Aminophenols
Apexbio Technology LLC Clemizole hydrochloride 1163-36-6 10mM (in 1mL DMSO)
Clemizole hydrochloride is a histamine H1 receptor antagonist reported to inhibit hepatitis C virus (HCV) replication by targeting the viral NS4B protein a component essential for viral RNA replication Clemizole demonstrates antiviral activity in vitro against HCV genotype 2a subgenomic replicons exhibiting an IC50 value around 8 mM When combined with HCV protease inhibitors (such as VX950 or SCH503034) clemizole displays synergistic antiviral effects In contrast additive antiviral effects occur in combination with interferon ribavirin or polymerase inhibitors Clemizole is utilized in research contexts aimed at evaluating its efficacy potential antiviral combinations metabolism pathways and pharmacokinetics relevant to its consideration as a therapeutic candidate for HCV infection
Medchemexpress LLC UNC9994 hydrochloride | 2108826-33-9 | 99.5% | 457.84 | 10 MG
UNC9994 hydrochloride is a functionally selective, β-arrestin-biased dopamine D2 receptor (D2R) agonist. It selectively activates β-arrestin recruitment and signaling, demonstrating antipsychotic-like activity. It also acts as an antagonist of Gi-regulated cAMP production and a partial agonist for D2R/β-arrestin-2 interactions.
- Selectively activates β-arrestin recruitment and signaling.
- Antagonist of Gi-regulated cAMP production.
- Partial agonist for D2R/β-arrestin-2 interactions.
- Shows antipsychotic-like activity.
- Induces D2-mediated β-arrestin-2 translocation with EC50s of 6.1 nM and 448 nM.
- Acts as an antagonist at 5HT2A and 5HT2B receptors.
- Acts as an agonist at 5HT2C and 5HT1A receptors.
Medchemexpress LLC HAIYPRH hydrochloride | 99.97% | 929.46 | 50 MG
HAIYPRH hydrochloride is a targeting ligand that specifically binds to the transferrin receptor (TfR), facilitating the transport of nanocarriers across the blood-brain barrier. It is a heptapeptide investigated for targeting gliomas and enhancing cellular uptake and gene expression in co-delivery systems.
- Specifically binds to transferrin receptor (TfR).
- Mediates transport of nanocarriers across the blood-brain barrier.
- Utilized as a targeting agent for gliomas.
- Enhances cellular uptake and gene expression in co-delivery systems.
- Conjugated to liposomes for ischemic stroke targeting treatment.
Medchemexpress LLC S-14506 hydrochloride | 286369-38-8 | 99.92% | 443.94 | 100 MG
S-14506 hydrochloride is a potent 5-HT1A agonist and a 5-HT2A/2C antagonist. It also exhibits dopamine antagonist properties by blocking dopamine D2 receptors, inhibiting the in vivo binding of [3H]raclopride in striatum and olfactory bulbs. This compound has potential for research as an anxiolytic agent.
- Potent 5-HT1A agonist
- 5-HT2A/2C antagonist
- Exhibits dopamine D2 receptor blocking properties
- Potential for research as an anxiolytic agent
Medchemexpress LLC CX-6258 (hydrochloride) | 1353859-00-3 | 99.0% | 498.40 | 1 ML
CX-6258 hydrochloride is a potent and kinase selective pan-Pim kinases inhibitor, with IC50s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively. It is for research use only and not sold to patients.
- Potent and kinase selective pan-Pim kinases inhibitor
- Inhibits Pim-1 with an IC50 of 5 nM, Pim-2 with an IC50 of 25 nM, and Pim-3 with an IC50 of 16 nM
- Causes dose-dependent inhibition of the phosphorylation of pro-survival proteins Bad and 4E-BP1 at specific Pim kinase sites (S112, S65, T37/46)
- Diminishes steady-state levels of ectopic NKX3.1 in PC3 cells and reduces NKX3.1 half-life
- Exhibits robust in vivo efficacy in two Pim kinases driven tumor models, with 50 mg/kg producing 45% tumor growth inhibition (TGI) and 100 mg/kg producing 75% TGI
Medchemexpress LLC R 59-022 hydrochlori 10mg | 93076-98-3 | 10MG
R 59-022 (DKGI-I) hydrochloride is a DGK inhibitor (IC50 2 8 M) R 59-022 hydrochloride inhibits the phosphorylation of OAG to OAPA R 59-022 hydrochloride is a 5-HT Receptor antagonist and activates protein kinase C (PKC) R 59-022 hydrochloride potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils[1 [2 [3 [4
Cayman Chemical NG-amino-L-Arginine (hydrochloride), Purity: ≥97%, CAS: 1031799-40-2, 50 mg
Inhibits nNOS, iNOS, and eNOS (Ki = 0.3, 3, and 2.5 μM, respectively); can be used both in cell culture and in vivo
eMolecules 6291-01-6 | Cyclobutanamine hydrochloride | ChemScene | MFCD00034953 | 107.580 | C4H10ClN | 97.000 | Cl.NC1CCC1 | 1g | 582633316
Cyclobutanamine hydrochloride | ChemScene | 6291-01-6 | MFCD00034953 | 107.580 | C4H10ClN | 97.000 | Cl.NC1CCC1 | 1g | 582633316
eMolecules 56621-99-9 | Ambeed | N2N2-Dimethylpyrimidine-25-diamine | 250mg | 552737660 | A497416 | MFCD11656641 | 138.174 | C6H10N4
Ambeed | N2N2-Dimethylpyrimidine-25-diamine | 250mg | 552737660 | A497416 | 56621-99-9 | MFCD11656641 | 138.174 | C6H10N4
TARGETMOL CHEMICALS INC Biotin-4-aminophenol 10MG
Also available in 1 mg, 5 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Biotin-4-aminophenol (BP) is a selective and potent biotin-phenol analog that works by generating free radicals and binding to tyrosine residues in proteins. Purity 98.99%
Medchemexpress LLC AZD9056 hydrochloride | 345303-91-5 | 98.2% | 455.46 | 50 MG
AZD9056 hydrochloride is a selective orally active inhibitor of P2X7, which plays a significant role in inflammation and pain-causing diseases. It is for research use only and not sold to patients.
- Selective orally active inhibitor of P2X7.
- Blocks P2X7 receptors with an IC50 of 11.2 nM in HEK-hP2X7 cell line.
- Exhibits high selectivity for the P2X7 receptor.
- Has an inhibitory effect (IC50=1-3 μM) in mouse microglia BV2 cells.
- Weakly inhibits BCRP-mediated transport of methotrexate (IC50=92 μM).
- Exerts pain-relieving and anti-inflammatory effects in vivo.
- Reverses upregulated expression of IL-1β, IL-6, TNF-α, MMP-13, SP, and PGE2 induced by MIA in cartilage tissues.
