Quinolines and derivatives
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Filtered Search Results
Aobchem 2-Trimethyl-6-quinolinemethanol | 97% | CAS 1515644-29-7 | C13H15NO | 250mg
2-Trimethyl-6-quinolinemethanol | 97% | CAS 1515644-29-7 | C13H15NO | 250mg
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Aobchem 2 2 4-Trimethyl-3-oxopentanenitrile | 95% | CAS 20101-98-8 | C8H13NO | 250mg
2 2 4-Trimethyl-3-oxopentanenitrile | 95% | CAS 20101-98-8 | C8H13NO | 250mg
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Medchemexpress LLC PVD-06 | 3032975-48-4 | 98.3% | 1074.13 | 25 MG
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PVD-06 is a selective PROTAC PTPN2 degrader with a DC50 of 217 nM (selectivity index >60-fold over PTP1B). It induces PTPN2 degradation via a VHL-, ubiquitin, and proteasome-dependent pathway. PVD-06 can promote T cell activation and amplify IFN-γ-mediated anticancer activity. It can be used to further investigate PTPN2 in diseases such as leukemia and melanoma.
- Induces PTPN2 degradation
- Reduces PTPN2 protein levels
- Enhances phosphorylation of STAT1 in Jurkat cells
- Promotes T cell proliferation under CD3/CD28 stimulation
- Amplifies B16F10 cell growth inhibition in the presence of IFN-γ
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000743514 MPEG-AMINE MW 5000 5G
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000743742 MPEG-AMINE MW 20000 5G
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000745960 BENZYL-PEG5-AMINE 10MG
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Medchemexpress LLC M-PEG12-AMINE 5G
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M-PEG12-AMINE 5G
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Medchemexpress LLC CYANINE7.5 AMINE 10 mg
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CYANINE7.5 AMINE 10MG
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Apexbio Technology LLC Zotarolimus(ABT-578) 221877-54-9 25mg
Zotarolimus ABT-578 is a small-molecule inhibitor targeting the immunophilin FKBP12 It is designed to form a complex with FKBP12 thereby inhibiting mTOR pathway signaling and suppressing the proliferation of T-cells vascular smooth muscle cells (VSMCs) and endothelial cells (ECs) Zotarolimus ABT-578 exerts its biological activity primarily through mTOR pathway inhibition In cell-based studies zotarolimus demonstrates nanomolar-level inhibitory potency against human coronary artery cell proliferation and T-cell activation Based on these pharmacological properties zotarolimus ABT-578 holds research potential in vascular restenosis prevention neointimal hyperplasia reduction and immunological studies involving T-cell function
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eMolecules 343926-69-2 | 4-bromopyrimidin-2-amine | Pharmablock | MFCD09999168 | 174.001 | C4H4BrN3 | 97.000 | Nc1nccc(Br)n1 | 5g | 551195285
4-bromopyrimidin-2-amine | Pharmablock | 343926-69-2 | MFCD09999168 | 174.001 | C4H4BrN3 | 97.000 | Nc1nccc(Br)n1 | 5g | 551195285
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eMolecules 343926-69-2 | 4-bromopyrimidin-2-amine | Pharmablock | MFCD09999168 | 174.001 | C4H4BrN3 | 97.000 | Nc1nccc(Br)n1 | 10g | 551195286
4-bromopyrimidin-2-amine | Pharmablock | 343926-69-2 | MFCD09999168 | 174.001 | C4H4BrN3 | 97.000 | Nc1nccc(Br)n1 | 10g | 551195286
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Ambeed Pyrazine2carbaldehyde
Pyrazine-2-carbaldehyde, 5780-66-5, 95%
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Ambeed Methyl 2 triphenylphosphoranyl
Methyl 2-(triphenylphosphoranylidene)acetate, 2605-67-6, 98%
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Aobchem Trimethyl((2 4 5-trifluorophenyl)ethynyl)silane | 95% | CAS 1097876-22-6 | C11H11F3Si | 500mg
Trimethyl((2 4 5-trifluorophenyl)ethynyl)silane | 95% | CAS 1097876-22-6 | C11H11F3Si | 500mg
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Aobchem 4 5-Dimethoxy-2-fluorobenzaldehyde | ≥97% | CAS 71924-62-4 | C9H9FO3 | 25g
4 5-Dimethoxy-2-fluorobenzaldehyde | ≥97% | CAS 71924-62-4 | C9H9FO3 | 25g
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