Fluorobenzenes
Selleck Chemical LLC ELR-510444 S3725-5mg
ELR-510444 is a novel microtubule disruptor with potential antivascular effects and in vivo antitumor efficacy causing a loss of cellular microtubules and the formation of aberrant mitotic spindles and leading to mitotic arrest and apoptosis of cancer cells
Medchemexpress LLC TC11 | 100823-03-8 | 99.6% | 10 MG
TC11 is an MCL1 degrader and a Caspase-9 and CDK1 activator. It functions as a phenylacetylamide derivative and is structurally related to immunomodulatory active molecules. TC11 induces the degradation of MCL1, leading to apoptotic death during prolonged mitotic arrest.
Selleck Chemical LLC MM-102
MM-102 (HMTase Inhibitor IX) is a high-affinity peptidomimetic inhibitor of the WDR5/MLL1 protein-protein interaction which bind to WDR5 with Ki 1 nM and IC50 2 4nM This product may precipitate when dissolved in saline solution or PBS solution It is recommended to prepare the stock solution in DMSO solution
Medchemexpress LLC TC11 | 100823-03-8 | 99.6% | 100 MG
TC11 is a phenylacetylamide derivative that functions as an MCL1 degrader and an activator of Caspase-9 and CDK1. It induces the degradation of MCL1, leading to apoptotic cell death during prolonged mitotic arrest.
- Functions as an MCL1 degrader
- Activates Caspase-9 and CDK1
- Induces apoptotic cell death
- Downregulates MCL1 expression
Biotang Inc Foretinib, Free Base, > 99%, 50MG, CAS#849217-64-7, M.W.632.65, Exel-2880; GSK-1363089; GSK089; XL-880. RS310-50MG
Foretinib, Free Base, > 99%, 50MG, CAS#849217-64-7, M.W.632.65, Exel-2880; GSK-1363089; GSK089; XL-880. RS310-50MG. Lead time of this kit is 1-2 weeks. Shipped by FedEx air. Storage: 2 - 8 C. Shelf Time: 6 months. Kit Experimental Time:< 2 hs. TSZELISA brand.
Medchemexpress LLC CCR2 antagonist 1 | 1683534-96-4 | 98.0% | 549.47 | 50 MG
CCR2 antagonist 1 (compound 15a) is a high-affinity and long-residence-time CCR2 antagonist, with a Ki of 2.4 nM. It is for research use only.
- Target: CCR2, Ki = 2.4 nM
- In vitro: The compound was discovered through a combination of SAR and SKR in a hit-to-lead process, showing high affinity and long residence time.
Medchemexpress LLC 1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]- | 100823-03-8 | 99.55% | 50 MG
TC11 is a MCL1 degrader and Caspase-9 and CDK1 activator. It is a phenylacetylamide derivative structurally related to immunomodulatory active molecules. TC11 induces the degradation of MCL1, leading to apoptotic death during prolonged mitotic arrest.
- MCL1 degrader
- Caspase-9 and CDK1 activator
- Induces apoptotic death
- Phenylacetylamide derivative
- Purity: 99.55%
- Soluble in DMSO (50 mg/mL)
Medchemexpress LLC HY-100591 10mg Medchemexpress, SirReal2 CAS:709002-46-0 Purity:>98%
Medchemexpress, HY-100591 10mg SirReal2 CAS:709002-46-0 SirReal2 is a potent, isotype-selective Sirt2 inhibitor with an IC50 value of 140 nM and has very little effect on the activities of Sirt3-5. SirReal2 leads to tubulin hyperacetylation in HeLa cells and induces destabilization of the checkpoint protein BubR1. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Abemaciclib metabolite M18 hydrochloride | 2704316-82-3 | 98.2% | 100 MG
Abemaciclib metabolite M18 hydrochloride (LSN3106729) is a metabolite of Abemaciclib with antitumor activity, acting as a CDK inhibitor. It has been utilized in the design of PROTAC CDK4/6 degraders.
