Pyridines and derivatives

Aromatic organic compounds consist of an aromatic six-membered ring containing one nitrogen atom and five carbon atoms; includes compounds derived from pyridines.

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5,941 – 5,955 of 178,527 results

5,941

Medchemexpress LLC PRT062607 | 1370261-96-3 | C19H23N9O | 50 MG

PRT062607 is an orally active ATP-competitive Syk inhibitor with an IC50 of 1 nM, demonstrating at least 80-fold selectivity over other kinases. It blocks B cell antigen receptor-mediated activation, Fcε receptor 1-mediated basophil degranulation and microglial phagocytosis, and induces caspase-dependent apoptosis and microglial death. It inhibits tumor growth and peripheral nerve injury-induced mechanical allodynia, and prevents neuronal loss.

Blocks B cell antigen receptor-mediated activation, Fcε receptor 1-mediated basophil degranulation, and microglial phagocytosis.
Induces caspase-dependent apoptosis and microglial death.
Inhibits tumor growth and peripheral nerve injury-induced mechanical allodynia.
Prevents neuronal loss.
Used in research for rheumatoid arthritis, chronic lymphocytic leukemia, non-Hodgkin's lymphoma, neurodegenerative diseases, and neuropathic pain.

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5,942

Medchemexpress LLC Dermaseptin | 136212-91-4 | 99.7% | 3455.10 | 5 MG

Dermaseptin is a peptide isolated from frog skin that exhibits potent antimicrobial activity against bacteria, fungi, and protozoa at micromolar concentration. It is a water-soluble, thermostable, and nonhemolytic peptide with highly potent antimicrobial activity against pathogenic fungi at micromolar concentrations.

Exerts lytic action on bacteria, protozoa, yeasts, and filamentous fungi.
Mechanism involves an amphipathic alpha-helix perturbing membrane functions.
Broad spectrum: Inhibits 100% proliferation of most microorganisms (5-100 μg/ml).
Low in vitro toxicity to human cells, not inhibiting KJ3 cell proliferation or permeating guinea pig lymphocytes.
Hemolysis of rabbit erythrocytes observed at doses above 200 μg/ml.
Active against *Aeromonas cauiae*, *Pseudomonas aeroginusa*, *Escherichia coli*, *Enterococcus faecalis*, *L. mezicana*, and *Microsporum canis*.

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5,943

Medchemexpress LLC N-acetyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-3-(2-naphthalenyl)-L-alaninamide | 475498-26-1 | 99.9% | 609.72 g·mol⁻¹ | C34H39N7O4 | 25 MG

MCL0020 is a potent, selective melanocortin MC4 receptor antagonist used as a research tool to investigate MC4-mediated signaling and feeding behavior. It has a reported IC50 of 11.63 nM and has been reported to attenuate restraint stress-induced anorexia in vivo without affecting normal food intake. Use appropriate laboratory controls and institutional safety procedures when handling this research chemical.

Selective melanocortin MC4 receptor antagonist.
Reported IC50 of 11.63 nM for MC4 receptor.
High chemical purity reported (99.93%).
Molecular weight 609.72 g·mol⁻¹.
Peptide-like sequence: Ac-D-2Nal-Arg-D-2Nal-NH2.
Supplied in small milligram quantities for research use.

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5,944

Medchemexpress LLC Collagen, Type II, from bovine snout membrane | 9007-34-5 | 50 MG

Collagen, Type II, from bovine snout membrane is a type II collagen that can be used for cell culture. This product consists of enzymatically hydrolyzed collagen peptides, suitable for various research applications.

Used for cell culture
Consists of enzymatically hydrolyzed collagen peptides
Intended for research use only

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5,945

Medchemexpress LLC Nelonicline (ABT-126) | 1026134-63-3 | 99.8% | 313.42 | 1 MG

Nelonicline (ABT-126) is an orally active and selective α7 nicotinic receptor agonist. It has high affinity for α7 nAChRs in the human brain (Ki=12.3 nM) and is used in the research of schizophrenia and Alzheimer's disease. It activates currents in Xenopus oocytes expressing recombinant human α7 nAChRs (EC50=2 μM; intrinsic activity of 74% relative to acetylcholine) and binds to α3β4* nAChRs in human IMR-32 neuroblastoma cells (Ki=60 nM). Nelonicline is also a 5-HT3 receptor antagonist.

