Pyridines and derivatives
Medchemexpress LLC Angelicain | 49624-66-0 | 1 MG
Angelicain (Norcimifugin) is a chemical compound found in Cimicifuga foetida, known for its anti-inflammatory properties. It is provided as a white to off-white solid.
- A constituent of Cimicifuga foetida.
- Exhibits anti-inflammatory activity.
- High purity (99.91%).
- Soluble in DMSO.
Medchemexpress LLC Netarsudil | 1254032-66-0 | 99.9% | 10 MG
Netarsudil (AR-13324) is a competitive inhibitor of Rho-associated protein kinases (ROCK I and ROCK II) and a reversible inhibitor of the norepinephrine transporter (NET). It reduces intraocular pressure by inhibiting ROCK, which causes relaxation of trabecular meshwork cells and dilation of episcleral veins, thereby increasing the ease of aqueous humor outflow. This compound also inhibits NET to reduce aqueous humor production. Netarsudil is primarily used in the study of ocular hypertension and primary open-angle glaucoma.
- Reduces intraocular pressure
- Inhibits NET to reduce aqueous humor production
- Used in the study of ocular hypertension and primary open-angle glaucoma
- For research use only
Medchemexpress LLC Cyproterone | 2098-66-0 | 99.9% | 50 MG
Cyproterone is an antiandrogen that suppresses the actions of testosterone by blocking androgen receptors. Its acetate form can be used in the research of hypersexuality and prostate cancer. This product is intended for research use only and not for patient use.
- Functions by blocking androgen receptors
- Suppresses the actions of testosterone
- Acetate form used in hypersexuality and prostate cancer research
- Intended for research use only
Apexbio Technology LLC CD 1530 107430-66-0 10mg
CD1530 (CAS 107430-66-0) is a selective retinoic acid receptor (RAR) agonist targeting primarily RAR with lower affinity for RAR and RAR It is designed to activate RAR -mediated pathways thereby regulating cellular growth and apoptosis CD1530 exerts its biological activity by selectively activating RAR In transcriptional assays CD1530 demonstrates potent activation of RAR with an AC50 of approximately 1 8 nM It also inhibits the CYP26A1 enzyme (IC50 530 nM) Based on these pharmacological properties CD1530 holds research potential in preclinical cancer studies particularly in oral cavity tumorigenesis models and investigations of retinoid signaling and metabolism
Apexbio Technology LLC CD 1530 107430-66-0 1mg
CD1530 (CAS 107430-66-0) is a selective retinoic acid receptor (RAR) agonist targeting primarily RAR with lower affinity for RAR and RAR It is designed to activate RAR -mediated pathways thereby regulating cellular growth and apoptosis CD1530 exerts its biological activity by selectively activating RAR In transcriptional assays CD1530 demonstrates potent activation of RAR with an AC50 of approximately 1 8 nM It also inhibits the CYP26A1 enzyme (IC50 530 nM) Based on these pharmacological properties CD1530 holds research potential in preclinical cancer studies particularly in oral cavity tumorigenesis models and investigations of retinoid signaling and metabolism
Apexbio Technology LLC PH-797804 586379-66-0 25mg
PH-797804 (CAS 586379-66-0) is a potent reversible ATP-competitive inhibitor of human p38 mitogen-activated protein kinase (MAPK) demonstrating selectivity for the p38 isoform with an IC50 of 26 nM and a Ki of 5 8 nM In cellular assays PH-797804 inhibits LPS-induced production of TNF- and IL-1 in monocytes in a concentration-dependent manner and blocks osteoclast formation induced by RANKL and M-CSF in primary rat bone marrow cells Oral administration in animal models reduces LPS-stimulated TNF- levels and suppresses chronic inflammation in arthritis models indicating utility for studying inflammatory and autoimmune mechanisms
Medchemexpress LLC Netarsudil | 1254032-66-0 | 99.94% | 25 MG
Netarsudil (AR-13324) is a competitive inhibitor of Rho-associated protein kinases (ROCK I and ROCK II) and a reversible inhibitor of the norepinephrine transporter (NET). It reduces intraocular pressure by inhibiting ROCK, which causes relaxation of trabecular meshwork cells and dilation of episcleral veins, thereby increasing aqueous humor outflow. It also inhibits NET to reduce aqueous humor production. Netarsudil is primarily used in the study of ocular hypertension and primary open-angle glaucoma.
- Reduces intraocular pressure by inhibiting ROCK.
- Increases aqueous humor outflow.
- Inhibits norepinephrine transporter (NET) to reduce aqueous humor production.
- Used in the study of ocular hypertension.
- Used in the study of primary open-angle glaucoma.
