Aminophenols
Medchemexpress LLC G-5555 hydrochloride | 2319590-15-1 | 98.3% | 529.42 | 25 MG
G-5555 hydrochloride is a potent and selective p21-activated kinase 1 (PAK1) inhibitor with a Ki of 3.7 nM. This compound is intended for research use only.
- Potent and selective p21-activated kinase 1 (PAK1) inhibitor.
- Exhibits excellent kinase selectivity.
- Shows low blood clearance and acceptable half-life.
- Offers good oral exposure and high oral bioavailability.
- Demonstrates tumor growth inhibition in xenograft models.
Medchemexpress LLC LY266097 hydrochloride | 172895-39-5 | MFCD00949080 | 99.6% | 407.33 | C21H24Cl2N2O2 | 50 MG
LY266097 hydrochloride is the hydrochloride salt of LY266097, a selective serotonin 5-HT2B receptor antagonist used in pharmacological research. It is supplied as a solid powder with reported molecular formula C21H24Cl2N2O2, molecular weight 407.33, and high purity suitable for in vitro and in vivo studies. Reported binding affinities include pKi values of 9.8 (5-HT2B), 7.7 (5-HT2A), and 7.6 (5-HT2C).
- High purity (99.6%).
- Solid powder, light yellow to light brown.
- Molecular formula C21H24Cl2N2O2; molecular weight 407.33.
- Selective 5-HT2B receptor antagonist (reported pKi 9.8 for 5-HT2B).
- Storage: store sealed at 4°C, away from moisture and light; in solvent -80°C (6 months) or -20°C (1 month).
- Intended for research use.
Medchemexpress LLC S-14506 hydrochloride | 286369-38-8 | 99.9% | 443.94 g/mol | C24H27ClFN3O2 | 5 MG
S-14506 hydrochloride is the hydrochloride salt of S-14506, a potent 5-HT1A receptor agonist that also shows 5-HT2A/2C antagonist and dopamine antagonist activity. It is supplied as a high-purity research reagent for preclinical pharmacology, receptor-binding, and cell-based assays, available as solid material and DMSO solutions.
- Potent 5-HT1A agonist with 5-HT2A/2C antagonist properties.
- Also displays dopamine antagonist activity.
- High purity (99.92%), suitable for analytical and biological assays.
- Available as solid and 10 mM DMSO solution formats.
- Supplied in small research pack sizes (for example, 5 mg).
Medchemexpress LLC (E)-3-(2-((4-chlorophenyl)thio)phenyl)-N-(4-(dimethylamino)butyl)acrylamide hydrochloride | 1217201-17-6 | >99.0% | 425.41 | C21H25ClN2OS·HCl | 5 MG
A-350619 hydrochloride is a research-grade small-molecule activator of soluble guanylate cyclase (sGC). Supplied as the hydrochloride salt with high purity, it is used in preclinical studies probing NO-sGC signalling pathways and pharmacology related to erectile dysfunction.
- Activates soluble guanylate cyclase (sGC) in biochemical and cellular assays.
- Supplied as the hydrochloride salt for improved solubility.
- High purity suitable for research use (>99% HPLC).
- Molecular weight 425.41.
- Store at 4 °C to maintain stability.
- Applicable to preclinical studies of NO-sGC signalling and erectile dysfunction models.
Medchemexpress LLC 3-pyridinecarboxylic acid, 1,2,5,6-tetrahydro-, hydrochloride | 6027-91-4 | MFCD00055191 | 99.9% | 163.60 g/mol | C6H10ClNO2 | 50 MG
Guvacine hydrochloride is the hydrochloride salt of guvacine, a pyridine alkaloid that inhibits GABA transporters. Supplied for research use to study GABA uptake and transporter pharmacology, it has reported activity across cloned human and rat GAT subtypes.
- Inhibits GABA transporter activity; reported IC50s include 14 μM (human GAT-1).
- High purity (≈99.9%) confirmed by COA.
- Molecular weight 163.60 g/mol; molecular formula C6H10ClNO2.
- Available in multiple pack sizes, including 50 mg, and solution formats in DMSO.
