Thiophenes
Medchemexpress LLC Meclizine dihydrochloride | 1104-22-9 | 99.9% | 5 G
Meclizine dihydrochloride is an antihistamine that reversibly inhibits histamine interaction at H1 receptors. It belongs to the piperazine class of H1 antagonists and is an effective anti-motion sickness agent. This compound can cross the blood-brain barrier and is used for research into polyQ toxicity disorders such as Huntington's disease. Meclizine dihydrochloride acts as an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for Human CAR.
- Reversibly inhibits histamine at H1 receptors.
- Effective anti-motion sickness agent.
- Crosses the blood-brain barrier.
- Used for research of polyQ toxicity disorders, such as Huntington's disease.
- Agonist ligand for mouse constitutive androstane receptor (CAR).
- Inverse agonist for Human CAR.
eMolecules Ambeed / Thiophen-2-ylboronic acid / 5g / 552669675 / A240460 / / 6165-68-0 / MFCD00151850 / 127.950 / C4H5BO2S
Ambeed / Thiophen-2-ylboronic acid / 5g / 552669675 / A240460 / / 6165-68-0 / MFCD00151850 / 127.950 / C4H5BO2S
Medchemexpress LLC 2-Methylthiophene | 554-14-3 | 99.94% | 98.16 | 5 G
2-Methylthiophene is an intermediate used in the synthesis of aromatic sulfur compounds. It is for research use only and not sold to patients. It appears as a colorless to light yellow liquid.
- Purity: 99.94%
- Available in various sizes
- Documentation includes Data Sheet, COA, SDS, and Handling Instructions
- Soluble in DMSO for in vitro use
- Storage at 4°C under nitrogen
Medchemexpress LLC Alexidine dihydrochloride | 1715-30-6 | 99.7% | 581.71 | 10 MG
Alexidine dihydrochloride is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis. It also has antifungal and antibiofilm activity against a diverse range of fungal pathogens.
- Anticancer agent targeting mitochondrial tyrosine phosphatase, PTPMT1.
- Causes mitochondrial apoptosis.
- Antifungal and antibiofilm activity against a diverse range of fungal pathogens.
- Displays activity against most Candida spp., including fluconazole-resistant isolates.
- Complete inhibition of filamentation or proliferation of imaged fungi.
- Able to decimate mature biofilms of Candida, Cryptococcus, and Aspergillus spp. at low concentrations.
- Inhibits fungal biofilm growth and viability in a murine biofilm model.
Medchemexpress LLC SB 242084 dihydrochloride | 1049747-87-6 | MFCD02684417 | 98.1% | C21H21Cl3N4O2 | 10MG
SB 242084 dihydrochloride is a selective, high-affinity 5-HT2C receptor antagonist used in neuroscience research. It crosses the blood-brain barrier and is used to study serotonergic regulation of dopaminergic neurons, behavioral effects, and metabolic changes. Provided as a dihydrochloride salt and available in solution formats, it is intended for research use only.
- Selective 5-HT2C receptor antagonist
- High affinity (pKi = 9.0)
- Crosses the blood-brain barrier
- Suitable for in vitro and in vivo studies
- Available as solid salt and DMSO solution formats
- Intended for research use only
Selleck Chemical LLC H 89 2HCl S1582-1g
H 89 2HCl is a potent PKA inhibitor with Ki of 48 nM in a cell-free assay 10-fold selective for PKA than PKG 500-fold greater selectivity than PKC MLCK calmodulin kinase II and casein kinase I/II H 89 2HCl induces autophagy
Medchemexpress LLC Histamine dihydrochloride | 56-92-8 | 99.9% | 25 MG
Histamine dihydrochloride is an organic nitrogen compound that participates in local immune responses, regulates intestinal physiological functions, and acts as a neurotransmitter. It is also an agonist for the histamine receptor and a vasodilator. It affects the p38 MAPK/Akt signaling pathway and shows antitumor, antioxidant, and anti-inflammatory activities.
- Regulates intestinal physiological functions
- Acts as a neurotransmitter
- Affects the p38 MAPK/Akt signaling pathway
- Shows antitumor, antioxidant, and anti-inflammatory activities
- Used in research for acute myeloid leukemia, malignant melanoma, and renal cell carcinoma
Apexbio Technology LLC Dorsomorphin 2HCl 1219168-18-9 50mg
Dorsomorphin 2HCl (CAS 1219168-18-9) is a small-molecule inhibitor targeting BMP signaling through selective blockade of BMP type I receptors ALK2 ALK3 and ALK6 It prevents phosphorylation of downstream effectors SMAD1/5/8 with an IC50 of approximately 0 47 mM Originally identified by zebrafish phenotypic screening as a disruptor of embryonic dorsoventral patterning Dorsomorphin has been employed to dissect BMP-regulated pathways in iron homeostasis significantly affecting hepcidin expression and iron metabolism in vitro and in vivo It is widely utilized in mechanistic studies of BMP function and signaling regulation
Medchemexpress LLC Bisantrene dihydrochloride | 71439-68-4 | MFCD01743164 | 98.9% | 471.39 g/mol | C22H24Cl2N8 | 10 MG
Bisantrene dihydrochloride is the dihydrochloride salt of an anthracene-derived antitumor compound supplied as a solid for research use. It intercalates DNA and inhibits eukaryotic type II topoisomerases, making it useful in cytotoxicity, mechanism-of-action, and drug resistance studies.
