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Filtered Search Results
Medchemexpress LLC HPV16 E7 (86-93) (TFA) | 98.0% | 929.06 | 10 MG
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HPV16 E7 (86-93) TFA is a human leukocyte antigen (HLA)-A2.1 restricted HPV16 E7-derived peptide, immunogenic in cervical carcinomas. It is for research use only. Precursor T cells specific for the peptide are able to differentiate into HPV-specific effector cells. Peptide-loaded autologous dendritic cells can stimulate a specific cytotoxic CD8+ T-cell response.
- Specific T cells are expandable upon in vitro stimulation with peptide-pulsed dendritic cells.
- Response against K562 cells pulsed with the peptide was significantly blocked by anti-HLA class I Ab w6/32.
- Peptide in IVS culture shows specific T cell expansion.
- The peptide can induce cytotoxic T lymphocyte (CTL) responses if loaded on antigen presenting HLA class I molecules.
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Medchemexpress LLC Pravastatin sodium | 81131-70-6 | 99.4% | 200 MG
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Pravastatin sodium is an HMG-CoA reductase inhibitor that acts against sterol synthesis, with an IC50 of 5.6 μM. It belongs to the statin drug class and is utilized alongside diet, exercise, and weight-loss strategies to lower cholesterol and help prevent cardiovascular disease.
- Functions as an HMG-CoA reductase inhibitor.
- Targets sterol synthesis.
- Exhibits an IC50 of 5.6 μM for HMG-CoA reductase.
- Demonstrates inhibitory activity against cellular steroidogenesis in HepG2 cells with an IC50 of 1.37 μM.
- Inhibits cholesterol synthesis from [14C]-Acetate in isolated rat hepatocytes with an IC50 of 0.1 μM.
- Aids in lowering cholesterol.
- Contributes to the prevention of cardiovascular disease.
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Medchemexpress LLC Imiquimod (hydrochloride) | 99011-78-6 | 10 MM 1 ML
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Imiquimod hydrochloride, also known as R 837 hydrochloride, is an immune response modifier and a selective toll-like receptor 7 (TLR7) agonist. This compound exhibits antiviral and antitumor effects in vivo, making it valuable for various research applications.
- Used for research of external genital, perianal warts, cancer, and COVID-19
- Can induce psoriasis models
- Exhibits antiviral effects in vivo
- Exhibits antitumor effects in vivo
- Acts as a selective toll-like receptor 7 (TLR7) agonist
- Functions as an immune response modifier
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Medchemexpress LLC Pazufloxacin (mesylate) | 163680-77-1 | 100.0% | 1 ML
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Pazufloxacin mesylate is an orally active fluoroquinolone antimicrobial agent. It inhibits DNA gyrase with IC50 values of 0.88 μg/mL (E. coli) and 1.9 μg/mL (P. aeruginosa). This agent exhibits broad-spectrum antimicrobial activity with MIC90 values ranging from 0.025 to 100 μg/mL against Gram-positive and Gram-negative bacteria, non-fermenting bacteria, Legionella spp., and anaerobic bacteria. It is indicated for research on systemic infections, lung infections, urinary tract infections, and Legionella pneumonia.
- Orally active fluoroquinolone antimicrobial agent
- Inhibits DNA gyrase
- Exhibits broad-spectrum antimicrobial activity against a variety of bacteria, including gram-positive, gram-negative, non-fermenting, Legionella spp., and anaerobic bacteria
- Indicated for research on systemic infections, lung infections, urinary tract infections, and Legionella pneumonia
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Medchemexpress LLC Orlistat | 96829-58-2 | 99.97% | 200 MG
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Orlistat (Tetrahydrolipstatin) is an irreversible inhibitor of pancreatic and gastric lipases, and fatty acid synthase (FASN). It is used orally for long-term research of obesity and exhibits an anti-atherosclerotic effect.
- Inhibits pancreatic and gastric lipases
- Inhibits fatty acid synthase (FASN)
- Used for long-term research of obesity
- Demonstrates anti-atherosclerotic effects
- Suitable for in vitro and in vivo studies
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Medchemexpress LLC Angeloylgomisin Q | 72561-28-5 | 1 MG
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Angeloylgomisin Q is a new dibenzocyclooctadiene lignan isolated from the stems of *Schisandra sphaerandra*. It has potential for Alzheimer's disease research.
- New dibenzocyclooctadiene lignan
- Isolated from *Schisandra sphaerandra* stems
- Potential for Alzheimer's disease research
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Medchemexpress LLC 31-Norlanostenol | 16910-39-7 | 5 MG
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31-Norlanostenol is a triterpenic compound isolated from the latex of *Euphorbia officinarum*. It can act as an efficient insect growth regulator on *S. frugiperda* and *Tenebrio molitor*.