- Targets cyclin-dependent kinases (CDK4 and CDK6)
- Exhibits antitumor activity
- Soluble in DMSO up to 125 mg/mL for in vitro studies
- Soluble in H2O up to 100 mg/mL for in vitro studies
- Soluble in PBS up to 50 mg/mL for in vivo applications
- Appears as an off-white to light yellow solid
Medchemexpress LLC GPLGIAGQ TFA | 99.9% | 825.83 | 10 MG
GPLGIAGQ TFA is a polypeptide that is cleavable by Matrix Metalloproteinase-2 (MMP2). It is utilized as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting, and can be used in the synthesis of unique MMP2-targeted photosensitizers for photodynamic therapy (PDT).
- Cleavable by matrix metalloproteinase-2 (MMP2)
- Functions as a stimulus-sensitive linker in nanocarriers
- Facilitates MMP2-triggered tumor targeting
- Used for synthesizing MMP2-targeted photosensitizers in photodynamic therapy (PDT)
- Triggers PEG deshielding of liposomal carriers
- Leads to enhanced cellular internalization
- For research use only
Medchemexpress LLC CCT369260 | 2647503-57-7 | >99.67% | 10 MG
CCT369260 is a chemical probe and an orally active B-cell lymphoma 6 (BCL6) inhibitor with anti-tumor activity. It exhibits an IC50 of 520 nM. In an in vivo study, CCT369260 (15 mg/kg, orally, single dose) significantly inhibited BCL6 in an OCI-Ly1 DLBCL xenograft model in female SCID mice, leading to decreased levels of BCL6 in the tumor observed up to 10 hours after administration.
- Orally active B-cell lymphoma 6 (BCL6) inhibitor
- Demonstrates anti-tumor activity
- Exhibits an IC50 of 520 nM
- Significant inhibition of BCL6 in OCI-Ly1 DLBCL xenograft model
Medchemexpress LLC Ac-Phe-Lys-Pro-Leu-Ala-Ala-Ala-Arg | 2891606-02-1 | MFCD34676951 | 99.8% | 915.09 g/mol | C43H70N12O10 | 5 MG
BM213 is an acetylated octapeptide agonist of the complement C5a receptor 1 (C5aR1) employed in research to stimulate neutrophil activation and promote neutrophil extracellular trap (NET) formation. It is provided as a high-purity solid with characterized molecular properties and solubility suitable for in vitro and in vivo studies.
- Peptide sequence: Ac-Phe-Lys-Pro-Leu-Ala-Ala-Ala-Arg.
- High purity (99.8%).
- Molecular weight 915.09 g/mol.
- CAS number 2891606-02-1.
- Soluble in water and PBS; may require sonication.
- Storage: solid at -20°C; solutions stored at -80°C for long-term stability.
- For research use only; not for human or diagnostic use.
Medchemexpress LLC SLMP53-2 | 1826116-38-4 | C26H22N2O2 | 5 MG
SLMP53-2 is a mutant p53 reactivator that restores wild-type-like conformation and DNA-binding ability of mutp53-Y220C by enhancing its interaction with Hsp70, leading to the reestablishment of p53 transcriptional activity. It can induce cell cycle arrest, apoptosis, and endoplasmic reticulum (ER) stress, and exhibits antitumor activity.
- Restores wild-type-like function to mutant p53.
- Enhances interaction with Hsp70 to reestablish p53 transcriptional activity.
- Induces cell cycle arrest, apoptosis, and endoplasmic reticulum (ER) stress.
- Exhibits antitumor activity.
- Inhibits growth of various cancer cell lines.
- Reduces tumor volume and weight in xenograft mouse models.
Medchemexpress LLC Abemaciclib metabolite M18 | 2704316-81-2 | 98.01% | 10 MG
Abemaciclib metabolite M18 (LSN3106729) is a metabolite of Abemaciclib and acts as a CDK inhibitor with antitumor activity. It has been utilized in conjunction with a CRBN ligand to engineer a PROTAC CDK4/6 degrader. The primary mechanism of action for CDK4/6 inhibitors involves the inhibition of retinoblastoma (RB) protein phosphorylation, leading to the induction of cell cycle arrest.
- Acts as a CDK inhibitor with antitumor activity.
- Utilized in conjunction with a CRBN ligand to engineer a PROTAC CDK4/6 degrader.
- Inhibits retinoblastoma (RB) protein phosphorylation.
- Induces cell cycle arrest.
- Promotes T-cell persistence and increases immunologic memory in mice that receive tumor-specific CD8+ T cells.
- Appears as an off-white to light yellow solid.