- Suitable for biochemical assays and transporter studies.
- Supplied with analytical documentation such as datasheet and COA.
Medchemexpress LLC CPI-455 hydrochloride | 2095432-28-1 | 100.0% | 314.77 | C16H15ClN4O | 10 MG
CPI-455 hydrochloride is the hydrochloride salt of a potent pan-KDM5 inhibitor used as a research tool to probe KDM5-dependent epigenetic mechanisms. It inhibits KDM5 enzymes (IC50 = 10 nM for KDM5A), elevates H3K4me3 levels in cells, and is supplied with high purity for in vitro studies and mechanism-of-action experiments.
- Potent KDM5 inhibition (IC50 = 10 nM).
- Elevates global H3K4me3 levels in cells.
- High purity for reliable biochemical and cellular assays.
- Multiple package sizes for experimental flexibility.
- Recommended storage conditions provided to preserve stability.
- For research use only; not for clinical or human use.
Medchemexpress LLC Acetaminophen (Standard) | 103-90-2 | 100.0% | C8H9NO2 | 25 MG
Acetaminophen (Standard) is an analytical standard of Acetaminophen, primarily used for research and analytical applications. Also known as Paracetamol or 4-Acetamidophenol, it is a selective cyclooxygenase-2 (COX-2) inhibitor and a widely recognized antipyretic and analgesic agent. It also acts as a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.
- Analytical standard for research and analytical applications
- Reference standard for assays
- Suitable for HPLC, GC, and MS experiments
- Functions as a selective cyclooxygenase-2 (COX-2) inhibitor
- Widely used as an antipyretic and analgesic agent
- Acts as a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor
Medchemexpress LLC A 85380 hydrochloride | 174740-86-4 | 97.0% | 237.13 g/mol | C9H14Cl2N2O | 5 MG
A 85380 hydrochloride is a selective neuronal nicotinic acetylcholine receptor agonist with preference for the α4β2 subtype. Supplied as the hydrochloride salt in small research quantities, it is intended for in vitro pharmacology and receptor profiling studies and formulation work.
Medchemexpress LLC CC-401 hydrochloride | 1438391-30-0 | 99.35% | 100 MG
CC-401 hydrochloride is a potent inhibitor of all three forms of JNK, with a Ki ranging from 25 to 50 nM. It demonstrates significant selectivity for JNK over other related kinases and provides specific JNK inhibition in cell-based assays. This compound achieves its effect by competitively binding to the ATP binding site in JNK, thereby inhibiting the phosphorylation of the N-terminal activation domain of c-Jun.
- Potent inhibitor of all three forms of JNK (Ki: 25-50 nM).
- Exhibits at least 40-fold selectivity for JNK compared to other related kinases.
- Provides specific JNK inhibition at concentrations of 1 to 5 μM in cell-based assays.
- Competitively binds the ATP binding site in JNK.
- Inhibits phosphorylation of the N-terminal activation domain of c-Jun.
- Inhibits sorbitol-induced phosphorylation of c-Jun in HK-2 human tubular epithelial cells.
- Slows progression of proteinuria and prevents renal impairment in animal models.
Medchemexpress LLC LDC4297 hydrochloride | 2319747-14-1 | 98.2% | 10 MG
LDC4297 hydrochloride is a selective inhibitor of CDK7 with an IC50 value of 0.13 nM. It demonstrates broad antiviral activities against various viruses, including human cytomegalovirus (HCMV) replication with an EC50 value of 24.5 nM. Its antiviral spectrum extends to Herpesviridae, Adenoviridae, Poxviridae, Retroviridae, and Orthomyxoviridae, with EC50 values ranging from 0.02-1.21 μM. This compound is suitable for research related to infection.
- Selective inhibitor of CDK7
- Inhibits human cytomegalovirus (HCMV) replication
- Shows broad antiviral activities against multiple virus families
- Exhibits anti-proliferative activity against human fibroblast primary cultures
- Interferes with virus-induced Rb phosphorylation
- Demonstrates promising pharmacokinetic properties in CD1 mice