Quinolines and derivatives
Medchemexpress LLC Amino-PEG3-C2-amine | 929-75-9 | MFCD00628164 | 99.1% | 192.26 g/mol | C8H20N2O3 | 1 G
Amino-PEG3-C2-amine is a short polyethylene glycol (PEG) spacer bearing a terminal primary amine, intended for use as a PROTAC linker and general bioconjugation. It provides three ethylene glycol units to improve solubility and flexibility, while the amino group enables straightforward coupling chemistry for building complex conjugates.
- Short PEG spacer (three ethylene glycol units) for flexibility and solubility.
- Terminal primary amine suitable for coupling to carboxylic acids and activated esters.
- Liquid form simplifies handling and accurate dosing.
- High purity supports reliable synthetic outcomes.
- Useful in PROTAC linker synthesis and general bioconjugation applications.
Medchemexpress LLC Azido-PEG9-amine | 1207714-69-9 | 98.5% | 482.57 g/mol | C20H42N4O9 | 250 MG
Azido-PEG9-amine is an azide-terminated polyethylene glycol linker containing nine ethylene glycol units and a terminal primary amine, used as a click-chemistry reagent and as a non-cleavable PEG9 linker in bioconjugation applications.
- Azide-terminated PEG linker with nine ethylene glycol units.
- Terminal primary amine for further conjugation.
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted azide-alkyne cycloaddition (SPAAC).
- Suitable for antibody-drug conjugate (ADC) and proteolysis targeting chimera (PROTAC) synthesis and general bioconjugation.
- CAS number 1207714-69-9; molecular weight 482.57 g/mol; formula C20H42N4O9; purity 98.5%.
- Supplied as 250 mg quantity for laboratory-scale synthesis.
Medchemexpress LLC M-PEG9-amine | 211859-73-3 | 97.0% | 427.53 g/mol | C19H41NO9 | 100 MG
m-PEG9-amine is a methoxy-terminated polyethylene glycol (PEG) linker containing nine ethylene glycol units and a terminal primary amine. It is supplied as a liquid (colorless to light yellow) and is used as a PEG-based linker for proteolysis-targeting chimera (PROTAC) synthesis and as a cleavable linker in antibody-drug conjugate (ADC) development.
- Methoxy-terminated polyethylene glycol (PEG) linker with a terminal primary amine.
- Suitable for use as a PEG-based linker in PROTAC synthesis.
- Functions as a cleavable linker for antibody-drug conjugates (ADCs).
- High purity (97.0%) for research and conjugation workflows.
- Molecular weight about 427.53 g/mol; formula C19H41NO9; CAS 211859-73-3.
- Available in laboratory-scale sizes, including 100 mg, 250 mg, 1 g, and 5 g.
Medchemexpress LLC Azido-PEG9-amine | 1207714-69-9 | MFCD30723241 | 98.5% | 482.57 g/mol | C20H42N4O9 | 100 MG
Azido-PEG9-amine is an azide-terminated nine-unit polyethylene glycol (PEG) linker with a terminal primary amine used for bioconjugation and linker design. It is suitable for click chemistry and linker-based constructs, providing hydrophilic spacing between functional groups.
- Azide-terminated PEG linker compatible with CuAAC and SPAAC click reactions.
- Contains a primary amine for orthogonal functionalization.
- Nine ethylene glycol units provide hydrophilicity and spacing for conjugates.
- Reported high purity supports conjugation and analytical workflows.
- Available in small research-scale quantities for method development.
Medchemexpress LLC Azido-PEG7-amine | 1333154-77-0 | MFCD13185016 | >98.0% | 394.46 g/mol | C16H34N4O7 | 50 MG
Azido-PEG7-amine is a bifunctional polyethylene glycol (PEG) linker bearing an azide and a primary amine terminus. It is used as a click-chemistry building block and as a linker in antibody-drug conjugate (ADC) and PROTAC synthesis.
- Bifunctional azide and primary amine termini suitable for conjugation.
