Phenoxy compounds
Diphenyl phosphorochloridate, 97%
CAS: 2524-64-3 Molecular Formula: C12H10ClO3P Molecular Weight (g/mol): 268.633 MDL Number: MFCD00003030 InChI Key: BHIIGRBMZRSDRI-UHFFFAOYSA-N Synonym: diphenyl chlorophosphate,diphenyl phosphorochloridate,diphenylchlorophosphate,phosphorochloridic acid, diphenyl ester,chlorodiphenyl phosphate,o,o-diphenyl chlorophosphate,chlorodiphenoxyphosphine oxide,diphenoxychlorophosphine oxide,diphenyl chlorophosphonate,diphenylphosphoric acid monochloride PubChem CID: 75654 IUPAC Name: [chloro(phenoxy)phosphoryl]oxybenzene SMILES: C1=CC=C(C=C1)OP(=O)(OC2=CC=CC=C2)Cl
p-Tolyl chlorothionoformate, 97%
CAS: 937-63-3 Molecular Formula: C8H7ClOS Molecular Weight (g/mol): 186.65 MDL Number: MFCD00014466 InChI Key: UNCAXIZUVRKBMN-UHFFFAOYSA-N Synonym: 4-methylphenyl chlorothioformate,o-p-tolyl chlorothioformate,p-tolyl chlorothionoformate,4-tolyl chlorothionoformate,4-methylphenyl chloromethanethioate,o-4-methylphenyl chlorothioformate,carbonochloridothioic acid, o-4-methylphenyl ester,o-4-methylphenyl carbonochloridothioate,chlorothioformic acid p-tolyl ester,4-methylphenoxy methanethioyl chloride PubChem CID: 70305 IUPAC Name: O-(4-methylphenyl) chloromethanethioate SMILES: CC1=CC=C(OC(Cl)=S)C=C1
Medchemexpress LLC PND-1186 hydrochloride | 1356154-94-3 | 99.9% | 537.96 | 50 MG
PND-1186 hydrochloride is a potent, highly-specific, and reversible inhibitor of FAK with an IC50 of 1.5 nM. It selectively promotes tumor cell apoptosis.
- Potent, highly-specific, and reversible FAK inhibitor.
- IC50 of 1.5 nM for FAK.
- Selectively promotes tumor cell apoptosis.
- Inhibits FAK Tyr-397 phosphorylation in breast carcinoma cells.
- Reduces tumor growth by inducing apoptosis in vivo.
Medchemexpress LLC Bay-320 | 1445830-50-1 | MFCD31657346 | 99.7% | 492.52 g/mol | C26H26F2N6O2 | 50 MG
BAY-320 is a selective, ATP-competitive inhibitor of the Bub1 kinase used in biochemical and cellular research. It inhibits Bub1 catalytic activity (IC50 ≈ 680 nM), disrupts Bub1-mediated Sgo1 localization, alters mitotic chromosome arrangement and spindle assembly, and reduces cell proliferation, making it useful in cancer research applications such as studies of ovarian and cervical cancer.
- Selective ATP-competitive Bub1 kinase inhibitor
- Biochemical and cellular activity with reported IC50 ≈ 680 nM
- Disrupts Sgo1 localization and mitotic chromosome arrangement
- Available as powder and as a 10 mM solution in DMSO for flexible use
- High purity suitable for research applications
Medchemexpress LLC BAY-320 | 1445830-50-1 | MFCD31657346 | 99.7% | 492.52 g/mol | C26H26F2N6O2 | 10 MG
BAY-320 is a small-molecule, ATP-competitive inhibitor of the Bub1 serine/threonine kinase used as a research tool to probe Bub1 catalytic function, mitotic progression, and sensitivity to microtubule-targeting agents. It demonstrates selective biochemical and cellular activity and is supplied for research use as a solid or as a 10 mM solution in DMSO.
- Selective ATP-competitive Bub1 kinase inhibitor.
- Documented biochemical and cellular activity at low micromolar concentrations.
- Useful for studying mitosis, chromosome segregation, and drug sensitization.
- Available as a solid and as a 10 mM solution in DMSO for convenience.
- High purity suitable for research applications.
- Stable when stored at recommended cold temperatures.
Medchemexpress LLC Berotralstat (BCX7353) | 1809010-50-1 | MFCD33023491 | 99.7% | 562.6 g/mol | C30H26F4N6O | 5 MG
Berotralstat is a selective, orally active plasma kallikrein inhibitor used in research and clinical development, including prophylaxis studies for hereditary angioedema and investigational work on edema and glioblastoma models. This item is provided as a research-grade solid standard (5 mg) intended for analytical, preclinical, and formulation studies, with documented batch-level characterization and supporting analytical data.
- Selective plasma kallikrein inhibitor for HAE and related research
- Supplied as a 5 mg research-grade solid suitable for analytical use
- High HPLC purity (reported ~99.7%) for reliable results
- Documented certificate of analysis and batch data available
- Suitable for biochemical assays, formulation studies, and reference standards
Medchemexpress LLC 1-(5-chloronaphthalen-1-yl)sulfonyl-1,4-diazepane hydrochloride | 105637-50-1 | MFCD00065525 | 99.9% | 361.29 g/mol | C15H18Cl2N2O2S | 100 MG
ML-9 is a small-molecule research inhibitor of Akt kinase that also inhibits myosin light-chain kinase (MLCK) and STIM1. It shows reported Ki values of 4 μM (MLCK), 32 μM (PKA), and 54 μM (PKC), and can induce autophagy by stimulating autophagosome formation. Intended for laboratory research use; handle and store under dry, sealed conditions.
