Quinolines and derivatives
Medchemexpress LLC Trovafloxacin mesylate | 147059-75-4 | MFCD00913361 | 99.8% | 512.46 g/mol | C21H19F3N4O6S | 1 ML
Trovafloxacin mesylate is the mesylate salt of trovafloxacin, a broad-spectrum fluoroquinolone antibiotic that inhibits DNA gyrase and topoisomerase IV. It is used in research to study antibacterial activity and pannexin 1 (PANX1) channel function and inhibition.
- Broad-spectrum fluoroquinolone antibiotic that inhibits DNA gyrase and topoisomerase IV.
- Also reported as a pannexin 1 (PANX1) inhibitor with an IC50 around 4 μM.
- Available as a 10 mM solution in DMSO (1 mL) and as solid quantities for experimental flexibility.
- High purity: 99.8% (HPLC) as reported by supplier.
- CAS number 147059-75-4; molecular weight 512.46 g/mol.
Medchemexpress LLC Bromocriptine mesylate | 22260-51-1 | 99.90% | 200 MG
Bromocriptine mesylate is a potent dopamine D2/D3 receptor agonist, binding to the D2 dopamine receptor with a pKi of 8.05. It is permeable to the blood-brain barrier. This compound also acts as a strong inhibitor of brain nitric oxide synthase (NOS) with an IC50 of 10±2 μM for purified neuronal NOS, and poorly inhibits inducible macrophage NOS (IC50>100 μM). Additionally, it is a potent inhibitor of CYP3A4, with a calculated IC50 value of 1.69 μM.
- Potent dopamine D2/D3 receptor agonist
- Permeable to the blood-brain barrier
- Strong inhibitor of brain nitric oxide synthase (NOS)
- Potent inhibitor of CYP3A4
- Shows anti-immobility action in mice (in FST and TST)
- Potentiates the anti-immobility action of MPE
- Decreases static mechanical allodynia (SMA) score in rats
Medchemexpress LLC Almonertinib mesylate | 2134096-06-1 | 99.7% | 621.75 | 25 MG
Almonertinib mesylate (HS-10296 mesylate) is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. It shows great inhibitory activity against T790M, T790M/L858R, and T790M/Del19 (IC50: 0.37, 0.29, and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). It is used for the research of non-small cell lung cancer, and can also inhibit other EGFR sensitive mutations, including G719X, del19, L858R, and L861Q.
- Orally available
- Irreversible
- Third-generation EGFR tyrosine kinase inhibitor
- High selectivity for EGFR-sensitizing and T790M resistance mutations
- Great inhibitory activity against T790M, T790M/L858R and T790M/Del19
- Used for research of non-small cell lung cancer
- Inhibits EGFR sensitive mutations (G719X, del19, L858R, L861Q)
Medchemexpress LLC Almonertinib (mesylate) | 2134096-06-1 | 99.7% | 621.75 | 1 ML
Almonertinib mesylate is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor. It shows high selectivity for EGFR-sensitizing and T790M resistance mutations, with inhibitory activity against T790M, T790M/L858R, and T790M/Del19. It is used for the research of non-small cell lung cancer (NSCLC). This compound can also inhibit other EGFR sensitive mutations, including G719X, del19, L858R, and L861Q.
- Orally available inhibitor
- Irreversible, third-generation EGFR tyrosine kinase inhibitor
- High selectivity for EGFR-sensitizing and T790M resistance mutations
- Inhibitory activity against T790M, T790M/L858R, and T790M/Del19
- Less effective against wild type EGFR
- Used for non-small cell lung cancer research
- Can inhibit other EGFR sensitive mutations like G719X, del19, L858R, and L861Q
Medchemexpress LLC Firmonertinib mesylate | 2130958-55-1 | 100.0% | 664.70 | 50 MG
Firmonertinib mesylate is an orally active, mutant-selective, and blood-brain barrier penetrant EGFR inhibitor. It inhibits EGFR active mutations as well as the T790M acquired resistant mutation. It has potential for the research of cancer diseases, especially advanced non-small cell lung cancer (NSCLC) with EGFR ex20ins mutation.