![eMolecules Methyl 2-aminobenzo[d]thiazole-7-carboxylate | 209459-11-0 | MFCD09263762 | 1g](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502189384.JPG-250.jpg)
eMolecules Methyl 2-aminobenzo[d]thiazole-7-carboxylate | 209459-11-0 | MFCD09263762 | 1g
Combi-Blocks | Methyl 2-aminobenzo[d]thiazole-7-carboxylate | 1g | 205399018 | QA-2936 | 98.000 | 209459-11-0 | MFCD09263762 | 208.240 | C9H8N2O2S
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Apexbio Technology LLC Clozapine N-oxide(CNO) dihydrochloride(Synonyms: CNO dihydrochloride, Clozapine N-oxide hydrochloride,Clozapine N-oxide dihydrochloride), 50mg, CAS: 2250025-93-3.
Clozapine N-oxide (CNO) dihydrochloride (CAS 2250025-93-3) is a synthetic metabolite derived from clozapine commonly utilized as an agonist for designer receptors exclusively activated by designer drugs (DREADDs) In neuroscience research CNO selectively binds and activates engineered muscarinic receptors particularly hM3Dq and hM4Di thereby influencing neuronal signaling upon penetrating the blood-brain barrier Due to its specificity CNO dihydrochloride serves as a valuable tool for dissecting neuronal circuits and elucidating their functional roles in behavioral studies
Medchemexpress LLC Bisantrene dihydrochloride | 71439-68-4 | MFCD01743164 | >98.0% | 471.39 g/mol | C22H24Cl2N8 | 100 MG
Bisantrene dihydrochloride is the dihydrochloride salt of bisantrene, an anthracene-derived antitumor agent used in research for its DNA intercalation and topoisomerase II inhibitory activity. It is supplied as a solid for laboratory use and is suitable for in vitro and preclinical studies where a high-purity research reagent is required.
- Dihydrochloride salt form improves aqueous solubility for experimental work.
- High purity (≥98% HPLC) suitable for biological and analytical assays.
- Molecular weight 471.39 g/mol supports accurate dosing and calculations.
- Acts as a DNA intercalator and topoisomerase II inhibitor for mechanistic studies.
- Provided as a solid convenient for handling, storage, and formulation.
Medchemexpress LLC DDP-38003 dihydrochloride | 1831167-98-6 | 99.3% | 423.38 | 100 MG
DDP-38003 dihydrochloride is a novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC50 of 84 nM. It exhibits in vivo efficacy after oral administration, determining a 62% increased survival in mouse leukemia models with evidence of KDM1A inhibition. The half-life of DDP-38003 is 8 hours. A significant dose-dependent increase of mice survival is obtained by DDP-38003 treatment. DDP-38003 is a potential oral anticancer agent.
- Novel, orally available inhibitor of KDM1A/LSD1
- IC50 of 84 nM against KDM1A
- More active in reducing colony forming ability and inducing differentiation of THP-1 cells compared to the 1R, 2S analogue
- Exhibits in vivo efficacy after oral administration
- Determines 62% increased survival in mouse leukemia models
- Half-life of 8 hours
- Potential oral anticancer agent
- Appearance: Solid, brown to reddish brown
Medchemexpress LLC Lomerizine dihydrochloride | 101477-54-7 | 99.95% | 50 MG
Lomerizine dihydrochloride is an antagonist of L- and T-type voltage-gated calcium channels. It also antagonizes transient receptor potential channel 5. Lomerizine is a dual L/T-type channel blocker that is used for prophylaxis of migraine.
- Antagonist of L- and T-type voltage-gated calcium channels.
- Demonstrates neuroprotective effects.
- Possesses activity in reversing multidrug resistance.
- Increases cerebral blood flow.
Medchemexpress LLC (E)-1,3-Di(thiophen-2-yl)prop-2-en-1-one | 42811-88-1 | 99.4% | 220.31 | 250 MG
(E)-1,3-Di(thiophen-2-yl)prop-2-en-1-one is a chemical compound primarily used as a drug intermediate for the synthesis of various active compounds. It is intended for laboratory research by experienced personnel in appropriately equipped and authorized facilities and has not been fully validated for medical applications.
- Used as a drug intermediate for synthesizing active compounds.
- Intended for laboratory research.
- Appears as a light yellow to yellow solid.
- Requires storage in a cool, well-ventilated area, away from direct sunlight and ignition sources.
- Store powder at -20°C for 3 years, or 4°C for 2 years.
- When in solvent, store at -80°C for 6 months, or -20°C for 1 month.
- Avoid breathing dust or vapors.
- Wear appropriate personal protective equipment during handling.