Olopatadine hydrochloride is a second-generation selective histamine H1-receptor antagonist and a potent anti-allergic drug with mast cell stabilizing and anti-histamine properties. It is primarily used for the treatment of allergic conjunctivitis and allergic rhinitis. It significantly inhibits ear swelling and the production of several interleukins (IL-4, IL-1beta, IL-6), GM-CSF, and NGF in lesioned ears. It is rapidly absorbed and inhibits histamine release from human conjunctival mast cells in vitro.
- Second-generation selective histamine H1-receptor antagonist
- Potent anti-allergic drug
- Mast cell stabilizing and anti-histamine properties
- Used to treat allergic conjunctivitis and allergic rhinitis
- Inhibits ear swelling and production of IL-4, IL-1beta, IL-6, GM-CSF, and NGF
- Rapidly absorbed in healthy human volunteers
- Inhibits histamine release from human conjunctival mast cell preparations in vitro