Carboximidamides
Medchemexpress LLC PIN1 inhibitor API-1 100mg | 680622-70-2 | 366.30 | C15H13F3N6O2 | 100 MG
PIN1 inhibitor API-1 is a small-molecule research compound that inhibits PIN1 activity and functions as a microRNA activator. It is supplied as a research-grade powder (100 mg) intended for preclinical in vitro and in vivo studies; consult the certificate of analysis and safety data sheet for storage, purity, and handling instructions.
- High purity: documented at about 99.6%.
- Molecular weight: 366.30; chemical formula: C15H13F3N6O2.
- High DMSO solubility: up to 250 mg/mL with ultrasonic assistance.
- Manufacturer provides in vivo formulation examples and solubility protocols.
- Data sheet and safety data sheet available for characterization and safe handling.
eMolecules 50-01-1 | Guanidine hydrochloride | Chem-Impex | MFCD00013026 | 95.530 | CH6ClN3 | 99.000 | Cl.NC(N)=N | 10kg | 342450114
Guanidine hydrochloride | Chem-Impex | 50-01-1 | MFCD00013026 | 95.530 | CH6ClN3 | 99.000 | Cl.NC(N)=N | 10kg | 342450114
Medchemexpress LLC BX430 | 688309-70-8 | 99.2% | 413.11 | 1 ML
BX430 is a potent and selective noncompetitive allosteric human P2X4 receptor channels antagonist with an IC50 of 0.54 μM. It exhibits species specificity and is used for chronic pain and cardiovascular disease.
- Has virtually no functional impact on all other P2X subtypes (P2X1-P2X3, P2X5, and P2X7).
- Potent antagonist of zebrafish P2X4.
- Reduces intracellular calcium rise evoked by ATP in human P2X4-expressing cells.
- Markedly reduces the amplitude of ATP-evoked intracellular calcium responses in THP-1 cells.
Medchemexpress LLC Guanidine-d5 hydrochloride | 108694-93-5 | MFCClD6N3 | 98% | 25 MG
Guanidine-d5 (hydrochloride) is the deuterium labeled Guanidine hydrochloride. Guanidine hydrochloride (Guanidinium chloride) is a strong chaotrope and also a strong denaturant of proteins.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules largely as tracers for quantitation during the drug development process.
- Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Yuanhuacine (Gnidilatidin) | 60195-70-2 | 1 MG
Yuanhuacine (Gnidilatidin), a diterpene from *Daphne genkwa*, is an effective and highly selective inhibitor of the basal-like 2 (BL2) subtype of TNBC. It can induce G2/M cell cycle arrest and exhibits broad anti-tumor activity. Yuanhuacine is an orally active DNA damaging agent.
- Highly selective inhibitor for the BL2 subtype of TNBC.
- Induces G2/M cell cycle arrest.
- Exhibits broad anti-tumor activity.
- Acts as an orally active DNA damaging agent.
- Inhibits proliferation in various cancer cell lines including H1993, H358, H460, Calu-1, H1299, A549, UMUC3, and HCT116.
- Downregulates mTOR activation.
- Inhibits migration of H1993 cells.
- Upregulates p21 transcription and protein expression by regulating Sp1 protein stability.
Medchemexpress LLC 11R-VIVIT | 592517-80-1 | 99.6% | 3573.15 | 1 MG
11R-VIVIT is a cell-permeable nuclear factor of activated T cells (NFAT) inhibitor. It can be used for the research of podocyte and diabetic nephropathy.
- Cell-permeable to inhibit NFAT activity
- Specifically targets and inhibits nuclear factor of activated T cells
- Useful for the study of podocyte and diabetic nephropathy
- Reduces NFAT2 expression in high glucose-treated podocytes in vitro
- Attenuates diabetic nephropathy symptoms and restores podocyte number in vivo
![Medchemexpress LLC 1-(4-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-3-methyl-1H-benzo[d]imidazol-2(3H)-one | 1121931-70-1 | 99.9% | C23H29N3O3 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000258307.png-250.jpg)
Medchemexpress LLC 1-(4-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-3-methyl-1H-benzo[d]imidazol-2(3H)-one | 1121931-70-1 | 99.9% | C23H29N3O3 | 10MG
CM398 is a selective, orally active sigma-2 receptor ligand used for receptor pharmacology and in vivo pain models. It has been characterized for receptor affinity and shows anti-inflammatory analgesic effects in preclinical studies.
- High potency and selectivity for sigma-2 receptor (Ki = 0.43 nM).
