Aminophenols
Medchemexpress LLC Hypidone hydrochloride | 1339058-04-6 | 99.7% | 334.84 g/mol | C18H23ClN2O2 | 1 ML
Hypidone hydrochloride is a research-grade small molecule reported to act as an orally active antidepressant agent with activity at serotonin (5-HT) receptors. It is provided for laboratory research use and is available both as solid quantities and as a ready-to-use solution in DMSO, with supporting product documentation and safety data.
- Research-grade 5-HT receptor agonist for laboratory studies.
- High purity suitable for research (reported 99.73%).
- Available as solids and as a 10 mM, 1 mL solution in DMSO.
- Chemical identifiers: CAS 1339058-04-6; formula C18H23ClN2O2; MW 334.84 g/mol.
- Intended for in vitro and in vivo research; not for human use.
- Supplied with datasheet and safety data sheet for handling and storage.
Medchemexpress LLC Harmane hydrochloride | 21655-84-5 | 99.4% | 218.68 g/mol | C12H11ClN2 | 5 MG
Harmane hydrochloride is the hydrochloride salt of a β-carboline alkaloid used in neuropharmacology research. It modulates imidazoline receptors and monoamine oxidase and is supplied as a high-purity analytical reagent for assays, receptor profiling, and mechanistic studies.
- High purity (99.35%) suitable for analytical use.
- Molecular formula C12H11ClN2 and molecular weight 218.68 g/mol.
- Provided in small vials for assay and analytical workflows.
- Active compound for studies of imidazoline receptors and MAO-related pathways.
- Certificate of analysis and safety data sheet available for quality and safety information.
Medchemexpress LLC CPI-455 hydrochloride | 2095432-28-1 | 100.0% | 314.77 | C16H15ClN4O | 10 MG
CPI-455 hydrochloride is the hydrochloride salt of a potent pan-KDM5 inhibitor used as a research tool to probe KDM5-dependent epigenetic mechanisms. It inhibits KDM5 enzymes (IC50 = 10 nM for KDM5A), elevates H3K4me3 levels in cells, and is supplied with high purity for in vitro studies and mechanism-of-action experiments.
- Potent KDM5 inhibition (IC50 = 10 nM).
- Elevates global H3K4me3 levels in cells.
- High purity for reliable biochemical and cellular assays.
- Multiple package sizes for experimental flexibility.
- Recommended storage conditions provided to preserve stability.
- For research use only; not for clinical or human use.
Medchemexpress LLC CX-6258 hydrochloride hydrate | 1353858-99-7 | 99.2% | 516.42 | 25 MG
CX-6258 hydrochloride hydrate is a potent and selective pan-Pim kinases inhibitor. It effectively inhibits Pim-1, Pim-2, and Pim-3, making it suitable for research into cancer and metabolic diseases.
- Potent and kinase selective pan-Pim kinases inhibitor
- Inhibits Pim-1 (IC50: 5 nM), Pim-2 (IC50: 25 nM), and Pim-3 (IC50: 16 nM)
- Causes dose-dependent inhibition of phosphorylation of pro-survival proteins, Bad and 4E-BP1
- Diminishes steady-state levels of ectopic NKX3.1 in PC3 cells
- Exhibits robust in vivo efficacy in Pim kinases driven tumor models
- Achieves 45% tumor growth inhibition at 50 mg/kg and 75% at 100 mg/kg in vivo
Medchemexpress LLC Sotorasib-d7 | 98.9% | 567.64 | 1 MG
Sotorasib-d7 (AMG-510-d7) is a deuterium-labeled Sotorasib. Sotorasib is a first-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor. It irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state, leading to the regression of KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer (NSCLC).
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules for quantitation during the drug development process.
- Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC His-Pro hydrochloride | 2415727-78-3 | 99.8% | 288.73 | 50 MG
His-Pro (Histidyl-proline) hydrochloride is a dipeptide consisting of histidyl and proline. It is for research use only and not sold to patients.
- Solid appearance
- White to off-white color
- Ships at room temperature in continental US
- Sealed storage, away from moisture and light
- Powder stable at -80°C for 2 years, -20°C for 1 year
- In solvent stable at -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC MRE-269-d7 | 1265295-20-2 | 99.6% | C25H22D7N3O3 | 1 MG
MRE-269-d7 is a deuterium-labeled form of MRE-269. It functions as an active metabolite of selexipag and acts as a selective IP receptor agonist. Stable heavy isotopes, such as deuterium, are incorporated into drug molecules primarily as tracers for quantitative analysis during drug development. Deuteration can also impact the pharmacokinetic and metabolic profiles of drugs.
- This compound can be used as a tracer.
- It can be used as an internal standard for quantitative analysis.
- It is an isotope-labeled compound.
- It is suitable for use in in vivo cell experiments.
- It is useful for therapeutic drug monitoring.
