS, H NMR, RP-HPLC.
- Intended for research use; follow SDS for handling and storage.
Medchemexpress LLC 1,2-pyrrolidinedicarboxylic acid, 5-oxo-, 1-(1,1-dimethylethyl) 2-(phenylmethyl) ester, (2R)- | 400626-71-3 | MFCD14635665 | 250mg
Avibactam impurity 1 is an impurity of Avibactam (HY-14879)
Apexbio Technology LLC Nelfinavir 159989-64-7 10mM (in 1mL Ethanol)
Nelfinavir is a selective inhibitor of HIV-1 protease which is responsible for cleaving viral precursor proteins into functional units essential for HIV replication By disrupting this proteolytic step nelfinavir inhibits viral maturation and subsequent infectivity In biochemical assays nelfinavir demonstrates inhibitory activity against HIV-1 protease with an IC50 value typically ranging from 2 to 10 nM Due to its defined mechanism of action nelfinavir is commonly utilized in biomedical research focusing on HIV pathogenesis including antiviral activity studies viral resistance profiling and therapeutic combination assessments in vitro and in cell-based experimental models
Medchemexpress LLC 1,2-pyrrolidinedicarboxylic acid, 5-oxo-, 1-(1,1-dimethylethyl) 2-(phenylmethyl) ester, (2R)- | 400626-71-3 | MFCD14635665 | 10g
Avibactam impurity 1 is an impurity of Avibactam (HY-14879)
Apexbio Technology LLC Ropivacaine HCl 98717-15-8 10mM (in 1mL H2O)
Ropivacaine HCl (CAS 98717-15-8) is a local anesthetic agent commonly employed in biomedical research to examine neuronal function and signal transmission Mechanistically ropivacaine hydrochloride acts by reversibly blocking the influx of sodium ions across neuronal membranes thereby inhibiting the conduction of nerve impulses Due to this mode of action it serves as a useful pharmacological tool in studies designed to elucidate pain signaling pathways sodium channel behavior and peripheral nerve function
eMolecules Medchem Express / IPSU / 5mg / 446263520 / HY-13796 / / 1373765-19-5 / MFCD25976654 / 405.502 / C23H27N5O2
Medchem Express / IPSU / 5mg / 446263520 / HY-13796 / / 1373765-19-5 / MFCD25976654 / 405.502 / C23H27N5O2
Medchemexpress LLC Mepivacaine hydrochloride | 1722-62-9 | 99.68% | 1 G
Mepivacaine hydrochloride is a local anesthetic that inhibits nerve impulse initiation and conduction by binding to voltage-gated sodium ion channels in neuronal cell membranes. This action blocks sodium influx and membrane depolarization, leading to a reversible loss of sensation. It is characterized by a rapid onset and moderate duration of action compared to other local anesthetics.
- Exhibits a more rapid onset than some other local anesthetics.
- Provides a moderate duration of action.
- Shows preferential use-dependent block of Na(v)1.8 channels.
- For research use only.
Medchemexpress LLC Levobupivacaine hydrochloride | 27262-48-2 | >99.8% | 5 MG
Levobupivacaine hydrochloride is a long-acting amide local agent that can suppress or relieve pain. It exerts analgesic effects through reversible blockade of neuronal sodium channels. It can inhibit impulse transmission and conduction in cardiovascular and other tissues, possessing certain cardiac and CNS toxicity. It is metabolized by hepatic cytochrome P450 (CYP450) enzymes in vivo and can also induce ferroptosis by miR-489-3p/SLC7A11 signaling in gastric cancer.
- Long-acting amide local agent
- Suppresses or relieves pain
- Exerts analgesic effects through reversible blockade of neuronal sodium channels
- Inhibits impulse transmission and conduction in cardiovascular and other tissues
- Metabolized by hepatic cytochrome P450 (CYP450) enzymes in vivo
- Induces ferroptosis by miR-489-3p/SLC7A11 signaling in gastric cancer
Medchemexpress LLC Ropivacaine hydrochloride monohydrate | 132112-35-7 | 99.9% | 1 ML
Ropivacaine hydrochloride monohydrate is a potent sodium channel blocker that inhibits impulse conduction by reversibly blocking sodium ion influx in nerve fibers. It also acts as an inhibitor of K2P (two-pore domain potassium channel) TREK-1. This product is extensively used for regional anesthesia and the management of neuropathic pain in vivo.
