Pyrrolidines

Organic heterocyclic compounds that consist of a five-membered ring with four carbon atoms and one nitrogen atom that form a cyclic secondary amine.

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2,521 – 2,535 of 6,160 results

2,521

Selleck Chemical LLC Ombitasvir (ABT-267) S5403-5mg

Ombitasvir (ABT-267) is an inhibitor of the HCV non-structural protein 5A with antiviral activity

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2,522

Strem, An Ascensus Company CAS 1402851-52-8. 50mg. 1-[(4S)-4-tert-Butyl-45-dihydro-2-oxazolyl]isoquinoline 98%.

CAS 1402851-52-8. 50mg. 1-[(4S)-4-tert-Butyl-45-dihydro-2-oxazolyl]isoquinoline 98%. . Molecular Weight 254.3. Molecular Formula C16H18N2O. Color/form white-light yellow pwdr. Strem 07-1370. http//www.strem.com/catalog/v/07-1370/

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2,523

Medchemexpress LLC Milademetan | 1398568-47-2 | MFCD31692325 | 98.9% | 618.53 g/mol | C30H34Cl2FN5O4 | 1 MG

Milademetan is a potent, orally active small-molecule inhibitor of the MDM2-p53 interaction used in preclinical oncology research. It restores p53 activity and induces G1 cell-cycle arrest, senescence, and apoptosis in p53 wild-type cancer models.

Orally active MDM2-p53 inhibitor suitable for in vitro and in vivo research.
Applicable to acute myeloid leukemia and various solid tumor studies.
Induces G1 cell-cycle arrest, senescence, and apoptosis in p53 wild-type models.
High reported purity for research use (≈98.9%).
Well-characterized molecular properties (molecular weight 618.53 g/mol).

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2,524

Medchemexpress LLC (S,R,S)-AHPC-O-Ph-PEG1-NH2 | 2361117-24-8 | 97.0% | 50 MG

(S,R,S)-AHPC-O-Ph-PEG1-NH2 is an E3 ligase ligand-linker conjugate that incorporates a VHL ligand for the E3 ubiquitin ligase and a PROTAC linker. It is utilized in PROTAC EED degrader-1 (HY-130614), which is a PROTAC targeting EED with a pKD of 9.02.

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2,525

Medchemexpress LLC PMX 205 Trifluoroacetate | 99.5% | 953.06 | 50 MG

PMX 205 Trifluoroacetate | 99.5% | 953.06 | 50 MG

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2,526

Medchemexpress LLC PROTAC MDM2 Degrader-2 | 2249944-99-6 | 95.0% | 10 MG

PROTAC MDM2 Degrader-2 is an MDM2 PROTAC degrader that induces the self-ubiquitination and degradation of MDM2, leading to the upregulation of p53 protein. It exhibits anti-tumor activity and is used in cancer research.

Induces self-ubiquitination and degradation of MDM2
Upregulates p53 protein
Exhibits anti-tumor activity
Used in cancer research
Inhibits MDM2 protein in A549 cells
Increases p53 in A549 cells

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2,527

Medchemexpress LLC BAY-298 | 2471978-97-7 | 100.0% | 100 MG

BAY-298 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist. It has IC50s of 96 nM for human LH (hLH), 23 nM for rat LH (rLH), and 78 nM for cynomolgus monkey LH (cLH). This compound is capable of reducing sex hormone levels and is intended for research use only.

Orally active and selective luteinizing hormone receptor (LH-R) antagonist
Capable of reducing sex hormone levels
IC50 of 96 nM for human LH, 23 nM for rat LH, and 78 nM for cynomolgus monkey LH
Solid appearance
Off-white to light yellow color

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2,528

Medchemexpress LLC Protac IDO1 degrader-1 | 2488851-89-2 | 99.0% | 966.80 g·mol⁻¹ | C40H53BrFN9O13 | 5 MG

PROTAC IDO1 Degrader-1 is a research-grade proteolysis targeting chimera (PROTAC) that selectively induces degradation of indoleamine 2,3-dioxygenase 1 (IDO1) by recruiting cereblon E3 ligase, leading to ubiquitination and proteasomal degradation. Cellular studies demonstrate dose-dependent IDO1 degradation and functional enhancement of tumor-killing activity in CAR-T assays.

Induces selective IDO1 degradation in cells (DC50 = 2.84 μM).
Displays IDO1 inhibitory potency (IC50 = 1.07 μM).
Produces up to 93% maximum degradation in HeLa cells.
Soluble in DMSO at 100 mg/mL; in vivo co-solvent formulations reported with ≥2.5 mg/mL solubility.
Store sealed at -20°C; in solution: -80°C up to 6 months, -20°C up to 1 month.
For research use in cellular and in vivo studies.

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2,529

New England Biolabs, Inc. NEBridge Ligase MM - 250 rxn

NEBridge Ligase Master Mix is a 3X master mix for Golden Gate Assembly. Designed for use with NEB Type IIS restriction enzymes, this master mix contains T4 DNA Ligase in an optimized reaction buffer with a proprietary ligation enhancer. Users need only choose their preferred NEB Type IIS restriction enzyme and add DNA substrates to be assembled. Low complexity single fragment insertions, as well as moderate complexity (3-6 fragment) and high complexity (7-25 fragment) assemblies, are all supported with this optimized reagent and accompanying protocols.

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2,530

Medchemexpress LLC 12-azido-dodecanoyl-OSu | 2489524-00-5 | ≥97.0% | 338.40 g/mol | C16H26N4O4 | 10 MG

12-Azido-dodecanoyl-OSu is an azide-functionalized N-hydroxysuccinimide (OSu) ester used as a hydrophobic linker for bioconjugation and click-chemistry applications. The reagent introduces a 12-carbon azidododecanoyl group that facilitates azide-alkyne cycloaddition and enables efficient conjugation to primary amines via NHS-ester chemistry. Supplied as a solid with high purity for labeling and linker synthesis.