- Orally active
- Mutant-selective
- Blood-brain barrier penetrant EGFR inhibitor
- Inhibits EGFR active mutations and T790M acquired resistant mutation
- Potential for research of cancer diseases, especially advanced NSCLC with EGFR ex20ins mutation
Medchemexpress LLC Deferoxamine (mesylate) (Standard) | 138-14-7 | 99.8% | 25 MG
Deferoxamine mesylate (Deferoxamine B mesylate) is an iron chelator that binds to Fe(III) and many other metal cations. It is widely used to reduce iron accumulation and deposition in tissues. It upregulates HIF-1α levels with good antioxidant activity and also shows anti-proliferative activity, inducing apoptosis and autophagy in cancer cells. Deferoxamine mesylate can be used in studies of diabetes, neurodegenerative diseases, as well as anti-cancer and anti-COVID-19 research.
- Binds to Fe(III) and many other metal cations.
- Reduces iron accumulation and deposition in tissues.
- Upregulates HIF-1α levels.
- Exhibits good antioxidant activity.
- Shows anti-proliferative activity.
- Induces apoptosis and autophagy in cancer cells.
- Used in studies of diabetes and neurodegenerative diseases.
- Used in anti-cancer and anti-COVID-19 research.
Medchemexpress LLC Dihydroergocristine mesylate | 24730-10-7 | 1 ML
Dihydroergocristine mesylate (DHEC mesylate) is an inhibitor of γ-secretase (GSI) that effectively reduces the production of amyloid-β peptides associated with Alzheimer's disease. It directly binds to γ-secretase and Nicastrin, exhibiting high affinity. This product is for research use only.
- Inhibits γ-secretase activity in T100 cells without affecting cell viability
- Decreases cellular Aβ production
- Causes dose-dependent accumulation of carboxy-terminal fragments of APP (APP-CTFs)
- Reduces γ-secretase activity in fibroblast cells
Medchemexpress LLC Bromocriptine mesylate | 22260-51-1 | 99.9% | 10 MG
Bromocriptine mesylate is a potent dopamine D2/D3 receptor agonist that binds to the D2 dopamine receptor with a pKi of 8.05. It is permeable to the blood-brain barrier.
- Potent dopamine D2/D3 receptor agonist
- Binds D2 dopamine receptor with pKi of 8.05
- Permeable to the blood-brain barrier
- Stimulates [35S]-GTPγS binding at D2 dopamine receptor expressed in CHO cells with pEC50 of 8.15±0.05
- Strong inhibitor of brain nitric oxide synthase (NOS) (IC50=10±2 μM)
- Poorly active towards inducible macrophage NOS (IC50>100 μM)
- Potent inhibitor of CYP3A4 with a calculated IC50 value of 1.69 μM
- Demonstrates significant anti-immobility action in forced swimming test (FST) and tail suspension test (TST) in mice
- Potentiates the anti-immobility action of MPE
- Decreases static mechanical allodynia (SMA) score in rats
- Induces a significant, dose-dependent decrease in pain scores in the CCI-IoN group
Medchemexpress LLC Dosimertinib-d5 mesylate | 2403760-72-3 | 99.4% | C29H32D5N7O5S | 1 MG
Dosimertinib-d5 (mesylate) is a potent, orally active Epidermal Growth Factor Receptor (EGFR) inhibitor. It decreases the expression of p-EGFR and p-ERK protein levels, demonstrating antiproliferative and anti-tumor activity. It has potential for research into non-small-cell lung cancer (NSCLC).
- Potent and orally active EGFR inhibitor.
- Decreases p-EGFR and p-ERK protein levels.
- Antiproliferative and anti-tumor activity.
- Suitable for use as a tracer or an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Decreases p-EGFR and p-ERK protein levels in A431 and H1975 cells in a dose-dependent manner.
