Aminophenols
Medchemexpress LLC Acetaminophen | 103-90-2 | 99.97% | C8H9NO2 | 10 G
Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor and a widely used antipyretic and analgesic agent. It is also a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor that induces ferroptosis and can lead to acute liver injury in mice models.
- Selective COX-2 inhibitor with an IC50 of 25.8 μM
- Widely used as an antipyretic and analgesic
- Potent hepatic N-acetyltransferase 2 (NAT2) inhibitor
- Induces ferroptosis
- Can lead to acute liver injury in mice models
Medchemexpress LLC ZZW-115 hydrochloride | 10122-45-9 | 98.1% | 573.97 | 1 ML
ZZW-115 hydrochloride is a potent NUPR1 inhibitor with a Kd of 2.1 μM. It demonstrates anticancer activity by inducing tumor cell death through both necroptosis and apoptosis.
- Potent NUPR1 inhibitor.
- Induces tumor cell death.
- Leads to necroptosis and apoptosis.
- Exhibits anticancer activity.
Medchemexpress LLC Sotorasib-d7 | 2296729-00-3 | 98.9% | 567.64 | 10 MG
Sotorasib-d7 is a deuterium-labeled Sotorasib and a first-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor. It irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state, leading to the regression of KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer (NSCLC).
- Deuterium-labeled Sotorasib.
- First-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor.
- Irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state.
- Leads to the regression of KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer (NSCLC).
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Apexbio Technology LLC 2,4-Di-tert-butylphenol 96-76-4 1g
2 4-Di-tert-butylphenol (CAS 96-76-4) is an endogenous metabolic compound recognized for its antioxidant and anti-inflammatory properties Mechanistic studies have demonstrated that 2 4-Di-tert-butylphenol modulates the expression of genes involved in apoptotic pathways leading to the induction of apoptosis in cancer cell models Additionally experimental evidence indicates antiviral and antifungal activities supporting its use in investigations of infection mechanisms This compound is therefore relevant for research in oncology inflammation and the study of pathogen-host interactions
Medchemexpress LLC Acetaminophen (Paracetamol) | 103-90-2 | MFCD00002328 | 99.97% | C8H9NO2 | 500 MG
Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM. It is widely used as an antipyretic and analgesic agent. It has also been identified as a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor and can induce ferroptosis, leading to acute liver injury in a mice model.
- Selective cyclooxygenase-2 (COX-2) inhibitor
- Functions as an antipyretic and analgesic agent
- Potent hepatic N-acetyltransferase 2 (NAT2) inhibitor
- Induces ferroptosis
Apexbio Technology LLC MOG (35-55) 149635-73-4 1mg
MOG (35-55) (CAS 149635-73-4) is a truncated peptide derived from human myelin oligodendrocyte glycoprotein (MOG) MOG an immunoglobulin superfamily glycoprotein specifically expressed in the central nervous system serves as a target antigen in experimental autoimmune encephalomyelitis (EAE) an animal model resembling multiple sclerosis (MS) The MOG (35-55) peptide induces strong inflammatory responses via activation of autoreactive T cells and promotion of autoantibody production leading to extensive demyelination Due to its prominent encephalitogenic properties it is widely utilized in preclinical research for studying MS pathogenesis and therapeutic interventions
Medchemexpress LLC Nefopam (hydrochloride) | 23327-57-3 | 99.9% | 1 ML
Nefopam hydrochloride is a centrally-acting, non-opioid analgesic drug used for the relief of moderate to severe pain. It targets β-catenin protein levels in mesenchymal cells both in-vitro and in-vivo. This non-opioid, non-steroidal analgesic is derived from benzoxazocine. Constitutively elevated β-catenin leads to delayed and fibrous fracture repair, and Nefopam inhibits β-catenin mediated signaling during skin wound repair.
- Centrally-acting, non-opioid analgesic
- Relieves moderate to severe pain
- Targets β-catenin protein levels
- Inhibits β-catenin mediated signaling
Medchemexpress LLC Sotorasib-d7 | 98.9% | 567.64 | 1 MG
Sotorasib-d7 (AMG-510-d7) is a deuterium-labeled Sotorasib. Sotorasib is a first-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor. It irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state, leading to the regression of KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer (NSCLC).
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules for quantitation during the drug development process.
- Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC CBL0137 hydrochloride | 1197397-89-9 | 99.7% | 372.89 | 25 MG
CBL0137 hydrochloride is a potent inhibitor of the histone chaperone FACT, known to activate p53 and inhibit NF-κB. It has demonstrated significant activity in vitro, leading to the absence of living cells at concentrations above 2.5 μM, and enhancing the efficacy of gemcitabine in pancreatic cancer cell lines. In vivo studies show it suppresses tumor growth in various xenograft models, including colon, renal cell carcinoma, and melanoma, both as monotherapy and in combination with gemcitabine. This product is intended for research use only.
- Inhibits histone chaperone FACT.
- Activates p53 and inhibits NF-κB.
- Suppresses tumor growth in xenograft models.
- Enhances gemcitabine antitumor activity.
- Suitable for in vitro and in vivo studies in cancer research.
Medchemexpress LLC V-9302 hydrochloride | 2416138-42-4 | 99.1% | 575.14 | 10 MM * 1 ML
V-9302 hydrochloride is a competitive antagonist of transmembrane glutamine flux, selectively targeting the amino acid transporter ASCT2 (SLC1A5) but not ASCT1. It inhibits ASCT2-mediated glutamine uptake with an IC50 of 9.6 μM in HEK-293 cells. This product is for research use only and not intended for patient use. Pharmacological blockade with this compound leads to attenuated cancer cell growth and proliferation, increased cell death, and increased oxidative stress. In vivo, it prevents tumor growth in both HCT-116 and HT29 xenograft models.
