Flavonoids
TARGETMOL CHEMICALS INC TANGERETIN 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Tangeretin (NSC-618905) a flavonoid from citrus fruit peels has been proven to play an important role in anti-inflammatory responses and neuroprotective effects in several disease models and was also selected as a Notch-1 inhibitor. purity: 99%
Medchemexpress LLC Apigenin 7-O-glucuronide | 29741-09-1 | MFCD23699539 | >95.0% | 10 MG
Apigenin 7-O-glucuronide is a flavonoid glucuronide supplied as an analytical standard for research and analytical applications. It has reported inhibitory activity against matrix metalloproteinases, with IC50s of 12.87 μM (MMP-3), 22.39 μM (MMP-8), 17.52 μM (MMP-9), and 0.27 μM (MMP-13). CAS: 29741-09-1; molecular weight: 446.36 g/mol.
- Provided as a 10 mg analytical standard for research use only.
- Reported inhibitory activity against multiple MMP enzymes with published IC50 values.
- Chemical formula C21H18O11 and molecular weight 446.36 g/mol.
- Commonly used in biochemical and analytical assays to characterize apigenin metabolites.
Medchemexpress LLC Catechin | 154-23-4 | 290.27 | 5 MG
Catechin ((+)-Catechin) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM.
- 15+ Cited publications
- Also known as (+)-Catechin; Cianidanol; Catechuic acid
- Targeting COX apoptosis, influenza virus, and endogenous metabolite pathways
- Research area: Cancer
- Structural classification: Anti-aging, Camellia sinensis (L.) O. Ktze. plants, endogenous metabolite, flavonoids, sunscreen, flavanols, phenols, polyphenols
- Application fields: Cosmetic research, disease research fields
- Source classification: Theaceae
Medchemexpress LLC Apigenin | 520-36-5 | 270.24 | 5 MG
Apigenin (4',5,7-Trihydroxyflavone) is a competitive CYP2C9 inhibitor with a Ki of 2 μM. It inhibits cell proliferation in SGC-7901 cells in a dose- and time-dependent manner and possesses a broad spectrum of biological properties including antioxidative, anti-inflammatory, anticancer, and neuroprotective effects.
- Inhibits cell proliferation
- Suppresses clone formation of SGC-7901 cells
- Alleviates adriamycin-induced myocardial injury
- Reduces serum aspartate amino transferase release
- Reduces serum lactate dehydrogenase release
- Reduces serum creatine kinase contents
TARGETMOL CHEMICALS INC PINOCEMBRIN 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Pinocembrin (57-Dihydroxyflavanone) is a flavanone a type of flavonoid. It is an antioxidant found in damiana honey fingerroot and propolis. purity: 98%
TARGETMOL CHEMICALS INC APIGENIN-7-GLUCURONIDE 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Apigenin-7-glucuronide (Apigenin 7-O-glucuronide) possesses multiple activities including antioxidant anti-inflammatory and aldose reductase inhibitory activities it can inhibit MMP activities (IC50s 12.87 22.39 17.52 0.27 uM for MMP-3 MMP-8 MMP-9 MMP-13 respectively). purity: 99%
Sigma Aldrich Fine Chemicals Biosciences Luteolin 98 TLC powder50MG
Luteolin (3AE 4AE 5AE 7AE-tetrahydroxyflavone) a polyphenolic compound belongs to flavones subclass of flavonoids. Luteolin is commonly found in plants like celery green peppers and chamomile tea. Luteolin is one of the major flavonoids present in the flower extract of Hieracium pannosum Boiss aerial part of Dracocephalum kotschyi and contributes to the antioxidant potential of the plant. Luteolin possesses antioxidant anti-inflammatory properties and exerts anti-tumor potential primarily through apoptosis. Luteolin exerts its apoptotic activity through downregulation of protein kinase B (Akt) pathway leading to caspase mediated apoptosis. Luteolin also resensitizes cancer cells to therapeutics. Luteolin regulates the inflammatory genes and reduces nitric oxide and inflammatory cytokine production. The anti-inflammatory property of luteolin implicates it as a potential therapeutic agent for the neurodegenerative disease like Alzheimer disease. In plants luteolin induces nodu
Medchemexpress LLC Luteolin 7-O-glucuronide | 29741-10-4 | 462.36 | 1 MG
Luteolin 7-O-glucuronide inhibits Matrix Metalloproteinases (MMP) activities, with IC50s of 17.63, 7.99, 11.42, 12.85, and 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, and MMP-13, respectively. It also inhibits NO production and mRNA expression of inflammatory mediators (COX-2, IL-6, IL-1β, and TNF-α) as well as NF-κB, p38, and JNK activation in LPS-stimulated RAW 264.7 macrophages. In a mouse sleep deprivation model, this compound improved depression-like and stress coping behaviors.
