Pyridines and derivatives
Apexbio Technology LLC MPEP 96206-92-7 10mg
MPEP (CAS 96206-92-7) is a highly selective and systemically active antagonist of the metabotropic glutamate receptor subtype 5 (mGlu5) It demonstrates potent inhibitory activity with an IC50 of 36 nM for mGlu5-mediated phosphoinositide (PI) hydrolysis in human mGlu1b-expressing L (tk-) cells and exhibits no detectable effect on mGlu1b or on group II and III mGlu receptor subtypes at concentrations up to 100 M MPEP also effectively inhibits DHPG-induced PI hydrolysis in hippocampal striatal and cortical slices (IC50 values of 8 nM 20 5 nM and 17 9 nM respectively) It is widely utilized as a pharmacological tool to investigate mGlu5 function and has demonstrated anxiolytic and antidepressant-like effects in animal behavioral models
Apexbio Technology LLC MPEP 96206-92-7 50mg
MPEP (CAS 96206-92-7) is a highly selective and systemically active antagonist of the metabotropic glutamate receptor subtype 5 (mGlu5) It demonstrates potent inhibitory activity with an IC50 of 36 nM for mGlu5-mediated phosphoinositide (PI) hydrolysis in human mGlu1b-expressing L (tk-) cells and exhibits no detectable effect on mGlu1b or on group II and III mGlu receptor subtypes at concentrations up to 100 M MPEP also effectively inhibits DHPG-induced PI hydrolysis in hippocampal striatal and cortical slices (IC50 values of 8 nM 20 5 nM and 17 9 nM respectively) It is widely utilized as a pharmacological tool to investigate mGlu5 function and has demonstrated anxiolytic and antidepressant-like effects in animal behavioral models
Apexbio Technology LLC Trimethobenzamide hydrochloride 554-92-7 500mg
Trimethobenzamide hydrochloride is a dopamine D2 receptor antagonist frequently utilized in biomedical research investigating mechanisms underlying emesis and anti-emetic responses The compound exerts pharmacological effects by inhibiting dopamine receptor-mediated neurotransmission within the chemoreceptor trigger zone (CTZ) of the central nervous system a key regulatory area implicated in nausea and vomiting reflexes Through selective receptor blockade trimethobenzamide hydrochloride allows researchers to elucidate dopamine-dependent molecular and physiological pathways contributing to vomiting in experimental animal models This compound is commonly applied in laboratory settings to characterize the pharmacodynamic profiles of novel anti-emetic agents and to evaluate dopamine receptor-involved emetic signaling The reported IC50 value for dopamine D2 receptor inhibition is approximately 320 nM
Medchemexpress LLC Cloprostenol | 40665-92-7 | 99.9% | 5 MG
Cloprostenol is a prostaglandin F2α (PGF2α) analogue used in research as a luteolytic agent and for studies such as open-cervix pyometra.
- acts as a prostaglandin F2α analogue and induces luteolysis.
- white to off-white solid appearance suitable for analytical use.
- characterized by HPLC, 1H NMR, and MS to confirm identity and purity.
- long-term storage stable at room temperature for the solid form; solvent storage conditions vary.
Medchemexpress LLC Pilocarpine | 92-13-7 | 99.9% | 1 ML
Pilocarpine is a selective M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist, intended for research use only. Studies have shown its effects both in vitro and in vivo.
- In vitro: induces dose- and time-dependent proliferation retardation and morphological abnormalities in human corneal stromal (HCS) cells at concentrations above 0.625 g/L.
- In vitro: evokes concentration-dependent relaxation with an EC50 of 2.4 mM in isolated segments of rat tail artery.
- In vivo: significantly increases saliva secretion in exercised rats compared to control rats.
- In vivo: leads to significantly lower Na+ concentration in the saliva of exercised rats compared to control rats.
Medchemexpress LLC Apronal | 528-92-7 | 98.0% | 1 ML
Apronal (Allylisopropylacetylurea, Apronalide) is utilized in the research of neuropsychiatry disorders. Research indicates that allylisopropylacetylurea elevates the levels of porphyrins in the liver and urine of animals, also causing a distinct green pigmentation of the liver. Animals treated with high doses over long periods exhibit good recovery, with measured parameters returning to normal values.
- Used for neuropsychiatry research
- Elevates porphyrins in liver and urine
- Causes green pigmentation of the liver
- Long-term treatment is reversible with good recovery
Medchemexpress LLC Cloprostenol | 40665-92-7 | 99.9% | 10 MG
Cloprostenol is a synthetic prostaglandin F2α (PGF2α) analogue used as a luteolytic agent in research. It acts as a prostaglandin receptor agonist and is used to induce luteolysis and to study reproductive conditions such as open-cervix pyometra. CAS number 40665-92-7; molecular weight 424.92; molecular formula C22H29ClO6.
- prostaglandin receptor agonist
- induces luteolysis in animal models
- suitable for reproductive and veterinary research
- high purity suitable for analytical and in vitro studies
- stable when stored per manufacturer recommendations
Medchemexpress LLC Rosavin | 84954-92-7 | 428.43 | 1 ML
Rosavin, an orally bioactive phenylpropanoid from Rhodiola rosea L. (RRL), is an adaptogen that enhances the body's response to environmental stress. It significantly influences bone tissue metabolism by inhibiting osteoclastogenesis and promoting osteoblast differentiation. Rosavin also demonstrates antidepressant, adaptogenic, and anxiolytic effects in mouse models. Additionally, it improves survival by reducing intestinal damage in irradiated rats and protects against Ischemia-reperfusion (I/R)-induced cerebral injury in vivo.
