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Filtered Search Results
Medchemexpress LLC Revumenib | 2169919-21-3 | 99.99% | 630.82 | 200 MG
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Revumenib (SNDX-5613) is a potent and specific Menin-MLL inhibitor with a binding Ki of 0.149 nM and a cell-based IC50 of 10-20 nM. It is intended for the research of MLL-rearranged (MLL-r) acute leukemias, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). For research use only; not for sale to patients.
- Potent and specific Menin-MLL inhibitor.
- Applicable for research in MLL-rearranged acute leukemias (ALL and AML).
- Shows in vivo plasma IC50 of 53 nM.
- Provides significant survival benefit and leukemic control in aggressive MOLM-13 disseminated xenografts in vivo.
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Ambeed Dimethyl cyclohexane1 3dicarbo
Dimethyl cyclohexane-1,3-dicarboxylate, 62638-06-6, 95%
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Medchemexpress LLC Trifluoperazine dihydrochloride | 440-17-5 | 99.9% | 50 MG
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Trifluoperazine dihydrochloride is an antipsychotic agent that functions by blocking central dopamine receptors. It also acts as a potent α1-adrenergic receptor antagonist and a NUPR1 inhibitor, demonstrating anticancer activity. Furthermore, it is a calmodulin inhibitor and inhibits P-glycoprotein. This compound is utilized in research for schizophrenia and acts as a reversible inhibitor of influenza virus morphogenesis by interfering with cellular CaM and/or CaM-dependent functions.
- Blocks central dopamine receptors
- Potent α1-adrenergic receptor antagonist
- Potent NUPR1 inhibitor with anticancer activity
- Calmodulin inhibitor
- Inhibits P-glycoprotein
- Utilized in research for schizophrenia
- Acts as a reversible inhibitor of influenza virus morphogenesis
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Medchemexpress LLC Danofloxacin mesylate | 119478-55-6 | 99.9% | 1 ML
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Danofloxacin mesylate is a potent fluoroquinolone antibiotic primarily utilized as a veterinary drug. It exhibits broad-spectrum bactericidal activity by targeting bacterial DNA gyrase, an essential enzyme for bacterial replication. Furthermore, this compound functions as a substrate for ATP-dependent efflux transporters, including P-glycoprotein (P-gp) and Multidrug Resistance-associated Protein 2 (MRP2), which are involved in drug transport mechanisms within cells.
- Fluoroquinolone antibiotic for veterinary use
- Possesses broad-spectrum bactericidal activity
- Inhibits bacterial DNA gyrase
- Acts as a substrate for ATP-dependent efflux transporters
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Medchemexpress LLC Sulfo-Cy5.5 azide | 1955527-41-9 | MFCD28334525 | ≥95.0% | 999.16 | C44H50N6O13S4 | 10 MG
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Sulfo-Cy5.5 Azide is a water-soluble, far-red fluorescent click-chemistry reagent containing an azide functional group for covalent labeling of peptides, proteins, and oligonucleotides. It is suitable for imaging applications and reacts via copper-catalyzed azide-alkyne cycloaddition (CuAAC) or strain-promoted alkyne-azide cycloaddition (SPAAC); excitation is ~673 nm with emission ~707 nm.
- Water-soluble fluorescent dye suitable for aqueous labeling reactions.
- Azide functional group enables CuAAC and SPAAC click chemistries.
- Far-red emission for reduced background and deep-tissue imaging.
- High purity (≥95.0%) for reliable labeling results.
- Soluble in DMSO at 50 mg/mL with gentle warming and sonication.
- Store protected from light; in solvent store at -80°C for long term.
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Medchemexpress LLC Propidium (iodide) | 25535-16-4 | 99.7% | 5 MG
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Propidium Iodide (PI) is a nuclear staining agent that stains DNA. It is an analogue of ethidine bromide, emitting red fluorescence when embedded in double-stranded DNA. PI cannot pass through living cell membranes but can pass through damaged cell membranes to stain the nucleus. It is commonly used in detecting apoptosis or necrosis and in flow cytometry analysis.