- Potent sodium channel blocker
- Inhibits impulse conduction by blocking sodium ion influx
- Inhibitor of K2P (two-pore domain potassium channel) TREK-1
- Purity of 99.93%
- Appearance: white to off-white solid
- Recommended storage for solid: 4°C, sealed, away from moisture
- Recommended storage in solvent: -80°C for 6 months; -20°C for 1 month
Medchemexpress LLC Ropivacaine | 84057-95-4 | MFCD00078774 | 100.0% | 50 MG
Overview of Ropivacaine
Ropivacaine is a potent sodium channel blocker. It works by blocking impulse conduction through reversible inhibition of sodium ion influx in nerve fibers. Additionally, Ropivacaine acts as an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane. It is utilized in the research of neuropathic pain management.
Features and Benefits
- Potent sodium channel blocker.
- Blocks impulse conduction by inhibiting sodium ion influx.
- Inhibits K2P TREK-1 (IC50 of 402.7 μM).
- Used for neuropathic pain management research.
- Epidural administration blocks neuropathic pain and delays its development.
- Inhibits pressure-induced increases in filtration coefficient.
- Prevents pressure-induced lung edema and hyperpermeability.
- Inhibits pressure-induced NO production.
Medchemexpress LLC Mepivacaine hydrochloride | 1722-62-9 | 99.7% | 1 ML
Mepivacaine hydrochloride binds to specific voltage-gated sodium ion channels in neuronal cell membranes, inhibiting both sodium influx and membrane depolarization. This blockage of nerve impulse initiation and conduction results in a reversible loss of sensation. It has a more rapid onset and moderate duration of action compared to other local anesthetics. It also displays a preferential use-dependent block of Na(v)1.8.
- Inhibits sodium influx and membrane depolarization
- Results in reversible loss of sensation
- Rapid onset of action
- Moderate duration of action
- Displays preferential use-dependent block of Na(v)1.8
Medchemexpress LLC Ropivacaine | 84057-95-4 | 100.0% | 5 MG
Ropivacaine is a potent sodium channel blocker that blocks impulse conduction by reversibly inhibiting sodium ion influx in nerve fibers. It also acts as an inhibitor of K2P (two-pore domain potassium channel) TREK-1. It is utilized in the research of neuropathic pain management.
- Blocks impulse conduction by reversibly inhibiting sodium ion influx in nerve fibers.
- Acts as an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane.
- Utilized in the research of neuropathic pain management.
Medchemexpress LLC Zidebactam | 1436861-97-0 | 100 MG
Zidebactam is a beta-lactamase inhibitor and a penicillin-binding protein 2 (PBP2) inhibitor supplied for laboratory research use. It is used to study beta-lactam resistance and to evaluate combination antibiotic therapies.
- Acts as a beta-lactamase inhibitor and PBP2 inhibitor.
- Reported PBP2 IC50 ≈ 0.26 μg/mL, suitable for potency benchmarking.
- Intended for in vitro research applications; not for human use.
- Useful for studying antibiotic resistance mechanisms and adjuvant therapies.
- Characterized by CAS 1436861-97-0 and molecular weight 391.40 g/mol.
eMolecules Medchem Express / Ropivacaine (mesylate) / 10mg / 527573892 / HY-B0563C / / 854056-07-8 / MFCD08458442 / 370.510 / C18H30N2O4S
Medchem Express / Ropivacaine (mesylate) / 10mg / 527573892 / HY-B0563C / / 854056-07-8 / MFCD08458442 / 370.510 / C18H30N2O4S
Medchemexpress LLC HY-111381 10mg Medchemexpress, BI-3812 CAS:2166387-64-8 Purity:>98%
Medchemexpress, HY-111381 10mg BI-3812 CAS:2166387-64-8 BI-3812 is potent and efficacious BCL6 inhibitor, inhibiting the BTB domain of BCL6, with an IC50 of ≤3 nM; BI-3812 has antitumor activity. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.