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Filtered Search Results
Apexbio Technology LLC Doripenem 148016-81-3 100mg
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Doripenem (148016-81-3) is a small-molecule inhibitor targeting penicillin-binding proteins (PBPs) It is designed to inhibit bacterial cell wall peptidoglycan synthesis thereby impairing cell wall integrity Doripenem exerts its biological activity primarily through inhibition of bacterial cell wall synthesis by binding to essential PBPs In in vitro studies Doripenem demonstrates inhibitory activity with IC50 values typically in the low micromolar range against representative bacterial isolates Based on these pharmacological properties Doripenem holds research potential in investigating microbial resistance mechanisms evaluating beta-lactamase enzyme inhibition and studying pharmacokinetic/pharmacodynamic profiles relevant to antimicrobial development
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Src inhibitor 1 | 179248-59-0 | MFCD01815300 | 100.0% | 373.40 | C22H19N3O3 | 50 MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Src Inhibitor 1 is a potent, ATP-competitive dual-site inhibitor of Src-family tyrosine kinases with reported IC50 values of 44 nM for Src and 88 nM for Lck. Supplied as a high-purity research chemical, it is intended for biochemical and cellular studies probing Src-family kinase signaling.
- Potent ATP-competitive inhibition of Src-family kinases.
- Dual-site binding profile enabling effective kinase blockade.
- Reported IC50 values: Src 44 nM, Lck 88 nM.
- High purity suitable for research applications.
- Available in multiple pack sizes, including 50 mg solid form.
- Appropriate for biochemical and cellular assay use.
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BIOHIPPO FOXM1-TAG-Puro LV
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FOXM1-TAG-Puro is a transcription factor reporter lentiviral vector designed to monitor the target signaling pathway in living cells The construct carries a fluorescent reporter gene under the control of pathway responsive elements and includes a puromycin selection marker to generate stable cell pools The lentivirus is provided as a ready to use VSV G pseudotyped preparation for efficient gene delivery and stable genomic integration Each vial provides a nominal titer of 5x10E6 transducing units TU Typical applications include pathway activation studies assay development compound screening and mechanism of action research The system is suitable for human and mouse cells and can be read using standard fluorescence microscopy flow cytometry or luciferase assays depending on the reporter gene This product is intended for research use only and is not for diagnostic or therapeutic procedures
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Medchemexpress LLC (Sar1)-Angiotensin II | 51833-69-3 | 99.8% | 1002.17 | 5 MG
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(Sar1)-Angiotensin II, an analogue of Angiotensin II, is a specific agonist of angiotensin AT1 receptor. It binds to brain membrane-rich particles with a Kd of 2.7 nM and can stimulate protein synthesis and cell growth in embryonic chick myocytes.
- Analogue of Angiotensin II
- Specific agonist of angiotensin AT1 receptor
- Binds to brain membrane-rich particles with a Kd of 2.7 nM
- Can stimulate protein synthesis and cell growth in embryonic chick myocytes
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![Medchemexpress LLC 1H-Indole-5-carboxylic acid, 3-[(4R)-7-chloro-10-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-3,4-dihy | 2131184-57-9 | 98.5% | 712.66 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000439263-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC 1H-Indole-5-carboxylic acid, 3-[(4R)-7-chloro-10-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-3,4-dihy | 2131184-57-9 | 98.5% | 712.66 | 25 MG
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VU661013 is a potent and selective MCL-1 inhibitor. It exhibits a Ki of 97±30 pM to human MCL-1 in a TR-FRET assay by displacing a fluorescently labeled peptide derived from the pro-apoptotic protein BAK. However, VU661013 does not significantly inhibit BCL-xL (Ki>40 μM) or BCL-2 (Ki=0.73 μM).
- VU661013 is a novel, potent, selective MCL-1 inhibitor that de-stabilizes BIM/MCL-1 association.
- It leads to apoptosis in AML.
- It is active in Venetoclax-resistant cells and patient derived xenografts.
- Treatment with VU661013 results in a dose-dependent decrease in tumor burden in disseminated human AML.
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Medchemexpress LLC 2-(3-chloro-4-fluorophenyl)-N-(1-methylethyl)-6-(3-morpholinylpropoxy)pyridopyrimidine hydrochloride | 1642187-96-9 | 99.7% | 554.44 g·mol⁻¹ | C25H30Cl2FN5O4 | 25 MG
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TASP0390325 is a high-affinity, orally active arginine vasopressin V1B receptor antagonist used in preclinical pharmacology studies. It demonstrates antidepressant and anxiolytic activity in rodent models and antagonizes CRF/dDAVP-induced ACTH release. The compound is supplied as a white to off-white solid with high reported purity and is commonly handled as a research chemical.
- High-affinity V1B receptor antagonist.
- Orally active with demonstrated antidepressant and anxiolytic effects in rodent models.
- High purity (>99%) white to off-white solid.
- Soluble in DMSO (≈50 mg/mL); practically insoluble in water.
- Recommended storage: sealed, away from moisture; -20°C for solid; in solution keep at -80°C (6 months) or -20°C (1 month).
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Medchemexpress LLC Dextran T60 (MW 60,000) | 9004-54-0 | 54000-66000 | 25 G
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Dextran T60 MW 60,000 is a polymer of anhydroglucose with an average molecular weight of 60,000. It demonstrates good biodegradability and biocompatibility, making it suitable for use in food, pharmaceutics, cosmetics, and research applications.
- Utilized as an extender, anticoagulant, antithrombotic, osmotic agent, and intravenous plasma lubricant in the medical industry.
- Acts as a cryopreservative for vaccines and organs.