Orally active and selective α7 nicotinic receptor agonist
High affinity to α7 nAChRs in human brain (Ki=12.3 nM)
Used for the research of schizophrenia and Alzheimer's disease
Activates currents in Xenopus oocytes expressing recombinant human α7 nAChRs (EC50=2 μM)
Binds to α3β4* nAChRs in human IMR-32 neuroblastoma cells (Ki=60 nM)
5-HT3 receptor antagonist

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5,946

Medchemexpress LLC LDN-214117 | 1627503-67-6 | 99.5% | 419.52 | 100 MG

LDN-214117 is an orally active, well-tolerated ALK2 inhibitor demonstrating high selectivity and low cytotoxicity for ALK2 (IC50 24 nM). It also functions as a specific bone morphogenetic proteins (BMPs) signaling inhibitor, selectively targeting BMP6 (IC50 100 nM). This compound is valuable in research for fibrodysplasia ossificans progressiva (FOP) and diffuse intrinsic pontine glioma (DIPG).

Highly selective ALK2 inhibitor (IC50 24 nM), also inhibits ALK1, ALK3, and ALK5.
Selectively inhibits BMP6, BMP2, and BMP4 signaling, and TGF-β1-induced transcriptional activity.
Modulates gene regulation for ID1 targeting in cells.
Reduces viability, proliferation, and induces apoptosis in LCLC-103H cells.
Suppresses LCLC-103H wound healing, chemotaxis, and hinders spheroid growth.
Well-tolerated in mice.

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5,947

Medchemexpress LLC Ontunisertib | 2647949-48-0 | 99.95% | 469.49 | 50 MG

Ontunisertib (AGMB-129) is an orally active and selective inhibitor of ALK5 (TGFβR1) that is restricted to the gastrointestinal tract. It functions by blocking the signaling of the pro-fibrotic TGFβ pathway. This compound is being investigated for its potential use in the research of fibrostenotic Crohn's disease. It is designed to act locally in the gastrointestinal tract, providing high exposure to the target tissue, and is then rapidly inactivated in the liver after absorption to mitigate potential systemic toxicities associated with TGFβ signaling inhibition.

Orally active and selective ALK5 (TGFβR1) inhibitor.
Gastrointestinal-restricted action.
Blocks pro-fibrotic TGFβ pathway signaling.
Potential for research in fibrostenotic Crohn's disease.
Designed for local action in the GI tract with rapid inactivation in the liver to avoid systemic toxicity.

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5,948

Alkali Scientific Lactobacillus MRS Broth Powder, 500 G

Lactobacillus MRS Broth Powder is a specialized medium designed for the selective growth of Lactobacillus species, available in a 500g package. This nutrient-rich broth contains a combination of amino acids, vitamins, and minerals that promote the growth and fermentation of Lactobacillus. It is used in microbiology laboratories for studying probiotics, fermentation processes, and dairy production. The medium is formulated to support the rapid growth of Lactobacillus and similar bacteria, making it essential in industrial and research settings focused on probiotic development, dairy products, and microbial fermentation. Its versatile formulation also supports a variety of applications in food and beverage production.

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5,949

Medchemexpress LLC 3',4'-Dihydroxyflavonol | 6068-78-6 | 99.3% | 270.24 | 50 MG

3',4'-Dihydroxyflavonol (DiOHF) is an effective antioxidant that reduces superoxide and improves nitric oxide (NO) function in diabetic rat mesenteric arteries. This compound is for research use only.

Reduces superoxide.
Improves nitric oxide (NO) function in diabetic rat mesenteric arteries.
Preserves NO activity in the presence of elevated reactive oxygen species (ROS).
Reduces Nox2-dependent superoxide production in diabetes.
Prevents eNOS uncoupling to improve endothelial function.
Reduces vascular contraction through calcium desensitization.
Exhibits neuroprotective activity with an EC50 of 0.5 μM in HT-22 cells.

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5,950

Medchemexpress LLC H-β-HoPhe-OH.HCl | 138165-77-2 | 99.3% | 215.68 | 5 G

H-β-HoPhe-OH.HCl is a phenylalanine derivative. Amino acids and their derivatives, such as this product, are utilized as ergogenic supplements. They play a role in influencing the secretion of anabolic hormones, supplying fuel during exercise, enhancing mental performance in stress-related tasks, and preventing exercise-induced muscle damage. These compounds are recognized for their beneficial properties as dietary ergogenic substances.

It is a phenylalanine derivative.
It is used for research purposes only.
Amino acid derivatives can act as ergogenic supplements.
They can influence anabolic hormone secretion.
They can supply fuel during exercise.
They can improve mental performance during stress.
They can prevent exercise-induced muscle damage.

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5,951

Promega Corporation GLOMAX R GALAXY STANDARD SERV

PRSA1551 GLOMAX R GALAXY STANDARD SERV

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5,952

Medchemexpress LLC DMAPT (Dimethylamino parthenolide) | 791595-09-0 | 98.0% | 293.40 | 25 MG

DMAPT (Dimethylamino Parthenolide), an analogue of Parthenolide (PTL), is an oral active NF-κB inhibitor with potential anti-cancer and anti-metastatic effects. It has an LD50 of 1.7 μM for cell population in AML cells.