- Enhances the body's response to environmental stress.
- Influences bone tissue metabolism by inhibiting osteoclastogenesis and promoting osteoblast differentiation.
- Demonstrates antidepressant, adaptogenic, and anxiolytic effects.
- Improves survival, reducing intestinal damage in irradiated rats.
- Protects against Ischemia-reperfusion (I/R)-induced cerebral injury in vivo.
Medchemexpress LLC Ecopladib | 381683-92-7 | 748.11 | 1 MG
Ecopladib is a sub-micromolar inhibitor of cytosolic phospholipase A2α (cPLA2α), with IC50s of 0.15 μM in GLU micelle and 0.11 μM in rat whole blood assays. It inhibits cPLA2α in PAPE liposome assay at 73% at 37 nM and is inactive against COX-1 and COX-2. It also inhibits the production of prostaglandins and leukotrienes. In vivo, Ecopladib is orally efficacious for inhibiting COX-2 derived PGE2 formation and reducing carrageenan-induced paw swelling.
- Sub-micromolar inhibitor of cytosolic phospholipase A2α (cPLA2α)
- Inhibits cPLA2α in GLU micelle and rat whole blood assays
- Inactive against COX-1 and COX-2
- Inhibits production of prostaglandins and leukotrienes
- Orally efficacious for inhibiting COX-2 derived PGE2 formation
- Orally efficacious for reducing carrageenan-induced paw swelling
Apexbio Technology LLC ZM 39923 HCl 1021868-92-7 50mg
ZM 39923 HCl (CAS 1021868-92-7) is a small molecule that selectively inhibits Janus kinases JAK1 and JAK3 displaying pIC50 values of 4 4 and 7 1 respectively As JAK family kinases play a pivotal role in cytokine-mediated signaling via the JAK-STAT pathway ZM 39923 HCl is frequently employed to investigate signal transduction mechanisms linked to hematological malignancies autoimmune conditions and inflammatory disorders The compound also inhibits tissue transglutaminase 2 (TGM2) with an IC50 of 10 nM and exhibits equivalent inhibition of EGFR In cellular studies ZM 39923 HCl modulates T cell proliferation and apoptosis and affects pathways involving VEGF and TGF 2 underscoring its utility in cytokine oncology and cell biology research
Apexbio Technology LLC ZM 39923 HCl 1021868-92-7 10mg
ZM 39923 HCl (CAS 1021868-92-7) is a small molecule that selectively inhibits Janus kinases JAK1 and JAK3 displaying pIC50 values of 4 4 and 7 1 respectively As JAK family kinases play a pivotal role in cytokine-mediated signaling via the JAK-STAT pathway ZM 39923 HCl is frequently employed to investigate signal transduction mechanisms linked to hematological malignancies autoimmune conditions and inflammatory disorders The compound also inhibits tissue transglutaminase 2 (TGM2) with an IC50 of 10 nM and exhibits equivalent inhibition of EGFR In cellular studies ZM 39923 HCl modulates T cell proliferation and apoptosis and affects pathways involving VEGF and TGF 2 underscoring its utility in cytokine oncology and cell biology research
Medchemexpress LLC 2-chlorophenothiazine | 92-39-7 | MFCD00005016 | 500mg
2-Chlorophenothiazine is a phenothiazine derivative 2-Chlorophenothiazine has the activity of inhibiting DNA RNA and protein synthesis 2-Chlorophenothiazine is an intermediate in the synthesis of Chlorpromazine (HY-12708) and Perphenazine (HY-A0077)[1]
Medchemexpress LLC 2-chlorophenothiazine | 92-39-7 | MFCD00005016 | 50mg
2-Chlorophenothiazine is a phenothiazine derivative 2-Chlorophenothiazine has the activity of inhibiting DNA RNA and protein synthesis 2-Chlorophenothiazine is an intermediate in the synthesis of Chlorpromazine (HY-12708) and Perphenazine (HY-A0077)[1]
Medchemexpress LLC MPEP | 96206-92-7 | 99.4% | 193.24 | 100 MG
MPEP is a potent, selective, noncompetitive, orally active, and systemically active mGlu5 receptor antagonist. It completely inhibits quisqualate-stimulated phosphoinositide (PI) hydrolysis with an IC50 of 36 nM. MPEP exhibits anxiolytic- and antidepressant-like effects. It is also a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Potent, selective mGlu5 receptor antagonist
- Exhibits anxiolytic-like effects
- Shows antidepressant-like effects
- Functions as a click chemistry reagent
- No agonist or antagonist activity on human mGlu2, -3, -4a, -7b, -8a, and mGlu6 receptors
Medchemexpress LLC Yx968 | 2742732-92-7 | 98.06% | 831.12 | 50 MG
YX968 is a potent and selective HDAC3/8 PROTAC dual degrader that exhibits antitumor activity by promoting apoptosis. It consists of a target protein ligand, a linker, and an E3 ligase ligand.
- Induces cell apoptosis by blocking G1 phase
- Cleavage of CASP3 was induced in a dose-dependent manner
- Targets HDAC3 with a DC50 of 1.7 nM
- Targets HDAC8 with a DC50 of 6.8 nM