Phenols
Medchemexpress LLC Polyethylene glycol 8000 | 25322-68-3 | MFCD00081839 | 99.9% | Average molecular weight ≈8,000 g/mol | H(OCH2CH2)nOH | 100g
PEG8000 can be used for phage precipitation isolation of plasmid DNA and promotion of flat end-junction reactions[1]
Medchemexpress LLC Afm32a hydrochloride | 2988594-85-8 | 99.7% | 517.00 g/mol | C25H30ClFN6O3 | 5 MG
AFM32a hydrochloride is a benzimidazole-derived small-molecule inhibitor selective for protein arginine deiminase 2 (PAD2). Supplied as the hydrochloride salt for research use, it is suitable for biochemical assays and target validation, demonstrating approximately 95-fold selectivity for PAD2 versus PAD4 and 79-fold versus PAD3.
- Potent PAD2 inhibition with high selectivity over PAD3 and PAD4.
- Hydrochloride salt form for improved solubility and handling.
- High purity (≈99.7%) appropriate for biochemical assays.
- Available in small-mass and DMSO solution formats for screening.
- Characterized with molecular formula and molecular weight for analytical use.
Medchemexpress LLC MELK-8a hydrochloride | 2096992-20-8 | 99.3% | 469.02 g/mol | C25H33ClN6O | 25 MG
MELK-8a hydrochloride is a potent small-molecule inhibitor of maternal embryonic leucine zipper kinase (MELK) with a reported IC50 of 2 nM. Supplied as the hydrochloride salt with high chemical purity, it is intended for research use in biochemical and cellular studies targeting MELK-dependent pathways.
- Potent MELK inhibition with an IC50 of 2 nM.
- Hydrochloride salt for improved stability and handling.
- High purity suitable for biochemical and cellular assays.
- Molecular weight 469.02 g/mol and formula C25H33ClN6O.
- Soluble in DMSO; solution formats available for convenient dosing.
- Intended for research use only; not for human or diagnostic use.
Medchemexpress LLC Riluzole hydrochloride | 850608-87-6 | 99.87% | 1 G
Riluzole hydrochloride is an anticonvulsant agent that acts as a use-dependent Na+ channel blocker. It can also inhibit GABA uptake with an IC50 of 43 μM.
- Anticonvulsant agent
- Use-dependent Na+ channel blocker
- Can inhibit GABA uptake
- Inhibits peak autaptic IPSCs and prolongs IPSCs at 20 μM
- Causes a strong, concentration-dependent, readily reversible enhancement of responses to 2 μM GABA
Medchemexpress LLC Pirmenol hydrochloride | 61477-94-9 | MFCD01691662 | 98.8% | 374.95 g·mol⁻¹ | C22H31ClN2O | 100 MG
Pirmenol hydrochloride is an orally active antiarrhythmic research compound used in pharmacology and electrophysiology studies. It inhibits IK.ACh currents by blocking muscarinic acetylcholine receptors and is provided as a high-purity solid for laboratory research use.
- Orally active compound suitable for cellular and in vivo studies.
- Reported to inhibit IK.ACh with IC50 ≈ 0.1 μM.
- High purity solid for reproducible experimental results.
- Available in small-quantity packages appropriate for research workflows.
- Intended for laboratory research; not for human or diagnostic use.
Medchemexpress LLC CC-115 hydrochloride | 1300118-55-1 | 98.01% | 372.81 | 1 ML
CC-115 hydrochloride is a potent, dual DNA-PK and mTOR kinase inhibitor. It targets both mTORC1 and mTORC2 signaling, making it a valuable tool for research applications. This compound has demonstrated significant inhibitory effects against PC-3 cell proliferation and exhibits good in vivo pharmacokinetic profiles, including high oral bioavailability in various animal models.
- Potent DNA-PK inhibitor (IC50 of 13 nM)
- Potent mTOR kinase inhibitor (IC50 of 21 nM)
- Blocks both mTORC1 and mTORC2 signaling
- Inhibits PC-3 cell proliferation with an IC50 of 138 nM
- Exhibits good in vivo pharmacokinetic profiles
- Demonstrates high oral bioavailability in mouse, rat, and dog
- Sustains inhibition through 24 hours
- Shows tumor volume reductions in vivo studies
Medchemexpress LLC Dc-chol hydrochloride | 166023-21-8 | 99.9% | 537.26 | 50 MG
DC-Chol hydrochloride is a cationic lipid that can inhibit Aβ40 fibril formation and amyloidogenesis. It enhances the body's immune response by inducing Th1 (IL-2 and IFN-γ) and Th2 (IL-5) cytokines, making it suitable for various research applications.
- Inhibits Aβ40 fibril formation and amyloidogenesis.
