Phenols
Medchemexpress LLC GSK 1562590 (hydrochloride) | 1003878-07-6 | 99.0% | 617.95 | 50 MG
GSK 1562590 hydrochloride is a high affinity and selective antagonist of urotensin-II receptor (UT), with pKis of 9.14-9.66 for mammalian recombinant (mouse, rat, cat, monkey, human) and native UT.
- High affinity and selective antagonist of urotensin-II receptor (UT).
Medchemexpress LLC Levomilnacipran hydrochloride | 175131-60-9 | 99.95% | 100 MG
Levomilnacipran hydrochloride is the enantiomer of Milnacipran and a strong P-gp substrate capable of crossing the blood-brain barrier. It acts as a serotonin and norepinephrine reuptake inhibitor, demonstrating antidepressant and anxiolytic activities, making it suitable for depression research.
- Strong P-gp substrate, able to cross the blood-brain barrier.
- Serotonin and norepinephrine reuptake inhibitor.
- Exhibits antidepressant and anxiolytic activities.
- Used for research on depression.
- Ameliorates depression-like behaviors in rat models.
- Improves neuronal synaptic deficits and morphological changes.
- Upregulates synaptic-related proteins like PSD-95 and Syn.
- Activates the BDNF/TrkB mediated PI3K/Akt/mTOR signaling pathway.
- Suppresses neuroinflammation.
Medchemexpress LLC Olopatadine hydrochloride | 5 MG
Olopatadine hydrochloride is a second-generation selective histamine H1-receptor antagonist and a potent anti-allergic drug with mast cell stabilizing and anti-histamine properties. It is primarily used for the treatment of allergic conjunctivitis and allergic rhinitis. It significantly inhibits ear swelling and the production of several interleukins (IL-4, IL-1beta, IL-6), GM-CSF, and NGF in lesioned ears. It is rapidly absorbed and inhibits histamine release from human conjunctival mast cells in vitro.
- Second-generation selective histamine H1-receptor antagonist
- Potent anti-allergic drug
- Mast cell stabilizing and anti-histamine properties
- Used to treat allergic conjunctivitis and allergic rhinitis
- Inhibits ear swelling and production of IL-4, IL-1beta, IL-6, GM-CSF, and NGF
- Rapidly absorbed in healthy human volunteers
- Inhibits histamine release from human conjunctival mast cell preparations in vitro
Medchemexpress LLC Milnacipran hydrochloride | 101152-94-7 | 99.7% | 10 MM x 1 ML
Milnacipran hydrochloride is an orally active Serotonin and Norepinephrine reuptake inhibitor. It inhibits monoamine transporters, specifically the norepinephrine transporter and the serotonin transporter (Ki values of 31 and 8.5 nM, respectively). It also inhibits pERK1/2 activation.
- Antidepressant, anxiolytic, and analgesic properties.
- Inhibits biting behavior in mice.
- Can be used in the study of major depressive disorder, anxiety disorders, and neuropathic pain (e.g., fibromyalgia).
Medchemexpress LLC Milnacipran hydrochloride | 101152-94-7 | 99.7% | 50 MG
Milnacipran hydrochloride is an orally active Serotonin and Norepinephrine reuptake inhibitor. It inhibits monoamine transporters, specifically the norepinephrine transporter and the serotonin transporter. It also inhibits pERK1/2 activation and possesses antidepressant, anxiolytic, and analgesic properties. Milnacipran hydrochloride has been shown to inhibit biting behavior in mice and is used in the study of major depressive disorder, anxiety disorders, and neuropathic pain, including fibromyalgia.
Medchemexpress LLC Cyclobenzaprine hydrochloride | 6202-23-9 | 99.9% | 5 G
Cyclobenzaprine (MK130) hydrochloride is an orally active 5-HT2 receptor antagonist that acts centrally to provide skeletal muscle relaxation, alleviate muscle spasms, and reduce pain. It also exhibits antiparasitic activity and is considered promising for research into acute, painful skeletal muscle disorders and infectious diseases.
- Orally active 5-HT2 receptor antagonist
- Acts centrally to provide skeletal muscle relaxation
- Alleviates muscle spasms
- Reduces pain
- Exhibits antiparasitic activity
- Suitable for research into acute, painful skeletal muscle disorders
- Suitable for research into infectious diseases
Medchemexpress LLC SDZ 220-581 (hydrochloride) | 179411-93-9 | 50 MG
SDZ 220-581 hydrochloride is an orally active, potent, competitive NMDA receptor antagonist with a pKᵢ value of 7.7. It protects mice against maximal electroshock seizures (MES) in a dose-dependent manner, exhibiting a rapid onset and long duration of action upon oral administration. It targets iGluR, a membrane transporter/ion channel involved in neuronal signaling.
- Mechanism of action: Competitive NMDA receptor antagonist.
- Key features: Orally active, potent.
- Target: iGluR (NMDA receptor).
- Research application: Protection against maximal electroshock seizures (MES).