Medchemexpress LLC Cefoxitin | 35607-66-0 | 99.92% | 1 ML
Cefoxitin is a cephalosporin-class antibiotic that is highly stable against β-Lactamase. It has a broad spectrum of antibacterial activity, effective against both Gram-negative and Gram-positive bacteria. This product is for research use only.
- Cephalosporin-class antibiotic
- Highly stable against β-Lactamase
- Broad spectrum of antibacterial activity
- Effective against Gram-negative bacteria
- Effective against Gram-positive bacteria
- Inhibits mouse OAT3 expressed in CHO cells
- Effectively kills *B. burgdorferi* in mice
Medchemexpress LLC Netarsudil | 1254032-66-0 | 99.9% | 50 MG
Netarsudil is a competitive inhibitor of Rho-associated protein kinases (ROCK I and ROCK II) and a reversible inhibitor of the norepinephrine transporter (NET). It reduces intraocular pressure by acting on these pathways, primarily used in research for ocular hypertension and primary open-angle glaucoma.
- Inhibits Rho-associated protein kinases (ROCK I and ROCK II).
- Reversibly inhibits norepinephrine transporter (NET).
- Reduces intraocular pressure by increasing aqueous humor outflow.
- Used in the study of ocular hypertension.
- Used in the study of primary open-angle glaucoma.
Medchemexpress LLC Cyproterone | 2098-66-0 | 99.9% | 25 MG
Cyproterone is an antiandrogen that suppresses the actions of testosterone by blocking androgen receptors. Its acetate form can be used in the research of hypersexuality and prostate cancer.
- Antiandrogen
- Suppresses testosterone actions
- Blocks androgen receptors
- Acetate form used in research for hypersexuality and prostate cancer
Medchemexpress LLC N-acetyltyramine | 1202-66-0 | 99.7% | 25MG
N-acetyltyramine | 1202-66-0 | 99.7% | 25MG
Medchemexpress LLC PH-797804 10mg | 586379-66-0 | 10MG
PH-797804 is a ATP-competitive selective p38 /p38 inhibitor (IC50 26 nM and Ki 5 8 nM for p38 Ki 40 nM for p38 ) and does not inhibit JNK2
Medchemexpress LLC CD1530 | 107430-66-0 | 98.01% | 398.49 | 50 MG
CD1530 is an orally active, selective RARγ agonist and an antibacterial agent. It works by reducing Smad1/5/8 phosphorylation and overall Smad levels, as well as decreasing β-catenin, MMP9 protein, and Reactive Oxygen Species (ROS) levels. It has shown efficacy in inhibiting heterotopic ossification, promoting Achilles tendon healing, and inhibiting muscle fatty infiltration. It is suitable for research in orthopedic diseases, such as heterotopic ossification and Achilles tendon injury, and muscle diseases, including those related to muscle fatty infiltration.
- Orally active and selective RARγ agonist
- Functions as an antibacterial agent
- Reduces Smad1/5/8 phosphorylation and overall Smad levels
- Decreases β-catenin, MMP9 protein, and ROS levels
- Inhibits heterotopic ossification
- Promotes Achilles tendon healing
- Inhibits muscle fatty infiltration
Medchemexpress LLC Cyproterone | 2098-66-0 | MFCD00869226 | 99.9% | 5 MG
Cyproterone is an antiandrogen that suppresses the actions of testosterone via blocking androgen receptors. Cyproterone's acetate form can be used in the research of hypersexuality and prostate cancer.
Features and benefits
- Suppresses the actions of testosterone.
- Functions by blocking androgen receptors.
- Its acetate form can be used in the research of hypersexuality.
- Its acetate form can be used in the research of prostate cancer.
- Has been investigated in clinical trials for conditions such as acne vulgaris.
- Has been investigated in clinical trials for polycystic ovary syndrome.
- Has been investigated in clinical trials for gender dysphoria.
- Has been investigated in clinical trials for hirsutism, androgenetic alopecia, acne and seborrhea in women.
- Has been investigated in clinical trials for hyperandrogenism.
Medchemexpress LLC Pancuronium (dibromide) | 15500-66-0 | 98.0% | 50 MG
Pancuronium dibromide is a bis-quaternary steroid and a neuromuscular relaxant. It inhibits neuromuscular transmission by competing with acetylcholine for binding sites on nACh receptors, inhibits cardiac muscarinic receptors, and exhibits a sympathomimetic action. This compound is intended for research use only.
- Inhibits neuromuscular transmission by competing with acetylcholine for binding sites on nACh receptors
- Inhibits cardiac muscarinic receptors
- Exhibits sympathomimetic action
- Blocks SKCa channels, with an IC50 of 6.8 μM for inhibiting after hyperpolarization (AHP) in sympathetic neurons
- Reversibly inhibits transmembrane sodium conductance in dorsal root ganglion neurons
- Abolishes bradycardia induced by acetylcholine and vagal nerve stimulation in guinea pigs