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Medchemexpress LLC 9-(2-fluorobenzyl)-6-(methylamino)-9H-purine | 101155-02-6 | 95.0% | 257.27 g·mol⁻¹ | C13H12FN5 | 25 MG
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BW-A 78U is a small-molecule phosphodiesterase 4 (PDE4) inhibitor with reported in vitro potency (IC50 ≈ 3 μM). It is supplied for research use and is available as a powder and as a 10 mM solution in DMSO. The compound is characterized by formula C13H12FN5, molecular weight 257.27 g·mol⁻¹, and CAS 101155-02-6.
- PDE4 inhibition for biochemical and cellular assays.
- Moderate potency (IC50 ≈ 3 μM) suitable for target validation studies.
- Available in multiple pack sizes and solution format for assay flexibility.
- Characterized by CAS number 101155-02-6 and molecular formula C13H12FN5.
- Typical purity around 95% as reported in the safety data sheet.
- Intended for research use only; not for human therapeutic use.
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eMolecules 1374014-30-8 | 3-(Bromomethyl)oxetane | Accela ChemBio (ASD) | MFCD20278240 | 151.003 | C4H7BrO | 97.000 | BrCC1COC1 | 5g | 601089145
3-(Bromomethyl)oxetane | Accela ChemBio (ASD) | 1374014-30-8 | MFCD20278240 | 151.003 | C4H7BrO | 97.000 | BrCC1COC1 | 5g | 601089145
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Medchemexpress LLC WAY-600 | 1062159-35-6 | C28H30N8O | 2 MG
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WAY-600 is a potent, ATP-competitive, and selective mTOR inhibitor. It blocks mTOR complex 1/2 (mTORC1/2) assembly and activation, exhibiting concentration and time-dependent inhibition of HepG2 and Huh-7 cell viability. It also inhibits BrdU incorporation and increases caspase-3 and caspase-9 activity in HepG2 cells, and inhibits HepG2 tumor growth in nude mice.
- Potent, ATP-competitive, and selective mTOR inhibitor.
- Blocks mTOR complex 1/2 (mTORC1/2) assembly and activation.
- Inhibits HepG2 and Huh-7 cell viability.
- Decreases HepG2 cell colonies and inhibits BrdU incorporation.
- Increases caspase-3 and caspase-9 activity.
- Inhibits HepG2 tumor growth in nude mice.
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Medchemexpress LLC Sacubitril/Valsartan | 936623-90-4 | 99.99% | 957.99 | 1 ML
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Sacubitril/Valsartan, also known as LCZ696, is a first-in-class, orally bioavailable, dual-acting angiotensin receptor-neprilysin (ARN) inhibitor. Comprised of Valsartan and Sacubitril (AHU377) in a 1:1 molar ratio, it is used in research for hypertension and heart failure. This compound has been shown to improve diabetic cardiomyopathy by inhibiting inflammation, oxidative stress, and apoptosis.
- First-in-class, orally bioavailable, dual-acting inhibitor
- Ameliorates diabetic cardiomyopathy
- Inhibits inflammation, oxidative stress, and apoptosis
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![Medchemexpress LLC 3(2H)-Isothiazolone, 2-(1,1-dimethylethyl)-5-phenyl-4-[[4-(1-piperidinyl)phenyl)amino]-, 1,1-dioxide | 898800-26-5 | 99.77% | 439.57 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000387604-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 3(2H)-Isothiazolone, 2-(1,1-dimethylethyl)-5-phenyl-4-[[4-(1-piperidinyl)phenyl)amino]-, 1,1-dioxide | 898800-26-5 | 99.77% | 439.57 | 1 ML
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AZ876 is a selective, orally active agonist of liver X receptor (LXRα/β) that regulates lipid metabolism and anti-inflammatory effects. It induces the expression of target genes such as ABCA1 and ABCG1, and promotes reverse cholesterol transport (RCT). This product increases cardiac polyunsaturated fatty acid levels, reduces myocardial fibrosis, and decreases lesion area and monocyte adhesion in atherosclerosis models.
- Useful in cardiovascular disease research
- Prevents and treats β-adrenergic-induced cardiac diastolic dysfunction
- Inhibits atherosclerosis progression
- Time-dependently induces LXR target genes in HL-1 cardiomyocytes
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eMolecules 3196-73-4 | Methyl 3-Aminopropionate Hydrochloride | Accela ChemBio (ASD) | MFCD00039060 | 139.580 | C4H10ClNO2 | 95.000 | Cl.COC(=O)CCN | 100g | 588340284
Methyl 3-Aminopropionate Hydrochloride | Accela ChemBio (ASD) | 3196-73-4 | MFCD00039060 | 139.580 | C4H10ClNO2 | 95.000 | Cl.COC(=O)CCN | 100g | 588340284
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![Medchemexpress LLC 9-Octadecenoic acid (9Z)-, 1,1'-[1-[[(1-oxohexadecyl)oxy]methyl]-1,2-ethanediyl] ester | 2190-30-9 | 99.8% | 859.39 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000437212-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC 9-Octadecenoic acid (9Z)-, 1,1'-[1-[[(1-oxohexadecyl)oxy]methyl]-1,2-ethanediyl] ester | 2190-30-9 | 99.8% | 859.39 | 50 MG
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Palmitodiolein (Triglyceride POO) is a triacylglycerol found in vegetable oils. It is for research use only and not sold to patients.
- Forms an N-nitroso compound after interacting with morpholine in vitro.
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Selleck Chemical LLC AMG 811-A2938-1MG-5
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AMG 811 is a human monoclonal antibody (IgG1 isotype) that selectively targets human IFNgamma 7 It has potential to treat systemic lupus erythematosus (SLE) MW 144 36 KD
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