Pyridines and derivatives
- (4)
- (1)
- (5)
- (5)
- (520)
- (22)
- (2,105)
- (22)
- (2)
- (5)
- (5)
- (271)
- (175)
- (1)
- (14)
- (50)
- (300)
- (86)
- (225)
- (6)
- (4)
- (2)
- (2)
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- (1)
- (1)
- (1)
- (1)
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- (1)
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- (8)
- (7)
- (12)
- (60)
- (867)
- (5)
- (55)
- (60)
- (58)
- (19)
- (346)
- (2)
- (4)
- (2)
- (1)
- (1)
- (5)
- (275)
- (1)
- (1,700)
- (2)
- (27)
- (7)
- (1)
- (92)
- (4)
- (13)
- (77)
- (128)
- (54)
- (59)
- (2)
- (1)
- (1)
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- (1)
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- (1)
- (1)
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- (9)
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- (1)
- (2)
- (4)
- (2)
- (1)
- (5)
- (17)
- (23)
- (1)
- (1)
- (60)
- (21)
- (1)
- (1)
- (29)
- (49)
- (7)
- (2)
- (1)
- (5)
- (6)
- (12)
- (1)
- (1)
- (1)
- (18)
- (1)
- (14)
- (4)
- (1)
- (11)
- (5)
- (1)
- (10)
- (15)
- (2)
- (1)
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- (1)
- (1)
- (1)
- (9)
- (7)
- (1)
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- (1)
- (4)
- (6)
- (2)
- (1)
- (1)
- (1)
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- (4)
- (1)
- (1)
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- (15)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (12)
- (1)
- (1)
- (1)
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- (1)
- (1)
- (1)
- (1)
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- (2)
- (1)
- (15)
- (17)
- (4)
- (2)
- (2)
- (5)
- (2)
- (3)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (7)
- (5)
- (9)
- (1)
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- (1)
- (1)
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- (2)
- (1)
- (16)
- (7)
- (5)
- (1)
- (1)
- (3)
- (5)
- (10)
- (2)
- (1)
- (6)
- (6)
- (7)
- (12)
- (1)
- (1)
- (39)
- (1)
- (12)
- (11)
- (4)
- (2)
- (2)
- (15)
- (15)
- (1)
- (1)
- (1)
- (2)
- (9)
- (3)
- (2)
- (1)
- (1)
- (3)
- (6)
- (3)
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- (1)
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- (1)
- (1)
- (1)
- (3)
- (3)
- (1)
- (6)
- (5)
- (2)
- (1)
- (19)
- (9)
- (1)
- (2)
- (1)
- (1)
- (1)
- (22)
- (22)
- (2)
- (2)
- (1)
- (1)
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- (24)
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- (1)
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- (53)
- (1)
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- (33)
- (6)
- (1)
- (1)
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- (1)
- (9)
- (544)
- (5)
- (462)
- (42)
- (22)
- (130)
- (9)
- (1)
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- (1,015)
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- (1)
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- (12)
- (904)
- (7)
- (35)
- (7)
- (2)
- (1)
- (418)
- (26)
- (4)
- (10)
- (1)
- (1)
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- (1)
- (2)
- (6)
- (2)
- (4)
- (1)
- (4)
- (1)
- (3)
- (19)
- (2)
- (8)
- (72)
- (4)
- (1,561)
- (2)
- (4)
- (12)
- (9)
- (1)
- (14)
- (3)
- (9)
- (3)
- (2)
- (5)
- (4)
- (2)
- (1)
- (16)
- (3)
- (13)
- (11)
- (13)
- (10)
- (2)
- (2)
- (1)
- (2)
- (2)
- (408)
- (5)
- (6)
- (2)
- (7)
- (2)
- (3)
- (2)
- (237)
- (3)
- (2)
- (3)
- (18)
- (5)
- (2)
- (264)
- (3)
- (4)
- (4)
- (1)
- (2)
- (1)
- (4)
- (1)
- (2)
- (2)
- (2)
- (5)
- (2)
- (3)
- (9)
- (2)
- (2)
- (2)
- (2)
- (2)
- (7)
- (1)
- (1)
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- (2)
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- (5)
- (4)
- (1)
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- (1)
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- (1)
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- (1)
- (1)
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- (1)
- (1)
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- (1)
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- (1)
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- (1)
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- (1)
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- (1)
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- (1)
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- (2)
- (1)
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- (3)
- (2)
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- (1)
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- (1)
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- (1)
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- (3)
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- (1)
- (1)
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- (1)
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- (1)
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- (1)
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- (2)
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- (2)
- (1)
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- (2)
- (1)
- (2)
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- (1)
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- (3)
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- (2)
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- (1)
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- (1)
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- (2)
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- (1)
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- (4)
- (1)
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- (1)
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Filtered Search Results
Medchemexpress LLC NF-κB/MAPK-IN-1 | 2413940-56-2 | 98.7% | 477.51 | 5 MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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NF-κB/MAPK-IN-1 (compound 11a) is a potent inhibitor of NF-κB and MAPK pathway. It demonstrates inhibitory activity against NO production, with an IC50 of 6.96 μM. This compound suppresses LPS-induced iNOS, COX-2, ERK, and P38 signaling activation. NF-κB/MAPK-IN-1 can prevent LPS-induced inflammatory response in macrophages and is suitable for research on rheumatoid arthritis (RA).