- PEG7 spacer provides a short, flexible linker (seven ethylene glycol units).
- Compatible with copper-catalyzed azide-alkyne cycloaddition and strain-promoted click reactions.
- High reported purity, typically greater than 98%.
- Supplied in small laboratory pack sizes for research use.
Medchemexpress LLC m-PEG11-amine | 854601-60-8 | 515.64 g/mol | C23H49NO11 | 250 MG
m-PEG11-amine is a methoxy-terminated polyethylene glycol linker bearing a terminal primary amine. It provides an approximately 11-unit PEG spacer (hydrophilic) for conjugation to payloads or ligands, improving solubility and flexibility, and is used as a cleavable linker in antibody-drug conjugates (ADCs) and as a PEG-based linker in PROTAC synthesis.
- Cleavable PEG linker with a terminal primary amine.
- Approximately 11 ethylene glycol units; molecular weight 515.64 g/mol.
- Enhances solubility and linker flexibility for bioconjugation.
- Used in ADC and PROTAC syntheses and general bioconjugation applications.
- Available in small laboratory pack sizes (e.g., 250 MG) for research use.
Medchemexpress LLC m-PEG7-amine | 170572-38-0 | MFCD13184965 | 98.0% | 339.43 g/mol | C15H33NO7 | 5 G
m-PEG7-Amine is a methoxy-terminated polyethylene glycol (PEG) linker bearing a terminal primary amine. It is used as a PROTAC linker and as a cleavable ADC linker for antibody-drug conjugation and other bioconjugation applications. The reagent provides a flexible, hydrophilic spacer suitable for linker chemistry in targeted degraders and conjugates.
- Methoxy-terminated PEG with seven ethylene glycol units.
- Terminal primary amine for facile coupling to carboxylates and activated esters.
- Molecular weight 339.43 g/mol and CAS 170572-38-0.
- Suitable for use as a PROTAC linker and a cleavable ADC linker.
- Hydrophilic spacer that improves solubility and reduces aggregation in conjugates.
Medchemexpress LLC Amino-PEG3-C2-amine | 929-75-9 | MFCD00628164 | 98.0% | 192.26 g/mol | C8H20N2O3 | 10 G
Amino-PEG3-C2-Amine is a PEG-based linker containing three ethylene glycol units and a terminal primary amine. It functions as a flexible spacer for assembling proteolysis targeting chimera (PROTAC) molecules and other bioconjugates, offering aqueous solubility and a reactive amine handle for downstream coupling and functionalization in synthetic workflows.
- PEG-based spacer with three ethylene glycol units.
- Terminal primary amine for straightforward conjugation.
- Improves solubility and reduces steric hindrance in constructs.
- Molecular weight 192.26 g/mol for predictable stoichiometry.
- Suitable for PROTAC synthesis and other bioconjugation applications.
- Available in multiple laboratory-scale packaging options.
Medchemexpress LLC 38-azido-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxaoctatriacontan-1-amine | 2803478-25-1 | 98.0% | 614.73 g/mol | C26H54N4O12 | 25 MG
Azido-PEG12-amine is a PEG-based bifunctional linker with an azide at one terminus and a primary amine at the other. It functions as a water-soluble spacer (approximately 12 ethylene glycol units) used in click chemistry, bioconjugation, PROTAC and ADC linker design.
- Azide and primary amine functional groups enable click chemistry and amide coupling.
- Approximately 12 ethylene glycol units provide flexible, hydrophilic spacing.
- Molecular weight 614.73 g/mol for predictable linker length and mass.
- Purity 98.0% (NMR) as supplied in certificate of analysis.
- Colorless to light yellow liquid physical form for ease of handling.