Medchemexpress LLC Maprotiline hydrochloride (Standard) | 10347-81-6 | 99.9% | 5 MG
Maprotiline hydrochloride (Standard) is the analytical standard of Maprotiline (hydrochloride). It is a highly selective noradrenergic reuptake inhibitor with strong antidepressant, antitumor, and neuropathic pain-relieving effects. It induces cancer cell apoptosis by targeting the ERK signaling pathway and CRABP1. This compound is an analytical standard used for qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
- Highly selective noradrenergic reuptake inhibitor
- Strong antidepressant effects
- Antitumor effects
- Neuropathic pain-relieving effects
- Induces cancer cell apoptosis by targeting the ERK signaling pathway and CRABP1
- Used as an analytical standard for qualitative, quantitative, and methodological research experiments
Medchemexpress LLC Propafenone hydrochloride | 34183-22-7 | 98.5% | 5 G
Propafenone hydrochloride, also known as SA-79 hydrochloride, is an anti-arrhythmic medication used to treat illnesses involving rapid heartbeats such as atrial and ventricular arrhythmias. It functions by slowing the influx of sodium ions into cardiac muscle cells, thereby decreasing their excitability. Propafenone is more selective for cells with a high rate and blocks normal cells more effectively than Class Ia or Ib antiarrhythmics. Unlike typical Class Ic antiarrhythmics, it also exhibits beta-adrenergic blocker activity, which can lead to bradycardia and bronchospasm.
- More selective for cells with a high rate
- Blocks normal cells more effectively than Class Ia or Ib antiarrhythmics
- Exhibits beta-adrenergic blocker activity
Medchemexpress LLC Oxyphencyclimine hydrochloride | 125-52-0 | 99.6% | 50 MG
Oxyphencyclimine hydrochloride is a new tertiary amine that has been investigated for its effects on the peripheral parasympathetic system. It is provided as a white to off-white solid and is soluble in DMSO at concentrations of ≥ 30 mg/mL. This product is intended for research use only.
- Investigated for effects on the peripheral parasympathetic system
- Molecular weight: 380.91
- Formula: C20H29ClN2O3
- Appearance: White to off-white solid
- Solubility: Soluble in DMSO at concentrations of ≥ 30 mg/mL
- Storage (powder): 4°C, sealed, away from moisture and light
- Storage (in solvent): -80°C for 6 months; -20°C for 1 month
- Related signaling pathways include GPCR/G protein, neuronal signaling, and mAChR
- Classified as a muscarinic acetylcholine receptor (mAChR) antagonist
Medchemexpress LLC Tetrahydrozoline hydrochloride (Tetryzoline hydrochloride) | 522-48-5 | 99.9% | 1 ML
Tetrahydrozoline hydrochloride is an alpha-adrenergic agonist and a derivative of imidazoline that causes vasoconstriction. It is widely used in research for nasal congestion and conjunctival congestion, and induces the synthesis of collagen types I and III in primary human gingival fibroblasts. This product is for research use only.
- Causes vasoconstriction
- Used in research for nasal congestion
- Used in research for conjunctival congestion
- Induces the synthesis of collagen types I and III in primary human gingival fibroblasts
- Functions as an alpha-adrenergic agonist
Medchemexpress LLC Methoxamine hydrochloride | 61-16-5 | 99.32% | 1 ML
Methoxamine hydrochloride is a selective alpha1-adrenergic receptor agonist. It causes vasoconstriction and increased peripheral vascular resistance. It also significantly increased the overflow of ATP, ADP, and AMP, but not adenosine, via a prazosin-sensitive mechanism in the rabbit pulmonary artery.
- Selective alpha1-adrenergic receptor agonist
- Causes vasoconstriction
- Increases peripheral vascular resistance
- Significantly increases the overflow of ATP, ADP, and AMP (but not adenosine)
- Acts via a prazosin-sensitive mechanism in the rabbit pulmonary artery
eMolecules 23761-23-1 | 3-Oxo-Cyclobutanecarboxylicacid | AA Blocks LLC | MFCD00100900 | 114.100 | C5H6O3 | 0.000 | OC(=O)C1CC(=O)C1 | 10g | 410165109
3-Oxo-Cyclobutanecarboxylicacid | AA Blocks LLC | 23761-23-1 | MFCD00100900 | 114.100 | C5H6O3 | 0.000 | OC(=O)C1CC(=O)C1 | 10g | 410165109
Medchemexpress LLC 1,3-bis(carboxyethoxy)-2,2-bis(carboxyethoxy)propane | 35638-19-8 | >98% | C17H28O12 | 25 G
1,3-bis(carboxyethoxy)-2,2-bis(carboxyethoxy)propane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This product is for research use only.
- PEG-based PROTAC linker
- Can be used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
Medchemexpress LLC Flibanserin hydrochloride (propan-2-ol) hydrate | 99.0% | C20H22ClF3N4O.0.5C3H8O.0.5H2O | 5 MG
Flibanserin hydrochloride (propan-2-ol) hydrate is an orally active serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist. It demonstrates anti-depression and anti-anxiety effects and is used in research for hypoactive sexual desire disorder (HSDD).
- Orally active serotonin 5-HT1A receptor agonist
- Serotonin 5-HT2A receptor antagonist
- Binds to dopamine D4 receptors
- Exhibits anti-depression and anti-anxiety effects
- Used in research for hypoactive sexual desire disorder (HSDD)
- Shows no toxicity potential after oxidative degradation in vitro
- Activates brain regions involved in sexual motivation
- Produces anxiolytic effects without locomotor side effects in rat models