Aminophenols
Medchemexpress LLC Cal-130 hydrochloride | 1431697-78-7 | 98.7% | 462.93 g/mol | C23H23ClN8O | 10 MG
Cal-130 hydrochloride is the hydrochloride salt of a small-molecule inhibitor selective for PI3Kδ (p110δ) and PI3Kγ (p110γ). It is supplied as a solid research reagent and shows low-nanomolar potency against its primary targets, with weaker activity toward other PI3K isoforms.
- Selective inhibition of PI3Kδ and PI3Kγ, low-nanomolar IC50 values
- Demonstrates activity against additional PI3K isoforms at higher concentrations
- High chemical purity suitable for in vitro and preclinical research
- Supplied as a solid, with common pack sizes suitable for laboratory studies
- Provided with documentation that includes molecular formula, molecular weight, and CAS number
Medchemexpress LLC Melk-8a hydrochloride | 2096992-20-8 | 99.3% | 469.02 g·mol⁻¹ | C25H33ClN6O | 1 ML
MELK-8a hydrochloride is a small-molecule inhibitor of maternal embryonic leucine zipper kinase (MELK) with an in vitro IC50 of 2 nM. It is provided for research use in solution and solid formats and is used in biochemical and cellular studies to probe MELK-associated signaling pathways.
- Potent MELK inhibitor with an IC50 of 2 nM.
- Supplied as a 10 mM solution in DMSO (1 mL) and as solids (5-500 mg).
- High purity (≈99.3%) suitable for research applications.
- Molecular weight 469.02 g·mol⁻¹.
- CAS number 2096992-20-8 for unambiguous identification.
- For research use only; not for human or clinical use.
Medchemexpress LLC Hypidone hydrochloride | 1339058-04-6 | 99.7% | 334.84 g/mol | C18H23ClN2O2 | 5 MG
Hypidone hydrochloride is a research-grade, orally active antidepressant used in preclinical pharmacology to study serotonergic mechanisms. It functions as a selective serotonin uptake inhibitor and a potent 5-HT1A receptor agonist, showing low-nanomolar activity in uptake and receptor assays. Supplied as a white to off-white solid with high purity for laboratory use.
- Orally active antidepressant with dual mechanism of action.
- Highly potent 5-HT uptake inhibitor and 5-HT1A receptor agonist.
- High purity suitable for preclinical research.
- Available in small milligram package sizes and DMSO solution format.
- Soluble in DMSO and supplied with recommended storage conditions.
Medchemexpress LLC Lavendustin B | 125697-91-8 | MFCD00133446 | 98.0% | 365.38 | C21H19NO5 | 5 MG
Lavendustin B is a small-molecule research reagent that inhibits HIV-1 integrase interaction with LEDGF/p75, functions as an ATP-competitive GLUT1 inhibitor, and exhibits weak tyrosine kinase inhibition. Supplied as a solid for laboratory research use, it is characterized by its CAS number 125697-91-8 and defined molecular properties.
- High purity (98.0%).
- Molecular weight 365.38 g/mol.
- Chemical formula C21H19NO5.
- Available in small milligram quantities suitable for screening and assays.
- Stable as powder when stored at -20°C for long-term storage.
- Suitable for biochemical and cell-based assay applications.
Medchemexpress LLC ZZW-115 hydrochloride | 10122-45-9 | 98.09% | 573.97 | 25 MG
ZZW-115 hydrochloride is a potent NUPR1 inhibitor with a Kd of 2.1 μM. It induces tumor cell death through necroptosis and apoptosis, demonstrating anticancer activity.
- Effective in killing cancer cells with IC50 values ranging from 0.84 μM to 4.93 μM in various cell lines in vitro.
- Induces pancreatic cell death by necrosis and apoptosis, leading to decreased ATP production and increased ROS overproduction.
- Causes higher LDH release and greater caspase 3/7 activity in a concentration-dependent manner.
- Inhibits the growth of pancreatic xenografted tumors in mice when administered at 0.5-5 mg/kg daily for 30 days via injection.
- Dosage of 5 mg/kg for 30 days resulted in almost unmeasurable tumor sizes in some cases of C57BL/6 mice.
- Caused tumors to progressively decrease and almost disappear by the end of treatment in nude mice xenografted with MiaPaCa-2 cells at a 5 mg/kg dose.
![Medchemexpress LLC 2-[[(3R)-3-(4-fluorophenyl)-3-(4-phenylphenoxy)propyl]-methylamino]acetic acid hydrochloride | 200006-08-2 | MFCD09971056 | 98.2% | 429.91 | C24H25ClFNO3 | 1 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000239773.png-250.jpg)
Medchemexpress LLC 2-[[(3R)-3-(4-fluorophenyl)-3-(4-phenylphenoxy)propyl]-methylamino]acetic acid hydrochloride | 200006-08-2 | MFCD09971056 | 98.2% | 429.91 | C24H25ClFNO3 | 1 MG
ALX-5407 hydrochloride is the hydrochloride salt of a selective glycine transporter 1 (GlyT1) inhibitor used in preclinical research to increase extracellular glycine and probe GlyT1 biology. It is provided as a high-purity research chemical for in vitro and in vivo studies.
- Selective glycine transporter 1 inhibitor with high potency (IC50 ≈ 3 nM).
- Hydrochloride salt form for improved solubility.
- High purity (98.2%) suitable for research applications.
- Available in small quantities for dose-response and pilot studies.
- Molecular weight 429.91 and formula C24H25ClFNO3 for precise calculations.