- Stains DNA
- Emits red fluorescence when embedded in double-stranded DNA
- Used in detection of apoptosis or necrosis
- Commonly used in flow cytometry analysis
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TARGETMOL CHEMICALS INC SCIADOPITYSIN 10MG
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Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Sciadopitysin may prevent the development of diabetic osteopathy it exerts its therapeutic effects via upregulation of mitochondrial biogenesis.Sciadopitysin shows protective effects on antimycin A-induced toxicity in osteoblastic MC3T3-E1 cells it may reduce or prevent osteoblasts degeneration.Sciadopitysin can inhibit the A(beta) aggregation and reduce A(beta)-induced toxicity in the primary cortical neurons. purity: 99%
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Medchemexpress LLC Sulfo DBCO-amine | 2028284-70-8 | 99.00% | 10 MG
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Sulfo DBCO-amine is an alkyl chain-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, possessing a DBCO group capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. PROTACs operate by exploiting the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Alkyl chain-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains a DBCO group
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) with azide groups
- Utilizes intracellular ubiquitin-proteasome system to degrade target proteins
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Medchemexpress LLC m-PEG6-Amine | 184357-46-8 | ≥97.0% | 25 G
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m-PEG6-Amine is a PEG-based PROTAC linker primarily used in the synthesis of PROTACs. It also functions as a cleavable ADC linker for the creation of antibody-drug conjugates (ADCs). PROTACs are designed to exploit the intracellular ubiquitin-proteasome system, selectively degrading target proteins by connecting an E3 ubiquitin ligase ligand to a target protein ligand via a linker. ADCs, on the other hand, consist of an antibody attached to a cytotoxin through an ADC linker.
- Functions as a PEG-based PROTAC linker
- Acts as a cleavable ADC linker
- Used in the synthesis of PROTACs
- Applied in the synthesis of antibody-drug conjugates (ADCs)
- Enables selective protein degradation via the ubiquitin-proteasome system (for PROTACs)
- Targets cleavable linkers and PEGs (in vitro)
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Apexbio Technology LLC APEXBIO TECHNOLOGY LLC
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5000569650 S-INDOXIMOD-200MG
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![Medchemexpress LLC Trimethyl[2,3-(dioleyloxy)propyl]ammonium chloride | 104162-48-3 | MFCD00145456 | 98.0% | 670.57 g/mol | C42H84ClNO2 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000282662.png-250.jpg)
Medchemexpress LLC Trimethyl[2,3-(dioleyloxy)propyl]ammonium chloride | 104162-48-3 | MFCD00145456 | 98.0% | 670.57 g/mol | C42H84ClNO2 | 50 MG
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Trimethyl[2,3-(dioleyloxy)propyl]ammonium chloride is a quaternary ammonium, lipid-like reagent used in life-science research. It acts as an amphiphilic cationic lipid for formulation and membrane studies, and can be used as a surfactant or helper lipid in experimental delivery systems. The material is supplied with product documentation and handling information and is intended for research use only.
- Quaternary ammonium headgroup provides cationic charge.
- Two dioleoyl chains confer lipid-like amphiphilicity.
- Amphiphilic character supports bilayer and vesicle formulation.
- Soluble in common organic solvents for formulation workflows.
- Provided with documentation and safety data for lab use.
- Store sealed and away from moisture; refrigerate for prolonged stability.
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Medchemexpress LLC m-PEG9-Amine | 211859-73-3 | >97.0% | 5 G
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m-PEG9-Amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs, and also functions as a cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs). It facilitates the construction of compounds that either selectively degrade target proteins via the ubiquitin-proteasome system or enable targeted delivery of cytotoxic drugs.
- Functions as a PEG-based PROTAC linker
- Suitable for the synthesis of PROTACs
- Acts as a cleavable ADC linker
- Used in the synthesis of antibody-drug conjugates (ADCs)
- Supports targeted protein degradation via the ubiquitin-proteasome system
- Enables targeted delivery of cytotoxic drugs
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Medchemexpress LLC Sulfo DBCO-amine | 2028284-70-8 | 99.0% | 50 MG
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Sulfo DBCO-amine is an alkyl chain-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, incorporating a DBCO group capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing azide groups. This product is intended for research use only.
- Designed for use in the synthesis of PROTACs.
- Contains a DBCO group for SPAAC reactions with azide-containing molecules.
- Classified as an alkyl chain-based linker.
- Intended for research use only.
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TARGETMOL CHEMICALS INC MECAMYLAMINE HYDROCHLORI 25MG
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Also available in 5 mg 10 mg 50 mg 100 mg 200 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Mecamylamine hydrochloride (Mevasin) is a nicotinic antagonist used as a ganglionic blocker in hypertension. purity: 99%
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TARGETMOL CHEMICALS INC AP 18 5MG
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Also available in 1mg 2mg 10mg 25mg 50mg 100mg 500mg and bulk. Please contact Fisher for quotes. AP-18 is a potent and selective TRPA1 inhibitor. AP-18 inhibits activation of TRPA1 induced by 50 μM Cinnamaldehyde with an IC50 of 3.1 μM and 4.5 μM for human and mouse TRPA1 respectively. AP-18 could reverse complete Freund's adjuvant (CFA)-induced mechanical hyperalgesia in mice. AP-18 could attenuate Yo-Pro uptake induced by 30 μM AITC in a concentration-dependent manner (IC50= 10.3 μM). purity: 99%
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