- Demonstrated efficacy in the formalin inflammatory pain model.
- High purity suitable for research applications (99.85%).
- Soluble in DMSO (100 mg/mL); supports multiple in vivo formulation options.
- Stable under recommended storage conditions for long-term use.
Matrix Scientific 1-METHYLGUANIDINE HYDROCHLOR-5
1-methylguanidine Hydrochloride Mf C2h8cln3 Mw 109.56 Cas 21770-81-0 Mdl MFCD00012576
![Medchemexpress LLC Pyrrolo[3,4-b]pyrrole-5(1H)-carboxamide, N-[4-[(3-ethynylphenyl)amino]-7-methoxy-6-quinazolinyl] | 1353644-70-8 | 99.7% | 442.51 g/mol | C25H26N6O2 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000243817.png-250.jpg)
Medchemexpress LLC Pyrrolo[3,4-b]pyrrole-5(1H)-carboxamide, N-[4-[(3-ethynylphenyl)amino]-7-methoxy-6-quinazolinyl] | 1353644-70-8 | 99.7% | 442.51 g/mol | C25H26N6O2 | 50 MG
Theliatinib is a potent, ATP-competitive, orally active, and highly selective epidermal growth factor receptor (EGFR) inhibitor provided for research use in preclinical biochemical and cell-based studies.
- Potent ATP-competitive EGFR inhibitor with low-nanomolar activity.
- High chemical purity (99.72%).
- Molecular weight 442.51 g/mol; formula C25H26N6O2.
- Soluble in DMSO (~1 mg/mL) with recommended warming and pH adjustment.
- Stable when stored under recommended powder and solution conditions.
- Suitable for studies of wild-type and mutant EGFR signaling.
Medchemexpress LLC Clonidine hydrochloride | 4205-91-8 | MFCD00036705 | 99.9% | 500 MG
Clonidine hydrochloride is an agonist of α2-adrenoceptor and a potent antihypertensive agent. It is intended for research use only.
- Agonist of α2-adrenoceptor
- Potent antihypertensive agent
- Induces CGRP mRNA expression
- Increases NO level in endothelial cells
- Decreases body temperature in rats
- Suppresses dopamine efflux in the prefrontal cortex
Medchemexpress LLC (+)-Columbianetin | 3804-70-4 | 246.26 | 5 MG
(+)-Columbianetin is an active compound that functions as an inhibitor of JNK and ERK, and an activator of TGFβ signaling. It effectively mitigates UVA-induced cellular damage by reducing phosphorylation of JNK and ERK, decreasing MMP-1 production, and reversing collagen degradation. Additionally, it provides protection against UVB-induced harm to human keratinocytes.
- Inhibits JNK and ERK pathways.
- Activates TGFβ signaling.
- Reduces MMP-1 production.
- Reverses UVA-induced collagen degradation.
- Alleviates UVA-mediated inhibition of Smad2/3 phosphorylation.
- Regulates AP-1 and ASK1-MAPK signaling pathways.
- Inhibits ROS production.
- Protects human keratinocytes against UVB-induced damage.
- Applicable for research related to skin aging.
Medchemexpress LLC Glycyrrhisoflavone | 116709-70-7 | 99.4% | 354.35 g·mol⁻¹ | C20H18O6 | 10 MG
Glycyrrhisoflavone is an active prenylflavonoid that inhibits α-glucosidase, provided as an analytical standard for research and analytical applications. It is supplied with defined purity and molecular characterization useful for assay development and analytical workflows.
- High purity of 99.43%.
- Provided as a 10 mg analytical standard.
- Useful as an α-glucosidase inhibitor in biochemical assays.
- Well-characterized molecular properties: C20H18O6, molecular weight 354.35 g·mol⁻¹.
- CAS number 116709-70-7 for unambiguous identification.
- For research use only; not for human or clinical use.
Medchemexpress LLC 11R-VIVIT | 592517-80-1 | 99.6% | 3573.15 | 10 MG
11R-VIVIT | 592517-80-1 | 99.6% | 3573.15 | 10 MG
Chem-Impex International, Inc. 2-tert-Butyl-1,3-diisopropylisourea | 71432-55-8 | MFCD06657672 | 1G
2-tert-Butyl-1,3-diisopropylisourea, 71432-55-8, MFCD06657672, 1G
Selleck Chemical LLC Clonidine HCl S2458-1g
Clonidine HCl(Kapvay) is a direct-acting 2 adrenergic agonist with an ED50 of 0 02 0 01 mg/kg