- Induces Th1 and Th2 cytokine production to enhance immune response.
- Used as a gene delivery vector.
- Utilized in research for hepatitis B vaccines to improve vaccine immunity.
Medchemexpress LLC ZLN024 hydrochloride | 1883548-91-1 | 98.5% | 361.69 | 100 MG
ZLN024 hydrochloride is an allosteric activator of AMPK. It directly activates recombinant AMPK α1β1γ1, AMPK α2β1γ1, AMPK α1β2γ1, and AMPK α2β2γ1 heterotrimers.
- Allosterically stimulates active AMPK heterotrimers and inactive α1 subunit truncations.
- AMPK activation requires pre-phosphorylation of Thr-172 and protects AMPK Thr-172 against dephosphorylation by PP2Cα.
- Activates AMPK in L6 myotubes, stimulating glucose uptake and fatty acid oxidation without increasing the ADP/ATP ratio.
- Increases the activity of α1β1γ1 by 1.5-fold (EC50 of 0.42 μM), α2β1γ1 by 1.7-fold (EC50 of 0.95 μM), α1β2γ1 by 1.7-fold (EC50 of 1.1 μM), and α2β2γ1 by 1.6-fold (EC50 of 0.13 μM).
- Improves glucose tolerance in C57BKS db/db mice after 4 weeks of treatment.
- Reduces fasting blood glucose by 15%, liver tissue weight, triacylglycerol, and total cholesterol content in mice.
BIOHIPPO Di-Methyllysine Rabbit mAb
U-Blot Pan-Di-Methyllysine Rabbit mAb is a Rabbit-derived monoclonal antibody that specifically recognizes Di-Methyllysine a lysine di-methylation modification at -amino group (N ) of the lysine (Lys K) side chain Di-Methyllysine (Kme2) is a crucial reversible post-translational modification of proteins which occurs on the -amino group of lysine residues including symmetric and asymmetric dimethylation forms It is widely distributed in histones and non-histone proteins and participates in regulating chromatin remodeling gene transcription RNA splicing DNA damage repair cell cycle progression and signal transduction Aberrant lysine dimethylation is closely associated with tumorigenesis inflammation neurodegeneration and metabolic disorders serving as a vital biomarker for epigenetic and pathological research Supplied as 100 uL
eMolecules 504-07-4 | hexahydropyrimidine-2,4-dione | Synthonix | MFCD00006029 | 114.104 | C4H6N2O2 | 97.000 | O=C1CCNC(=O)N1 | 25g | 808576089
hexahydropyrimidine-2,4-dione | Synthonix | 504-07-4 | MFCD00006029 | 114.104 | C4H6N2O2 | 97.000 | O=C1CCNC(=O)N1 | 25g | 808576089
Aobchem Tetrahydro-4-(8-hydroxy-1 4-dioxaspiro[4 5]dec-8-yl)-2H-pyran-4-carbonitrile | 95% | CAS 1521009-01-7 | C14H21NO4 | 5g
Tetrahydro-4-(8-hydroxy-1 4-dioxaspiro[4 5]dec-8-yl)-2H-pyran-4-carbonitrile | 95% | CAS 1521009-01-7 | C14H21NO4 | 5g
eMolecules 161265-03-8 | Xantphos | Ambeed | MFCD00233866 | 578.632 | C39H32OP2 | 98.000 | CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(cccc12)P(c1ccccc1)c1ccccc1 | 25g | 552589291
Xantphos | Ambeed | 161265-03-8 | MFCD00233866 | 578.632 | C39H32OP2 | 98.000 | CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(cccc12)P(c1ccccc1)c1ccccc1 | 25g | 552589291
Medchemexpress LLC Melamine | 108-78-1 | MFCD00006055 | 126.12 g/mol | C3H6N6 | 1000g
Melamine is an orally active inducer of Apoptosis Melamine induces animal disease models Melamine affects the activity of Sertoli cell and can be used for research on male reproductive function Melamine also has neurotoxicity and nephrotoxicity Melamine induces cognitive impairment and acute kidney injury models Melamine can also be used to induce bladder cancer and urinary stone models[1][2][3][4][5][6]
Medchemexpress LLC DI-1859 | 2247061-09-0 | 99.6% | C30H45N5O3S | 1 ML
DI-1859 is a potent, selective, and covalent inhibitor of DCN1. It inhibits neddylation of cullin 3 in cells at low nanomolar concentrations. DI-1859 increases NRF2 protein, a CRL3 substrate, in mouse liver and protects mice from acetaminophen-induced liver damage.
- Potent, selective, and covalent inhibitor of DCN1
- Inhibits neddylation of cullin 3 in cells
- Increases NRF2 protein in mouse liver
- Protects mice from acetaminophen-induced liver damage
- For research use only