- Potent inhibitor of NF-κB and MAPK pathway.
- Exhibits inhibitory activity against NO production with an IC50 of 6.96 μM.
- Suppresses LPS-induced iNOS, COX-2, ERK, and P38 signaling activation.
- Prevents LPS-induced inflammatory response in macrophages.
- Suitable for research on rheumatoid arthritis (RA).
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Ascaridole | 512-85-6 | 98.7% | 168.23 g/mol | C10H16O2 | 1 ML
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Ascaridole is a naturally occurring monoterpene peroxide used as an anthelmintic and studied for antimalarial activity. Supplied as a research-grade solution, this product is intended for laboratory use and is not for human or veterinary use.
- Ready-to-use 10 mM solution in DMSO, 1 mL.
- Purity 98.65% (typical).
- Molecular weight 168.23 g/mol.
- Chemical formula C10H16O2.
- Colorless to light yellow liquid appearance.
- Intended for research applications only.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC NODAGA-LM3 | 1415238-78-6 | 99.7% | 1521.11 | 1 MG
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NODAGA-LM3 can be labeled by 68Ga for PET imaging and is a SSTR2 antagonist. It can be used for imaging of SSTR positive paragangliomas. NODAGA-LM3 can also be labeled with [68Ga] for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).
- Target is SSTR2
- Used in clinical trials for neuroendocrine tumors
- Suitable for research use only
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![Medchemexpress LLC (5,5-dioxo-4H-thieno[3,2-c]thiochromen-2-yl)-[4-(4-methoxyphenyl)piperazin-1-yl]methanone | 890819-86-0 | MFCD14808090 | >98.0% | 454.56 g/mol | C23H22N2O4S2 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000212101.png-250.jpg)
Medchemexpress LLC (5,5-dioxo-4H-thieno[3,2-c]thiochromen-2-yl)-[4-(4-methoxyphenyl)piperazin-1-yl]methanone | 890819-86-0 | MFCD14808090 | >98.0% | 454.56 g/mol | C23H22N2O4S2 | 100 MG
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ML349 is a selective, reversible inhibitor of acyl protein thioesterase 2 (APT2)/lysophospholipase 2 (LYPLA2) used in biochemical and cell biology research to probe protein depalmitoylation. It shows reported nanomolar potency and is provided as a solid research reagent for laboratory studies.
- Selective APT2/LYPLA2 inhibition with low-nanomolar potency.
- Reversible inhibition suitable for mechanistic studies.
- Enables investigation of protein palmitoylation and signaling pathways.
- Supplied as a stable powder for low-temperature storage.
- Characterized with CAS, formula, and molecular weight for reproducibility.
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Medchemexpress LLC Acoltremon | 68489-09-8 | 99.1% | 289.41 | 50 MG
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Acoltremon is a potent and selective TRPM8 agonist, which is a menthol derivative that acts as a cooling agent. This compound demonstrates an analgesic effect and can be utilized in chronic neuropathic pain research.
- Acts as a potent and selective TRPM8 agonist.
- Functions as a cooling agent.
- Shows analgesic effect.
- Can be used in chronic neuropathic pain research.
- Displays TRPM8 agonism in tests on heterologously expressed TRP ion channels in vitro.
- Exhibits highly potent and specific TRPM8 channel agonist activity in DRG neurons in vitro.
- Activates mouse TRPM8 but does not activate or inhibit mouse TRPA1 in HEK293T cells.
- Produces an obvious analgesic effect in mice via selective TRPM8 activation.
- Reduces capsaicin-induced nocifensive behavior in mice.
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Medchemexpress LLC 3-[[(3-Amino-3-carboxypropyl)methoxyphosphinyl]oxy]benzeneacetic acid | 926281-37-0 | ≥95% | 331.26 | 25 MG
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GGsTop (Nahlsgen) is a potent, non-toxic, highly selective, and irreversible γ-glutamyl transpeptidase (GGT) inhibitor. It shows a Ki of 170 μM for Human GGT and exhibits Kons of 150 M-1 s-1 against E.coli GGT and 51 M-1 s-1 against human GGT. GGsTop protects against hepatic ischemia-reperfusion injury in a rat model. It does not inhibit glutamine amidotransferases or asparagine synthetase, and suppresses oxidative stress by inhibiting GGT activation. It also prevents ischemia/reperfusion-induced acute kidney injury in rats in vivo.
