Flavonoids
Medchemexpress LLC Luteolin 7-O-glucuronide | 29741-10-4 | 462.36 | 5 MG
Luteolin 7-O-glucuronide is a compound that inhibits Matrix Metalloproteinases (MMP) activities, with specific IC50 values for MMP-1, MMP-3, MMP-8, MMP-9, and MMP-13. It also demonstrates biological activity by inhibiting NO production and the mRNA expression of various inflammatory mediators, as well as NF-κB, p38, and JNK activation in LPS-stimulated RAW 264.7 macrophages. In vivo studies suggest it can improve depression-like and stress coping behaviors in sleep-deprived mice models.
- Inhibits matrix metalloproteinases (MMPs) activities
- Inhibits NO production in LPS-stimulated RAW 264.7 macrophages
- Reduces mRNA expression of inflammatory mediators
- Suppresses NF-κB, p38, and JNK activation
- Improves depression-like and stress coping behaviors in sleep deprivation models
- Decreases immobility time and plasma corticosterone levels
- Enhances BDNF mRNA expression in the hippocampus
Cayman Chemical ApIgenIn 7-glucosIde 25mg
A flavonoid with anti-inflammatory and anxiolytic activities; inhibits LPS-induced nitric oxide production in RAW 264.7 cells from 0.16-10 μM; reduces pulmonary edema and lung inflammation in a mouse model of LPS-induced acute lung injury at 10 mg/kg; increases the number of entries and the time spent in the open arms of the elevated plus maze in rats
Medchemexpress LLC (-)-Epicatechin gallate (standard) | 1257-08-5 | 442.37 | 1 MG
(-)-Epicatechin gallate (Standard) is the analytical standard of (-)-Epicatechin gallate. This product is intended for research and analytical applications. It inhibits cyclooxygenase-1 (COX-1) with an IC50 of 7.5 μM, and is a GLUT1 and GLUT5 inhibitor, decreasing cell growth of GLUT5-expressing hxt 0 yeast cells.
- Targets: COX, autophagy, virus protease, GLUT
- Research areas: Infection, cancer
- Structural classification: Flavonoids, flavanols, phenols, polyphenols
- Source classification: *Camellia sinensis* (L.) O. Ktze. plants, Theaceae
Medchemexpress LLC Luteolin 5-O-glucoside | 20344-46-1 | 448.38 | 25 MG
Luteolin 5-O-glucoside is a major flavonoid found in *Cirsium maackii* that exhibits anti-inflammatory activity. It is effective in inhibiting LPS-induced NO production and t-BHP-induced ROS generation, and it also suppresses the expression of iNOS and COX-2 in macrophages.
- Inhibits LPS-induced NO production
- Suppresses expression of iNOS and COX-2
- Inhibits t-BHP-induced ROS generation
- Appears as a light yellow to yellow solid
Medchemexpress LLC Luteolin monohydrate | 6113-16-2 | MFCD00017309 | 99.1% | 304.25 g/mol | C15H12O7 | 250 MG
Luteolin monohydrate is the monohydrate form of luteolin, a naturally occurring flavonoid used in life-science research. It is reported to act as an Nrf2 pathway modulator and shows anti-inflammatory and anticancer activity in cellular studies. It is supplied as a solid and provided in small research quantities for biochemical assays and mechanistic investigations.
- Monohydrate form of luteolin
- Reported Nrf2 inhibitor and bioactive flavonoid
- High purity (99.13%)
- Available in small research quantities, e.g., 250 mg
- Storage: 4°C, sealed, away from moisture; in solution: -80°C (6 months)
Abcam Apigenin, Anticancer agent, 10MG
MW 270.24 Da, Purity >98%. Plant flavone. Antioxidant, anti-inflammatory and anticancer properties. Effects a wide range of molecular targets including caspases, fatty acid synthase, topoisomerase and nuclear factor-κB.
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical Luteolin Inhibitors
A common dietary phenolic flavone; inhibits soybean and reticulocyte 15-lipoxygenases (IC50 = 0.6 µM); inhibits the release of TNFα from neutrophils; inhibits matrix metalloproteinases
TARGETMOL CHEMICALS INC Luteolin 7-diglucuronide 5MG
Also available in 1 mg, 10 mg, 25 mg, 50 mg and bulk. Please contact Fisher for quotes. Luteolin 7-diglucuronide, the major flavonoid isolated from Verbena officinalis and Aloysia triphylla. Purity 98.44%
TARGETMOL CHEMICALS INC Luteolin 500MG
Also available in 1 g, 1 mL, 10 mg, 50 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes. Luteolin (Luteolol) belongs to the flavonoid group of natural products and is a Nrf2 inhibitor, PDE inhibitor. Luteolin has a wide range of biological activities including antitumor, antioxidant, anti-inflammatory, antimicrobial, antiviral, antiallergic, and procoagulant. Purity 97.39%
Selleck Chemical LLC 4.7-Dimethoxy-5-Hydroxyflavone S3918-5mg
4 7-Dimethoxy-5-Hydroxyflavone (4 7-dimethylapigenin apigenin dimethylether apigenin 7 4 -dimethyl ether) inhibits -glucosidase and -amylase enzymes and enhances 2-NBDG uptake in L6 cells
Indofine Chemical Epicatechin With Hplc, 10 Mg
EPICATECHIN with HPLC 10 MG, Herbal Standards, 3,5,7,3',4'-Pentahydroxyflavan, C15H14O6, MW: 290.28, 99% by HPLC, 490-46-0, MFCD00075648
Selleck Chemical LLC Luteolin S2320-1g
Luteolin (Luteoline Luteolol Digitoflavone) is a flavonoid found in Terminalia chebula which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15 0 M 6 4 M 13 9 M 11 1 M and 9 5 M respectively
Medchemexpress LLC (-)-Epigallocatechin Gallate (EGCG) | 989-51-5 | 99.75% | 458.37 | 10 MM * 1 ML
(-)-Epigallocatechin Gallate (EGCG) is a major polyphenol found in green tea. It can inhibit cell proliferation and induce cell apoptosis, and it inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity. EGCG possesses potent anticancer, antioxidant, and anti-inflammatory properties against various types of cancers such as colorectal cancer, myeloid leukemia, and thyroid carcinoma.
- Can inhibit cell proliferation and induce cell apoptosis.
- Inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity.
- Potent anticancer, antioxidant, and anti-inflammatory properties against various types of cancers such as colorectal cancer, myeloid leukemia, thyroid carcinoma.
Medchemexpress LLC Catechin ((+)-Catechin) | 154-23-4 | 290.27 | 25 MG
Catechin ((+)-Catechin) is an inhibitor of cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. It demonstrates a high purity of 99.30% and is used in various research applications, including those related to cancer, neuronal cytotoxicity, and episodic memory.
- Exhibits >95% inhibitory activity at 70 μg/mL against COX-1.
- Induces apoptosis in MCF-7 cells in a dose- and time-dependent manner.
- Prevents time-induced episodic memory deficits in Wistar rats.
- Shows anti-inflammatory and antiaggregatory activities.
- Demonstrates antiviral activity against HIV1 3B infected human H9 cells.