Pyridines and derivatives
6-Phenyl-2-pyridone 98.0+%, TCI America™
CAS: 19006-82-7 Molecular Formula: C11H9NO Molecular Weight (g/mol): 171.20 MDL Number: MFCD00059760 InChI Key: ZLUIDXRFWSPPCC-UHFFFAOYSA-N PubChem CID: 87889 IUPAC Name: 6-phenyl-1,2-dihydropyridin-2-one SMILES: O=C1NC(=CC=C1)C1=CC=CC=C1
Apexbio Technology LLC LY2835219 1231930-82-7 100mg
LY2835219 (CAS 1231930-82-7) is a selective orally bioavailable inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6) It targets CDK4 and CDK6 with reported IC50 values of 2 nM and 10 nM respectively thereby reducing phosphorylation of the retinoblastoma protein (Rb) This mechanism leads to cell-cycle arrest during the G1 phase and subsequent inhibition of tumor cell proliferation LY2835219 demonstrates the capacity to cross the blood-brain barrier indicating its potential utility in research involving primary or metastatic intracranial tumors
Medchemexpress LLC Pulegone | 89-82-7 | 152.24 | 1 ML
Pulegone is a monoterpene ketone compound found in the essential oils of many plants. It is known for its anti-inflammatory, antibacterial, antifungal, and anti-hyperalgesic properties, and can also be used as a bird repellent. Pulegone is particularly effective against bacteria of the Salmonella species.
- Inhibits inflammatory mediators by downregulating iNOS, COX-2, NF-κB, and MAPK signaling pathways.
- Upregulates Nrf-2/HO-1.
- Increases intracellular calcium concentration in chicken sensory neurons.
- Activates TRPM8 and TRPA1 channels.
- Shows beneficial anti-hyperalgesic effects in inflammatory pain models.
Medchemexpress LLC Pulegone | 89-82-7 | 152.24 | 500 MG
Pulegone is a monoterpene ketone compound commonly found in the essential oils of various plants. It acts as a bird repellent and demonstrates diverse biological activities, including anti-inflammatory, antibacterial, antifungal, and anti-hyperalgesic effects. It is notably effective against bacteria of the Salmonella species.
- Inhibits expression of inflammatory mediators by downregulating iNOS, COX-2, NF-κB, and MAPK signaling pathways.
- Upregulates Nrf-2/HO-1.
- Increases intracellular Ca2+ concentration in chicken sensory neurons.
- Activates TRPM8 and TRPA1.
- Exhibits anti-hyperalgesic effects in inflammatory pain models.
- Appears as a colorless to light yellow liquid.
- Has a purity of 99.57%.
Apexbio Technology LLC PF-4981517 1390637-82-7 5mg
PF-4981517 (CAS 1390637-82-7) also known as CYP3cide is a potent and time-dependent inhibitor selective for human cytochrome P450 3A4 (CYP3A4) Acting via mechanism-based inactivation it distinguishes CYP3A4 from closely related isoform CYP3A5 allowing for the delineation of each enzyme s contribution to drug metabolism As a cationic lipophilic molecule at physiological pH PF-4981517 may undergo non-specific breakdown with high microsomal protein concentrations potentially influencing its observed inhibitory potency This compound serves as a valuable tool for investigating the impact of CYP3A5 genetic variation on pharmacokinetics and the relative metabolism of CYP3A substrates in vitro
Apexbio Technology LLC PF-4981517 1390637-82-7 10mg
PF-4981517 (CAS 1390637-82-7) also known as CYP3cide is a potent and time-dependent inhibitor selective for human cytochrome P450 3A4 (CYP3A4) Acting via mechanism-based inactivation it distinguishes CYP3A4 from closely related isoform CYP3A5 allowing for the delineation of each enzyme s contribution to drug metabolism As a cationic lipophilic molecule at physiological pH PF-4981517 may undergo non-specific breakdown with high microsomal protein concentrations potentially influencing its observed inhibitory potency This compound serves as a valuable tool for investigating the impact of CYP3A5 genetic variation on pharmacokinetics and the relative metabolism of CYP3A substrates in vitro
Apexbio Technology LLC PF-4981517 1390637-82-7 50mg
PF-4981517 (CAS 1390637-82-7) also known as CYP3cide is a potent and time-dependent inhibitor selective for human cytochrome P450 3A4 (CYP3A4) Acting via mechanism-based inactivation it distinguishes CYP3A4 from closely related isoform CYP3A5 allowing for the delineation of each enzyme s contribution to drug metabolism As a cationic lipophilic molecule at physiological pH PF-4981517 may undergo non-specific breakdown with high microsomal protein concentrations potentially influencing its observed inhibitory potency This compound serves as a valuable tool for investigating the impact of CYP3A5 genetic variation on pharmacokinetics and the relative metabolism of CYP3A substrates in vitro
Apexbio Technology LLC PF-4981517 1390637-82-7 25mg