- Triterpenic compound
- Isolated from the latex of *Euphorbia officinarum*
- Acts as an efficient insect growth regulator on *S. frugiperda* and *Tenebrio molitor*
- White to off-white solid
- Molecular weight: 414.71
- Formula: C29H50O
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Medchemexpress LLC Domperidone (R33812) | 57808-66-9 | 99.9% | 200 MG
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Domperidone is an orally active and selective dopamine-2 receptor antagonist. It acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine. Unlike Metoclopramide, Domperidone does not cause adverse neurological symptoms due to minimal penetration through the blood-brain barrier, and it is rapidly absorbed after oral administration with few reported side effects.
- Orally active and selective dopamine-2 receptor antagonist.
- Acts as an antiemetic and a prokinetic agent.
- Minimal penetration through the blood-brain barrier.
- Rapidly absorbed after oral administration.
- Few reported side effects.
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Medchemexpress LLC Etravirine | 269055-15-4 | MFCD09837879 | 99.1% | C20H15BrN6O | 200 MG
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Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and a potent antiviral drug primarily used in the treatment of human immunodeficiency virus (HIV) type 1 infection. It is effective against various strains of HIV-1, including those resistant to other NNRTI treatments. This product is intended for research use only.
- Targets HIV-1 and HIV-2
- Inhibits non-nucleoside reverse transcriptase
- Effective against resistant HIV-1 strains
- Suitable for research applications
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Medchemexpress LLC Cilazapril monohydrate | 92077-78-6 | 99.9% | C22H33N3O6 | 50 MG
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Cilazapril monohydrate is an orally active prodrug of an angiotensin-converting enzyme (ACE) inhibitor. It functions by reducing plasma ACE activity and is utilized in research concerning hypertension, including essential and renal hypertension, and congestive heart failure.
- Used in research of hypertension (including essential and renal hypertension) and congestive heart failure.
- Evokes maximum degree of plasma ACE inhibition in rats.
- Dose-dependently reduces plasma ACE activity and pressor response to angiotensin in cats.
- Gradually reduces blood pressure in dogs with volume-depleted renal hypertension.
- Decreases blood pressure, reduces heart weight to body weight ratio, and improves postischemic myocardial function in hyperthyroid rats.
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Medchemexpress LLC 2-Hydroxyquinoline | 59-31-4 | 145.16 | 10 G
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2-Hydroxyquinoline is an inhibitor of α-glucosidase and α-amylase with IC50 values of 64.4 μg/mL and 130.5 μg/mL, respectively. It can be used in the study of diabetes. This product is for research use only and has not been fully validated for medical applications.
- Inhibitor of α-glucosidase and α-amylase
- Suitable for diabetes studies
- High purity product
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Medchemexpress LLC Sugammadex sodium | 343306-79-6 | 98.0% | C72H104Na8O48S8 | 200 MG
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Sugammadex sodium is a synthetic γ-cyclodextrin derivative that acts as a reversal agent for neuromuscular block. It also shows a nephroprotective effect in ischemia-reperfusion injury.
- Acts as a reversal agent for neuromuscular block.
- Exhibits nephroprotective effects in ischemia-reperfusion injury.
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Medchemexpress LLC Verteporfin | 129497-78-5 | 98.2% | 200 MG
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Verteporfin (CL 318952) is a photosensitizer used in photodynamic therapy to eliminate abnormal blood vessels in the eye, especially those associated with age-related macular degeneration. It functions as a YAP inhibitor by disrupting YAP-TEAD interactions, inducing cell apoptosis. This compound also acts as an autophagy inhibitor, blocking autophagosome formation at an early stage.
- Acts as a YAP inhibitor, disrupting YAP-TEAD interactions.
- Induces cell apoptosis.
- Inhibits autophagy by blocking autophagosome formation at an early stage.
- Utilized as a photosensitizer for photodynamic therapy.
- Shows light-independent anti-leukemic activity.
- Reduces mitochondrial membrane potential in PDX cells.
- Reverses certain drug resistances by inhibiting YAP expression.
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Medchemexpress LLC Vidarabine monohydrate | 24356-66-9 | MFCD00150980 | 1 ML
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Vidarabine monohydrate is an adenine arabinoside and a potent antiviral agent. It effectively targets herpes simplex viruses (HSV) and varicella zoster viruses.
- Adenine arabinoside
- Antiviral agent
- Active against herpes simplex viruses (HSV)
- Active against varicella zoster viruses
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Medchemexpress LLC Difloxacin hydrochloride | 91296-86-5 | 100 MG
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Difloxacin hydrochloride is a broad-spectrum antibacterial agent. It inhibits bacterial DNA gyrase and exhibits a concentration-dependent bactericidal effect by interfering with the activity of DNA gyrase and topoisomerase IV.
- Inhibits bacterial DNA gyrase
- Exhibits a concentration-dependent bactericidal effect
- Interferes with DNA gyrase and topoisomerase IV activity
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