Aminophenols
Medchemexpress LLC AC-099 hydrochloride | 849335-07-5 | C9H9Cl2F3N4 | 50 MG
AC-099 hydrochloride (compound 3) is a selective NPFF2R full agonist (EC50=1189 nM) and NPFF1R partial agonist (EC50=2370 nM). It has been shown to attenuate spinal nerve ligation-induced hypersensitivity in rats. This product is for research use only.
- Storage for powder: -20°C for 3 years, 4°C for 2 years
- Storage in solvent: -80°C for 6 months, -20°C for 1 month
- Appearance: Solid, white to off-white
- Purity: 99.92%
- Molecular weight: 301.10
Medchemexpress LLC MRT-83 (hydrochloride) | 1359944-60-7 | 99.6% | 575.05 | 25 MG
MRT-83 (hydrochloride) is a potent antagonist of the Smoothened (Smo) receptor. It inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. MRT-83 (hydrochloride) has potential for researching cancer disease.
- Potent antagonist of Smoothened (Smo) receptor.
- Inhibits the Hedgehog (Hh) signaling pathway.
- Inhibits BODIPY-cyclopamine binding to human Smo.
- Potential for researching cancer disease.
Medchemexpress LLC Pre-084 hydrochloride | 75136-54-8 | 99.92% | 353.88 | 50 MG
PRE-084 hydrochloride is a highly selective σ1 receptor (S1R) agonist with an IC50 of 44 nM. It demonstrates neuroprotective effects, improves motor function, and enhances motor neuron survival in mice. Additionally, it can mitigate myocardial ischemia-reperfusion injury in rats by activating the Akt-eNOS pathway.
- Highly selective σ1 receptor (S1R) agonist.
- Exhibits neuroprotective effects.
- Can improve motor function and motor neuron survival.
- Ameliorates myocardial ischemia-reperfusion injury by activating the Akt-eNOS pathway.
Medchemexpress LLC Acetaminophen | 103-90-2 | 99.97% | C8H9NO2 | 10 G
Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor and a widely used antipyretic and analgesic agent. It is also a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor that induces ferroptosis and can lead to acute liver injury in mice models.
- Selective COX-2 inhibitor with an IC50 of 25.8 μM
- Widely used as an antipyretic and analgesic
- Potent hepatic N-acetyltransferase 2 (NAT2) inhibitor
- Induces ferroptosis
- Can lead to acute liver injury in mice models
Medchemexpress LLC Acetaminophen-d7 | 1219798-53-4 | 99.9% | C8H2D7NO2 | 1 MG
Acetaminophen-d7 is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; it is a widely used antipyretic and analgesic agent and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC LMP744 hydrochloride | 308246-57-3 | 488.92 | 1 ML
LMP744 hydrochloride (MJ-III65 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity. It is intended for research use only.
- Dose-dependent accumulation of cells in the S and G2 phases of the cell cycle
- Antiproliferative activity against various human cell lines
- Moderately active against human A253 and FaDu tumor xenografts in nude mice
Medchemexpress LLC LMP744 hydrochloride | 308246-57-3 | 488.92 | 5 MG
LMP744 hydrochloride (MJ-III65 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor exhibiting antitumor activity. It is a solid, light brown to brown in appearance, with a purity of 99.08%.
- DNA intercalator
- Topoisomerase I (Top1) inhibitor
- Exhibits antitumor activity
- Induces dose-dependent accumulation of cells in the S and G2 phases of the cell cycle
- Moderately active against human A253 and FaDu tumor xenografts in vivo
Cayman Chemical N-acetyl-2-AmInophenol 250g
A derivative of acetaminophen; inhibits ADP- or arachidonic acid-induced platelet aggregation in isolated human platelet-rich plasma at 50 µM; decreases disease severity and prevents increases in paw volume in a rat model of collagen-induced arthritis at 1 mg/kg; has been used as a synthetic intermediate in the synthesis of compounds with antimalarial activity; a potential impurity in commercial preparations of acetaminophen
TARGETMOL CHEMICALS INC L-Azidohomoalanine hydrochlori
Also available in 5 mg, 10 mg, 25 mg, 50 mg, 200 mg and bulk. Please contact Fisher for quotes. L-Azidohomoalanine hydrochloride (H-L-Aha-OH hydrochloride) is an alkyl chain-based PROTAC linker. Purity 98.16%
Medchemexpress LLC CP94253 hydrochloride | 845861-39-4 | MFCD03453293 | 98.8% | 293.79 g·mol⁻¹ | C15H20ClN3O | 1 ML
CP94253 hydrochloride is a potent, selective serotonin 5-HT1B receptor agonist supplied for research use and commonly provided as a 10 mM solution in DMSO for in vitro and in vivo studies.
