Pyridines and derivatives
2-Chloro-3-hydroxypyridine 98.0+%, TCI America™
CAS: 6636-78-8 Molecular Formula: C5H4ClNO Molecular Weight (g/mol): 129.54 MDL Number: MFCD00006235 InChI Key: RSOPTYAZDFSMTN-UHFFFAOYSA-N Synonym: 2-chloro-3-hydroxypyridine,2-chloro-3-pyridinol,3-pyridinol, 2-chloro,unii-vy212q0s3j,2-chloro-3-hydroxy pyridine,2-chloro-3-hydroxypyridine 2-chloro-3-pyridinol,2-chlorpyridin-3-ol,pubchem2577,2-chloro-pyridin-3-ol,2-chloro-pyridine-3-ol PubChem CID: 81136 IUPAC Name: 2-chloropyridin-3-ol SMILES: OC1=CC=CN=C1Cl
1-Methyl-3,5-dinitro-2-pyridone 98.0+%, TCI America™
CAS: 14150-94-8 Molecular Formula: C6H5N3O5 Molecular Weight (g/mol): 199.12 MDL Number: MFCD00456280 InChI Key: QARVELJVEBLWGK-UHFFFAOYSA-N Synonym: 1-Methyl-3,5-dinitropyridin-2(1H)-one PubChem CID: 3621236 IUPAC Name: 1-methyl-3,5-dinitro-1,2-dihydropyridin-2-one SMILES: CN1C=C(C=C(C1=O)[N+]([O-])=O)[N+]([O-])=O
Apexbio Technology LLC Desonide 638-94-8 100mg
Desonide (CAS 638-94-8) is a nonfluorinated topical corticosteroid targeting intracellular corticosteroid (glucocorticoid) receptors It is designed to modulate inflammatory pathways thereby regulating cytokine expression inflammatory cell migration and dermal vascular tone Desonide exerts its biological activity primarily through receptor-mediated transcriptional changes that decrease the synthesis and release of pro-inflammatory mediators suppress inflammatory cell migration and induce vasoconstriction Based on these pharmacological properties Desonide holds research potential in experimental models of dermatological inflammation dermatitis and cutaneous immune responses especially in studies exploring corticosteroid-mediated signaling and dermal pharmacokinetics/dynamics
Apexbio Technology LLC Desonide 638-94-8 10mg
Desonide (CAS 638-94-8) is a nonfluorinated topical corticosteroid targeting intracellular corticosteroid (glucocorticoid) receptors It is designed to modulate inflammatory pathways thereby regulating cytokine expression inflammatory cell migration and dermal vascular tone Desonide exerts its biological activity primarily through receptor-mediated transcriptional changes that decrease the synthesis and release of pro-inflammatory mediators suppress inflammatory cell migration and induce vasoconstriction Based on these pharmacological properties Desonide holds research potential in experimental models of dermatological inflammation dermatitis and cutaneous immune responses especially in studies exploring corticosteroid-mediated signaling and dermal pharmacokinetics/dynamics
Apexbio Technology LLC BT2 34576-94-8 10mg
BT2 (CAS 34576-94-8) is a small-molecule inhibitor of branched-chain -ketoacid dehydrogenase kinase (BCKDK) By binding to BCKDK BT2 induces conformational changes in the N-terminal domain promoting dissociation from the branched-chain -ketoacid dehydrogenase complex (BCKDC) BT2 suppresses BCKDK activity with an IC50 of 3 19 M and demonstrates selective inhibition as indicated by an IC50 of 59 M in relevant assays This compound serves as a valuable tool for investigating BCKDK-regulated metabolic pathways and the role of BCKDK in branched-chain amino acid metabolism
Apexbio Technology LLC BT2 34576-94-8 50mg
BT2 (CAS 34576-94-8) is a small-molecule inhibitor of branched-chain -ketoacid dehydrogenase kinase (BCKDK) By binding to BCKDK BT2 induces conformational changes in the N-terminal domain promoting dissociation from the branched-chain -ketoacid dehydrogenase complex (BCKDC) BT2 suppresses BCKDK activity with an IC50 of 3 19 M and demonstrates selective inhibition as indicated by an IC50 of 59 M in relevant assays This compound serves as a valuable tool for investigating BCKDK-regulated metabolic pathways and the role of BCKDK in branched-chain amino acid metabolism
Apexbio Technology LLC Desonide 638-94-8 50mg
Desonide (CAS 638-94-8) is a nonfluorinated topical corticosteroid targeting intracellular corticosteroid (glucocorticoid) receptors It is designed to modulate inflammatory pathways thereby regulating cytokine expression inflammatory cell migration and dermal vascular tone Desonide exerts its biological activity primarily through receptor-mediated transcriptional changes that decrease the synthesis and release of pro-inflammatory mediators suppress inflammatory cell migration and induce vasoconstriction Based on these pharmacological properties Desonide holds research potential in experimental models of dermatological inflammation dermatitis and cutaneous immune responses especially in studies exploring corticosteroid-mediated signaling and dermal pharmacokinetics/dynamics
Apexbio Technology LLC DiSC3(5) 53213-94-8 100mg
DiSC3 5 (CAS 53213-94-8) is a fluorescent probe targeting mitochondrial membrane potential and mitochondrial NAD-dependent respiration It is designed to monitor transmembrane potential changes thereby assessing mitochondrial function DiSC3 5 exerts its biological activity primarily through specific interference with mitochondrial NAD-related respiratory pathways In cell-based studies DiSC3 5 demonstrates inhibitory activity with an IC50 value of 8 M in mitochondrial NAD-dependent respiratory systems In the presence of Na /K -ATPase inhibitor ouabain DiSC3 5 induces plasma membrane hyperpolarization in Ehrlich ascites tumor cells Based on these pharmacological properties DiSC3 5 holds research potential in mitochondrial membrane potential detection and cellular bioenergetics studies
Medchemexpress LLC BT2 500mg | 34576-94-8 | 500 MG
3,6-dichlorobenzo[b]thiophene-2-carboxylic acid (BT2, CAS 34576-94-8) is a research reagent used as an allosteric inhibitor of branched-chain α-ketoacid dehydrogenase kinase (BDK) to modulate branched-chain amino acid metabolism in biochemical studies. It is supplied as a solid powder for laboratory research.
