Aminophenols
Medchemexpress LLC LMP744 hydrochloride | 308246-57-3 | 488.92 | 1 ML
LMP744 hydrochloride (MJ-III65 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity. It is intended for research use only.
- Dose-dependent accumulation of cells in the S and G2 phases of the cell cycle
- Antiproliferative activity against various human cell lines
- Moderately active against human A253 and FaDu tumor xenografts in nude mice
Medchemexpress LLC Delapril hydrochloride | 83435-67-0 | MFCD00884619 | 98.0% | 489.00 | C26H33ClN2O5 | 50 MG
Delapril hydrochloride is the hydrochloride salt of delapril, a lipophilic angiotensin-converting enzyme (ACE) inhibitor commonly used in cardiovascular research. Supplied for research use only, the compound is characterized for identity and analytical purity to support experimental studies.
- Hydrochloride salt form for improved solubility and stability.
- High purity: 98.0% (NMR).
- Molecular formula C26H33ClN2O5; molecular weight 489.00.
- Available in solid quantities including 50 mg.
- Analytical documentation available: COA and SDS.
- Intended for in vitro and preclinical ACE inhibition studies.
Medchemexpress LLC SKI-I | 5MG
SKI-I is a potent and selective inhibitor of human sphingosine kinase (SK) with an IC50 of 1 2 M for ST-hSK SKI-I also inhibits hERK2 (IC50 11 M) SKI-I induces apoptosis in tumor cell lines[1][2]
Medchemexpress LLC HJC0416 hydrochloride | 2415263-08-8 | 98.7% | 429.32 g/mol | C18H18Cl2N2O4S | 25MG
HJC0416 hydrochloride is the hydrochloride salt of HJC0416, a potent, orally active small-molecule STAT3 inhibitor used in preclinical anticancer research. Supplied as a white to off-white solid with high chemical purity, it is intended for in vitro and in vivo studies assessing STAT3 pathway modulation.
- Potent STAT3 inhibition in preclinical models.
- Oral activity demonstrated in animal studies.
- High purity suitable for research applications.
- Available in small research pack sizes, including 25 mg.
- Store protected from light and under inert gas at recommended temperatures.
Medchemexpress LLC MRL-494 hydrochloride | 2699937-04-5 | 98.6% | 1 MG
MRL-494 hydrochloride is an antibacterial agent that functions as an inhibitor of β-barrel assembly machine A (BamA), remaining impervious to efflux and the outer membrane permeability barrier. It effectively inhibits both Gram-positive and Gram-negative bacteria by lethally disrupting the cytoplasmic membrane and inhibiting Outer Membrane Proteins (OMPs) biogenesis.
- Antibacterial agent
- Inhibitor of β-barrel assembly machine A (BamA)
- Impervious to efflux and the outer membrane permeability barrier
- Inhibits gram-positive bacteria
- Inhibits gram-negative bacteria
- Lethally disrupts the cytoplasmic membrane
- Inhibits outer membrane proteins (OMPs) biogenesis
Medchemexpress LLC Ozanimod hydrochloride | 1618636-37-5 | 98.1% | 10 MG
Ozanimod hydrochloride is the hydrochloride salt of ozanimod (RPC-1063), a selective sphingosine 1-phosphate (S1P) receptor modulator supplied for laboratory research use only. It is used in studies of immune modulation and relapsing multiple sclerosis.
- Purity 98.1%.
- Molecular weight 440.92.
- Molecular formula C23H25ClN4O3.
- White to off-white solid; also available as 10 mM solution in DMSO.
- Storage: 4°C sealed; in solvent: -80°C (6 months), -20°C (1 month).
- Intended for laboratory research on S1P receptor biology and multiple sclerosis models.
Medchemexpress LLC Zzw-115 hydrochloride | 10122-45-9 | 98.1 % | 573.97 | 5 MG
ZZW-115 hydrochloride is a potent NUPR1 inhibitor with a Kd of 2.1 μM. It induces tumor cell death through necroptosis and apoptosis, demonstrating anticancer activity. It is efficient in killing various cancer cells with IC50 values ranging from 0.42 μM to 4.93 μM. This compound also induces a decrease in ATP production and a ROS overproduction.
- Efficient in killing cancer cells with IC50 values ranging from 0.42 μM to 7.75 μM
- Induces tumor cell death via necroptosis and apoptosis
- Decreases ATP production and induces ROS overproduction
- Inhibits the growth of pancreatic xenografted tumors in vivo
- Demonstrates potent anticancer activity
Medchemexpress LLC Riluzole hydrochloride | 850608-87-6 | 99.87% | 1 G
Riluzole hydrochloride is an anticonvulsant agent that acts as a use-dependent Na+ channel blocker. It can also inhibit GABA uptake with an IC50 of 43 μM.