Medchemexpress LLC Acetaminophen | 103-90-2 | 99.97% | C8H9NO2 | 50 MG
Acetaminophen (Standard) is the analytical standard of Acetaminophen, intended for research and analytical applications. Also known as Paracetamol, it is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM, and a widely used antipyretic and analgesic agent. It also acts as a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.
- Analytical standard grade
- Reference standard supplied assay
- Used in qualitative research experiments
- Used in quantitative research experiments
- Used in methodological research experiments
- Suitable for HPLC
- Suitable for GC
- Suitable for MS
Medchemexpress LLC Cyclohexanecarboxylic acid, 1-phenyl-, 2-(4-morpholinyl)ethyl ester, hydrochloride (1:1) | 75136-54-8 | 99.9% | 353.88 | 100 MG
PRE-084 hydrochloride is a highly selective sigma 1 receptor (S1R) agonist (IC50 of 44 nM). It exhibits neuroprotective effects, improves motor function and motor neuron survival, and ameliorates myocardial ischemia-reperfusion injury by activating the Akt-eNOS pathway. This product is for research use only.
- Protects cultured cortical neurons against β-amyloid toxicity and reduces proapoptotic protein Bax.
- Improves motor performance, neuron survival, paw abnormality, and grip strength in mice.
- Increases BDNF levels and modifies glial cell populations.
- Protects heart by activating Akt-eNOS pathway, decreasing myocardial apoptosis.
- Increases expression of p-Akt and p-eNOS.
- Appears as a white to off-white solid.
- Store at 4°C sealed, away from moisture; in solvent at -80°C for 6 months or -20°C for 1 month.
Medchemexpress LLC ZZW-115 hydrochloride | 10122-45-9 | 98.1% | 573.97 | 1 ML
ZZW-115 hydrochloride is a potent NUPR1 inhibitor with a Kd of 2.1 μM. It demonstrates anticancer activity by inducing tumor cell death through both necroptosis and apoptosis.
- Potent NUPR1 inhibitor.
- Induces tumor cell death.
- Leads to necroptosis and apoptosis.
- Exhibits anticancer activity.
![Medchemexpress LLC Benzamide, 2-chloro-5-[3-[(3-hydroxypropyl)amino]propyl]-N-(tricyclo[3.3.1.13,7]dec-1-ylmethy-1)- | 345303-91-5 | 98.2% | 455.46 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000385590-logo.png-250.jpg){kind=logo}
Medchemexpress LLC Benzamide, 2-chloro-5-[3-[(3-hydroxypropyl)amino]propyl]-N-(tricyclo[3.3.1.13,7]dec-1-ylmethy-1)- | 345303-91-5 | 98.2% | 455.46 | 25 MG
AZD9056 hydrochloride is a selective and orally active inhibitor of P2X7, a receptor that plays a significant role in inflammatory and pain-causing diseases. This compound is intended for research use only.
- Blocks P2X7 receptors with an IC50 of 11.2 nM in HEK-hP2X7 cell lines, demonstrating high selectivity for the P2X7 receptor.
- Exhibits an inhibitory effect (IC50=1-3 μM) in mouse microglia BV2 cells.
- Weakly inhibits BCRP-mediated transport of methotrexate (IC50=92 μM).
- Displays pain-relieving and anti-inflammatory effects.
- Reverses the upregulated expression of interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), matrix metalloproteinase-13 (MMP-13), substance P (SP), and prostaglandin E2 (PGE2) induced by MIA in cartilage tissues.
Medchemexpress LLC Chromotropic acid disodium dihydrate | 5808-22-0 | MFCD00150612 | 400.29 g/mol | C10H10Na2O10S2 | 25G
Chromotropic acid disodium dihydrate is the disodium salt dihydrate of chromotropic acid used as an analytical reagent for colorimetric detection of formaldehyde and as a staining/dyeing reagent. It is supplied in multiple pack sizes, including a 25 g unit, and is characterized by the molecular formula C10H10Na2O10S2 and a molecular weight of 400.29 g/mol.
- Reagent for colorimetric detection of formaldehyde.
- Available in multiple pack sizes, including 25 g.
- Provided as the disodium salt dihydrate form.
- Molecular formula C10H10Na2O10S2; molecular weight 400.29 g/mol.
- Suitable for analytical and staining applications.
Medchemexpress LLC Di-4-ANEPPDHQ | 797785-10-5 | 98.7% | 665.54 | 1 MG
Di-4-ANEPPDHQ is a polarity-sensitive membrane probe with a doubly positive charge. It can be used to visualize membrane microdomains in living Arabidopsis cells. It produces a fluorescence spectrum shift by changing the polarity of the lipid environment after embedding into the cell membrane, which allows for quantifying the degree of lipid accumulation. It is often used for fluorescence imaging studies of membrane microstructure, lipid order, and membrane tension response in living cells.
- Polarity-sensitive membrane probe
- Doubly positive charge
- Can visualize membrane microdomains in living Arabidopsis cells
- Produces a fluorescence spectrum shift to quantify lipid accumulation
- Used for fluorescence imaging studies of membrane microstructure, lipid order, and membrane tension response in living cells