Pyridines and derivatives
3-Amino-2-pyridone 96.0+%, TCI America™
CAS: 33630-99-8 Molecular Formula: C5H6N2O Molecular Weight (g/mol): 110.12 MDL Number: MFCD03411556 InChI Key: VTSFNCCQCOEPKF-UHFFFAOYSA-N Synonym: 3-amino-2-hydroxypyridine,3-aminopyridin-2-ol,3-amino-2-pyridinol,3-aminopyridin-2 1h-one,2 1h-pyridinone, 3-amino,3-amino-2-pyridone,3-amino-pyridin-2-ol,2-pyridinol, 3-amino,2-hydroxy-3-aminopyridine,3-aminohydropyridin-2-one PubChem CID: 322353 IUPAC Name: 3-amino-1,2-dihydropyridin-2-one SMILES: NC1=CC=CNC1=O
Medchemexpress LLC Clinafloxacin (hydrochloride) | 105956-99-8
Clinafloxacin hydrochloride is a potent and broad-spectrum fluoroquinolone antibiotic. It demonstrates inhibitory activity against gram-positive and gram-negative bacteria, as well as anaerobic pathogens, in vitro.
- Potent and broad-spectrum fluoroquinolone antibiotic
- Inhibitory activity against gram-positive bacteria
- Inhibitory activity against gram-negative bacteria
- Inhibitory activity against anaerobic pathogens
- Targets DNA gyrase and topoisomerase IV of *S. aureus*
- Active in antibiotic and infection research
Apexbio Technology LLC EPZ-6438 1403254-99-8 20mg
EPZ-6438 is a selective inhibitor targeting EZH2 the catalytic subunit of polycomb repressive complex 2 (PRC2) By competitively binding to EZH2 s S-adenosylmethionine (SAM) pocket EPZ-6438 suppresses EZH2-driven trimethylation of histone H3 lysine 27 (H3K27me3) a key epigenetic modification implicated in transcriptional regulation and oncogenesis This selective inhibition of EZH2 exhibits reduced affinity for EZH1 In biological studies EPZ-6438 has demonstrated anti-tumor activity in preclinical malignant rhabdoid tumor models making it useful for examining EZH2-dependent cancer pathways and epigenetic research
Medchemexpress LLC Xevinapant | 1071992-99-8 | C32H43N5O4 | 25 MG
Xevinapant | 1071992-99-8 | C32H43N5O4 | 25 MG
Medchemexpress LLC DiI | 41085-99-8 | 99.98% | 100 MG
DiI is a long-chain carbocyanine dye. This lipophilic carbocyanine fluorescent dye exhibits red fluorescence and is suitable for cell membrane and nuclei labeling, long-term monitoring of cells, immunofluorescence staining of exosomes, and exosome uptake assays. It is for research use only.
- Used to label cells, organelles, liposomes, viruses, and lipoproteins.
- Ideal for staining cytoplasmic membranes of cells.
- Diffuses laterally within the plasma membrane, staining the entire cell.
- Exhibits distinct orange fluorescence, facilitating multicolor imaging and flow cytometric analysis of live cells.
- Can be used with standard TRITC filters.
- Exhibits very low cell toxicity.
- Widely used for determining lipoproteins such as LDL and HDL.
- Labeled motoneurons have remained viable for up to 4 weeks in culture and up to one year in vivo.
Medchemexpress LLC Xevinapant | 1071992-99-8 | C32H43N5O4 | 500 MG
Xevinapant is a potent and orally bioavailable Smac mimetic that acts as an antagonist of IAPs, binding to XIAP, cIAP1, and cIAP2 proteins.
- Potent Smac mimetic
- Orally bioavailable compound
- Antagonizes IAP proteins
- Binds to XIAP, cIAP1, and cIAP2
- Used as a laboratory chemical
- Suitable for manufacturing substances
Medchemexpress LLC Tazemetostat | 1403254-99-8 | 572.74 | 25 MG
Tazemetostat (EPZ-6438) is a potent, selective, and orally available EZH2 inhibitor. It inhibits human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 with a Ki value of 2.5 nM. It inhibits EZH2 with IC50s of 11 and 16 nM in peptide and nucleosome assays, respectively, and rat EZH2 with an IC50 of 4 nM. Tazemetostat also inhibits EZH1 with an IC50 of 392 nM. It induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells.
- Potent, selective, and orally available EZH2 inhibitor.
- Induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells.
Medchemexpress LLC DiI | 41085-99-8 | 99.98% | 5 MG
DiI is a long-chain carbocyanine dye frequently used to label cells, organelles, liposomes, viruses, and lipoproteins. This lipophilic fluorescent dye exhibits red fluorescence and is particularly effective for labeling cell membranes. Its very low cell toxicity makes it suitable for various biological applications, including the determination of lipoproteins such as LDL and HDL.
- Long-chain carbocyanine dye
- Labels cells, organelles, liposomes, viruses, and lipoproteins
- Lipophilic fluorescent dye
- Exhibits red fluorescence
- Can label cell membranes and liposomes
- Very low cell toxicity
- Used for determining lipoproteins
Medchemexpress LLC Tazemetostat | 1403254-99-8 | 572.74 | 1 G
Tazemetostat (EPZ-6438) is a potent, selective, and orally available EZH2 inhibitor. It inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 with a Ki value of 2.5 nM. It also inhibits EZH2 with IC50s of 11 nM in peptide assay and 16 nM in nucleosome assay. Tazemetostat induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells.
