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Filtered Search Results
TARGETMOL CHEMICALS INC Mitoxantrone 200MG
Also available in 1 mL, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Mitoxantrone (mitozantrone) is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisomerase II, resulting in DNA strand breaks and inhibition of DNA repair. Mitoxantrone is less cardiotoxic compared to doxorubicin. Purity 98.74%
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TARGETMOL CHEMICALS INC MQAE 200MG
Also available in 1 mL, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. MQAE, a fluorescent chloride ion indicator, is more sensitive and selective than 36Cl and microelectrode-based methods for chloride measurement in cells. MQAE is quenched via collision with chloride.
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TARGETMOL CHEMICALS INC SRS16-86 10MG
Also available in 1 mL, 1 mg, 2 mg, 5 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. SRS16-86 is a novel third-generation ferrostatin, is an inhibitor offerroptosis. Purity 99.85%
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TARGETMOL CHEMICALS INC Bosutinib 200MG
Also available in 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Bosutinib (SKI-606) is a synthetic quinolone derivative and dual kinase inhibitor that targets both Abl (IC50 1 nM) and Src (IC50 1.2 nM) kinases. Purity 99.84%
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TARGETMOL CHEMICALS INC Matrine 200MG
Also available in 1 mL, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist. Purity 97.16%
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Ambeed Ferrocenemethanol
Ferrocenemethanol, 1273-86-5, 98%
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Medchemexpress LLC Tetrabenazine | 200MG
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Tetrabenazine | 200MG
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Apexbio Technology LLC LY2940680 1258861-20-9 200mg
LY2940680 (CAS 1258861-20-9) is a selective antagonist of the Smoothened (Smo) receptor a seven-transmembrane G protein-coupled receptor involved in regulating Hedgehog (Hh) signalling LY2940680 binds primarily to the extracellular loops of Smo distinguishing it from previously described inhibitors such as SANT-1 which bind to the transmembrane domain By blocking Smo function LY2940680 suppresses downstream Hh pathway activation resulting in reduced cell proliferation observed in cell lines with Smo mutations or resistance to vismodegib Investigations of LY2940680 in basal cell carcinoma and medulloblastoma highlight its potential utility as a single-agent therapeutic targeting cancer stem cell populations
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Apexbio Technology LLC AS 602801 848344-36-5 200mg
AS 602801 (CAS 848344-36-5) is a selective small-molecule inhibitor targeting c-Jun N-terminal kinase (JNK) a kinase implicated in immune and apoptotic signaling pathways Preclinical studies indicate that AS 602801 suppresses T-cell proliferation and promotes apoptosis altering gene expression in RRMS-derived CD4 and CD8 T-cells and innate receptor expression in RRMS-associated CD11b cells Animal models show beneficial effects in autoimmune disorders and neuronal apoptosis scenarios Thus AS 602801 is investigated primarily for therapeutic potential in multiple sclerosis and fibrotic conditions
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Apexbio Technology LLC Trospium chloride 10405-02-4 200mg
Trospium chloride (CAS 10405-02-4) is a quaternary ammonium compound that functions as a competitive antagonist at muscarinic acetylcholine receptors thereby inhibiting cholinergic stimulation of the bladder detrusor muscle This action reduces involuntary bladder contractions leading to decreased urinary urgency frequency and urge incontinence Trospium chloride displays pharmacological properties distinct from tertiary amine antimuscarinics including limited central nervous system penetration It is widely utilized in preclinical and clinical research focused on urinary disorders and muscarinic receptor pharmacology
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Medchemexpress LLC Tavaborole | 174671-46-6 | 99.7% | 151.93 | 1 ML
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Tavaborole is an antifungal agent primarily active against Trichophyton species, developed as a topical solution for the treatment of onychomycosis. It is intended strictly for research purposes and not sold to patients.
- Antifungal agent with activity against Trichophyton species.
- Used in a topical solution formulation for the potential treatment of onychomycosis.
- Demonstrates an 8-fold increase in activity against C. neoformans and A. fumigatus in vitro.
- Inhibits cells expressing GlLeuRS-D444A.
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Apexbio Technology LLC Sparteine 492-08-0 200mg
Sparteine (CAS 492-08-0) is a naturally occurring alkaloid recognized for its activity as a ganglionic blocker It acts by competitively inhibiting neuronal nicotinic acetylcholine receptors thereby modulating synaptic transmission within the nervous system Owing to this specific mechanism sparteine is widely employed in neurobiological and pharmacological research to investigate neuronal signaling pathways and to elucidate mechanisms involved in central nervous system disorders Its use facilitates the exploration of neurotransmitter regulation and receptor function in experimental models
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Cayman Chemical DImethyl sulfon 5g
An organic sulfur derivative described to have anti-inflammatory and analgesic properties; commonly found as an adulterant in methamphetamine samples
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Medchemexpress LLC Cinchonine | 118-10-5 | MFCD00064372 | 99.7% | 294.39 | C19H22N2O | 5g
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Cinchonine is a natural compound present in Cinchona bark with antimalarial antitumor anti-inflammatory anti platelet-aggregation and anti-obesity properties Cinchonine inhibits cells proliferation and autophagy and induces apoptosis through activation of Caspase-3 Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells[1]
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Medchemexpress LLC Hydroquinidine (Dihydroquinidine) | 1435-55-8 | 99.9% | 50 G
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Hydroquinidine (Dihydroquinidine) is a potent ion channel blocker that demonstrates strong anti-cancer activity against colon, pancreatic, and hepatocellular cancer cells. It also prolongs the QT interval and possesses antiarrhythmic efficacy.
- Exhibits anti-clonogenic and anti-tumorigenic activities in pancreatic cancer cells in vitro.
- Gene expression profiling shows changes in CDKN1A, CDKN1B, PUMA, BIRC5, AKT, MKI67, PCNA, and CCNE1 in various cancer cell lines.
- Investigated for Brugada Syndrome in a Phase 3 clinical trial.
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