- Allosteric BDK inhibitor for biochemical research.
- High purity, typically >98% (HPLC).
- Chemical formula C9H4Cl2O2S, molecular weight 247.10 g/mol.
- Supplied as a solid powder; store at 0-4 °C short-term or -20 °C long-term.
Medchemexpress LLC Pralsetinib | 2097132-94-8 | 533.60 | 1 ML
Pralsetinib is a highly potent and selective RET inhibitor that effectively targets wild-type RET and various RET mutants, including V804L, V804M, M918T, and CCDC6-RET fusion. It demonstrates significantly increased potency compared to approved MKIs against oncogenic RET variants and resistance mutants, and suppresses RET pathway signaling in a range of RET-driven cell lines.
- Highly potent and selective RET inhibitor
- Targets wild-type RET and specific RET mutants (V804L, V804M, M918T) and fusions (CCDC6-RET)
- Increased potency against oncogenic RET variants and resistance mutants
- Suppresses RET pathway signaling in various RET-driven cell lines
- Inhibits growth of NSCLC and thyroid cancer xenografts
- Does not inhibit vascular endothelial growth factor receptor 2 (VEGFR-2)
Medchemexpress LLC Pralsetinib | 2097132-94-8 | 533.60 | 25 MG
Pralsetinib (BLU-667) is a highly potent, selective RET inhibitor. It inhibits WT RET, RET mutants V804L, V804M, M918T and CCDC6-RET fusion with IC50s of 0.4, 0.3, 0.4, 0.4, and 0.4 nM, respectively. This compound demonstrates potent activity against common oncogenic RET alterations, including RET M918T and the CCDC6-RET fusion, suppressing RET pathway signaling in various cell lines.
- Highly potent and selective RET inhibitor.
- Inhibits various RET mutants and fusions with high efficacy.
- Effective against oncogenic RET alterations.
- Suppresses RET pathway signaling.
- Powder stable at -20°C for 3 years, 4°C for 2 years.
- In solvent stable at -80°C for 2 years, -20°C for 1 year.
Medchemexpress LLC Chlorindanol | 145-94-8 | 98.0% | 100 MG
Chlorindanol (7-Chloro-4-indanol) is a topical antiseptic or sanitizer. It is rapidly lethal in vitro to vegetative bacteria, Trichophyton sp., C. albicans, E. histolytica cysts and trophozoites, T. vaginalis, and spermatozoa. Chlorindanol has low systemic toxicity, good skin/eyes/genital mucosa tolerance, and is nonallergenic.
- Topical antiseptic or sanitizer
- Rapidly lethal to various microorganisms in vitro
- Low systemic toxicity
- Good skin, eyes, and genital mucosa tolerance
- Nonallergenic
Medchemexpress LLC Desonide | 638-94-8 | 99.2% | 500 MG
Desonide is a non-fluorinated corticosteroid anti-inflammatory agent that acts on the glucocorticoid receptor. It can also specifically bind to the mutant huntingtin protein (mHTT), reducing its level and toxicity. Desonide is used in the research of Huntington's disease and inflammatory diseases such as atopic dermatitis.
- Non-fluorinated corticosteroid anti-inflammatory agent
- Acts on the glucocorticoid receptor
- Binds to mutant huntingtin protein (mHTT)
- Reduces mHTT levels and toxicity
- Used in research for Huntington's disease
- Used in research for inflammatory conditions such as atopic dermatitis
Medchemexpress LLC Chlorindanol | 145-94-8 | 98.0% | 1 ML
Chlorindanol (7-Chloro-4-indanol) is a topical antiseptic or sanitizer. It is rapidly lethal to vegetative bacteria, Trichophyton sp., C. albicans, E. histolytica cysts and trophozoites, T. vaginalis, and spermatozoa in vitro. Chlorindanol is noted for its low systemic toxicity, good skin/eyes/genital mucosa tolerance, and nonallergenic properties. It is for research use only.
- Topical antiseptic or sanitizer
- Rapidly lethal to vegetative bacteria
- Effective against Trichophyton sp. and C. albicans
- Effective against E. histolytica cysts and trophozoites
- Effective against T. vaginalis and spermatozoa in vitro
- Low systemic toxicity
- Good skin, eyes, and genital mucosa tolerance
- Nonallergenic properties
- For research use only
Medchemexpress LLC Desonide | 638-94-8 | 99.2% | 100 MG
Desonide is a non-fluorinated corticosteroid anti-inflammatory agent that acts on the glucocorticoid receptor. It also specifically binds to the mutant huntingtin protein (mHTT), which helps in reducing the level and toxicity of mHTT. This agent is useful in the research of Huntington's disease and various inflammatory conditions like atopic dermatitis.
- Significantly inhibits mHTT-induced cytotoxicity.
- Reduces apoptotic signals.
- Improves cell survival in striatal cells of HD mice, neurons from HD patients, and Drosophila expressing mHTT.
- Rescues behavioral deficits in Huntington's disease mouse models.
- Lowers mHTT aggregates.
- Partially restores levels of HD molecular biomarkers.