- Anticonvulsant agent
- Use-dependent Na+ channel blocker
- Can inhibit GABA uptake
- Inhibits peak autaptic IPSCs and prolongs IPSCs at 20 μM
- Causes a strong, concentration-dependent, readily reversible enhancement of responses to 2 μM GABA
Medchemexpress LLC ZLN024 hydrochloride | 1883548-91-1 | 98.5% | 361.69 | 100 MG
ZLN024 hydrochloride is an allosteric activator of AMPK. It directly activates recombinant AMPK α1β1γ1, AMPK α2β1γ1, AMPK α1β2γ1, and AMPK α2β2γ1 heterotrimers.
- Allosterically stimulates active AMPK heterotrimers and inactive α1 subunit truncations.
- AMPK activation requires pre-phosphorylation of Thr-172 and protects AMPK Thr-172 against dephosphorylation by PP2Cα.
- Activates AMPK in L6 myotubes, stimulating glucose uptake and fatty acid oxidation without increasing the ADP/ATP ratio.
- Increases the activity of α1β1γ1 by 1.5-fold (EC50 of 0.42 μM), α2β1γ1 by 1.7-fold (EC50 of 0.95 μM), α1β2γ1 by 1.7-fold (EC50 of 1.1 μM), and α2β2γ1 by 1.6-fold (EC50 of 0.13 μM).
- Improves glucose tolerance in C57BKS db/db mice after 4 weeks of treatment.
- Reduces fasting blood glucose by 15%, liver tissue weight, triacylglycerol, and total cholesterol content in mice.
Medchemexpress LLC AFM32a hydrochloride | 2988594-85-8 | 99.4% | 517.00 | 1 ML
AFM32a hydrochloride, also known as PAD2-IN-1 hydrochloride, is a potent and selective benzimidazole-based derivative that inhibits protein arginine deiminase 2 (PAD2). It demonstrates high selectivity, being 95-fold more selective for PAD2 over PAD4 and 79-fold more selective over PAD3.
- Potent and selective PAD2 inhibitor.
- Exhibits superior selectivity over PAD4 and PAD3.
- Effective in inhibiting histone H3 citrullination in HEK293T/PAD2 cells.
Medchemexpress LLC LCKLSL hydrochloride | 533902-29-3 | 98.05% | 712.34 | 25 MG
LCKLSL hydrochloride is a N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. It potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2. Additionally, this peptide has anti-angiogenic roles and inhibits the generation of plasmin.
- N-terminal hexapeptide
- Acts as a competitive annexin A2 (AnxA2) inhibitor
- Potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2
- Inhibits the generation of plasmin
- Exhibits anti-angiogenic properties
- Suppresses VEGF-induced tPA activity under hypoxic conditions
- Decreases vascular length in angiogenesis models
Aobchem 3-Azetidineacetic acid 1 1-dimethylethyl ester hydrochloride (1 1) | ≥95% | CAS 2173991-98-3 | 5g
3-Azetidineacetic acid 1 1-dimethylethyl ester hydrochloride (1 1) | ≥95% | CAS 2173991-98-3 | 5g
Aobchem 3-Azetidineacetic acid 1 1-dimethylethyl ester hydrochloride (1 1) | ≥95% | CAS 2173991-98-3 | 250mg
3-Azetidineacetic acid 1 1-dimethylethyl ester hydrochloride (1 1) | ≥95% | CAS 2173991-98-3 | 250mg
Medchemexpress LLC Chromotropic acid disodium dihydrate | 5808-22-0 | MFCD00150612 | 400.29 g/mol | C10H10Na2O10S2 | 50G
Chromotropic acid disodium dihydrate is a solid laboratory reagent used primarily for the colorimetric detection of formaldehyde. The disodium salt dihydrate form is formulated for analytical and research use and dissolves in water with heating and ultrasonic assistance, enabling preparation of aqueous assay solutions.
- Can be used for the detection of formaldehyde.
- Soluble in water (≈50 mg/mL) with ultrasonic and warming.
- Molecular weight 400.29 g/mol.
- Available in laboratory-scale pack sizes for analytical use.
Aobchem 3-Azetidineacetic acid 1 1-dimethylethyl ester hydrochloride (1 1) | ≥95% | CAS 2173991-98-3 | 500mg
3-Azetidineacetic acid 1 1-dimethylethyl ester hydrochloride (1 1) | ≥95% | CAS 2173991-98-3 | 500mg