Aminophenols
Medchemexpress LLC MELK-8a hydrochloride | 2096992-20-8 | 99.3% | 469.02 g/mol | C25H33ClN6O | 25 MG
MELK-8a hydrochloride is a potent small-molecule inhibitor of maternal embryonic leucine zipper kinase (MELK) with a reported IC50 of 2 nM. Supplied as the hydrochloride salt with high chemical purity, it is intended for research use in biochemical and cellular studies targeting MELK-dependent pathways.
- Potent MELK inhibition with an IC50 of 2 nM.
- Hydrochloride salt for improved stability and handling.
- High purity suitable for biochemical and cellular assays.
- Molecular weight 469.02 g/mol and formula C25H33ClN6O.
- Soluble in DMSO; solution formats available for convenient dosing.
- Intended for research use only; not for human or diagnostic use.
Apexbio Technology LLC OTS964 hydrochloride 1338545-07-5 2mg
OTS964 hydrochloride (CAS 1338545-07-5) is a selective inhibitor of T-lymphokine-activated killer cell-originated protein kinase (TOPK) demonstrating an IC50 of 28 nM against its target As a dimethylated derivative of OTS514 OTS964 displays high affinity and selectivity for TOPK a serine/threonine kinase implicated in various human malignancies In vitro OTS964 potently suppresses proliferation of multiple TOPK-positive cancer cell lines (IC50 values ranging from 7 6 to 73 nM) while showing markedly reduced activity in TOPK-negative models In in vivo studies OTS964 administered intravenously to mice bearing LU-99 xenografts resulted in significant tumor growth inhibition without notable toxicity Research applications include studying TOPK-related oncogenic pathways and hematopoietic cell differentiation
Medchemexpress LLC Sotorasib-d7 | 2296729-00-3 | 98.9% | 567.64 | 10 MG
Sotorasib-d7 is a deuterium-labeled Sotorasib and a first-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor. It irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state, leading to the regression of KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer (NSCLC).
- Deuterium-labeled Sotorasib.
- First-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor.
- Irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state.
- Leads to the regression of KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer (NSCLC).
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC GSK2945 (hydrochloride) | 2517771-89-8 | 98.5% | 457.80 | 1 ML
GSK2945 hydrochloride is a tertiary amine and a highly specific Rev-erbα/REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist with EC50s of 21.5 μM and 20.8 μM, respectively. It enhances cholesterol 7α-hydroxylase (CYP7A1) levels and cholesterol metabolism. For research use only.
- Highly specific Rev-erbα/REV-ERBα antagonist.
- Enhances cholesterol 7α-hydroxylase (CYP7A1) levels.
- Promotes cholesterol metabolism.
- Suitable for research applications.
eMolecules 6291-01-6 | Cyclobutanamine hydrochloride | ChemScene | MFCD00034953 | 107.580 | C4H10ClN | 97.000 | Cl.NC1CCC1 | 1g | 582633316
Cyclobutanamine hydrochloride | ChemScene | 6291-01-6 | MFCD00034953 | 107.580 | C4H10ClN | 97.000 | Cl.NC1CCC1 | 1g | 582633316
Medchemexpress LLC Melk-8a (hydrochloride) | 2096992-20-8 | 99.3% | 469.02 | C25H33ClN6O | 500 MG
MELK-8a hydrochloride is a potent, selective inhibitor of maternal embryonic leucine zipper kinase (MELK) with an enzymatic IC50 of 2 nM. Supplied as the hydrochloride salt, the compound shows cellular activity in cancer cell lines, with reported good solubility and permeability, and is intended for research use only.
- Potent MELK inhibition (IC50 2 nM).
- High purity (>99%).
- Good solubility and permeability in cellular assays.
- Demonstrated activity in cancer cell lines (MDA-MB-468, MCF-7).
- Documentation available: product data sheet and safety data sheet.
Medchemexpress LLC Pre-084 hydrochloride | 75136-54-8 | 99.92% | 353.88 | 50 MG
PRE-084 hydrochloride is a highly selective σ1 receptor (S1R) agonist with an IC50 of 44 nM. It demonstrates neuroprotective effects, improves motor function, and enhances motor neuron survival in mice. Additionally, it can mitigate myocardial ischemia-reperfusion injury in rats by activating the Akt-eNOS pathway.
- Highly selective σ1 receptor (S1R) agonist.
- Exhibits neuroprotective effects.
- Can improve motor function and motor neuron survival.
- Ameliorates myocardial ischemia-reperfusion injury by activating the Akt-eNOS pathway.
Medchemexpress LLC Imiloxan hydrochloride | 81167-22-8 | 98.5% | 280.75 g/mol | C14H17ClN2O2 | 5 MG
Imiloxan hydrochloride is a potent, selective α2B-adrenoceptor antagonist used in pharmacological research to probe α2-adrenergic receptor subtype function. It is supplied as a characterized solid with defined purity and molecular weight for use in receptor-binding studies, in vitro assays, and in vivo experiments.
- Selective α2B-adrenoceptor antagonist
- High purity suitable for research applications
- Supplied in small research pack sizes for lab use
- Supported by analytical data (HNMR, LC-MS)
- Provided with SDS, COA, and handling instructions
Medchemexpress LLC Guvacine hydrochloride | 6027-91-4 | MFCD00055191 | 99.9% | 163.60 g/mol | C6H10ClNO2 | 1 ML
Guvacine hydrochloride is a GABA transporter inhibitor used in neuroscience research to investigate GABAergic signaling and transporter pharmacology. It is supplied with documented purity, molecular data, and recommended storage conditions to support reliable in vitro experiments.
- Inhibits GABA transporter activity with reported IC50 values for multiple transporter subtypes.
- Supplied as a ready-to-use 10 mM solution in DMSO (1 ML) for immediate use in assays.
- Also available as a solid for custom preparation and long-term storage.
- High reported purity supports reproducible experimental results.
- Storage guidance provided to maintain stability of solid and solution forms.
Medchemexpress LLC SKI-I | 5MG
SKI-I is a potent and selective inhibitor of human sphingosine kinase (SK) with an IC50 of 1 2 M for ST-hSK SKI-I also inhibits hERK2 (IC50 11 M) SKI-I induces apoptosis in tumor cell lines[1][2]