Pyrazines
TARGETMOL CHEMICALS INC AVE5688 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. AVE5688 is an inhibitor of glycogen phosphorylase (GP IC50s 430 nM and 915 nM; Kds 170 nM and 530 nM for rmGPb and rmGPa). It can be used for the research of type 2 diabetes. purity: 100%
TARGETMOL CHEMICALS INC ML385 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. ML385 is a new-type and selective NRF2 inhibitor. purity: 99%
TARGETMOL CHEMICALS INC TALNIFLUMATE 25MG
Also available in 1 mg 2 mg 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Talniflumate (Somalgen) is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It possesses anti-inflammatory actions via inhibition of Cox (cyclooxygenase) and inhibits Cl-/HCO3- exchange activity. It also increases survival in a cystic fibrosis mouse model of the distal intestinal obstructive syndrome. purity: 99%
TARGETMOL CHEMICALS INC INDOPROFEN 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Indoprofen ((±)-Indoprofe) is a non-steroidal anti-inflammatory drug. purity: 100%
TARGETMOL CHEMICALS INC ARN25068 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. ARN25068 is a potent inhibitor of GSK-3(beta) FYN and DYRK1A protein kinases exerting its activity in the sub-micromolar range. This compound effectively addresses tau hyperphosphorylation [1]. purity: 99%
TARGETMOL CHEMICALS INC KHK-IN-2 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. KHK-IN-2 is a selective inhibitor of ketohexokinase with an IC50 value of 0.45 uM. purity: 98%
TARGETMOL CHEMICALS INC GCN2IB 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. GCN2iB is an ATP-competitive inhibitor of general control nonderepressible 2 (GCN2) with an IC50 of 2.4 nM. purity: 98%
TARGETMOL CHEMICALS INC UK-101 5MG
Also available in 1 mg 10 mg 25 mg 50 mg and bulk. Please contact Fisher for quotes. UK-101 is a potent and selective inhibitor of the immunoproteasome LMP2 inhibiting (beta)1i (LMP2) (beta)1c (LMP2) and (beta)5 (LMP2) with IC50s of 104 nM 15 uM and 1 uM. UK-101 has a 144-fold and 10-fold higher affinity for (beta)1i than for the distribution of (beta)1c and (beta)5 subunits. UK-101 induces apoptosis and can be used to study prostate cancer related diseases. purity: 99%
TARGETMOL CHEMICALS INC AMG 517 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. AMG 517 is an effective and specific TRPV1 antagonist antagonizes proton (IC50 0.76 nM) capsaicin (IC50 0.62 nM) and heat activation (IC50 1.3 nM) of TRPV1. purity: 99%
TARGETMOL CHEMICALS INC IXAZOMIB 10MG
Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Ixazomib (MLN2238) a second generation boron-containing peptide proteasome inhibitor (PI) inhibits the chymotrypsin-like proteolytic ((beta)5) site of the 20S proteasome (IC50/Ki 3.4/0.93 nM in cell-free assays) also inhibits the caspase-like ((beta)1) and trypsin-like ((beta)2) proteolytic sites (IC50 31/3500 nM). purity: 98%
TARGETMOL CHEMICALS INC PBRM1-BD2-IN-5 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. PBRM1-BD2-IN-5 is a potent PBRM1 Bromodomain inhibitor with Kd values of 1.5 uM and 3.9 uM for PBRM1-BD2 and PBRM1-BD5 respectively and an IC50 value of 0.26 uM for PBRM1-BD2. PBRM1-BD2-IN-5 reduces the binding of full-length PBRM1 within the PBAF complex in cell lysates to acetylated histone peptide. PBRM1-BD2-IN-5 can be used to research anticancer. purity: 99%
Medchemexpress LLC HY-10227 200mg , Bortezomib PS-341;Brotezamide;DPBA;LDP 341;MG 341;Radiciol;NSC 681239 CAS:179324-69-7 Purity:98%
Medchemexpress, HY-10227 200mg Bortezomib PS-341;Brotezamide;DPBA;LDP 341;MG 341;Radiciol;NSC 681239 CAS:179324-69-7 Formula:C19H25BN4O4 Ki: 0.6 nM (20S proteasome) Purity:98% Bortezomib is a potent 20S proteasome inhibitor with K i of 0.6 nM. Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.