- Stable when stored sealed and protected from moisture and light; in solvent: -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC 3,6,9,12,15,18-Hexaoxanonadecan-1-amine | 184357-46-8 | ≥97.0% | 295.37 | C13H29NO6 | 250 MG
m-PEG6-Amine (3,6,9,12,15,18-Hexaoxanonadecan-1-amine, CAS 184357-46-8) is a methoxy-terminated polyethylene glycol (PEG6) primary amine linker used as a flexible, hydrophilic spacer for assembling PROTAC molecules and as a cleavable linker in antibody-drug conjugates (ADCs). The compound has formula C13H29NO6, molecular weight 295.37, and typical purity ≥97.0%.
- Provides a six-unit polyethylene glycol spacer to improve solubility and flexibility.
- Terminal primary amine enables straightforward conjugation chemistry for amide or carbamate coupling.
- Suitable for PROTAC and ADC synthesis as a cleavable, hydrophilic linker.
- High reported purity (≥97.0%) suitable for research applications.
- Recommended storage: 4°C protected from light; in solvent, store at -80°C (6 months) or -20°C (1 month) when protected from light.
Medchemexpress LLC M-PEG12-amine | 1977493-48-3 | MFCD11041151 | ≥98.0% | 559.69 g/mol | C25H53NO12 | 25 MG
m-PEG12-amine is a monodisperse polyethylene glycol (PEG) linker bearing a terminal primary amine, used for bioconjugation, PROTAC synthesis, and as a non-cleavable 12-unit PEG spacer for antibody-drug conjugates.
- Monodisperse 12-unit PEG spacer
- Terminal primary amine for conjugation
- Molecular weight 559.69 g/mol
- Molecular formula C25H53NO12
- Purity ≥98.0% (as stated on COA)
Medchemexpress LLC 3,6,9-trioxa-12-azaheptadecan-17-oic acid, folate conjugate | 710323-40-3 | 99.7% | 615.64 | C27H37N9O8 | 10 MG
Folate-PEG3-amine is a cleavable three-unit polyethylene glycol linker bearing a folate moiety, used for targeted conjugation and antibody-drug conjugate synthesis. It provides a hydrophilic spacer with an amine for coupling to drugs or biomolecules.
- cleavable three-unit PEG spacer
- folate targeting motif for receptor-mediated delivery
- primary amine functional group for easy coupling
- high purity suitable for research applications
- hydrophilic spacer to improve solubility and reduce aggregation
Medchemexpress LLC Amino-PEG6-amine | 76927-70-3 | MFCD30343546 | 97.0% | 324.41 | 250 MG
Amino-PEG6-amine is a PROTAC linker, based on a PEG (polyethylene glycol) chain with 6 units, which can be utilized in the synthesis of PROTACs. PROTACs are molecules that contain two different ligands connected by a linker: one ligand binds to an E3 ubiquitin ligase, and the other binds to the target protein. This mechanism allows PROTACs to leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based (6 units) PROTAC linker
- Can be used in the synthesis of PROTACs
Medchemexpress LLC 3,6,9,12,15,18,21,24-octaoxapentacosan-1-amine | 869718-81-0 | >98.0% | 383.48 | C17H37NO8 | 500 MG
m-PEG8-Amine is a cleavable polyethylene glycol (PEG8) linker with a terminal primary amine used for conjugation in antibody-drug conjugates (ADCs) and other bioconjugation chemistries for research applications.
- Cleavable ADC linker with PEG8 spacer and terminal primary amine for conjugation.
- High purity: >98.0%.
- Molecular weight 383.48 g/mol and formula C17H37NO8.
- Suitable for ADC and PROTAC linker synthesis and bioconjugation research.
- Available as 500 MG pack for laboratory use.
Medchemexpress LLC Peg-bis-amine (MW 2000) | 24991-53-5 | 99.4% | (C2H4O)nC4H12N2O | 250 MG
PEG-bis-amine (Poly(ethylene glycol)-bis-amine) (MW 2000) is a PEG-based PROTAC linker. It is used in the synthesis of PROTACs, which are molecules designed to exploit the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- Can be used in the synthesis of PROTACs
- PROTACs contain two different ligands connected by a linker
- Ligands are for an E3 ubiquitin ligase and a target protein
- PROTACs exploit the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins