Aminophenols
Medchemexpress LLC CX-6258 hydrochloride hydrate | 1353858-99-7 | 99.2% | 516.42 | 1 ML
CX-6258 hydrochloride hydrate is a potent and kinase selective pan-Pim kinases inhibitor, with IC50s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively.
- Potent and kinase selective pan-Pim kinases inhibitor
- IC50s of 5 nM (Pim-1), 25 nM (Pim-2), 16 nM (Pim-3)
- Causes dose-dependent inhibition of the phosphorylation of pro-survival proteins Bad and 4E-BP1 at specific Pim kinase sites (S112, S65, T37/46)
- Diminishes steady-state levels and reduces half-life of ectopic NKX3.1 in PC3 cells
- Exhibits robust in vivo efficacy in two Pim kinases driven tumor models (e.g., MV-4-11 xenograft models in nude mice)
Medchemexpress LLC MRT-83 (hydrochloride) | 1359944-60-7 | 99.6% | 575.05 | 25 MG
MRT-83 (hydrochloride) is a potent antagonist of the Smoothened (Smo) receptor. It inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. MRT-83 (hydrochloride) has potential for researching cancer disease.
- Potent antagonist of Smoothened (Smo) receptor.
- Inhibits the Hedgehog (Hh) signaling pathway.
- Inhibits BODIPY-cyclopamine binding to human Smo.
- Potential for researching cancer disease.
![Medchemexpress LLC 8-methyl-8-azabicyclo[3.2.1]octan-3-yl 2-oxo-1,4-dihydroquinazoline-3-carboxylate hydrochloride | 131780-48-8 | MFCD00911718 | 99.0% | 351.83 g/mol | C17H22ClN3O3 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000242163.png-250.jpg)
Medchemexpress LLC 8-methyl-8-azabicyclo[3.2.1]octan-3-yl 2-oxo-1,4-dihydroquinazoline-3-carboxylate hydrochloride | 131780-48-8 | MFCD00911718 | 99.0% | 351.83 g/mol | C17H22ClN3O3 | 5 MG
DAU 5884 hydrochloride is a potent, selective muscarinic M3 receptor antagonist provided as the hydrochloride salt for research use. It is used in vitro to study muscarinic receptor-mediated signaling, including methacholine-dependent cell proliferation and smooth muscle contractility.
- Potent M3 receptor antagonist suitable for in vitro pharmacology.
- Inhibits methacholine-dependent cell proliferation and muscle contractility.
- High reported purity for reliable experimental results.
- Available in small milligram quantities for screening and characterization.
- Soluble in water and DMSO for diverse assay formats.
- Provided as a hydrochloride salt for improved stability and handling.
![Medchemexpress LLC Benzamide, 2-(3-aminopropoxy)-5-chloro-N-(1,1-dioxidobenzo[b]thien-6-yl)-hydrochloride | 2415263-08-8 | 98.7% | 429.32 | C18H18Cl2N2O4S | 5MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000236424.png-250.jpg)
Medchemexpress LLC Benzamide, 2-(3-aminopropoxy)-5-chloro-N-(1,1-dioxidobenzo[b]thien-6-yl)-hydrochloride | 2415263-08-8 | 98.7% | 429.32 | C18H18Cl2N2O4S | 5MG
HJC0416 hydrochloride is the hydrochloride salt of a small-molecule STAT3 inhibitor that reduces STAT3 phosphorylation, inhibits cell proliferation in vitro, and has shown antitumor activity in preclinical models. It is supplied as a white to off-white solid with high analytical purity and is intended for laboratory research use only.
- Potent STAT3 inhibitor with reported in vitro IC50 0.04-1.97 μM.
- Demonstrated oral bioavailability and antitumor activity in preclinical models.
- High purity (98.7% by HPLC).
- Molecular weight 429.32 and chemical formula C18H18Cl2N2O4S.
- White to off-white solid appearance.
- Storage: -20 °C, protect from light; in solvent: -80 °C (6 months) or -20 °C (1 month).
- For laboratory research use only; not for human or clinical use.
Medchemexpress LLC 2,4-di-tert-butylphenol | 96-76-4 | MFCD00008828 | 100.0% | 206.33 g/mol | C14H22O | 1 ML
2,4-di-tert-butylphenol is a substituted phenol supplied as a 10 mM solution in DMSO for research and analytical applications. The compound has a molecular weight of 206.33 g/mol, a molecular formula of C14H22O, and high reported purity, with supporting COA and SDS documents available from the manufacturer.
- High purity suitable for analytical and research use.
- Provided as a ready-to-use 10 mM solution in DMSO for convenience.
- Small 1 mL volume ideal for screening and small-scale experiments.
- Accompanied by certificate of analysis and safety data sheet for traceability.
- Stable storage and handling information available in SDS.
Medchemexpress LLC 4-((4-(4-chlorophenyl)-2-thiazolyl)amino)phenol | 312636-16-1 | MFCD00733553 | 99.3% | C15H11ClN2OS | 10MG
SKI II is a small-molecule research inhibitor of sphingosine kinase used to probe SK1 and SK2 activity in biochemical and cellular studies. It is supplied as a white to off-white solid with high purity and is intended for research use only.
- High purity (~99.3% by LCMS) suitable for analytical and biological experiments.
- Inhibits sphingosine kinase with reported IC50 values of ~78 μM (SK1) and ~45 μM (SK2).
- Cell-permeable, enabling use in cell-based assays.
- Stable when stored as recommended: powder at -20°C, in solvent at -80°C.
- Provided with certificate of analysis and safety data for quality and handling information.
Medchemexpress LLC O-(6-Chlorobenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate | 330645-87-9 | 99.4% | 413.69 | 1000 G
HCTU is a biochemical reagent that can be used as a biological material or organic compound for life science related research. It is for research use only and not sold to patients.
Medchemexpress LLC Acetaminophen | 103-90-2 | 99.97% | C8H9NO2 | 10 G
Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor and a widely used antipyretic and analgesic agent. It is also a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor that induces ferroptosis and can lead to acute liver injury in mice models.
- Selective COX-2 inhibitor with an IC50 of 25.8 μM
- Widely used as an antipyretic and analgesic
- Potent hepatic N-acetyltransferase 2 (NAT2) inhibitor
- Induces ferroptosis
- Can lead to acute liver injury in mice models
Medchemexpress LLC Fasudil (hydrochloride) | 105628-07-7 | MFCD00943198 | 100.0% | 327.83 g·mol⁻¹ | C14H18ClN3O2S | 1 ML
Fasudil hydrochloride is a small-molecule Rho-associated kinase (ROCK) inhibitor used in biochemical and cellular research. It inhibits ROCK1/2 and several protein kinases, and acts as a calcium channel antagonist and vasodilator. The compound is supplied as a purified solid or as a ready-to-use 10 mM solution in DMSO (1 mL). Molecular formula C14H18ClN3O2S; molecular weight 327.83 g·mol⁻¹. For research use only - not for human or clinical use.
- Ready-to-use 10 mM solution in DMSO, 1 mL.
- Also available as purified solid in multiple pack sizes.
- High purity (≈99.97%).
- Stable when stored sealed at 4°C; in solution store at -20°C to -80°C.
- Intended for biochemical and cellular assays targeting ROCK signaling.