Pyridines and derivatives
2-Methylquinoline 98.0+%, TCI America™
CAS: 91-63-4 Molecular Formula: C10H9N Molecular Weight (g/mol): 143.19 MDL Number: MFCD00006756 InChI Key: SMUQFGGVLNAIOZ-UHFFFAOYSA-N Synonym: quinaldine,chinaldine,khinaldin,quinoline, 2-methyl,2-methyl-quinoline,methylquinoline,2-methylchinolin,ccris 1155,2-methylchinoline,2-methylchinolin czech PubChem CID: 7060 IUPAC Name: 2-methylquinoline SMILES: CC1=CC=C2C=CC=CC2=N1
2-Chloro-4-fluoropyridine 98.0+%, TCI America™
CAS: 34941-91-8 Molecular Formula: C5H3ClFN Molecular Weight (g/mol): 131.534 MDL Number: MFCD04039345 InChI Key: FGSAQRJRWCZLOB-UHFFFAOYSA-N Synonym: pyridine, 2-chloro-4-fluoro,2-chloro-4-fluoro pyridine,2-chloro-4-fluoro-pyridine,pubchem6180,acmc-1aft7,2-chlro-4-fluoroxypyridine,ksc222e0n,pyrimidine, 4-chloro-6-fluoro,abbypharma ap-14-5731 PubChem CID: 2782792 IUPAC Name: 2-chloro-4-fluoropyridine SMILES: C1=CN=C(C=C1F)Cl
2,2'-Biquinoline 98.0+%, TCI America™
CAS: 119-91-5 Molecular Formula: C18H12N2 Molecular Weight (g/mol): 256.308 MDL Number: MFCD00006740 InChI Key: WPTCSQBWLUUYDV-UHFFFAOYSA-N Synonym: 2,2'-biquinoline,cuproin,cuproine,2,2'-diquinolyl,2,2'-biquinolyl,2,2'-quinolyl,2-2-quinolyl quinoline,2,2-biquinoline,2,2-diquinolyl,2,2;-biquinoline PubChem CID: 8412 IUPAC Name: 2-quinolin-2-ylquinoline SMILES: C1=CC=C2C(=C1)C=CC(=N2)C3=NC4=CC=CC=C4C=C3
Dimethyl 4-Hydroxy-2,6-pyridinedicarboxylate 98.0+%, TCI America™
CAS: 19872-91-4 Molecular Formula: C9H9NO5 Molecular Weight (g/mol): 211.173 MDL Number: MFCD00185834 InChI Key: FERASHUCDLDGHK-UHFFFAOYSA-N Synonym: 4-Hydroxy-2,6-pyridinedicarboxylic Acid Dimethyl Ester PubChem CID: 592568 IUPAC Name: dimethyl 4-oxo-1H-pyridine-2,6-dicarboxylate SMILES: COC(=O)C1=CC(=O)C=C(N1)C(=O)OC
Apexbio Technology LLC WWL 70 947669-91-2 10mg
WWL 70 (CAS 947669-91-2) is a small molecule inhibitor targeting / hydrolase domain-containing protein 6 (ABHD6) a serine hydrolase implicated in lipid metabolism Developed as an O-arylated derivative of carbamate 18 WWL 70 demonstrates approximately five-fold enhanced potency exhibiting an IC50 of 70 nM for ABHD6 inhibition Activity-based protein profiling and proteomic studies indicate that WWL 70 selectively inhibits ABHD6 over a panel of 27 serine hydrolases with minimal activity against ABHD10 at concentrations up to 100 M WWL 70 serves as a valuable chemical probe for elucidating ABHD6 function and investigating lipid signaling pathways in neurological research
Apexbio Technology LLC WWL 70 947669-91-2 50mg
WWL 70 (CAS 947669-91-2) is a small molecule inhibitor targeting / hydrolase domain-containing protein 6 (ABHD6) a serine hydrolase implicated in lipid metabolism Developed as an O-arylated derivative of carbamate 18 WWL 70 demonstrates approximately five-fold enhanced potency exhibiting an IC50 of 70 nM for ABHD6 inhibition Activity-based protein profiling and proteomic studies indicate that WWL 70 selectively inhibits ABHD6 over a panel of 27 serine hydrolases with minimal activity against ABHD10 at concentrations up to 100 M WWL 70 serves as a valuable chemical probe for elucidating ABHD6 function and investigating lipid signaling pathways in neurological research
Apexbio Technology LLC WWL 70 947669-91-2 5mg
WWL 70 (CAS 947669-91-2) is a small molecule inhibitor targeting / hydrolase domain-containing protein 6 (ABHD6) a serine hydrolase implicated in lipid metabolism Developed as an O-arylated derivative of carbamate 18 WWL 70 demonstrates approximately five-fold enhanced potency exhibiting an IC50 of 70 nM for ABHD6 inhibition Activity-based protein profiling and proteomic studies indicate that WWL 70 selectively inhibits ABHD6 over a panel of 27 serine hydrolases with minimal activity against ABHD10 at concentrations up to 100 M WWL 70 serves as a valuable chemical probe for elucidating ABHD6 function and investigating lipid signaling pathways in neurological research
Medchemexpress LLC Atrasentan | 173937-91-2 | C29H38N2O6 | 1 ML
Atrasentan is an endothelin receptor antagonist known for its potent activity against the ETA receptor, with an IC50 of 0.0551 nM. Also identified as ABT-627, it plays a role in the GPCR/G Protein pathway and has a molecular formula of C29H38N2O6 and a molecular weight of 510.62. This compound is utilized in research studying various biological activities.
