Thiophenes
Medchemexpress LLC Alexidine (dihydrochloride) | 1715-30-6 | 99.7% | 581.71 | 250 MG
Alexidine dihydrochloride is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis. It also exhibits antifungal and antibiofilm activity against a diverse range of fungal pathogens.
- Anticancer agent targeting PTPMT1.
- Causes mitochondrial apoptosis.
- Exhibits antifungal and antibiofilm activity against diverse fungal pathogens.
- Effective against most Candida spp. with low MIC values.
- Inhibits filamentation and proliferation of imaged fungi.
- Decimates mature biofilms of Candida, Cryptococcus, and Aspergillus spp. at low concentrations.
- Inhibits lateral yeast formation and biofilm dispersal.
- Significantly reduces the density of C. albicans biofilms in jugular vein catheters of mice.
Medchemexpress LLC DDP-38003 dihydrochloride | 1831167-98-6 | 99.3% | 423.38 | 50 MG
DDP-38003 dihydrochloride is a novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC50 of 84 nM. It demonstrates significant in vitro and in vivo efficacy, inhibiting KDM1A and reducing colony forming ability in THP-1 cells. In mouse leukemia models, oral administration of DDP-38003 dihydrochloride led to increased survival.
- Inhibits histone lysine-specific demethylase 1A (KDM1A/LSD1)
- Orally available
- IC50 of 84 nM for KDM1A
- Reduces colony forming ability and induces differentiation of THP-1 cells
- Shows in vivo efficacy in mouse leukemia models
- Potential oral anticancer agent
Medchemexpress LLC Acetyl-CoA Carboxylase-IN-1 | 179343-23-8 | C13H9Br2N5 | 5 MG
Acetyl-CoA Carboxylase-IN-1 is a potent acetyl-CoA carboxylase (ACC) inhibitor with an IC50 value of ＜5 nM. It also demonstrates antibacterial activity.
- Potent acetyl-CoA carboxylase (ACC) inhibitor with an IC50 value of <5 nM.
- Exhibits antibacterial activity.
- Purity: 99.18%.
Medchemexpress LLC Chroman 1 dihydrochloride | 1273579-40-0 | C24H30Cl2N4O4 | 25 MG
Chroman 1 dihydrochloride is a highly potent and selective ROCK inhibitor, demonstrating greater potency against ROCK2 (IC50=1 pM) compared to ROCK1 (IC50=52 pM). It also exhibits inhibitory activity against MRCK (IC50=150 nM) and has been shown to inhibit caspase-3/7 activation and reduce apoptosis in human pluripotent stem cells.
- Highly potent and selective ROCK inhibitor
- More potent against ROCK2 (IC50=1 pM) than ROCK1 (IC50=52 pM)
- Exhibits inhibitory activity against MRCK (IC50=150 nM)
- Inhibits caspase-3/7 activation
- Reduces apoptosis in human pluripotent stem cells
Medchemexpress LLC 5-Methyl-2-thiophenecarboxaldehyde | 13679-70-4 | 99.9% | 126.18 | 100 G
5-Methyl-2-thiophenecarboxaldehyde acts as a candidate to microscopic third order non-linear optical (NLO) material. It is also an analytical standard intended for research and analytical applications.
- Acts as a candidate to microscopic third order non-linear optical (NLO) material.
- Analytical standard for research and analytical applications.
Apexbio Technology LLC Canertinib dihydrochloride 289499-45-2 100mg
Canertinib dihydrochloride (CAS 289499-45-2) is a small-molecule inhibitor targeting the pan-ErbB family of receptor tyrosine kinases It is designed to irreversibly inhibit ErbB receptors thereby disrupting Akt and MAPK signaling pathways Canertinib dihydrochloride exerts its biological activity primarily through irreversible binding to ErbB receptor family members In cell-based studies Canertinib dihydrochloride demonstrates apoptotic induction and reduced cell viability with an IC50 value of 3 5 nM Apoptosis induction was observed in BT474 (ErbB2-overexpressing breast cancer) and SK-N-SH (neuroblastoma) cell lines Based on these pharmacological properties Canertinib dihydrochloride holds research potential in oncology specifically for investigating ErbB signaling pathways and evaluating anti-tumor effects in cancer models
Cayman Chemical ThIophen-2-amIdoxIme 5g
A synthetic intermediate useful for pharmaceutical synthesis
Medchemexpress LLC Minaprine dihydrochloride | 25953-17-7 | 99.9% | 1 ML
Minaprine dihydrochloride | 25953-17-7 | 99.9% | 1 ML
Medchemexpress LLC Methyl 3-oxohexanoate | 30414-54-1 | 144.17 | 10 G
Methyl 3-oxohexanoate (Methyl Butyrylacetate) is an organic compound commonly used in the manufacture of fragrances, drugs, and other chemicals. It functions as a condensation, diazotization, and addition reagent, playing a catalytic role in various organic synthesis reactions and drug synthesis.