Azide-functionalized OSu ester for click chemistry.
Reactive toward primary amines for amide bond formation.
Hydrophobic 12-carbon spacer useful for membrane-targeting conjugates.
Purity ≥97.0%.
Molecular weight 338.40 g/mol; formula C16H26N4O4.
Available in small research sizes, including 10 mg.
Store sealed, away from moisture; solid at 4°C; in solution store at -80°C (6 months) or -20°C (1 month).

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2,531

Medchemexpress LLC (tert-butoxycarbonyl)-L-valyl-L-valine | 69209-73-0 | 97.0% | 316.39 | C15H28N2O5 | 100 G

(tert-Butoxycarbonyl)-L-valyl-L-valine is a Boc-protected dipeptide derivative of L-valine used as an intermediate in peptide synthesis and organic chemistry. It is supplied as a white to off-white solid for research use.

Purity 97.0%.
Molecular weight 316.39 g/mol.
Chemical formula C15H28N2O5.
Appearance white to off-white solid.
Storage: powder -20°C for 3 years, 4°C for 2 years; in solvent -80°C for 6 months, -20°C for 1 month.
Available in laboratory quantities including 100 G.

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2,532

Medchemexpress LLC (Rac)-apremilast | 253168-86-4 | 99.5% | 460.50 g·mol⁻¹ | C22H24N2O7S | 10 MG

Racemic apremilast is the racemate of apremilast, a small-molecule phosphodiesterase 4 (PDE4) inhibitor used for anti-inflammatory research. Supplied as a pre-weighed 10 mg solid, this research-grade reagent is suitable for biochemical assays, analytical reference standards, and method development.

Racemic mixture of apremilast for research applications.
PDE4 inhibitor used to study inflammatory signaling pathways.
High purity (reported ~99.5%).
Molecular weight: 460.50 g·mol⁻¹.
CAS number: 253168-86-4.
Supplied as a 10 mg pre-weighed sample for analytical use.

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2,533

eMolecules 1009075-44-8 | Tert-Butyl ((1R,3R)-3-Aminocyclopentyl)Carbamate | AA Blocks LLC200.282 | C10H20N2O2 | 0.000 | CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](N)C1 | 10g | 410143416

Tert-Butyl ((1R,3R)-3-Aminocyclopentyl)Carbamate | AA Blocks LLC | 1009075-44-8200.282 | C10H20N2O2 | 0.000 | CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](N)C1 | 10g | 410143416

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2,534

eMolecules 625471-18-3 | tert-butyl (3S)-3-aminopiperidine-1-carboxylate | Pharmablock | MFCD03094718 | 200.282 | C10H20N2O2 | 97.000 | CC(C)(C)OC(=O)N1CCC[C@H](N)C1 | 250mg | 551316934

tert-butyl (3S)-3-aminopiperidine-1-carboxylate | Pharmablock | 625471-18-3 | MFCD03094718 | 200.282 | C10H20N2O2 | 97.000 | CC(C)(C)OC(=O)N1CCC[C@H](N)C1 | 250mg | 551316934

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2,535

Medchemexpress LLC N-5-benzothiazolyl-6-[(1-methylethyl)sulfonyl]-4-quinolinamine | 1346546-69-7 | MFCD30481302 | 99.9% | 383.49 g/mol | C19H17N3O2S2 | 1 MG

A potent, selective small-molecule inhibitor of receptor-interacting protein kinase 3 (RIPK3) for research use to block necroptosis and study RIPK3-dependent signaling. The compound has molecular weight 383.49 g/mol, chemical formula C19H17N3O2S2, CAS 1346546-69-7, and is supplied at high purity, making it suitable for biochemical and cell-based assays.

Selective RIPK3 kinase inhibitor with low-nanomolar potency.
Potent biochemical inhibition (IC50 ≈ 1.8 nM).
High purity (99.9%) suitable for sensitive assays.
Available in small research quantities, including 1 mg units.
Stable under recommended storage conditions for powder and solutions.

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Pyrrolidines

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Medchemexpress LLC Milademetan | 1398568-47-2 | MFCD31692325 | 98.9% | 618.53 g/mol | C30H34Cl2FN5O4 | 1 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC (S,R,S)-AHPC-O-Ph-PEG1-NH2 | 2361117-24-8 | 97.0% | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC PMX 205 Trifluoroacetate | 99.5% | 953.06 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC PROTAC MDM2 Degrader-2 | 2249944-99-6 | 95.0% | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC BAY-298 | 2471978-97-7 | 100.0% | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Protac IDO1 degrader-1 | 2488851-89-2 | 99.0% | 966.80 g·mol⁻¹ | C40H53BrFN9O13 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

New England Biolabs, Inc. NEBridge Ligase MM - 250 rxn Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 12-azido-dodecanoyl-OSu | 2489524-00-5 | ≥97.0% | 338.40 g/mol | C16H26N4O4 | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC (tert-butoxycarbonyl)-L-valyl-L-valine | 69209-73-0 | 97.0% | 316.39 | C15H28N2O5 | 100 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC (Rac)-apremilast | 253168-86-4 | 99.5% | 460.50 g·mol⁻¹ | C22H24N2O7S | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC N-5-benzothiazolyl-6-[(1-methylethyl)sulfonyl]-4-quinolinamine | 1346546-69-7 | MFCD30481302 | 99.9% | 383.49 g/mol | C19H17N3O2S2 | 1 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More