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Methoxyacetic acid is a metabolite of ethylene glycol monomethyl ether When the concentration of methoxyacetic acid reaches a certain level it can inhibit the respiratory function of hepatic mitochondria and testicular mitochondria Methoxyacetic acid is somewhat toxic[1][2]
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Amino-PEG2-C2-acid (CAS 791028-27-8) is a bifunctional polyethylene glycol (PEG)-based linker featuring both amino and carboxyl functional groups It is primarily utilized in the synthesis of antibody-drug conjugates (ADCs) facilitating the covalent attachment of active pharmaceutical molecules to antibodies By introducing a short hydrophilic PEG spacer Amino-PEG2-C2-acid can enhance solubility and modulate the pharmacokinetic properties of conjugated compounds The compound s dual reactivity enables efficient conjugation strategies in biomedical research and drug development
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Amino-PEG3-C2-acid is a bifunctional PEG-based linker with terminal amino and carboxylic acid groups, designed for conjugation chemistry in PROTAC and antibody-drug conjugate synthesis. Intended for research use only.
Short PEG spacer with three ethylene glycol units.
Terminal amino and carboxylic acid functional groups.
Suitable for PROTAC and ADC linker synthesis.
High purity (99.94%).
Available in pack sizes including 1 g.
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Acid-PEG3-SS-PEG3-acid is a cleavable six-unit polyethylene glycol (PEG) linker used in the synthesis of antibody-drug conjugates (ADCs). The molecule has carboxylic acid termini that enable amide-coupling bioconjugation and a disulfide (SS) linkage that allows intracellular cleavage under reducing conditions.
Cleavable six-unit PEG linker
Carboxylic acid termini for amide coupling
Disulfide (SS) cleavable linkage for intracellular release
Supplied in multiple pack sizes for research use
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Acid-PEG2-SS-PEG2-acid is a cleavable four-unit polyethylene glycol (PEG) linker used to synthesize antibody-drug conjugates (ADCs). It contains an internal disulfide bond that enables intracellular cleavage and release of conjugated payloads, and acid termini suitable for conjugation chemistry.
Provides cleavable disulfide linkage for intracellular release.
Four-unit PEG spacer increases solubility and flexibility.
Acid termini enable conjugation to carboxyl-reactive chemistries.
Suitable for ADC synthesis and bioconjugation research.
Available in small pack sizes for research use.
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Amino-PEG10-OH is a 10-unit polyethylene glycol (PEG) linker with a terminal amino group and a hydroxyl group, used as a non-cleavable, hydrophilic spacer in antibody-drug conjugate and PROTAC synthesis to improve solubility and control spacing between functional moieties.
Non-cleavable 10-unit PEG spacer suitable for ADC and PROTAC chemistry.
Terminal amino and hydroxyl groups enable versatile conjugation chemistries.
Enhances aqueous solubility of conjugates.
Provides a predictable linker length for spatial control.
Available in small-scale quantities for laboratory research.
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This cleavable six-unit polyethylene glycol (PEG) linker is designed for the synthesis of antibody-drug conjugates (ADCs). It contains a central disulfide bond flanked by PEG3 spacers and terminating carboxylic acid groups, enabling conjugation to payloads and reductive intracellular release.
cleavable disulfide (SS) bond for controlled payload release.
six-unit PEG scaffold increases solubility and flexibility.
terminal carboxylic acid groups enable standard conjugation chemistries.
suitable for antibody-drug conjugate (ADC) and bioconjugation workflows.
provided in multiple small pack sizes for research use.
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Amino-PEG9-acid is a polyethylene glycol (PEG)-based linker with a terminal amino group and a carboxylic acid, used as a PROTAC linker and as a non-cleavable ADC linker for antibody-drug conjugates. It provides a hydrophilic spacer useful for conjugation chemistry in bioconjugation and linker design.
Is a PEG-based PROTAC linker.
Can be used in the synthesis of PROTACs.
Functions as a non-cleavable ADC linker for antibody-drug conjugates.
Provides a hydrophilic spacer with terminal amino and carboxylic acid groups.