- Inhibits matrix metalloproteinases (MMPs) activities.
- Reduces NO production and inflammatory mediators.
- Inhibits NF-κB, p38, and JNK activation.
- Improves depression-like and stress coping behaviors.
- Suitable for in vitro and in vivo studies.
Medchemexpress LLC Myricetin 3-O-α-L-arabinopyranoside | 132679-85-7 | 450.35 | 1 MG
Myricetin 3-O-α-L-arabinopyranoside is a quercetin derivative and plant flavonoid. It has antioxidant, antibacterial, and antiurease effects.
- Inhibits A2E photooxidation-induced RPE cell death
- Protective against retinal degeneration
- Protects against blue light-induced damage in RPE cells and mouse models
Medchemexpress LLC Catechin | 154-23-4 | 290.27 | 10 MM 1 ML
Catechin ((+)-Catechin) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. It exhibits potent inhibitory activity against COX-1 and can induce apoptosis in certain cancer cells. Catechin has also shown a dose-dependent reduction in cell viability and an increase in apoptosis markers in vitro. In animal studies, it has demonstrated the ability to prevent episodic memory deficits.
- Inhibits cyclooxygenase-1.
- Reduces cell viability in a dose-dependent manner.
- Increases the induction of apoptosis.
- Prevents time-induced episodic memory deficits.
Medchemexpress LLC Catechin 7-O-β-D-glucopyranoside | 65597-47-9 | 452.41 | 1 MG
Catechin 7-O-β-D-glucopyranoside is an orally active natural product found in Ulmus davidiana and Paeonia obovata. It demonstrates antioxidant and anti-inflammatory activities, and mitigates mitochondrial dysfunction. This product can be utilized in research pertaining to intestinal inflammatory diseases.
- Exhibits antioxidant and anti-inflammatory activities
- Attenuates mitochondrial dysfunction
- Protective effect against Streptozotocin-induced cell damage
- Mild protective effect against LPS/D-GalN induced lethality in mice
- Prevents intestinal inflammatory damages in rat colitis models
Medchemexpress LLC Gallocatechin gallate | 5127-64-0 | 5 MG
Gallocatechin gallate is a flavonoid product isolated from the herbs of Celastrus orbiculatus. This chemical compound is provided as a solid, typically white to off-white in appearance, with a purity of 98%.
- Molecular weight: 458.37
- Chemical formula: C22H18O11
- Recommended storage at -20°C, sealed, away from moisture and light
- In solvent storage at -80°C for 6 months or -20°C for 1 month
- For research use only
TARGETMOL CHEMICALS INC ASTILBIN 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Astilbin (Neoastilbin) is actions Flavonoid phytochemical found in St. John′s wort and Traditional Chinese Medicine herbal preparations. purity: 99%
Medchemexpress LLC 7-Hydroxyflavone | 6665-86-7 | 10 MG
7-Hydroxyflavone is a flavonoid isolated from *Clerodendrum phlomidis* with anti-inflammatory activity. It protects renal cells from nicotine (NIC)-associated cytotoxicity via the ERK/Nrf2/HO-1 pathway. This compound inhibits PKM2 with an IC50 of 2.12 μM and also inhibits COX-2 and 5-LOX with IC50s of 27 μg/mL and 33 μg/mL, respectively. 7-Hydroxyflavone is orally active.
- Isolated from *Clerodendrum phlomidis*.
- Exhibits anti-inflammatory activity.
- Protects renal cells from nicotine-associated cytotoxicity.
- Inhibits PKM2, COX-2, and 5-LOX.
- Orally active.
- Inhibits EV71 3C protease and viral replication.
- Antioxidant properties: decreases MDA and ROS, increases SOD and GSH.
- Ameliorates ischemia/reperfusion injury and neuropathic pain.
- Improves hepatic steatosis and regulates blood glucose metabolism in NAFLD models.