Medchemexpress LLC Afm-30a hydrochloride | 99.8% | 502.97 | 50 MG
AFM-30a hydrochloride is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor with an EC50 value of 9.5 μM for PAD2. It also inhibits H3 citrullination with an EC50 value of 0.4 μM. This compound is intended for research related to certain cancers and various autoimmune diseases such as rheumatoid arthritis (RA), multiple sclerosis, lupus, and ulcerative colitis. It exhibits low cytotoxicity in HEK293T/PAD2 cells and can suppress NLRP3 signaling and decrease airway remodeling in PAD2-/- transgenic mice.
- Potent protein arginine deiminase 2 (PAD2) inhibitor.
- Excellent PAD2-selectivity.
- Inhibits H3 citrullination.
- Can be used for research of certain cancers and autoimmune diseases (rheumatoid arthritis, multiple sclerosis, lupus, ulcerative colitis).
- Low cytotoxicity in HEK293T/PAD2 cells.
- Suppresses NLRP3 signaling and decreases airway remodeling in PAD2-/- transgenic mice.
Medchemexpress LLC Guvacine hydrochloride | 6027-91-4 | MFCD00055191 | 99.9% | 163.60 g/mol | C6H10ClNO2 | 25 MG
Guvacine hydrochloride is the hydrochloride salt of guvacine, a pyridine alkaloid that acts as a GABA uptake inhibitor. Supplied as a high-purity research reagent, it is used in biochemical and neuropharmacological studies to probe GABA transporter activity. The substance is intended for laboratory research use only and is not for human or veterinary use.
- High purity (99.93%) for reliable experimental results.
- Molecular weight 163.60 g/mol.
- Molecular formula C6H10ClNO2.
- CAS number 6027-91-4 for unambiguous identification.
- Available in multiple pack sizes and solution formats for flexible use.
- Suitable for in vitro biochemical and pharmacology research.
Medchemexpress LLC RS100329 hydrochloride | 1215654-26-4 | 99.6% | 462.89 g/mol | C20H26ClF3N4O3 | 25 MG
RS100329 hydrochloride is the hydrochloride salt of RS100329, a potent and selective α1A-adrenoceptor antagonist used in pharmacological research, including studies of urethral reflex contractions and benign prostatic hyperplasia. It is supplied as a solid research chemical with high reported purity and defined storage recommendations.
- Potent, selective α1A-adrenoceptor antagonist (pKi 9.6 for α1A).
- High purity (≈99.6% by HPLC), suitable for biochemical assays.
- Well-characterized small molecule: molecular weight 462.89 g/mol, formula C20H26ClF3N4O3.
- Provided as a solid hydrochloride salt for accurate dosing in experiments.
- Recommended storage: 4°C protected from light; in solvent, -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Bi-9627 (hydrochloride) | 1422252-46-7 | 98.01% | 392.80 | 1 ML
BI-9627 hydrochloride is a potent inhibitor of sodium-hydrogen exchanger isoform 1 (NHE1), exhibiting high selectivity over NHE2 and no measurable activity against NHE3. This compound shows low agent-agent interaction potential, excellent pharmacokinetics, and potent activity in isolated heart models of ischemia-reperfusion injury. It is intended for research use only.
- Decreases autophagy in HTR-8/SVneo cells.
- Significantly reduces the pHi of human sperm and partially reverses the effect of DMA.
- Prolongs Ca2+ recovery time in KO hiPSC-CMs.
- Shows low DDI potential.
- Excellent pharmacokinetics in rat and dog.
- Potent activity in isolated heart models of ischemia-reperfusion injury.
Medchemexpress LLC His-pro (hydrochloride) | 2415727-78-3 | 99.8% | 288.73 | 10 MG
His-Pro hydrochloride, also known as Histidyl-proline hydrochloride, is a dipeptide composed of histidyl and proline. This compound is commonly used in laboratory research.
- Dipeptide
- Solid appearance
- White to off-white color
Medchemexpress LLC AZD9056 hydrochloride | 345303-91-5 | MFCD30533694 | 98.2% | 455.46 | 1 ML
AZD9056 hydrochloride is a selective, orally active inhibitor of P2X7, a receptor involved in inflammation and pain-causing diseases. It is for research use only.
- Selectively inhibits P2X7 receptors.
- Exhibits pain-relieving and anti-inflammatory effects.
- Blocks P2X7 receptors with an IC50 of 11.2 nM in HEK-hP2X7 cell line.
- Shows inhibitory effect (IC50=1-3 μM) in mouse microglia BV2 cells.
- Reverses upregulated expression of IL-1β, IL-6, TNF-α, MMP-13, SP, and PGE2 induced by MIA in cartilage tissues.
- Investigated in clinical trials for conditions like rheumatoid arthritis.
Medchemexpress LLC Delapril (hydrochloride) | 83435-67-0 | MFCD00884619 | 98.0% | 489.00 g·mol⁻¹ | C26H33ClN2O5 | 100 MG
Delapril hydrochloride is the hydrochloride salt of delapril, a lipophilic angiotensin-converting enzyme (ACE) inhibitor used in preclinical research on hypertension and cardiovascular pharmacology. The compound is supplied as a solid research reagent with confirmed identity and analytical data.
- Research reagent for ACE inhibition and cardiovascular studies.
- CAS number 83435-67-0.
- Molecular formula C26H33ClN2O5; molecular weight 489.00 g·mol⁻¹.
- Purity 98.0% (NMR) as stated on COA.
- Physical appearance solid.
- Recommended storage 4°C; in solvent -80°C for 6 months, -20°C for 1 month (sealed).
- Packaged as 100 mg research quantity.