Available in multiple package sizes, including 1 g for lab-scale work.
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Amino-PEG2-C2-acid is a cleavable three-unit polyethylene glycol (PEG) linker intended for research use in the synthesis of antibody-drug conjugates (ADCs) and PROTACs. It provides an amino-functionalized PEG spacer with a terminal propanoic acid group that facilitates conjugation chemistry and linker optimization in bioconjugation workflows.
Cleavable three-unit PEG spacer suitable for ADC and PROTAC synthesis.
Amino-functionalized for straightforward conjugation chemistry.
Terminal carboxylic acid enables diverse coupling strategies.
Reported high purity supports research applications.
Available in multiple package sizes, including a 500 mg option.
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Acid-PEG3-SS-PEG3-acid is a cleavable six-unit polyethylene glycol (PEG) linker that contains a central disulfide bond and terminal carboxylic acid groups. It is designed as a bioreducible spacer for use in the synthesis of antibody-drug conjugates (ADCs), providing hydrophilicity and a site for conjugation chemistry.
Cleavable disulfide (SS) linkage for intracellular payload release.
Two PEG3 units provide hydrophilicity and spacer length.
Terminal carboxylic acids enable common conjugation chemistries.
Molecular weight 474.59 g·mol⁻¹ and formula C18H34O10S2.
Available in small research quantities suitable for ADC development.
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Amino-PEG9-acid is a polyethylene glycol (PEG)-based linker used in the synthesis of proteolysis targeting chimeras (PROTACs) and as a non-cleavable linker for antibody-drug conjugates (ADCs). It is typically supplied as a solid with high purity for use in linker chemistry and bioconjugation applications.
PEG-based linker with an amino terminus and a terminal carboxylic acid.
Suitable for PROTAC and ADC synthesis and other bioconjugation reactions.
High purity, suitable for research and synthetic chemistry applications.
Soluble in common organic solvents and aqueous mixtures for coupling reactions.
Available in multiple package sizes to support small-scale and larger syntheses.
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Acid-PEG2-SS-PEG2-acid is a cleavable four-unit polyethylene glycol (PEG) linker that contains a central disulfide bond and terminal carboxylic acids. It is used as a spacer in antibody-drug conjugate (ADC) synthesis and general bioconjugation research, providing controlled release via reductive cleavage and improved solubility from PEGylation.
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N-(Amino-PEG4)-N-bis(PEG4-Boc) is a branched polyethylene glycol (PEG) linker with a Boc-protected amine terminus designed for use in the synthesis of PROTACs and other bioconjugates. It provides a protected amine handle and flexible PEG spacers to facilitate coupling and linker optimization in medicinal chemistry workflows.
Boc-protected amine enables selective deprotection and downstream coupling.
Branched bis-PEG4 architecture provides two tether points for dual-arm linkers.
PEG4 units increase aqueous solubility and spacer flexibility.
Supplied as a protected linker ready for synthetic coupling steps.
Suitable for PROTAC assembly and diverse bioconjugation strategies.
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Acid-PEG3-SS-PEG3-acid is a cleavable six-unit polyethylene glycol (PEG) linker comprising two PEG3 segments joined by a disulfide bond and terminating in carboxylic acid groups. It is formulated for use in antibody-drug conjugate (ADC) synthesis and related bioconjugation research, and is supplied in small research-scale packages.
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Amino-PEG16-acid is an amine-terminated polyethylene glycol (PEG16) linker designed for use in the chemical synthesis of proteolysis targeting chimeras (PROTACs) and other bifunctional conjugates. It provides a hydrophilic, flexible spacer with reactive termini suitable for orthogonal coupling strategies and is supplied as a research-grade reagent with a reported purity of 95%.
Amine-terminated PEG16 linker useful for PROTAC synthesis.
Hydrophilic and flexible spacer to improve solubility and reduce steric hindrance.
Terminal carboxylic acid and primary amine for orthogonal conjugation chemistries.
Reported purity 95.0% suitable for research applications.
Molecular weight ~793.93 Da; formula C35H71NO18.
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