- Used in the food industry for products like juices, beer, and confectionery.
- Functions as a condensation reagent.
- Functions as a diazotization reagent.
- Functions as an addition reagent.
- Catalytic role in organic synthesis reactions.
- Useful in drug synthesis.
- Biochemical reagent for life science-related research.
Apexbio Technology LLC Pramipexole 2HCl Monohydrate 191217-81-9 50mg
Pramipexole 2HCl Monohydrate is a synthetic non-ergoline dopamine receptor agonist targeting dopamine receptor subtypes particularly D3 D2S D2L and D4 It is designed to activate these receptors thereby modulating dopaminergic transmission pathways Pramipexole 2HCl Monohydrate exerts its biological activity primarily through selective receptor activation Based on these pharmacological properties Pramipexole 2HCl Monohydrate holds research potential in studies of receptor-ligand interactions receptor subtype functional analysis and dopamine-related neurologic or psychiatric disorders including Parkinson s disease and restless legs syndrome
Apexbio Technology LLC Ranolazine 2HCl 95635-56-6 10mg
Ranolazine 2HCl (CAS 95635-56-6) is a small molecule frequently utilized in cardiovascular research for its antianginal and antiarrhythmic activities It modulates cardiac metabolism by partially inhibiting fatty acid -oxidation thereby increasing reliance on glucose oxidation This metabolic shift is mediated through activation of pyruvate dehydrogenase in ischemic myocytes enhancing glucose utilization during myocardial ischemia Ranolazine 2HCl s ability to alter substrate preference and improve cellular energetics under hypoxic conditions supports its application in studies of cardiac ischemia arrhythmias and myocardial metabolism
eMolecules 69363-85-5 | Methyl 4-aminothiophene-3-carboxylate | MFCD00130102 | 1g
Ambeed | Methyl 4-aminothiophene-3-carboxylate | 1g | 600833576 | A202435 | 69363-85-5 | MFCD00130102 | 157.190 | C6H7NO2S
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool<|a>
Medchemexpress LLC Lubeluzole dihydrochloride | 144665-09-8 | 99.0% | 506.44 | C22H27Cl2F2N3O2S | 1 MG
Lubeluzole dihydrochloride is the dihydrochloride salt of lubeluzole, a neuroprotective research reagent that modulates neuronal voltage-gated sodium and calcium channels. It is provided as a high-purity solid intended for in vitro and preclinical pharmacology studies.
- 99.0% HPLC purity.
- White to off-white solid appearance.
- Molecular weight 506.44 g/mol.
- Molecular formula C22H27Cl2F2N3O2S.
- Storage: -20°C (sealed); in solution store at -80°C for long-term.
- Suitable for neuroscience and pharmacology research applications.
Apexbio Technology LLC NVP-BSK805 2HCl 1092499-93-8 (free base) 50mg
NVP-BSK805 2HCl is a selective ATP-competitive inhibitor targeting Janus kinase 2 (JAK2) JAK2 part of the JAK kinase family mediates signaling through cytokine receptor systems including type II cytokine GM-CSF receptor gp130 and single-chain receptor families By competitively binding the ATP-binding site of JAK2 NVP-BSK805 inhibits downstream STAT5 phosphorylation and JAK-mediated signaling It displays greater than 20-fold selectivity for JAK2 versus other JAK family members (JAK1 JAK3 TYK2) Cell-based assays demonstrate antiproliferative activity against cells expressing JAK2V617F mutations NVP-BSK805 is commonly employed in vitro and in vivo to investigate JAK2-mediated cellular responses oncogenesis and associated signaling pathways