- Shows anti-tumor activity in BALB/c nude mice with H1975 xenograft model.
- Soluble in DMSO at 100 mg/mL (166.46 mM), requiring ultrasonic and warming to 80°C.
TARGETMOL CHEMICALS INC SAFINAMIDE MESYLATE 25MG
Also available in 2 mg 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Safinamide mesylate (EMD 1195686 mesylate) a mesylate salt of Safinamide can reversibly and specifically inhibit MAO-B (IC50 98 nM) has 5918-fold selectivity against MAO-A. purity: 98%
TARGETMOL CHEMICALS INC OBATOCLAX MESYLATE 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Obatoclax Mesylate (GX15-070) is a Bcl-2 antagonist (Ki 0.22 uM) and can induce apoptosis with up-regulation of Bim induced cytochrome c release and activation of caspase-3. purity: 99%
Medchemexpress LLC Danofloxacin mesylate | 119478-55-6 | 99.9% | 1 ML
Danofloxacin mesylate is a potent fluoroquinolone antibiotic primarily utilized as a veterinary drug. It exhibits broad-spectrum bactericidal activity by targeting bacterial DNA gyrase, an essential enzyme for bacterial replication. Furthermore, this compound functions as a substrate for ATP-dependent efflux transporters, including P-glycoprotein (P-gp) and Multidrug Resistance-associated Protein 2 (MRP2), which are involved in drug transport mechanisms within cells.
- Fluoroquinolone antibiotic for veterinary use
- Possesses broad-spectrum bactericidal activity
- Inhibits bacterial DNA gyrase
- Acts as a substrate for ATP-dependent efflux transporters
Medchemexpress LLC Phentolamine mesylate | 65-28-1 | 99.9% | 500 MG
Phentolamine mesylate is a reversible, non-selective, and orally active blocker of α1 and α2 adrenergic receptors. It expands blood vessels to reduce peripheral vascular resistance and can be used for the research of pheochromocytoma-related hypertension, heart failure, and erectile dysfunction.
- Reversible, non-selective, and orally active blocker of α1 and α2 adrenergic receptors
- Expands blood vessels to reduce peripheral vascular resistance
- Used for research in pheochromocytoma-related hypertension, heart failure, and erectile dysfunction
- High purity of 99.9%
Medchemexpress LLC Dihydroergotamine mesylate | 6190-39-2 | 99.94% | 50 MG
Dihydroergotamine mesylate is a BBB-permeable ergot alkaloid for the research of migraines. It reduces cell survival in A549 and NCI-H226 cells and inhibits cell survival in Hep3B, PLC/PRF/5, Huh7, and HepG2 cells.
- Reduces cell survival in A549 and NCI-H226 cells
- Inhibits cell survival in Hep3B, PLC/PRF/5, Huh7, and HepG2 cells
- Induces mitochondrial morphologic alterations and dysfunction
- Increases ROS generation and induces apoptosis
- Disturbs ATP production in A549 cells
- Inhibits STAT3 activation and enhances protein stability of Mcl-1
Medchemexpress LLC Danofloxacin mesylate | 119478-55-6 | MFCD00673687 | 99.9% | 100 MG
Danofloxacin mesylate (CP 76136-27) is a fluoroquinolone used as a veterinary drug. It exhibits broad-spectrum bactericidal activity primarily by inhibiting bacterial DNA gyrase and also functions as a substrate for ATP-dependent efflux transporters such as P-gp and MRP2.
- Used as a veterinary drug
- Broad-spectrum bactericidal activity
- Inhibits bacterial DNA gyrase
- Substrate for ATP-dependent efflux transporters (P-gp and MRP2)
- Targets P-glycoprotein and bacterial components
- Involves membrane transporter/ion channel and anti-infection mechanisms
- Effective against bovine bacterial respiratory pathogens
- Demonstrates asymmetric transport across Caco-2 cells