Pyridines and derivatives
5,6-Dichloro-3-pyridinemethanol 96.0+%, TCI America™
CAS: 54127-30-9 Molecular Formula: C6H5Cl2NO Molecular Weight (g/mol): 178.012 MDL Number: MFCD00671515 InChI Key: ZOFUUOULXZPZHP-UHFFFAOYSA-N Synonym: 2,3-Dichloro-5-hydroxymethylpyridine, 5,6-Dichloronicotinyl Alcohol PubChem CID: 21882961 IUPAC Name: (5,6-dichloropyridin-3-yl)methanol SMILES: C1=C(C=NC(=C1Cl)Cl)CO
Apexbio Technology LLC GW4064 278779-30-9 50mg
GW4064 (CAS 278779-30-9) is a non-steroidal agonist targeting the farnesoid X receptor (FXR) a nuclear receptor involved in lipid and cholesterol regulation Reported EC50 values of GW4064 for FXR activation are approximately 15 nM in isolated receptor assays and 90 nM in human FXR-transfected cell studies In animal models including KK-Ay and ob/ob mice GW4064 administration was associated with reduced serum triglyceride (TG) concentrations and diminished very-low-density lipoprotein (VLDL) production However due to limitations such as poor solubility chemical instability under UV exposure and a potentially toxic stilbene pharmacophore GW4064 primarily serves as a research tool for investigating FXR signaling pathways
Apexbio Technology LLC GW4064 278779-30-9 10mg
GW4064 (CAS 278779-30-9) is a non-steroidal agonist targeting the farnesoid X receptor (FXR) a nuclear receptor involved in lipid and cholesterol regulation Reported EC50 values of GW4064 for FXR activation are approximately 15 nM in isolated receptor assays and 90 nM in human FXR-transfected cell studies In animal models including KK-Ay and ob/ob mice GW4064 administration was associated with reduced serum triglyceride (TG) concentrations and diminished very-low-density lipoprotein (VLDL) production However due to limitations such as poor solubility chemical instability under UV exposure and a potentially toxic stilbene pharmacophore GW4064 primarily serves as a research tool for investigating FXR signaling pathways
Medchemexpress LLC Raxatrigine | 934240-30-9 | 99.9% | 10 MG
Raxatrigine is a novel small molecule state-dependent sodium channel blocker and Nav1.7 sodium channel inhibitor. It is for research use only.
- Purity of 99.85%.
- CAS number 934240-30-9.
- Molecular weight of 314.35.
- Chemical formula C18H19FN2O2.
- Appears as a white to off-white solid.
- Inhibits Nav1.7 sodium channels.
- Received orphan-drug designation from the US Food and Drug Administration in July 2013.
Medchemexpress LLC Norartocarpetin | 520-30-9 | 286.24 | 1 MG
Norartocarpetin is a potent tyrosinase inhibitor (IC50 = 0.47 μM) and can act as an antibrowning agent in food research. It shows significant anticancer activity in lung carcinoma cells (NCI-H460, IC50 = 22 μM), mediating antiproliferative effects via the Ras/Raf/MAPK pathway, mitochondrial apoptosis, S-phase cell cycle arrest, and suppression of cell migration/invasion.
- Tyrosinase inhibitor (IC50 = 0.47 μM).
- Antibrowning agent for food systems research.
- Anticancer activity in lung carcinoma cells (NCI-H460, IC50 = 22 μM).
- Antiproliferative effects via Ras/Raf/MAPK pathway.
- Induces mitochondrial-mediated apoptosis.
- Causes S-phase cell cycle arrest.
- Suppresses cell migration and invasion.
Medchemexpress LLC GelMA, 30% methacrylation | 2280018-77-9 | 30% | 10 MG
GelMA (Gelatin Methacryloyl), 30% methacrylation, is a derivative obtained by the reaction of Methacrylic anhydride (MA) and gelatin. It exhibits excellent biocompatibility, biodegradability, and moldability. GelMA can be photocrosslinked into hydrogels.
- Used for research in tissue regeneration
- Suitable for drug delivery
- Applied in organ-on-a-chip research
- Used for biosensing
Medchemexpress LLC Oxadiazon (Standard) | 19666-30-9 | 98.64% | 25 MG
Oxadiazon (Standard) | 19666-30-9 | 98.64% | 25 MG
Medchemexpress LLC Picroside I | 27409-30-9 | 492.47 | 1 ML
Picroside I is the primary component of Picrorhiza scrophulariiflora, a valuable medicinal herb known for its abundant hepatoprotective metabolites, Picroside-I and Picroside-II. It shows promise as an agent for asthma management, significantly reducing inflammation at higher doses. Furthermore, Picroside I downregulates pSTAT6 and GATA3 expressions and dose-dependently increases serum levels of IFN-γ.