- Competitive antagonist of transmembrane glutamine flux
- Selectively targets ASCT2 (SLC1A5)
- Inhibits ASCT2-mediated glutamine uptake with an IC50 of 9.6 μM
- Attenuates cancer cell growth and proliferation
- Increases cell death and oxidative stress
- Prevents tumor growth in xenograft models
Medchemexpress LLC SKI-178 | 1259484-97-3 | 99.3% | 50 MG
SKI-178 is a potent inhibitor of both sphingosine kinase-1 (SphK1) and sphingosine kinase-2 (SphK2). It demonstrates cytotoxicity in various cancer cell lines, including agent-sensitive and multi-agent resistant types, with IC50 concentrations ranging from 0.1 to 1.8 μM. This compound has been shown to induce apoptosis in human acute myeloid leukemia cell lines in a CDK1-dependent manner and correlates with prolonged Bcl-2 phosphorylation. In in-vivo studies, SKI-178 inhibited leukemic progression in the MLL-AF9 mouse model, leading to a decrease in white blood cell counts.
- Potent SphK1 and SphK2 inhibitor
- Exhibits cytotoxicity in various cancer cell lines
- Induces apoptosis in human acute myeloid leukemia cells
- Correlates with prolonged Bcl-2 phosphorylation
- Inhibits leukemic progression in MLL-AF9 mouse model
Medchemexpress LLC Tas4464 hydrochloride | 1848959-11-4 | 98.9% | 1 ML
TAS4464 hydrochloride is a long-acting, highly selective covalent inhibitor that targets the NEDD8-activating enzyme (NAE) with an IC50 of 0.955 nM. It blocks the neddylation pathway, leading to the accumulation of CRL ubiquitin ligase substrates and subsequent induction of tumor cell apoptosis. This compound exhibits broad-spectrum antiproliferative and cytotoxic antitumor activity against various hematologic and solid tumor cell lines, as well as patient-derived tumor cells, while possessing a wide therapeutic window without obvious toxicity.
- Highly selective covalent inhibitor of NEDD8-activating enzyme (NAE)
- Blocks the neddylation pathway
- Induces tumor cell apoptosis
- Exhibits broad-spectrum antitumor activity
- Possesses a wide therapeutic window
- Suitable for research in hematologic malignancies and solid tumors
Medchemexpress LLC 4-tert-Octylphenol | 140-66-9 | 99.7% | 1000 G
4-tert-Octylphenol is an endocrine-disrupting chemical and an estrogenic agent, also a biodegradation product of non-ionic surfactants alkylphenol polyethoxylates. It induces apoptosis in neuronal progenitor cells in offspring mouse brain, reduces bromodeoxyuridine (BrdU), mitotic marker Ki67, and phospho-histone H3 (p-Histone-H3), which leads to a reduction of neuronal progenitor proliferation. 4-tert-Octylphenol disrupts brain development and behavior in mice.
- Endocrine-disrupting chemical
- Estrogenic agent
- Biodegradation product of non-ionic surfactants alkylphenol polyethoxylates
- Induces apoptosis in neuronal progenitor cells in offspring mouse brain
- Reduces neuronal progenitor proliferation by affecting BrdU, Ki67, and phospho-histone H3
- Disrupts brain development and behavior in mice
- Promising for research of immune response, neuro-related diseases and ethology
Medchemexpress LLC CC-115 hydrochloride | 1300118-55-1 | 98.0% | 372.81 | 100 MG
CC-115 hydrochloride is a potent dual DNA-PK and mTOR kinase inhibitor that blocks both mTORC1 and mTORC2 signaling. It inhibits PC-3 cell proliferation and demonstrates selectivity against other protein kinases and PIKKs, including good selectivity against PI3K-alpha, ATR, and ATM. It shows good in vivo PK profiles across multiple species.
- Potent and dual DNA-PK and mTOR kinase inhibitor (IC50s of 13 nM and 21 nM respectively)
- Blocks both mTORC1 and mTORC2 signaling
- Inhibits PC-3 cells proliferation with an IC50 of 138 nM
- Demonstrates selectivity against other protein kinases and PIKKs
- Shows good in vivo PK profiles across multiple species (53% in mouse, 76% in rat, and ~100% in dog oral bioavailability)
- Leads to significant tumor volume reductions and sustains inhibition in vivo
Medchemexpress LLC ZZW-115 hydrochloride | 10122-45-9 | 98.09% | 573.97 | 25 MG
ZZW-115 hydrochloride is a potent NUPR1 inhibitor with a Kd of 2.1 μM. It induces tumor cell death through necroptosis and apoptosis, demonstrating anticancer activity.
- Effective in killing cancer cells with IC50 values ranging from 0.84 μM to 4.93 μM in various cell lines in vitro.
- Induces pancreatic cell death by necrosis and apoptosis, leading to decreased ATP production and increased ROS overproduction.
- Causes higher LDH release and greater caspase 3/7 activity in a concentration-dependent manner.
- Inhibits the growth of pancreatic xenografted tumors in mice when administered at 0.5-5 mg/kg daily for 30 days via injection.
- Dosage of 5 mg/kg for 30 days resulted in almost unmeasurable tumor sizes in some cases of C57BL/6 mice.
- Caused tumors to progressively decrease and almost disappear by the end of treatment in nude mice xenografted with MiaPaCa-2 cells at a 5 mg/kg dose.