- Potent, selective, and irreversible γ-glutamyl transpeptidase (GGT) inhibitor
- Non-toxic compound
- Protects against hepatic ischemia-reperfusion injury
- Suppresses oxidative stress by inhibiting GGT activation
- Prevents ischemia/reperfusion-induced acute kidney injury
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Medchemexpress LLC 4-Pyridinecarboxylic acid, 2-[3-[2-chloro-4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl]methoxy]phenyl]-3-hydroxy-1-azetidinyl | 1418274-28-8 | MFCD31731099 | 99.8% | 586.85 | 25 MG
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Cilofexor is a potent, selective, and orally active nonsteroidal FXR agonist with an EC50 of 43 nM. It exhibits anti-inflammatory and antifibrotic effects and has potential for research in primary sclerosing cholangitis (PSC) and nonalcoholic steatohepatitis (NASH).
- Potent, selective, and orally active nonsteroidal FXR agonist
- Exhibits anti-inflammatory and antifibrotic effects
- Potential for research in primary sclerosing cholangitis
- Potential for research in nonalcoholic steatohepatitis
- Involved in various clinical trials
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Medchemexpress LLC Recombinant human insulin-like 6 (INSL6), C-terminal His-tag | >95.0% | 10 UG
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Recombinant human Insulin-like 6 (INSL6) expressed in HEK293 cells and supplied as a lyophilized C-terminal 6xHis-tagged protein for research use. Formulated from PBS (pH 7.4), it provides high purity and low endotoxin suitable for biochemical assays, structural studies, and cell-based experiments.
- Human origin, expressed in HEK293 cells.
- C-terminal 6xHis tag for purification and detection.
- Purity ≥95.0% by reducing SDS-PAGE.
- Endotoxin <1 EU/μg (LAL) for cell-based compatibility.
- Molecular weight approximately 28-40 kDa due to glycosylation.
- Lyophilized from 0.22 μm filtered PBS, pH 7.4.
- Store lyophilized at -20°C; reconstitute with carrier protein for long-term storage.
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Medchemexpress LLC 1,2-Benzisothiazole, 3-(1-piperazinyl)- | 87691-87-0 | 99.96% | 219.31 | 10MM/1ML
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Antidepressant agent 10 (Compound 4) is an orally active compound with IC50 values of 190 nM for 5-HT1A and 110 nM for 5-HT2. It can be used in the research of mental disorders.
- Orally active compound
- Can be used in the research of mental disorders
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Medchemexpress LLC Nivisnebart 1mg | 1mg
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HY-P991011 is an SORT1-targeting IgG1 type human antibody the recommed isotype control is Human IgG1 kappa Isotype Control (HY-P99001)[1]
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Medchemexpress LLC KGDS | 93674-95-4 | >99.8% | 405.40 | 1 MG
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KGDS is a synthetic peptide targeting integrin GPIIb-IIIa, found on human activated platelets. Its amino acid sequence is Lys-Gly-Asp-Ser. This product is for research use only and is not intended for patient use.
- Targets integrin GPIIb-IIIa
- Amino acid sequence is Lys-Gly-Asp-Ser
- Intended for research use only
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Medchemexpress LLC Semaphorin-7A/SEMA7A 500ug | 500ug
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Semaphorin-7A (SEMA7A) plays a key role in integrin-mediated signaling affecting multiple cellular functions including cell migration and immune responses SEMA7A promotes focal adhesion complex formation activates PTK2/FAK1 and induces phosphorylation of MAPK1 and MAPK3 Semaphorin-7A/SEMA7A Protein Human (HEK293 His) is the recombinant human-derived Semaphorin-7A/SEMA7A protein expressed by HEK293 with C-8 His labeled tag
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Aobchem AOBCHEM
5000932931 1- 2-CYCLOBUTOXYPHENYL ETHANON
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Medchemexpress LLC Azoreductase/NQO1 H 500ug
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Azo reductase/NQO1 protein is a flavin-containing quinone reductase that uses NADH or NADPH to catalyze the two-electron reduction of quinone to hydroquinone It regulates cellular redox status by detoxifying quinones and reducing plasma membrane redox components Azoreductase/NQO1 Protein Human is the recombinant human-derived Azoreductase/NQO1 protein expressed by E coli with tag free
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Aobchem AOBCHEM
5000933418 1- 5-BROMO-3 4-DICHLORO-2-FLUO
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