- Major ingredient of Picrorhiza scrophulariiflora.
- Source of hepatoprotective metabolites.
- Promising agent for the management of asthma.
- Reduces inflammation significantly at higher doses.
- Downregulates pSTAT6 and GATA3 expressions.
- Dose-dependently increases serum levels of IFN-γ.
Medchemexpress LLC Raxatrigine (Vixotrigine) | 934240-30-9 | 99.9% | 50 MG
Raxatrigine (Vixotrigine) is a novel small molecule state-dependent sodium channel blocker and a Nav1.7 sodium channel inhibitor. This compound is intended for research use only.
- Nav1.7 sodium channel inhibitor
- Available as a white to off-white solid
- Ships at room temperature in the continental US
- Store powder at -20°C for 3 years or 4°C for 2 years
- Store in solvent at -80°C for 6 months or -20°C for 1 month
- Purity of 99.9%
Medchemexpress LLC 5-Bromotetralone | 68449-30-9 | 225.08 | 5 G
5-Bromotetralone (5-Bromo-3,4-dihydro-2H-naphthalen-1-one) is a synthetic intermediate useful for pharmaceutical synthesis. Storage conditions:
- Store at room temperature for 3 years.
- In solvent, store at -80°C for 2 years or -20°C for 1 year.
Medchemexpress LLC Fusicoccin | 20108-30-9 | 96.3% | 680.82 | 1 MG
Fusicoccin is a fungal phytotoxin that stabilizes specific 14-3-3 protein-protein interactions, including the H+-ATPase/14-3-3 complex in plants. It also stabilizes 14-3-3 protein interactions with binding partners containing a C-terminal 14-3-3 recognition motif. This compound induces apoptosis in cancer cells and exhibits anticancer activity.
- Stabilizes specific 14-3-3 protein-protein interactions
- Induces apoptosis in cancer cells
- Exhibits anticancer activity
- Activates plasma membrane H+-ATPase in plants
- Decreases proliferation and migration of human GBM cell lines in vitro
Medchemexpress LLC Palmitodiolein | 2190-30-9 | 99.8% | 859.39 | 25 MG
Palmitodiolein (Triglyceride POO) is a triacylglycerol found in vegetable oils. It is used in research and forms an N-nitroso compound after interacting with morpholine.
- Liquid appearance
- Colorless to light yellow
- Ships at room temperature in continental US
- Pure form storage: -20°C for 3 years
- In solvent storage: -80°C for 6 months, -20°C for 1 month
- Soluble in DMSO (100 mg/mL)
- Various in vivo dissolution protocols available
Medchemexpress LLC 5-Bromotetralone | 68449-30-9 | 225.08 | 10 G
5-Bromotetralone is a synthetic intermediate that is useful for pharmaceutical synthesis. This product is intended for research use only and has not been fully validated for medical applications.
- Useful for pharmaceutical synthesis
- Functions as a drug intermediate
Medchemexpress LLC Balovaptan | 1228088-30-9 | 99.9% | 409.91 | 1 ML
Balovaptan (RG7314) is an orally available, selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with Kᵢs of 1 and 39 nM for human (hV1a) and mouse (mV1a) receptors. It is used for the research of autism and shows >30000-fold selectivity for hV1a over hV2 receptors, and 9891-fold selectivity over hOTR (human oxytocin receptor).
- Orally available
- Selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist
- Used for the research of autism
- Appearance: Solid
- Color: White to off-white
- Shipping at room temperature in continental US; may vary elsewhere
- Storage as powder at -20°C for 3 years, 4°C for 2 years
- Storage in solvent at -80°C for 2 years, -20°C for 1 year
Medchemexpress LLC ASP4132 | 1640294-30-9 | 99.8% | 937.06 | 25 MG
ASP4132 is an orally active, potent AMPK activator with an EC50 of 18 nM. It exhibits anti-cancer activity and induces tumor regression in breast cancer xenograft mouse models.
- Orally active, potent AMPK activator.
- Has anti-cancer activity.
- Causes tumor regression in breast cancer xenograft mouse models.
- Shows comparable cell growth inhibitory (IC50=0.014 μM) activity against MDA-MB-453 breast cancer cells.
- Stable in human liver microsomes.