- Potent, selective, and orally available EZH2 inhibitor.
- Inhibits wild-type EZH2 with a Ki of 2.5 nM.
- Inhibits rat EZH2 with an IC50 of 4 nM.
- Induces apoptosis and differentiation in SMARCB1-deleted MRT cells.
Medchemexpress LLC Tazemetostat | 1403254-99-8 | 572.74 | 5 MG
Tazemetostat is a potent, selective, and orally available EZH2 inhibitor. It inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 with a Ki value of 2.5 nM. It also inhibits EZH2 with IC50s of 11 nM in peptide assay and 16 nM in nucleosome assay. Additionally, it inhibits rat EZH2 with an IC50 of 4 nM and EZH1 with an IC50 of 392 nM. It induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells.
- Targets histone methyltransferase and apoptosis
- Inhibits wild-type EZH2 activity with a Ki value of 2.5 nM
- IC50 values for EZH2: 11 nM (peptide assay) and 16 nM (nucleosome assay)
- IC50 for rat EZH2: 4 nM
- IC50 for EZH1: 392 nM
- Induces apoptosis and differentiation in SMARCB1-deleted MRT cells
Medchemexpress LLC Chromeazurol S | 1667-99-8 | 5 G
Mordant Blue 29, also known as Chromeazurol S, is an azo dye used as an indicator in analytical chemistry to detect metal ions like copper, nickel, and cobalt. It changes color from yellow to blue in the presence of metal ions. It can be applied to a test strip or added directly to a solution for analysis. It is also a biochemical reagent for life science related research.
- Biochemical reagent for life science research.
Medchemexpress LLC Istradefylline | 155270-99-8 | 99.9% | 384.43 | 25 MG
Istradefylline is a very potent, selective, and orally active adenosine A2A receptor antagonist, primarily investigated in experimental models of Parkinson's disease. It is intended for research use only.
- Very potent and selective adenosine A2A receptor antagonist.
- Orally active compound.
- Attenuates dopamine and DOPAC depletions in Parkinson's disease models.
- Reverses drug-induced catalepsy and hypokinesia.
- Increases locomotor activity and improves motor disability in MPTP-treated marmosets.
- Shows potentially additive effects with L-DOPA on locomotor activity without increasing dyskinesia.
Medchemexpress LLC Alimemazine hemitartrate | 4330-99-8 | 98.4% | 1 ML
Alimemazine hemitartrate is an orally active antagonist of the histamine (HA) receptor and a partial agonist at other GPCR receptors. It exhibits various properties including anti-serotonin, antispasmodic, antihistamine, sedative, hypnotic, antiviral, and anti-nausea effects. It also promotes pancreatic β-cell growth and inhibits SARS-CoV-2.
- Antagonist of histamine (HA) receptor.
- Partial agonist at other GPCR receptors.
- Exhibits anti-serotonin, antispasmodic, antihistamine, sedative, hypnotic, antiviral, and anti-nausea properties.
- Promotes pancreatic β-cell growth and improves diabetes in mice.
- Reduces the formation of syncytia induced by SARS-CoV-2 and its variants.
- Inhibits SARS-CoV-2 in HEK293T/ACE2 and VeroE6/TMPRSS2 cells.
Medchemexpress LLC AZ194 | 2241651-99-8 | 99.8% | C34H31F2N3O3 | 1 ML
AZ194 is a first-in-class, orally active inhibitor of CRMP2-Ubc9 interaction and an inhibitor of NaV1.7 with an IC50 of 1.2 μM. It works by blocking SUMOylation of CRMP2, which selectively reduces the amount of surface-expressed NaV1.7, exhibiting antinociceptive effects.
- First-in-class orally active inhibitor
- Inhibits CRMP2-Ubc9 interaction
- Inhibits NaV1.7 (IC50 = 1.2 μM)
- Blocks SUMOylation of CRMP2
- Selectively reduces surface-expressed NaV1.7
- Exhibits antinociceptive effects
- Provides pain relief in rat models of neuropathic pain
- Restores mechanical sensitivity
- Does not affect motor performance
- Synergizes with commonly used painkillers
Medchemexpress LLC Xevinapant | 1071992-99-8 | 99.9% | 561.71 | 50 MG
Xevinapant is a potent and orally bioavailable Smac mimetic and an antagonist of IAPs, binding to XIAP, cIAP1, and cIAP2 proteins. It has been shown to inhibit tumor growth and induce apoptosis in various cancer cell lines.
- Potent and orally bioavailable Smac mimetic
- Antagonist of IAPs, binding to XIAP, cIAP1, and cIAP2 proteins
- Induces rapid cellular cIAP1 degradation and pulls down cellular XIAP protein
- Effectively inhibits various human cancer cell lines
- Shows low toxicity against normal-like human breast epithelial cells
- Induces apoptosis by activating caspase-3 and cleaving PARP
- Effective in inhibiting tumor growth in xenograft models with minimal toxicity