- Significantly inhibits LNCaP and C4-2b prostate cancer cell growth
- Enhances down-regulation of NF-κB DNA binding activity when combined with Taxotere
- Induces several CYPs and drug transporters, such as CYP3A4
- Functions as a moderate P-gp inhibitor and a weak BCRP inhibitor
- Inhibits pressor response induced by big endothelin-1 in pithed rats
- Inhibits C4-2b tumor growth within the bone environment in the SCID-hu model
Medchemexpress LLC Kakkanin | 63770-91-2 | 578.52 | 1 MG
Kakkanin is a compound derived from the roots of O. henryi, commonly used in research, particularly for studies related to anti-inflammatory effects.
- Stable under recommended storage conditions
- Optimal storage at 4°C, sealed and away from moisture
- For storage in solvent, -80°C for up to 6 months or -20°C for 1 month is recommended
- Can be shipped at room temperature for durations less than 2 weeks
- Identified as a solid form
Medchemexpress LLC Ethoxyquin | 91-53-2 | 98.8% | 1 ML
Ethoxyquin is an antioxidant commonly used in animal feed and acts as an inhibitor of heat shock protein 90 (Hsp90). It has been shown to provide neuroprotection in studies, with optimal efficacy in the nanomolar range. Ethoxyquin does not interfere with Paclitaxel's ability to induce cell death in breast cancer cell lines.
- Antioxidant properties
- Hsp90 inhibitor
- Provides neuroprotection at specific concentrations
- Does not block Paclitaxel-induced cell death
Medchemexpress LLC Ethoxyquin | 91-53-2 | 98.8% | 5 G
Ethoxyquin is an antioxidant that has been utilized in animal feed for numerous years, and it also functions as an inhibitor of heat shock protein 90 (Hsp90).
- Antioxidant
- Inhibitor of heat shock protein 90 (Hsp90)
- Provides neuroprotection against chemotherapy-induced neurotoxicity via Hsp90 modulation
- Provides neuroprotection against cisplatin-induced neurotoxicity
- Exhibits dose-dependent neuroprotection
Medchemexpress LLC Atrasentan | 173937-91-2 | C29H38N2O6 | 5 MG
Atrasentan (ABT-627) is an endothelin receptor antagonist that targets ETA with an IC50 of 0.055 nM. It significantly inhibits LNCaP and C4-2b prostate cancer cell growth and also induces several CYPs and drug transporters. It is intended for research use only.
- Endothelin receptor antagonist
- Targets ETA receptor
- Inhibits LNCaP and C4-2b prostate cancer cell growth
- Down-regulates NF-κB DNA binding activity
- Induces CYPs and drug transporters
- Moderate P-gp inhibitor
- Weak BCRP inhibitor
- Inhibits pressor response induced by big endothelin-1 in pithed rats
- Inhibits C4-2b tumor growth within the bone environment
Medchemexpress LLC Atrasentan | 173937-91-2 | C29H38N2O6 | 25 MG
Atrasentan (ABT-627) is an endothelin receptor antagonist with an IC50 of 0.0551 nM for ETA. It significantly inhibits LNCaP and C4-2b prostate cancer cell growth in vitro and demonstrates anti-tumor effects in vivo. It also induces several CYPs and acts as a moderate P-gp inhibitor.
- Endothelin A receptor antagonist with an IC50 of 0.0551 nM for ETA
- Inhibits LNCaP and C4-2b prostate cancer cell growth
- Elicits greater loss of viable prostate cancer cells when combined with Taxotere
- Down-regulates NF-κB DNA binding activity
- Induces several CYPs and drug transporters (e.g., CYP3A4)
- Moderate P-gp inhibitor (IC50 = 15.1 ± 1.6 μM in P388/dx cells)
- Weak BCRP inhibitor (IC50 = 59.8 ± 11 μM in MDCKII-BCRP cells)
- Inhibits pressor response induced by big endothelin-1 in pithed rats
- Inhibits C4-2b tumor growth within the bone environment in the SCID-hu model
Medchemexpress LLC CCT241161 | 1163719-91-2 | 99.8% | 1 MG
CCT241161 is an orally active pan-RAF inhibitor with IC50s of 3, 6, 10, 15 and 30 nM for LCK, CRAF, SRC, V600E-BRAF and BRAF, respectively. It demonstrates good activity in BRAF and NRAS mutant melanomas and also exhibits anticancer cell proliferative activity.
- Orally active
- Pan-RAF inhibitor
- Shows activity in BRAF and NRAS mutant melanomas
- Exhibits anticancer cell proliferative activity