- Inhibits Akt kinase, MLCK, and STIM1.
- Induces autophagy by stimulating autophagosome formation.
- High purity: 99.86%.
- Molecular weight: 361.29 g/mol.
- Chemical formula: C15H18Cl2N2O2S.
- Available as solids (including 100 mg) and 10 mM solutions in DMSO.
- Storage: solid at 4°C; in solvent -80°C (up to 6 months) or -20°C (up to 1 month).
Medchemexpress LLC Risarestat | 79714-31-1 | 98.03% | 323.41 | 50 MG
Risarestat (CT-112) is an aldose reductase inhibitor developed for the treatment of diabetic complications. It is intended for research use only and not for sale to patients.
- Aids in research of diabetic complications.
- Acts as an aldose reductase inhibitor.
- Supports biochemical investigations.
- Useful for studying metabolic pathways.
- Contributes to drug development efforts.
Medchemexpress LLC Mcoppb (trihydrochloride) | 1108147-88-1 | 100.0% | 50 MG
MCOPPB trihydrochloride is a nonpeptide nociceptin/orphanin FQ peptide (NOP)-receptor agonist, exhibiting a pKi of 10.07 for the human NOP receptor. It shows weaker activity at other opioid receptors. This compound is the trihydrochloride form of MCOPPB, making it suitable for various research applications.
- Acts as a nociceptin receptor agonist
- Demonstrates high purity of 99.98%
- Stable under recommended storage conditions
- Soluble in DMSO (100 mg/mL) for in vitro applications
- Can be formulated for in vivo studies with clear solutions
Medchemexpress LLC CSK-IN-1 | 2380027-49-4 | 98.6% | 50 MG
CSK-IN-1 (compound 13) is a potent, orally active c-terminal Src kinase (CSK) inhibitor with IC50 values below 3 nM and 4 nM in CSK HTRF and Caliper assay, respectively. It increases T cell proliferation induced by T cell receptor signaling. This product is for research use only.
- Potent, orally active c-terminal Src kinase (CSK) inhibitor
- Achieves IC50 values below 3 nM in CSK HTRF assay
- Achieves IC50 values below 4 nM in Caliper assay
- Increases T cell proliferation induced by T cell receptor signaling
- Reduces inhibitory LCK phosphorylation in vivo upon oral dosing
- Enhances T cell activation in response to antigen stimulation
- Shows EC50 of 41 nM on ZAP70 phosphorylation in human Jurkat cells
Medchemexpress LLC Galanthamine N-Oxide | 134332-50-6 | 1 MG
Galanthamine N-Oxide is an alkaloid derived from the bulbs of *Zephyranthes concolor*. This compound acts as an inhibitor of electric eel acetylcholinesterase (AChE) and is recognized for its role in inhibiting substrate accommodation within the active site of *Torpedo californica* AChE (TcAChE), human AChE (hAChE), and human BChE (hBChE) enzymes. It is intended for research use only.
- Derived from *Zephyranthes concolor* bulbs
- Inhibits electric eel acetylcholinesterase (AChE)
- Prominent inhibitor of substrate accommodation in AChE and BChE enzymes
- Target: Cholinesterase (ChE)
- Pathway: Neuronal Signaling
- Appears as a white to off-white solid
Medchemexpress LLC Lrrk2-IN-1 | 1234480-84-2 | 99.0% | 570.69 | 50 MG
Lrrk2-IN-1 | 1234480-84-2 | 99.0% | 570.69 | 50 MG
![eMolecules Medchem Express / BMS641 / 5mg / 769193238 / HY-119518 / / 369364-50-1 / [null] / 414.930 / C27H23ClO2](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502473828.JPG-250.jpg)
eMolecules Medchem Express / BMS641 / 5mg / 769193238 / HY-119518 / / 369364-50-1 / [null] / 414.930 / C27H23ClO2
Medchem Express / BMS641 / 5mg / 769193238 / HY-119518 / / 369364-50-1 / [null] / 414.930 / C27H23ClO2
Medchemexpress LLC PXS-5153A (monohydrochloride) | 2125956-82-1 | 99.6% | 438.95 | 50 MG
PXS-5153A monohydrochloride is a potent, selective, orally active and fast-acting lysyl oxidase like 2/3 enzymatic (LOXL2/LOXL3) inhibitor, with an IC50 of <40 nM for LOXL2 across all mammalian species and an IC50 of 63 nM for human LOXL3. PXS-5153A monohydrochloride could reduce crosslinks and ameliorate fibrosis.
- Exhibits an IC50 of <40 nM for LOXL2 across all mammalian species tested.
- Also inhibits human LOXL3 with an IC50 value of 63 nM.
- Is >40-fold selective for LOXL2 over both LOX and LOXL1 and >700-fold selective over other related amine oxidases.
- Is a fast acting inhibitor, with enzymatic activity almost entirely blocked within 15 minutes.
- Reduces crosslinks and ameliorates fibrosis.
Medchemexpress LLC EAAT2 activator 1 | 892415-28-0 | 98.9% | 331.80 | 50 MG
EAAT2 activator 1 is a potent activator of excitatory amino acid transporter 2 (EAAT2). EAAT2 is the primary glutamate transporter responsible for removing glutamate from synapses. This activator increases EAAT2 protein levels in a dose-dependent manner.
- Potent activator of EAAT2
- Removes glutamate from synapses
- Increases protein levels dose-dependently
- Solid appearance
- Light brown to brown color