- Potent 5-HT1B agonist (Ki ≈ 2 nM).
- High purity (≈98.8%).
- Supplied as a 10 mM, 1 mL solution in DMSO; also available as solid in multiple milligram quantities.
- Chemical formula C15H20ClN3O; molecular weight 293.79 g·mol⁻¹.
- Light yellow solid appearance; store sealed and away from moisture; in solvent: -80°C (up to 6 months) or -20°C (1 month).
Medchemexpress LLC AFM32a hydrochloride | 2988594-85-8 | 99.4% | 517.00 | 25 MG
This benzimidazole-based derivative is a potent and selective protein arginine deiminase 2 inhibitor. It exhibits superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold).
- Potent and selective protein arginine deiminase 2 inhibitor.
- Superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold).
Medchemexpress LLC Daurk-4 hydrochloride | 99.4% | 1071.93 | 50 MG
dAURK-4 hydrochloride is a potent and selective PROTAC AURKA (Aurora A) degrader, derived from Alisertib. This compound exhibits anticancer effects by targeting specific proteins involved in cell proliferation. It is composed of a ligand for the target protein, a linker, and a ligand for the E3 ligase Thalidomide-O-COOH, enabling dose-dependent degradation of AURKA in vitro.
- Potent and selective PROTAC AURKA degrader
- Derivative of Alisertib
- Exhibits anticancer effects
- Composed of specific ligands and a linker for targeted degradation
- Demonstrates dose-dependent degradation of AURKA in vitro
- High purity (99.44%)
Medchemexpress LLC Dc-chol hydrochloride | 166023-21-8 | 99.9% | 537.26 | 50 MG
DC-Chol hydrochloride is a cationic lipid that can inhibit Aβ40 fibril formation and amyloidogenesis. It enhances the body's immune response by inducing Th1 (IL-2 and IFN-γ) and Th2 (IL-5) cytokines, making it suitable for various research applications.
- Inhibits Aβ40 fibril formation and amyloidogenesis.
- Induces Th1 and Th2 cytokine production to enhance immune response.
- Used as a gene delivery vector.
- Utilized in research for hepatitis B vaccines to improve vaccine immunity.
Medchemexpress LLC AFM32a hydrochloride | 2988594-85-8 | 99.4% | 517.00 | 1 ML
AFM32a hydrochloride, also known as PAD2-IN-1 hydrochloride, is a potent and selective benzimidazole-based derivative that inhibits protein arginine deiminase 2 (PAD2). It demonstrates high selectivity, being 95-fold more selective for PAD2 over PAD4 and 79-fold more selective over PAD3.
- Potent and selective PAD2 inhibitor.
- Exhibits superior selectivity over PAD4 and PAD3.
- Effective in inhibiting histone H3 citrullination in HEK293T/PAD2 cells.
Medchemexpress LLC Iccb-19 hydrochloride | 1803605-68-6 | 99.3% | 291.84 | 1 ML
ICCB-19 hydrochloride is an inhibitor of TRADD (TNFRSF1A associated via death domain). It binds to the N-terminal domain of TRADD (TRADD-N), which prevents TRADD-N from binding to both TRADD-C and TRAF2. ICCB-19 hydrochloride also acts as an indirect inhibitor of RIPK1 kinase activity and effectively induces autophagy and the degradation of long-lived proteins.
- TRADD (TNFRSF1A associated via death domain) inhibitor.
- Binds with N-terminal domain of TRADD (TRADD-N), disrupting its binding to both TRADD-C and TRAF2.
- Indirect inhibitor of RIPK1 kinase activity.
- Induces autophagy and degradation of long-lived proteins.
- Inhibits Bortezomib-induced apoptosis and RIPK1-dependent apoptosis (RDA) with an IC50 of about 1 μM (In Vitro).
- Reduces inflammatory responses in Tradd-/- mice (In Vivo).