Oral active NF-κB inhibitor.
LD50 of 1.7 μM for cell population in AML cells.
Potential anti-cancer and anti-metastatic effect.
Decreased constitutive NF-κB binding activity and inhibits cell proliferation and viability of PC-3 and DU145 cells.
Increases sensitivity of PC-3 tumor xenografts to X-rays in vivo.
Slows normal tumor development in TRAMP mice.
Reduces metastatic area in lung tissues of TRAMP mice.

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5,953

Medchemexpress LLC Pyrido[4,3-b]indole derivatives and their use as pharmaceuticals | 2765273-11-6 | 99.7% | 341.23 | 1 ML

cGAS-IN-2 (compound 109) is a potent inhibitor of Cyclic GMP-AMP Synthase (cGAS), with an IC50 of 0.01512 μM for human cGAS. This product is intended for research use only.

Potent inhibitor of cyclic GMP-AMP synthase (cGAS).
Available in solid and solution forms.
Different unit sizes are available for various research needs.
Documentation including data sheet, COA, and SDS are provided.
Detailed solubility and storage information for in vitro and in vivo use.

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5,954

Medchemexpress LLC BNN6 | 106476-75-9 | 98.0% | 278.35 | 5 MG

BNN6 is a thermoresponsive nitric oxide (NO) donor. It functions by binding to a carrier and decomposes when stimulated by heat from photothermal action. This process releases high concentrations of nitric oxide, which exhibits anti-tumor effects by inducing apoptosis in tumor cells and inhibiting their repair. BNN6 can be used to create the multifunctional biosensor BNN6-BiTiS3-iRGD, which contributes to a synergistic anti-cancer effect when combined with photothermal therapy.

Works as a thermoresponsive nitric oxide donor.
Decomposes under heat stimulation to release nitric oxide.
Induces tumor cell apoptosis.
Inhibits tumor cell repair.
Can be used to synthesize a multifunctional biosensor for synergistic anti-cancer therapy with photothermal therapy.

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5,955

Medchemexpress LLC 1-(4-(4-(2-((4-Chloro-3-(piperazin-1-ylsulfonyl)phenyl)amino)pyrimidin-4-yl)pyridin-2-yl)phenyl)-3-methyl... | 3056394-59-0 | 99.1% | 579.07 | 5 MG

KVS0001 is a selective SMG1 inhibitor that elevates the expression of transcripts and proteins resulting from truncating mutations. It increases the presentation of immune-targetable HLA class I-associated peptides from nonsense-mediated decay (NMD)-downregulated proteins on the surface of cancer cells. KVS0001 exhibits anti-tumor properties and is suitable for research in NMD-related diseases, including cancer and inherited diseases.

Selectively inhibits SMG1 protein over 246 other protein or lipid kinases.
Elevates the expression of transcripts and proteins resulting from truncating mutations.
Enhances the presentation of immune-targetable HLA class I-associated peptides from NMD-downregulated proteins on cancer cell surfaces.
Exerts anti-tumor properties.
Can be studied in research for NMD-related diseases, including cancer and inherited diseases.

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Pyridines and derivatives

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Medchemexpress LLC PRT062607 | 1370261-96-3 | C19H23N9O | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Dermaseptin | 136212-91-4 | 99.7% | 3455.10 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC N-acetyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-3-(2-naphthalenyl)-L-alaninamide | 475498-26-1 | 99.9% | 609.72 g·mol⁻¹ | C34H39N7O4 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Collagen, Type II, from bovine snout membrane | 9007-34-5 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Nelonicline (ABT-126) | 1026134-63-3 | 99.8% | 313.42 | 1 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC LDN-214117 | 1627503-67-6 | 99.5% | 419.52 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Ontunisertib | 2647949-48-0 | 99.95% | 469.49 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Alkali Scientific Lactobacillus MRS Broth Powder, 500 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 3',4'-Dihydroxyflavonol | 6068-78-6 | 99.3% | 270.24 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC H-β-HoPhe-OH.HCl | 138165-77-2 | 99.3% | 215.68 | 5 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC DMAPT (Dimethylamino parthenolide) | 791595-09-0 | 98.0% | 293.40 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Pyrido[4,3-b]indole derivatives and their use as pharmaceuticals | 2765273-11-6 | 99.7% | 341.23 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC BNN6 | 106476-75-9 | 98.0% | 278.35 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 1-(4-(4-(2-((4-Chloro-3-(piperazin-1-ylsulfonyl)phenyl)amino)pyrimidin-4-yl)pyridin-2-yl)phenyl)-3-methyl... | 3056394-59-0 | 99.1% | 579.07 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More