PF-4981517 (CAS 1390637-82-7) also known as CYP3cide is a potent and time-dependent inhibitor selective for human cytochrome P450 3A4 (CYP3A4) Acting via mechanism-based inactivation it distinguishes CYP3A4 from closely related isoform CYP3A5 allowing for the delineation of each enzyme s contribution to drug metabolism As a cationic lipophilic molecule at physiological pH PF-4981517 may undergo non-specific breakdown with high microsomal protein concentrations potentially influencing its observed inhibitory potency This compound serves as a valuable tool for investigating the impact of CYP3A5 genetic variation on pharmacokinetics and the relative metabolism of CYP3A substrates in vitro
Apexbio Technology LLC MK 886 118414-82-7 5mg
MK 886 (CAS 118414-82-7) is a small-molecule inhibitor targeting 5-lipoxygenase-activating protein (FLAP) a protein essential for activating 5-lipoxygenase and initiating leukotriene biosynthesis It is designed to block FLAP function thereby inhibiting leukotriene production derived from arachidonic acid metabolism MK 886 exerts its biological activity primarily through non-competitive antagonism of FLAP to suppress 5-LO-mediated signaling In cell-based assays using whole leukocytes and human whole blood MK 886 demonstrates inhibitory activity with IC50 values of 3 nM and 1 1 M respectively Based on these pharmacological properties MK 886 holds research potential in studies on inflammatory signaling pathways leukotriene biology and disorders such as asthma arthritis and psoriasis
Medchemexpress LLC Pulegone | 89-82-7 | 152.24 | 1 G
Pulegone is a monoterpene ketone compound found extensively in the essential oils of various plants. It serves as a bird repellent and exhibits diverse activities including anti-inflammatory, antibacterial, antifungal, and anti-hyperalgesic effects. It is particularly effective against bacteria of the Salmonella species.
- Monoterpene ketone compound
- Widely present in essential oils of many plants
- Purity: 99.57%
- Appearance: Liquid (Density: 0.937 g/cm3)
- Color: Colorless to light yellow
- Bird repellent
- Anti-inflammatory agent
- Antibacterial agent, particularly against Salmonella species
- Antifungal agent
- Anti-hyperalgesic effects
Medchemexpress LLC Mefuparib | 1392502-82-7 | 99.8% | 298.31 | 25 MG
Mefuparib (CVL218) is a poly ADP-ribose polymerase (PARP) inhibitor used in cancer research that exhibits potent brain penetration due to its high protein binding.
- Acts as a poly ADP-ribose polymerase (PARP) inhibitor.
- Used in cancer research.
- Exhibits potent brain penetration.
- Known for its high protein binding.
Medchemexpress LLC Succinobucol | 216167-82-7 | 99.62% | 616.91 | 25 MG
Succinobucol is a phenolic antioxidant with anti-inflammatory and antiplatelet effects. It is primarily intended for research and analytical applications.
- Phenolic antioxidant
- Anti-inflammatory effects
- Antiplatelet effects
Medchemexpress LLC Pelitinib | 257933-82-7 | 98.5% | 467.92 | 100 MG
Pelitinib is an irreversible inhibitor of EGFR, also known to slightly inhibit Src, MEK/ERK, and ErbB2. It is intended for research use only.
- Irreversible EGFR inhibitor
- IC50 for EGFR is 38.5 nM
- Slightly inhibits Src, MEK/ERK, and ErbB2
- IC50s for Src, MEK/ERK, and ErbB2 are 282, 800, and 1255 nM, respectively
Medchemexpress LLC R112 | 575474-82-7 | 98.9% | 312.30 | 50 MG
R112 is a fast and reversible inhibitor of spleen tyrosine kinase (Syk). It inhibits Syk kinase activity with an IC50 value of 226 nM and a Ki value of 96 nM. R112 also inhibits the IgE-FcεRI signaling pathway.
- Inhibits Syk kinase activity
- Inhibits IgE-FcεRI signaling pathway
- Useful for research related to allergic rhinitis
- Dose-dependently inhibits anti-IgE-mediated tryptase and histamine release
- Inhibits secretion of LTC4, TNF-α, GM-CSF, and IL-8
- Inhibits phosphorylation of the Syk target LAT (Y191)
Medchemexpress LLC ART812 | 2607138-82-7 | 99.9% | 461.79 | 25 MG
ART812 is an orally active DNA polymerase Polθ inhibitor with an IC50 value of 7.6 nM. It also has an IC50 value of 240 nM for cell-based microhomology-mediated end joining (MMEJ). The compound elicits Polθ inhibitor sensitivity in MDA-MB-436 SHLD2 knockout cells and shows significant tumor inhibition in rats with MDA-MB-436 BRCA1/SHLD2 defective tumors.
- Orally active DNA polymerase Polθ inhibitor
- IC50 value of 7.6 nM for Polθ
- IC50 value of 240 nM for cell-based microhomology-mediated end joining (MMEJ)
- Elicits Polθ inhibitor sensitivity in MDA-MB-436 SHLD2 knockout cells
- Shows significant tumor inhibition in rats with MDA-MB-436 BRCA1/SHLD2 defective tumors
- Purity of 99.9%
- Molecular weight of 461.79